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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein metabolic process
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Accession:GO:0042982 term browser browse the term
Definition:The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP metabolic process;   APP metabolism;   amyloid precursor protein metabolism


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amyloid precursor protein metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO (PMID:25043039), (PMID:26280335) RGD PMID:25043039 PMID:26280335 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
(PMID:21593558)
GO_REF:0000107
RGD
Ensembl
PMID:21593558 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:109548 (MGI:3699445|PMID:17301176)
Ensembl
RGD
PMID:17301176 GO_REF:0000107 MGI:3699445 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 involved_in ISO (PMID:12805363) RGD PMID:12805363 NCBI chr 5:146,955,607...146,978,601
Ensembl chr 5:146,955,607...146,978,601
JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:25043039), (PMID:26280335)
(MGI:5293284|PMID:21597003)
GO_REF:0000024
RGD
UniProt
PMID:21597003 PMID:25043039 PMID:26280335 GO_REF:0000024 MGI:5293284 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4845784|PMID:21084623)
UniProt
RGD
PMID:21084623 GO_REF:0000024 MGI:4845784 NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514
JBrowse link
G Prnp prion protein NOT|involved_in ISO UniProtKB:P12023|UniProtKB:P49769 (MGI:4454612|PMID:20445063) RGD PMID:20445063 MGI:4454612 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Psen1 presenilin 1 involved_in ISO
ISS
(PMID:26280335)
GO_REF:0000024
RGD
UniProt
PMID:26280335 GO_REF:0000024 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISS
ISO
GO_REF:0000024
(PMID:25043039), (PMID:26280335)
UniProt
RGD
PMID:25043039 PMID:26280335 GO_REF:0000024 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192
JBrowse link
G Tmcc2 transmembrane and coiled-coil domain family 2 involved_in IBA
ISO
PMID:21873635
(PMID:21593558)
RGD PMID:21593558 PMID:21873635 RGD:13792537 NCBI chr13:43,794,029...43,831,716
Ensembl chr13:43,794,029...43,831,716
JBrowse link
amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:3773571|PMID:18201567) RGD PMID:18201567 MGI:3773571 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in ISO (PMID:28164773) RGD PMID:28164773 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO
IEA
(PMID:9774383)
GO_REF:0000107
RGD
Ensembl
PMID:9774383 GO_REF:0000107 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Adam19 ADAM metallopeptidase domain 19 involved_in ISO (PMID:17112471) RGD PMID:17112471 NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 involved_in ISO (PMID:12054541) RGD PMID:12054541 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:27608597 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597) RGD PMID:12763021 PMID:27608597 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
JBrowse link
G Bace1 beta-secretase 1 involved_in ISO UniProtKB:Q9BZC7 (MGI:6356260|PMID:20704561) RGD PMID:20704561 MGI:6356260 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISS
ISO
GO_REF:0000024
(PMID:10924275)
UniProt
RGD
PMID:10924275 GO_REF:0000024 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:3027024 (MGI:3614236|PMID:16407971) RGD PMID:16407971 MGI:3614236 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Ncstn nicastrin involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597) RGD PMID:12763021 PMID:27608597 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within
ISO
IBA
UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:27608597)
MGI:2149116|MGI:2179062|MGI:2449304 (MGI:1334955|PMID:10206645), (MGI:2150480|PMID:11567612), (MGI:3057045|PMID:15452145)
PMID:21873635
RGD PMID:10206645 PMID:11567612 PMID:12297508 PMID:12763021 PMID:15452145 More... MGI:1334955 MGI:2150480 MGI:3057045, RGD:13792537 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 involved_in ISO
IBA
(PMID:27608597)
PMID:21873635
RGD PMID:27608597 PMID:21873635 RGD:13792537 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021) RGD PMID:12660785 PMID:12763021 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192
JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
ISS
IEA
(PMID:26260791)
(MGI:5694857|PMID:26260791)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:26260791 GO_REF:0000024 GO_REF:0000107 MGI:5694857 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in IMP PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:25043039 PMID:26280335 PMID:27608597 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in
acts_upstream_of_or_within
ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597)
MGI:1202717|MGI:1891700 (MGI:3655012|PMID:16371134)
RGD PMID:12763021 PMID:16371134 PMID:27608597 MGI:3655012 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
JBrowse link
G Bace1 beta-secretase 1 involved_in ISO (PMID:24352696) RGD PMID:24352696 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in ISO (PMID:25556849) RGD PMID:25556849 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:1202717|MGI:3522097 (MGI:3655012|PMID:16371134)
UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597)
UniProt
RGD
PMID:12297508 PMID:12763021 PMID:16371134 PMID:25043039 PMID:26280335 More... GO_REF:0000024 MGI:3655012 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within
ISO
ISS
UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:26280335), (PMID:27608597)
MGI:1891700|MGI:2149116|MGI:3522097 (MGI:3655012|PMID:16371134), (MGI:4437371|PMID:20130175)
GO_REF:0000024
RGD
UniProt
