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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid precursor protein metabolic process
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Accession:GO:0042982 term browser browse the term
Definition:The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP metabolic process;   APP metabolism;   amyloid precursor protein metabolism


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amyloid precursor protein metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aph1a aph-1 homolog A, gamma secretase subunit ISO (PMID:25043039), (PMID:26280335) RGD PMID:25043039, PMID:26280335 NCBI chr 2:198,006,247...198,009,837
Ensembl chr 2:198,006,316...198,009,830
JBrowse link
G Apoe apolipoprotein E IEA
ISO
GO_REF:0000107
(PMID:21593558)
Ensembl
RGD
PMID:21593558 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO
IEA
MGI:MGI:109548 (MGI:MGI:3699445|PMID:17301176)
GO_REF:0000107
RGD
Ensembl
PMID:17301176 GO_REF:0000107, MGI:MGI:3699445 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 ISO (PMID:12805363) RGD PMID:12805363 NCBI chr 5:152,964,294...152,987,286
Ensembl chr 5:152,966,591...152,987,211
JBrowse link
G Ncstn nicastrin ISS
ISO
GO_REF:0000024
(MGI:MGI:5293284|PMID:21597003)
(PMID:25043039), (PMID:26280335)
UniProt
RGD
PMID:21597003, PMID:25043039, PMID:26280335 GO_REF:0000024, MGI:MGI:5293284 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 ISO
ISS
(MGI:MGI:4845784|PMID:21084623)
GO_REF:0000024
RGD
UniProt
PMID:21084623 GO_REF:0000024, MGI:MGI:4845784 NCBI chr14:77,380,264...77,402,007
Ensembl chr14:77,380,262...77,401,996
JBrowse link
G Prnp prion protein NOT ISO UniProtKB:P12023|UniProtKB:P49769 (MGI:MGI:4454612|PMID:20445063) RGD PMID:20445063 MGI:MGI:4454612 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Psen1 presenilin 1 ISO
ISS
(PMID:26280335)
GO_REF:0000024
RGD
UniProt
PMID:26280335 GO_REF:0000024 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit ISS
ISO
GO_REF:0000024
(PMID:25043039), (PMID:26280335)
UniProt
RGD
PMID:25043039, PMID:26280335 GO_REF:0000024 NCBI chr 1:89,016,093...89,017,449
Ensembl chr 1:89,016,096...89,017,290
JBrowse link
G Tmcc2 transmembrane and coiled-coil domain family 2 ISO
IBA
(PMID:21593558)
PMID:21873635
RGD PMID:21593558, PMID:21873635 RGD:13792537 NCBI chr13:49,132,685...49,169,771
Ensembl chr13:49,132,667...49,169,918
JBrowse link
amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncstn nicastrin ISO (MGI:MGI:3773571|PMID:18201567) RGD PMID:18201567 MGI:MGI:3773571 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO (PMID:28164773) RGD PMID:28164773 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit ISO (PMID:12297508) RGD PMID:12297508 NCBI chr 2:198,006,247...198,009,837
Ensembl chr 2:198,006,316...198,009,830
JBrowse link
G Bace1 beta-secretase 1 ISO UniProtKB:Q9BZC7 (MGI:MGI:6356260|PMID:20704561) RGD PMID:20704561 MGI:MGI:6356260 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin ISO
ISS
(PMID:10924275)
GO_REF:0000024
RGD
UniProt
PMID:10924275 GO_REF:0000024 NCBI chr 1:197,986,384...197,999,726
Ensembl chr 1:197,986,385...197,997,664
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO MGI:MGI:3027024 (MGI:MGI:3614236|PMID:16407971) RGD PMID:16407971 MGI:MGI:3614236 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Psen1 presenilin 1 ISO
IBA
MGI:MGI:2149116|MGI:MGI:2179062|MGI:MGI:2449304 (MGI:MGI:1334955|PMID:10206645), (MGI:MGI:2150480|PMID:11567612), (MGI:MGI:3057045|PMID:15452145)
PMID:21873635
RGD PMID:10206645, PMID:11567612, PMID:15452145, PMID:21873635 MGI:MGI:1334955, MGI:MGI:2150480, MGI:MGI:3057045, RGD:13792537 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psen2 presenilin 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:5694857|PMID:26260791)
(PMID:26260791)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:26260791 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5694857 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 IMP PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit ISO (PMID:25043039), (PMID:26280335) RGD PMID:25043039, PMID:26280335 NCBI chr 2:198,006,247...198,009,837
Ensembl chr 2:198,006,316...198,009,830
JBrowse link
G Bace1 beta-secretase 1 ISO (PMID:24352696) RGD PMID:24352696 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A ISO (PMID:25556849) RGD PMID:25556849 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Ncstn nicastrin ISS
ISO
GO_REF:0000024
(PMID:25043039), (PMID:26280335)
UniProt
RGD
PMID:25043039, PMID:26280335 GO_REF:0000024 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Psen1 presenilin 1 ISO
