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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation


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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS
(PMID:26260791)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) RGD PMID:28164773 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO UniProtKB:P05067 (PMID:24499793) RGD PMID:24499793 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (MGI:5795815|PMID:23070049) RGD PMID:23070049 MGI:5795815 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287
JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO (PMID:24612608) RGD PMID:24612608 NCBI chr10:65,304,901...65,329,332
Ensembl chr10:65,304,902...65,329,312
JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) RGD PMID:24305806 PMID:27853422 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5487687|PMID:23467355), (MGI:5553242|PMID:18429932), (MGI:5774886|PMID:27030769)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 MGI:5487687 MGI:5553242 MGI:5774886 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
(PMID:24259049)
GO_REF:0000107
(PMID:24154541)
RGD
Ensembl
PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA
(PMID:27179792)
(MGI:5811968|PMID:27179792)
GO_REF:0000107
RGD
Ensembl
PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:12047389), (PMID:17412999)
Alzheimers_University_of_Toronto
Ensembl
RGD
PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:104,137,655...104,156,576
Ensembl chr10:104,137,655...104,156,576
JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in IEA
ISO
GO_REF:0000107
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
Ensembl
RGD
PMID:27277332 GO_REF:0000107 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)
Ensembl
RGD
PMID:26094765 GO_REF:0000107 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Olfm1 olfactomedin 1 acts_upstream_of_or_within ISO (MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:5444053 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(MGI:3620333|PMID:16554819)
RGD PMID:16554819 PMID:25576397 MGI:3620333 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA
(PMID:24305806), (PMID:27853422)
GO_REF:0000107
RGD
Ensembl
PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rtn1 reticulon 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15286784)
UniProt
Ensembl
RGD
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:94,951,016...95,177,477
Ensembl chr 6:94,951,020...95,061,174
JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS
(PMID:15286784)
GO_REF:0000024
RGD
UniProt
PMID:15286784 GO_REF:0000024 NCBI chr 1:80,195,594...80,208,449
Ensembl chr 1:80,195,532...80,208,448
JBrowse link
G Rtn3 reticulon 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:15286784)
UniProt
RGD
PMID:15286784 GO_REF:0000024 NCBI chr 1:222,677,359...222,734,307
Ensembl chr 1:222,677,365...222,734,241
JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA
ISS
(PMID:15286784)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
(MGI:3801250|PMID:18362153), (MGI:3821635|PMID:19036982)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 PMID:21989385 PMID:22621900 PMID:24001769 PMID:24523320 MGI:3801250 MGI:3821635 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3607023|PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 MGI:3607023 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5811968|PMID:27179792)
(PMID:27179792)
Ensembl
RGD
PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385)
(MGI:3801250|PMID:18362153)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (MGI:3623864|PMID:16641999) RGD PMID:16641999 MGI:3623864 NCBI chr 6:109,169,739...109,205,004
Ensembl chr 6:109,169,741...109,205,004
JBrowse link
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5432454|PMID:22539346)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:22539346 GO_REF:0000024 GO_REF:0000107 MGI:5432454 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:17855360), (PMID:21989385)
(MGI:3801250|PMID:18362153)
RGD PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:46,228,077...46,287,171 JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO UniProtKB:P56818 (PMID:20704561), (PMID:22086926) RGD PMID:20704561 PMID:22086926 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of IGI PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr17:24,020,874...24,103,771
Ensembl chr17:24,021,736...24,103,515
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806)
(MGI:6114922|PMID:24305806)
RGD PMID:24305806 MGI:6114922 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3607023|PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 MGI:3607023 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISO
IMP
(PMID:22086926) RGD PMID:22086926, PMID:22086926 RGD:14697726 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541 PMID:24259049 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Casp3 caspase 3 involved_in IDA
ISO
PMID:17553422
(PMID:17553422)
