Abca2 (ATP binding cassette subfamily A member 2) - Rat Genome Database

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Gene: Abca2 (ATP binding cassette subfamily A member 2) Rattus norvegicus
Analyze
Symbol: Abca2
Name: ATP binding cassette subfamily A member 2
RGD ID: 620238
Description: Enables ATP binding activity. Involved in central nervous system myelin formation; negative regulation of lipid biosynthetic process; and positive regulation of amyloid-beta formation. Located in cytoplasmic vesicle; lysosomal membrane; and microtubule organizing center. Orthologous to human ABCA2 (ATP binding cassette subfamily A member 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abc2; ATP-binding cassette 2; ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A (ABC1), member 2; ATP-binding cassette, subfamily A (ABC1), member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,244,515 - 8,264,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,244,639 - 8,264,537 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,349,736 - 11,369,666 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,935,958 - 19,955,888 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,125,806 - 18,145,736 (+)NCBIRnor_WKY
Rnor_6.032,648,787 - 2,668,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,630,237 - 2,650,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,595,423 - 3,615,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,595,422 - 3,615,327 (+)NCBI
Celera33,069,743 - 3,089,646 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
central nervous system myelin formation  (IDA,ISO)
ceramide translocation  (IEA,ISO)
cholesterol homeostasis  (IEA,ISO,ISS)
ganglioside metabolic process  (ISO,ISS)
glycosphingolipid metabolic process  (ISO,ISS)
intracellular sphingolipid homeostasis  (IEA,ISO)
lipid transport  (IBA)
locomotory behavior  (ISO)
negative regulation of cholesterol efflux  (IEA,ISO)
negative regulation of intracellular cholesterol transport  (ISO)
negative regulation of low-density lipoprotein receptor activity  (IDA,IEA,ISO)
negative regulation of phospholipid biosynthetic process  (IEA,IMP,ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (IEA,ISO)
negative regulation of sphingolipid biosynthetic process  (IEA,IMP,ISO)
negative regulation of steroid metabolic process  (IMP)
positive regulation of amyloid precursor protein biosynthetic process  (IEA,ISO)
positive regulation of amyloid precursor protein catabolic process  (ISO)
positive regulation of amyloid-beta formation  (IEA,IMP,ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA,ISO)
regulation of cholesterol biosynthetic process  (ISO)
regulation of intracellular cholesterol transport  (ISO,ISS)
regulation of post-translational protein modification  (IEA,ISO)
regulation of protein glycosylation  (ISO)
regulation of protein localization to cell periphery  (ISO)
regulation of protein localization to cell surface  (ISO)
regulation of steroid metabolic process  (IEA,ISO)
response to cholesterol  (IEA,ISO)
response to steroid hormone  (IEA,ISO,ISS)
sphingomyelin metabolic process  (ISO,ISS)
sphingosine biosynthetic process  (IEA,ISO)
transmembrane transport  (IEA,NAS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ABCA2 is a marker of neural progenitors and neuronal subsets in the adult rodent brain. Broccardo C, etal., J Neurochem. 2006 Apr;97(2):345-55. Epub 2006 Mar 15.
2. The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. Davis W, Biochim Biophys Acta. 2011 Dec;1811(12):1152-64. doi: 10.1016/j.bbalip.2011.07.010. Epub 2011 Jul 23.
3. The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism. Davis W, Biochim Biophys Acta. 2014 Jan;1841(1):168-79. doi: 10.1016/j.bbalip.2013.10.019. Epub 2013 Nov 5.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization. Michaki V, etal., J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain. Tanaka Y, etal., J Comp Neurol 2003 Jan 13;455(3):353-67.
13. Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2. Zhao LX, etal., Biochem J 2000 Sep 15;350 Pt 3:865-72.
14. Atp-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths. Zhou C, etal., J Neurosci. 2001 Feb 1;21(3):849-57.
15. ATP-binding cassette transporter ABCA2 (ABC2) expression in the developing spinal cord and PNS during myelination. Zhou CJ, etal., J Comp Neurol 2002 Sep 30;451(4):334-45.
Additional References at PubMed
PMID:11178988   PMID:11309290   PMID:15238223   PMID:15999530   PMID:17060448   PMID:19946888   PMID:20704561   PMID:22871113   PMID:26510981  