ISS
MGI:MGI:2149116 (MGI:MGI:4437371|PMID:20130175)
GO_REF:0000024
(PMID:26280335)
RGD
UniProt
PMID:20130175, PMID:26280335 GO_REF:0000024, MGI:MGI:4437371 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit ISS
ISO
GO_REF:0000024
(PMID:12660785), (PMID:25043039), (PMID:26280335)
UniProt
RGD
PMID:12660785, PMID:25043039, PMID:26280335 GO_REF:0000024 NCBI chr 1:89,016,093...89,017,449
Ensembl chr 1:89,016,096...89,017,290
JBrowse link
negative regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aatf apoptosis antagonizing transcription factor ISO (MGI:MGI:3028747|PMID:14627703) RGD PMID:14627703 MGI:MGI:3028747 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 ISO
ISS
(MGI:MGI:5553242|PMID:18429932)
GO_REF:0000024
RGD
Alzheimers_University_of_Toronto
PMID:18429932 GO_REF:0000024, MGI:MGI:5553242 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Ago2 argonaute RISC catalytic component 2 IMP PMID:20395292 ARUK-UCL PMID:20395292 RGD:14390059 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Bace2 beta-secretase 2 ISO
ISS
(PMID:12801932)
GO_REF:0000024
RGD
UniProt
PMID:12801932 GO_REF:0000024 NCBI chr11:37,798,397...37,880,624
Ensembl chr11:37,798,370...37,880,821
JBrowse link
G Itm2a integral membrane protein 2A IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Itm2b integral membrane protein 2B ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:16027166), (PMID:18524908)
UniProt
RGD
PMID:16027166, PMID:18524908, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr15:55,254,703...55,277,713
Ensembl chr15:55,254,706...55,277,713
JBrowse link
G Itm2c integral membrane protein 2C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:92,916,469...92,930,306
Ensembl chr 9:92,916,469...92,930,279
JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 ISO (PMID:24612608) RGD PMID:24612608 NCBI chr10:65,304,901...65,329,332
Ensembl chr10:65,304,902...65,329,312
JBrowse link
G Prnp prion protein ISO UniProtKB:P12023 (MGI:MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:MGI:3714552 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 ISO (PMID:24305806), (PMID:27853422) RGD PMID:24305806, PMID:27853422 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISS
ISO
GO_REF:0000024
(MGI:MGI:5487687|PMID:23467355), (MGI:MGI:5553242|PMID:18429932), (MGI:MGI:5774886|PMID:27030769)
Alzheimers_University_of_Toronto
RGD
PMID:18429932, PMID:23467355, PMID:27030769 GO_REF:0000024, MGI:MGI:5487687, MGI:MGI:5553242, MGI:MGI:5774886 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Apoe apolipoprotein E IEA
ISO
GO_REF:0000107
(PMID:24154541), (PMID:24259049)
Ensembl
RGD
PMID:24154541, PMID:24259049 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bin1 bridging integrator 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5811968|PMID:27179792)
(PMID:27179792)
Ensembl
RGD
PMID:27179792 GO_REF:0000107, MGI:MGI:5811968 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO
IEA
UniProtKB:P05067 (PMID:20708605)
GO_REF:0000107
RGD
Ensembl
PMID:20708605 GO_REF:0000107 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clu clusterin IEA
ISO
ISS
GO_REF:0000107
(PMID:12047389), (PMID:17412999)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:12047389, PMID:17412999 GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:104,137,655...104,156,576
Ensembl chr10:104,137,655...104,156,576
JBrowse link
G Hap1 huntingtin-associated protein 1 IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Igf1 insulin-like growth factor 1 IEA
ISO
GO_REF:0000107
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
Ensembl
RGD
PMID:27277332 GO_REF:0000107 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO
IEA
UniProtKB:P05067-4 (PMID:26094765)
GO_REF:0000107
RGD
Ensembl
PMID:26094765 GO_REF:0000107 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Olfm1 olfactomedin 1 ISO (MGI:MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:MGI:5444053 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO (PMID:25576397)
(MGI:MGI:3620333|PMID:16554819)
RGD PMID:16554819, PMID:25576397 MGI:MGI:3620333 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Prnp prion protein ISO UniProtKB:P12023 (MGI:MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:MGI:3714552 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 IEA
ISO
GO_REF:0000107
(PMID:24305806), (PMID:27853422)
Ensembl
RGD
PMID:24305806, PMID:27853422 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
(MGI:MGI:3801250|PMID:18362153), (MGI:MGI:3821635|PMID:19036982)