RGD PMID:17553422, PMID:17553422 RGD:13825190 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107 MGI:4437154 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:2384259|PMID:12145324)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:12145324 GO_REF:0000024 GO_REF:0000107 MGI:2384259 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359
JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Gsap gamma-secretase activating protein involved_in IBA
ISO
PMID:21873635
(MGI:4830390|PMID:20811458)
(PMID:20811458)
RGD PMID:20811458, PMID:21873635 MGI:4830390, RGD:13792537 NCBI chr 4:10,423,090...10,517,887
Ensembl chr 4:10,423,139...10,517,848
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO UniProtKB:P49841 (PMID:12761548) RGD PMID:12761548 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (MGI:3697769|PMID:17255335)
RGD PMID:17255335 PMID:19808651 MGI:3697769 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01579|UniProtKB:P05067 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 involved_in
acts_upstream_of_or_within
ISO (PMID:17098871)
(MGI:3695648|PMID:17098871)
RGD PMID:17098871 MGI:3695648 NCBI chr20:25,990,304...26,163,656
Ensembl chr20:25,990,304...26,163,656
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
IEA
(PMID:24577224)
(MGI:5432454|PMID:22539346), (MGI:5560380|PMID:24577224)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:22539346 PMID:24577224 GO_REF:0000024 GO_REF:0000107 MGI:5432454 MGI:5560380 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO (MGI:6414694|PMID:21329555) RGD PMID:21329555 MGI:6414694 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:6114922|PMID:24305806)
(PMID:24305806)
Ensembl
RGD
PMID:24305806 GO_REF:0000107 MGI:6114922 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO UniProtKB:P05067-4 (PMID:26094765) RGD PMID:26094765 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO (PMID:14701757) RGD PMID:14701757 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA
UniProtKB:P05067:PRO_0000000093 (PMID:22406537)
GO_REF:0000107
RGD
Ensembl
PMID:22406537 GO_REF:0000107 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:Q15109 (PMID:22406537) RGD PMID:22406537 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Efna1 ephrin A1 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Efna3 ephrin A3 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,636,304...188,645,302
Ensembl chr 2:188,637,852...188,645,196
JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827|UniProtKB:P52797 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5432454|PMID:22539346)
GO_REF:0000107
Alzheimers_University_of_Toronto
RGD
Ensembl
PMID:22539346 GO_REF:0000024 GO_REF:0000107 MGI:5432454 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:6114922|PMID:24305806)
(PMID:24305806)
Ensembl
RGD
PMID:24305806 GO_REF:0000107 MGI:6114922 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm1 olfactomedin 1 acts_upstream_of_or_within ISO (MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:5444053 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO UniProtKB:P05067:PRO_0000000092 (MGI:5637941|PMID:26005850) RGD PMID:26005850 MGI:5637941 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO
ISS
(PMID:16641999)
GO_REF:0000024
RGD
UniProt
PMID:16641999 GO_REF:0000024 NCBI chr 6:109,169,739...109,205,004
Ensembl chr 6:109,169,741...109,205,004
JBrowse link
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
(PMID:24577224)
GO_REF:0000024
RGD
Alzheimers_University_of_Toronto
PMID:24577224 GO_REF:0000024 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19633
    metabolic process 11911
      regulation of metabolic process 6825
        regulation of macromolecule metabolic process 6310
          regulation of protein metabolic process 2734
            regulation of amyloid precursor protein catabolic process 45
              negative regulation of amyloid precursor protein catabolic process + 22
              positive regulation of amyloid precursor protein catabolic process + 26
              regulation of amyloid-beta formation + 37
              regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 11
              regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process + 2
Path 2
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  biological_process 19633
    metabolic process 11911
      organic substance metabolic process 11425
        macromolecule metabolic process 9877
          protein metabolic process 5996
            amyloid precursor protein metabolic process 74
              amyloid precursor protein catabolic process 59
                regulation of amyloid precursor protein catabolic process 45
                  negative regulation of amyloid precursor protein catabolic process + 22
                  positive regulation of amyloid precursor protein catabolic process + 26
                  regulation of amyloid-beta formation + 37
                  regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 11
                  regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process + 2
paths to the root