Genomics

Comparative Map Data
Abca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,244,515 - 8,264,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,244,639 - 8,264,537 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,349,736 - 11,369,666 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,935,958 - 19,955,888 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0318,125,806 - 18,145,736 (+)NCBIRnor_WKY
Rnor_6.032,648,787 - 2,668,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,630,237 - 2,650,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,595,423 - 3,615,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,595,422 - 3,615,327 (+)NCBI
Celera33,069,743 - 3,089,646 (+)NCBICelera
Cytogenetic Map3p13NCBI
ABCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,007,234 - 137,028,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9137,007,234 - 137,028,915 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,901,686 - 139,923,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,021,507 - 139,043,195 (-)NCBINCBI36Build 36hg18NCBI36
Build 349137,177,522 - 137,199,211NCBI
Celera9110,414,121 - 110,431,191 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,360,841 - 109,382,226 (-)NCBIHuRef
CHM1_19140,050,436 - 140,072,137 (-)NCBICHM1_1
T2T-CHM13v2.09149,241,651 - 149,263,357 (-)NCBIT2T-CHM13v2.0
Abca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,318,611 - 25,338,556 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,318,715 - 25,338,552 (+)EnsemblGRCm39 Ensembl
GRCm38225,428,599 - 25,448,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,428,703 - 25,448,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,284,194 - 25,304,059 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,250,779 - 25,270,208 (+)NCBIMGSCv36mm8
Celera225,156,185 - 25,176,102 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.25NCBI
Abca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,033,771 - 5,051,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,035,879 - 5,051,140 (-)NCBIChiLan1.0ChiLan1.0
ABCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,039,264 - 137,057,527 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,036,696 - 137,057,776 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,067,633 - 108,089,742 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ABCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,610,906 - 48,630,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,613,996 - 48,629,857 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,824,500 - 47,844,585 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,488,905 - 49,509,018 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1948,265,133 - 48,285,232 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,563,850 - 48,583,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,611,199 - 48,631,304 (+)NCBIUU_Cfam_GSD_1.0
Abca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,433,062 - 202,454,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669926,622 - 942,167 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936669922,978 - 941,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA2
(Sus scrofa - pig)		 No map positions available.
ABCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,161,340 - 1,183,807 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,162,865 - 1,183,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,118,329 - 4,134,713 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760880,148 - 898,751 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760880,216 - 898,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abca2
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:349
Count of miRNA genes:210
Interacting mature miRNAs:252
Transcripts:ENSRNOT00000020339
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat

Markers in Region
RH70531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,257,185 - 8,258,825 (+)MAPPERmRatBN7.2
Rnor_6.032,661,411 - 2,663,050NCBIRnor6.0
Rnor_5.032,642,824 - 2,644,463UniSTSRnor5.0
RGSC_v3.433,607,969 - 3,609,608UniSTSRGSC3.4
Celera33,082,289 - 3,083,928UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 13 24 9 18 9 74 35 33 11
Low 3 30 33 32 1 32 8 11 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020339   ⟹   ENSRNOP00000020339
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,244,639 - 8,264,537 (+)Ensembl
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109279   ⟹   ENSRNOP00000088059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,248,427 - 8,264,537 (+)Ensembl
RefSeq Acc Id: NM_024396   ⟹   NP_077372
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,244,639 - 8,264,545 (+)NCBI
Rnor_6.032,648,865 - 2,668,770 (+)NCBI
Rnor_5.032,630,237 - 2,650,183 (+)NCBI
RGSC_v3.433,595,423 - 3,615,328 (+)RGD
Celera33,069,743 - 3,089,646 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233645   ⟹   XP_006233707
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,244,516 - 8,264,545 (+)NCBI
Rnor_6.032,648,788 - 2,668,770 (+)NCBI
Rnor_5.032,630,237 - 2,650,183 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592052   ⟹   XP_017447541
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,244,516 - 8,264,545 (+)NCBI
Rnor_6.032,648,787 - 2,668,770 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592053   ⟹   XP_017447542
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,244,861 - 8,264,545 (+)NCBI
Rnor_6.032,649,017 - 2,668,770 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105895   ⟹   XP_038961823
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,244,861 - 8,264,545 (+)NCBI
RefSeq Acc Id: XR_005501988
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,244,515 - 8,263,166 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_077372   ⟸   NM_024396
- UniProtKB: Q9ESR9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233707   ⟸   XM_006233645
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447541   ⟸   XM_017592052
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447542   ⟸   XM_017592053
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000020339   ⟸   ENSRNOT00000020339
RefSeq Acc Id: XP_038961823   ⟸   XM_039105895
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000088059   ⟸   ENSRNOT00000109279
Protein Domains
ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESR9-F1-model_v2 AlphaFold Q9ESR9 1-2434 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691878
Promoter ID:EPDNEW_R2402
Type:multiple initiation site
Name:Abca2_1
Description:ATP binding cassette subfamily A member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,648,835 - 2,648,895EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620238 AgrOrtholog
BioCyc Gene G2FUF-50453 BioCyc
Ensembl Genes ENSRNOG00000014268 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000020339 ENTREZGENE
  ENSRNOP00000020339.6 UniProtKB/TrEMBL
  ENSRNOP00000088059 ENTREZGENE
  ENSRNOP00000088059.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020339 ENTREZGENE
  ENSRNOT00000020339.8 UniProtKB/TrEMBL
  ENSRNOT00000109279 ENTREZGENE
  ENSRNOT00000109279.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABCA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79248 UniProtKB/Swiss-Prot
NCBI Gene 79248 ENTREZGENE
PANTHER ABC TRANSPORTER A FAMILY MEMBER 7-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC2_membrane_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abca2 PhenoGen
PROSITE ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A5D9_RAT UniProtKB/TrEMBL
  ABCA2_RAT UniProtKB/Swiss-Prot
  G3V7X4_RAT UniProtKB/TrEMBL
  Q9ESR9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abca2  ATP binding cassette subfamily A member 2  Abca2  ATP-binding cassette, subfamily A (ABC1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abca2  ATP-binding cassette, subfamily A (ABC1), member 2  Abca2  ATP-binding cassette, sub-family A (ABC1), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Abca2  ATP-binding cassette, sub-family A (ABC1), member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Abca2  ATP-binding cassette, sub-family A (ABC1), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the ABC1 subfamily of the ATP-binding casette (ABC) transporter superfamily 631993
gene_protein 2434 amino acids 631993