RGD PMID:16407538, PMID:17855360, PMID:18362153, PMID:19036982, PMID:21989385, PMID:22621900, PMID:24001769, PMID:24523320 MGI:MGI:3801250, MGI:MGI:3821635 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Spon1 spondin 1 ISO
IEA
(MGI:MGI:3607023|PMID:16227578)
GO_REF:0000107
RGD
Ensembl
PMID:16227578 GO_REF:0000107, MGI:MGI:3607023 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5811968|PMID:27179792)
(PMID:27179792)
Ensembl
RGD
PMID:27179792 GO_REF:0000107, MGI:MGI:5811968 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (MGI:MGI:3801250|PMID:18362153)
(PMID:16407538), (PMID:17855360), (PMID:21989385)
RGD PMID:16407538, PMID:17855360, PMID:18362153, PMID:21989385 MGI:MGI:3801250 NCBI chr 8:46,228,077...46,287,171 JBrowse link
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein ISO
ISS
IEA
(MGI:MGI:5432454|PMID:22539346)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:22539346 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5432454 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (MGI:MGI:3801250|PMID:18362153)
(PMID:17855360), (PMID:21989385)
RGD PMID:17855360, PMID:18362153, PMID:21989385 MGI:MGI:3801250 NCBI chr 8:46,228,077...46,287,171 JBrowse link
positive regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO
IEA
(PMID:20704561)
GO_REF:0000107
RGD
Ensembl
PMID:20704561 GO_REF:0000107 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Ncstn nicastrin ISO (MGI:MGI:5569714|PMID:23826707) RGD PMID:23826707 MGI:MGI:5569714 NCBI chr13:90,451,046...90,467,256
Ensembl chr13:90,451,044...90,467,256
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO
IEA
(MGI:MGI:3028747|PMID:14627703)
GO_REF:0000107
RGD
Ensembl
PMID:14627703 GO_REF:0000107, MGI:MGI:3028747 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO
IEA
(PMID:17412327)
GO_REF:0000107
RGD
Ensembl
PMID:17412327 GO_REF:0000107 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO UniProtKB:P56818 (PMID:20704561), (PMID:22086926) RGD PMID:20704561, PMID:22086926 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Ranbp9 RAN binding protein 9 IGI PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr17:24,020,874...24,103,771
Ensembl chr17:24,021,736...24,103,515
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 ISO (PMID:24305806)
(MGI:MGI:6114922|PMID:24305806)
RGD PMID:24305806 MGI:MGI:6114922 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Spon1 spondin 1 ISO
IEA
(MGI:MGI:3607023|PMID:16227578)
GO_REF:0000107
RGD
Ensembl
PMID:16227578 GO_REF:0000107, MGI:MGI:3607023 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO
IMP
IEA
(PMID:22086926)
GO_REF:0000107
RGD
Ensembl
PMID:22086926, PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Apoe apolipoprotein E ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541, PMID:24259049 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein ISO UniProtKB:P49768 (PMID:23640054) RGD PMID:23640054 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Casp3 caspase 3 ISO
IDA
(PMID:17553422) RGD PMID:17553422, PMID:17553422 RGD:13825190 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107, MGI:MGI:4437154 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clu clusterin ISO
ISS
IEA
(MGI:MGI:2384259|PMID:12145324)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:12145324 GO_REF:0000024, GO_REF:0000107, MGI:MGI:2384259 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359
JBrowse link
G Efna1 ephrin A1 ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Epha4 Eph receptor A4 ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Gsap gamma-secretase activating protein ISO
IBA
(PMID:20811458)
PMID:21873635
(MGI:MGI:4830390|PMID:20811458)
RGD PMID:20811458, PMID:21873635 MGI:MGI:4830390, RGD:13792537 NCBI chr 4:10,423,090...10,517,887
Ensembl chr 4:10,423,139...10,517,848
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO UniProtKB:P49841 (PMID:12761548) RGD PMID:12761548 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Ifng interferon gamma ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (MGI:MGI:3697769|PMID:17255335)
RGD PMID:17255335, PMID:19808651 MGI:MGI:3697769 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO UniProtKB:P01579|UniProtKB:P05067 (MGI:MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:MGI:3697769 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 ISO (PMID:17098871)
(MGI:MGI:3695648|PMID:17098871)
RGD PMID:17098871 MGI:MGI:3695648 NCBI chr20:25,990,304...26,163,656
Ensembl chr20:25,990,304...26,163,656
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO
ISS
IEA
(PMID:24577224)