PMID:12297508 PMID:12763021 PMID:16371134 PMID:20130175 PMID:26280335 More... GO_REF:0000024 MGI:3655012 MGI:4437371 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 involved_in ISO (PMID:27608597) RGD PMID:27608597 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISS
ISO
GO_REF:0000024
UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021), (PMID:25043039), (PMID:26280335)
UniProt
RGD
PMID:12660785 PMID:12763021 PMID:25043039 PMID:26280335 GO_REF:0000024 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192
JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor acts_upstream_of_or_within ISO (MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:3028747 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5553242|PMID:18429932)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 GO_REF:0000024 MGI:5553242 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Bace2 beta-secretase 2 involved_in ISO
ISS
(PMID:12801932)
GO_REF:0000024
RGD
UniProt
PMID:12801932 GO_REF:0000024 NCBI chr11:36,707,473...36,789,550
Ensembl chr11:36,707,458...36,789,546
JBrowse link
G Itm2a integral membrane protein 2A involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:72,486,383...72,492,344
Ensembl chr  X:72,486,381...72,492,363
JBrowse link
G Itm2b integral membrane protein 2B involved_in ISO
IBA
ISS
(PMID:16027166), (PMID:18524908)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:16027166 PMID:18524908 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Itm2c integral membrane protein 2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:86,545,927...86,559,745
Ensembl chr 9:86,545,921...86,559,742
JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO (PMID:24612608) RGD PMID:24612608 NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) RGD PMID:24305806 PMID:27853422 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5487687|PMID:23467355), (MGI:5553242|PMID:18429932), (MGI:5774886|PMID:27030769)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 MGI:5487687 MGI:5553242 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
(PMID:24259049)
GO_REF:0000107
(PMID:24154541)
RGD
Ensembl
PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA
(PMID:27179792)
(MGI:5811968|PMID:27179792)
GO_REF:0000107
RGD
Ensembl
PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:12047389), (PMID:17412999)
Alzheimers_University_of_Toronto
Ensembl
RGD
PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:100,825,426...100,844,462
Ensembl chr10:100,825,426...100,844,462
JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107
RGD
Ensembl
PMID:27277332 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)
Ensembl
RGD
PMID:26094765 GO_REF:0000107 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Olfm1 olfactomedin 1 acts_upstream_of_or_within ISO (MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:5444053 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(MGI:3620333|PMID:16554819)
RGD PMID:16554819 PMID:25576397 MGI:3620333 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA
(PMID:24305806), (PMID:27853422)
GO_REF:0000107
RGD
Ensembl
PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rtn1 reticulon 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15286784)
UniProt
Ensembl
RGD
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436
JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS
(PMID:15286784)
GO_REF:0000024
RGD
UniProt
PMID:15286784 GO_REF:0000024 NCBI chr 1:78,935,056...78,948,069
Ensembl chr 1:78,935,104...78,948,069
JBrowse link
G Rtn3 reticulon 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:15286784)
UniProt
RGD
PMID:15286784 GO_REF:0000024 NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275
JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA
ISS
(PMID:15286784)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
(MGI:3801250|PMID:18362153), (MGI:3821635|PMID:19036982)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 PMID:21989385 More... MGI:3801250 MGI:3821635 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3607023|PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 MGI:3607023 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5811968|PMID:27179792)
(PMID:27179792)
Ensembl
RGD
PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385)
(MGI:3801250|PMID:18362153)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (MGI:3623864|PMID:16641999) RGD PMID:16641999 MGI:3623864 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
JBrowse link
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5432454|PMID:22539346)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:22539346 GO_REF:0000024 GO_REF:0000107 MGI:5432454 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:17855360), (PMID:21989385)
(MGI:3801250|PMID:18362153)
RGD PMID:17855360 PMID:18362153 PMID:21989385 MGI:3801250 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in ISO
IEA
(PMID:20704561)
GO_REF:0000107
RGD
Ensembl
PMID:20704561 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Ncstn nicastrin acts_upstream_of_or_within ISO (MGI:5569714|PMID:23826707) RGD PMID:23826707 MGI:5569714 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Pawr pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3028747|PMID:14627703)
Ensembl
RGD
PMID:14627703 GO_REF:0000107 MGI:3028747 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in ISO
IEA
(PMID:17412327)
GO_REF:0000107
RGD
Ensembl
PMID:17412327 GO_REF:0000107 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO UniProtKB:P56818 (PMID:20704561), (PMID:22086926) RGD PMID:20704561 PMID:22086926 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of IGI PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr17:21,220,807...21,303,009
Ensembl chr17:21,220,618...21,303,004
