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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta formation
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Accession:GO:0034205 term browser browse the term
Definition:The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP).
Comment:Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000).
Synonyms:exact_synonym: beta-amyloid polypeptide formation from APP;   beta-amyloid polypeptide formation from amyloid precursor protein


show annotations for term's descendants           Sort by:
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS		 (PMID:26260791)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in IMP PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:25043039 PMID:26280335 PMID:27608597 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in
acts_upstream_of_or_within		 ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597)
MGI:1202717|MGI:1891700 (PMID:16371134)		 RGD PMID:12763021 PMID:16371134 PMID:27608597 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Bace1 beta-secretase 1 involved_in ISO (PMID:24352696) RGD PMID:24352696 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in ISO
IEA		 (PMID:25556849)
GO_REF:0000107		 RGD
Ensembl		 PMID:25556849 GO_REF:0000107 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:1202717|MGI:3522097 (PMID:16371134)
UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597)		 UniProt
RGD		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:25043039 PMID:26280335 More... GO_REF:0000024 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 ISO
IBA
ISS		 UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:26280335), (PMID:27608597)
MGI:1891700|MGI:2149116|MGI:3522097 (PMID:16371134), (PMID:20130175)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:20130175 PMID:26280335 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO
IBA		 (PMID:27608597)
GO_REF:0000033		 RGD
GO_Central		 PMID:27608597 GO_REF:0000033 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021), (PMID:25043039), (PMID:26280335)		 UniProt
RGD		 PMID:12660785 PMID:12763021 PMID:25043039 PMID:26280335 GO_REF:0000024 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18429932), (PMID:23467355), (PMID:27030769)		 Alzheimers_University_of_Toronto
RGD		 PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:24154541)
GO_REF:0000107
(PMID:24259049)		 RGD
Ensembl		 PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA		 (PMID:27179792)
GO_REF:0000107		 RGD
Ensembl		 PMID:27179792 GO_REF:0000107 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clu clusterin involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:12047389), (PMID:17412999)
GO_REF:0000107		 Alzheimers_University_of_Toronto
RGD
Ensembl		 PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:100,825,427...100,843,422
Ensembl chr10:100,825,426...100,844,462 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107		 RGD
Ensembl		 PMID:27277332 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:22733824) RGD PMID:22733824 NCBI chr 6:138,163,595...138,163,681
Ensembl chr 6:138,163,595...138,163,681 		JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Mir24-2 microRNA 24-2 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr19:23,954,683...23,954,790
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mir298 microRNA 298 acts_upstream_of ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:163,052,291...163,052,372
Ensembl chr 3:163,052,291...163,052,372 		JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir339 microRNA 339 acts_upstream_of ISO (PMID:24352696) RGD PMID:24352696 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir361 microRNA 361 involved_in ISO (PMID:31601077) RGD PMID:31601077 NCBI chr  X:78,246,206...78,246,275
Ensembl chr  X:78,246,206...78,246,275 		JBrowse link
G Mir455 microRNA 455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) RGD PMID:25100943 PMID:31181293 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)		 Ensembl
RGD		 PMID:26094765 GO_REF:0000107 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(PMID:16554819)		 RGD PMID:16554819 PMID:25576397 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (PMID:17573534) RGD PMID:17573534 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA		 (PMID:24305806), (PMID:27853422)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rtn1 reticulon 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:15286784)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436 		JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS		 (PMID:15286784)
GO_REF:0000024		 RGD
UniProt		 PMID:15286784 GO_REF:0000024 NCBI chr 1:78,935,056...78,948,069
Ensembl chr 1:78,935,104...78,948,069 		JBrowse link
G Rtn3 reticulon 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:15286784)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275 		JBrowse link
G Rtn4 reticulon 4 involved_in ISO
ISS
IEA		 (PMID:15286784)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
(PMID:18362153), (PMID:19036982)		 RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 PMID:21989385 More... NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:16227578)		 Ensembl
RGD		 PMID:16227578 GO_REF:0000107 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA
IMP		 (PMID:22086926)
GO_REF:0000107		 RGD
Ensembl		 PMID:22086926 PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541 PMID:24259049 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Casp3 caspase 3 involved_in IDA
ISO		 PMID:17553422
(PMID:17553422)		 RGD PMID:17553422 PMID:17553422 RGD:13825190 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05067 (PMID:20164328)		 Ensembl
RGD		 PMID:20164328 GO_REF:0000107 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:12145324)
GO_REF:0000024		 Ensembl
RGD
Alzheimers_University_of_Toronto		 PMID:12145324 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794 		JBrowse link
G Efna1 ephrin A1 involved_in ISO
IEA		 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Gsap gamma-secretase activating protein involved_in ISO
IBA		 (PMID:20811458)
GO_REF:0000033		 RGD
GO_Central		 PMID:20811458 GO_REF:0000033 NCBI chr 4:13,813,046...13,907,875
Ensembl chr 4:13,813,046...13,907,814 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO
IEA		 UniProtKB:P49841 (PMID:12761548)
GO_REF:0000107		 RGD
Ensembl		 PMID:12761548 GO_REF:0000107 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (PMID:17255335)		 RGD PMID:17255335 PMID:19808651 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01579|UniProtKB:P05067 (PMID:17255335) RGD PMID:17255335 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO (PMID:17098871) RGD PMID:17098871 NCBI chr20:24,515,627...24,689,669
Ensembl chr20:24,515,627...24,689,669 		JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:27277332) RGD PMID:27277332 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
IEA		 (PMID:24577224)
(PMID:22539346), (PMID:24577224)
GO_REF:0000024
GO_REF:0000107		 RGD
Alzheimers_University_of_Toronto
Ensembl		 PMID:22539346 PMID:24577224 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO (PMID:21329555) RGD PMID:21329555 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO
IEA		 (PMID:24305806)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 GO_REF:0000107 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO UniProtKB:P05067-4 (PMID:26094765) RGD PMID:26094765 NCBI chr 7:122,399,329...122,726,605
Ensembl chr 7:122,399,330...122,726,605 		JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO (PMID:14701757) RGD PMID:14701757 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) RGD PMID:17255335 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO UniProtKB:P05067-PRO_0000000092 (PMID:26005850) RGD PMID:26005850 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO
IEA
ISS		 (PMID:16641999)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16641999 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        amide metabolic process 467
          amyloid-beta metabolic process 72
            amyloid-beta formation 57
              negative regulation of amyloid-beta formation 29
              positive regulation of amyloid-beta formation 21
              regulation of amyloid-beta formation + 48
Path 2
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        macromolecule metabolic process 9812
          protein metabolic process 5297
            amyloid precursor protein metabolic process 91
              amyloid precursor protein catabolic process 70
                amyloid-beta formation 57
                  negative regulation of amyloid-beta formation 29
                  positive regulation of amyloid-beta formation 21
                  regulation of amyloid-beta formation + 48
paths to the root