(MGI:MGI:5432454|PMID:22539346), (MGI:MGI:5560380|PMID:24577224)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:22539346, PMID:24577224 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5432454, MGI:MGI:5560380 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (MGI:MGI:6414694|PMID:21329555) RGD PMID:21329555 MGI:MGI:6414694 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:6114922|PMID:24305806)
(PMID:24305806)
Ensembl
RGD
PMID:24305806 GO_REF:0000107, MGI:MGI:6114922 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Slc2a13 solute carrier family 2 member 13 ISO UniProtKB:P05067-4 (PMID:26094765) RGD PMID:26094765 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Sp1 Sp1 transcription factor ISO (PMID:14701757) RGD PMID:14701757 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tnf tumor necrosis factor ISO (MGI:MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:MGI:3697769 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEA
ISO
GO_REF:0000107
UniProtKB:P05067:PRO_0000000093 (PMID:22406537)
Ensembl
RGD
PMID:22406537 GO_REF:0000107 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G App amyloid beta precursor protein ISO UniProtKB:Q15109 (PMID:22406537) RGD PMID:22406537 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Efna1 ephrin A1 ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Efna3 ephrin A3 ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,636,304...188,645,302
Ensembl chr 2:188,637,852...188,645,196
JBrowse link
G Epha4 Eph receptor A4 ISO UniProtKB:P20827|UniProtKB:P52797 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO
ISS
IEA
(MGI:MGI:5432454|PMID:22539346)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:22539346 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5432454 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:6114922|PMID:24305806)
(PMID:24305806)
Ensembl
RGD
PMID:24305806 GO_REF:0000107, MGI:MGI:6114922 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
regulation of amyloid precursor protein biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab1 N-terminal EF-hand calcium binding protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:28,507,596...28,737,556
Ensembl chr 5:28,504,558...28,737,719
JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:52,086,325...52,112,633
Ensembl chr19:52,086,325...52,112,629
JBrowse link
G Necab3 N-terminal EF-hand calcium binding protein 3 ISO (PMID:10833507) RGD PMID:10833507 NCBI chr 3:150,047,826...150,062,806
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISS
ISO
IEA
GO_REF:0000024
(PMID:26260791)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:26260791 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Apoe apolipoprotein E ISO (PMID:28164773) RGD PMID:28164773 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO UniProtKB:P05067 (PMID:24499793) RGD PMID:24499793 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Unc13a unc-13 homolog A ISO
IEA
(MGI:MGI:5795815|PMID:23070049)
GO_REF:0000107
RGD
Ensembl
PMID:23070049 GO_REF:0000107, MGI:MGI:5795815 NCBI chr16:20,056,398...20,103,951
Ensembl chr16:20,056,765...20,097,287
JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein NOT ISO UniProtKB:Q7M6Y3 (PMID:26005850) RGD PMID:26005850 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Olfm1 olfactomedin 1 ISO (MGI:MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:MGI:5444053 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT ISO UniProtKB:P05067:PRO_0000000092 (MGI:MGI:5637941|PMID:26005850) RGD PMID:26005850 MGI:MGI:5637941 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 ISO
ISS
(PMID:16641999)
GO_REF:0000024
RGD
UniProt
PMID:16641999 GO_REF:0000024 NCBI chr 6:109,169,739...109,205,004
Ensembl chr 6:109,169,741...109,205,004
JBrowse link
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Picalm phosphatidylinositol binding clathrin assembly protein ISO
ISS
(PMID:24577224)
GO_REF:0000024
RGD
Alzheimers_University_of_Toronto
PMID:24577224 GO_REF:0000024 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      primary metabolic process 10920
        protein metabolic process 6228
          amyloid precursor protein metabolic process 66
            amyloid precursor protein biosynthetic process + 14
            amyloid precursor protein catabolic process + 51
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        macromolecule metabolic process 10086
          protein metabolic process 6228
            amyloid precursor protein metabolic process 66
              amyloid precursor protein biosynthetic process + 14
              amyloid precursor protein catabolic process + 51
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.