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806)
(MGI:6114922|PMID:24305806)
RGD PMID:24305806 MGI:6114922 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3607023|PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 MGI:3607023 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISO
IEA
IMP
(PMID:22086926)
GO_REF:0000107
RGD
Ensembl
PMID:22086926 PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541 PMID:24259049 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Casp3 caspase 3 involved_in IDA
ISO
PMID:17553422
(PMID:17553422)
RGD PMID:17553422 PMID:17553422 RGD:13825190 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107 MGI:4437154 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:2384259|PMID:12145324)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:12145324 GO_REF:0000024 GO_REF:0000107 MGI:2384259 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Gsap gamma-secretase activating protein involved_in IBA
ISO
PMID:21873635
(MGI:4830390|PMID:20811458)
(PMID:20811458)
RGD PMID:20811458 PMID:21873635 MGI:4830390, RGD:13792537 NCBI chr 4:13,813,046...13,907,875
Ensembl chr 4:13,813,046...13,907,814
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO UniProtKB:P49841 (PMID:12761548) RGD PMID:12761548 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (MGI:3697769|PMID:17255335)
RGD PMID:17255335 PMID:19808651 MGI:3697769 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01579|UniProtKB:P05067 (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO (MGI:3695648|PMID:17098871)
(PMID:17098871)
RGD PMID:17098871 MGI:3695648 NCBI chr20:24,515,627...24,689,669
Ensembl chr20:24,515,627...24,689,669
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
IEA
(PMID:24577224)
(MGI:5432454|PMID:22539346), (MGI:5560380|PMID:24577224)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:22539346 PMID:24577224 GO_REF:0000024 GO_REF:0000107 MGI:5432454 MGI:5560380 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO (MGI:6414694|PMID:21329555) RGD PMID:21329555 MGI:6414694 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:6114922|PMID:24305806)
(PMID:24305806)
Ensembl
RGD
PMID:24305806 GO_REF:0000107 MGI:6114922 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO UniProtKB:P05067-4 (PMID:26094765) RGD PMID:26094765 NCBI chr 7:122,399,329...122,726,605
Ensembl chr 7:122,399,330...122,726,605
JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO (PMID:14701757) RGD PMID:14701757 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Tnf tumor necrosis factor involved_in ISO (MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:3697769 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA
UniProtKB:P05067:PRO_0000000093 (PMID:22406537)
GO_REF:0000107
RGD
Ensembl
PMID:22406537 GO_REF:0000107 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:Q15109 (PMID:22406537) RGD PMID:22406537 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Efna1 ephrin A1 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Efna3 ephrin A3 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736
JBrowse link
G Epha4 Eph receptor A4 involved_in ISO UniProtKB:P20827|UniProtKB:P52797 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5432454|PMID:22539346)
GO_REF:0000107
Alzheimers_University_of_Toronto
RGD
Ensembl
PMID:22539346 GO_REF:0000024 GO_REF:0000107 MGI:5432454 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:6114922|PMID:24305806)
(PMID:24305806)
Ensembl
RGD
PMID:24305806 GO_REF:0000107 MGI:6114922 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab1 N-terminal EF-hand calcium binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:28,357,859...28,578,642
Ensembl chr 5:28,357,859...28,578,642
JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:47,501,351...47,527,722
Ensembl chr19:47,501,302...47,527,684
JBrowse link
regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS
(PMID:26260791)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) RGD PMID:28164773 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO UniProtKB:P05067 (PMID:24499793) RGD PMID:24499793 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (MGI:5795815|PMID:23070049) RGD PMID:23070049 MGI:5795815 NCBI chr16:18,336,229...18,381,811
Ensembl chr16:18,336,229...18,381,872
JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm1 olfactomedin 1 acts_upstream_of_or_within ISO (MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:5444053 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO UniProtKB:P05067:PRO_0000000092 (MGI:5637941|PMID:26005850) RGD PMID:26005850 MGI:5637941 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO
ISS
(PMID:16641999)
GO_REF:0000024
RGD
UniProt
PMID:16641999 GO_REF:0000024 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753
JBrowse link
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
(PMID:24577224)
GO_REF:0000024
RGD
Alzheimers_University_of_Toronto
PMID:24577224 GO_REF:0000024 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    metabolic process 11798
      primary metabolic process 10531
        protein metabolic process 5892
          amyloid precursor protein metabolic process 73
            amyloid precursor protein biosynthetic process + 13
            amyloid precursor protein catabolic process + 59
Path 2
Term Annotations click to browse term
  biological_process 19494
    metabolic process 11798
      organic substance metabolic process 11338
        macromolecule metabolic process 9794
          protein metabolic process 5892
            amyloid precursor protein metabolic process 73
              amyloid precursor protein biosynthetic process + 13
              amyloid precursor protein catabolic process + 59
paths to the root