Unc13a (unc-13 homolog A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Unc13a (unc-13 homolog A) Rattus norvegicus
Analyze
Symbol: Unc13a
Name: unc-13 homolog A
RGD ID: 619722
Description: Enables several functions, including calmodulin binding activity; spectrin binding activity; and syntaxin-1 binding activity. Involved in long-term synaptic potentiation; regulated exocytosis; and regulation of synaptic vesicle priming. Located in several cellular components, including Golgi-associated vesicle; presynaptic active zone cytoplasmic component; and presynaptic membrane. Part of protein-containing complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A); PARTICIPATES IN insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Munc13-1; protein unc-13 homolog A; unc-13 homolog A (C. elegans); Unc13h1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,367,891 - 18,415,808 (-)NCBIGRCr8
mRatBN7.21618,333,910 - 18,381,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,336,229 - 18,381,872 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,384,673 - 18,432,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,516,945 - 19,565,015 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,437,617 - 18,485,341 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,056,398 - 20,103,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,056,765 - 20,097,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,917,585 - 19,964,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,827,405 - 18,872,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,827,402 - 18,872,453 (-)NCBI
Celera1618,539,912 - 18,584,310 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential expression of two novel Munc13 proteins in rat brain. Augustin I, etal., Biochem J. 1999 Feb 1;337 ( Pt 3):363-71.
2. Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. Betz A, etal., J Biol Chem. 1997 Jan 24;272(4):2520-6.
3. Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Betz A, etal., Neuron 2001 Apr;30(1):183-96.
4. Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. Brose N, etal., J Biol Chem 1995 Oct 20;270(42):25273-80.
5. Analysis of the UNC13A gene as a risk factor for sporadic amyotrophic lateral sclerosis. Daoud H, etal., Arch Neurol. 2010 Apr;67(4):516-7.
6. Structural insights into the calmodulin-Munc13 interaction obtained by cross-linking and mass spectrometry. Dimova K, etal., Biochemistry. 2009 Jun 30;48(25):5908-21. doi: 10.1021/bi900300r.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Binding of the Munc13-1 MUN domain to membrane-anchored SNARE complexes. Guan R, etal., Biochemistry. 2008 Feb 12;47(6):1474-81. Epub 2008 Jan 18.
9. Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1. Huang CC, etal., Traffic. 2011 Oct;12(10):1356-70. doi: 10.1111/j.1600-0854.2011.01237.x. Epub 2011 Jul 20.
10. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
11. Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site. Limbach C, etal., Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):E392-401. doi: 10.1073/pnas.1101707108. Epub 2011 Jun 28.
12. Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. Lu J, etal., PLoS Biol. 2006 Jul;4(7):e192.
13. Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Ma C, etal., Nat Struct Mol Biol. 2011 May;18(5):542-9. Epub 2011 Apr 17.
14. Formation of Golgi-derived active zone precursor vesicles. Maas C, etal., J Neurosci. 2012 Aug 8;32(32):11095-108. doi: 10.1523/JNEUROSCI.0195-12.2012.
15. Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Man KN, etal., Elife. 2015 Nov 17;4. pii: e10635. doi: 10.7554/eLife.10635.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity. Rodriguez-Castaneda F, etal., EMBO J. 2010 Feb 3;29(3):680-91. doi: 10.1038/emboj.2009.373. Epub 2009 Dec 10.
20. A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13. Sakaguchi G, etal., Biochem Biophys Res Commun 1998 Jul 30;248(3):846-51.
21. Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. van Es MA, etal., Nat Genet. 2009 Oct;41(10):1083-7. Epub 2009 Sep 6.
22. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
23. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
24. Munc13-1 is required for presynaptic long-term potentiation. Yang Y and Calakos N, J Neurosci. 2011 Aug 17;31(33):12053-7.
25. Characterization of Munc13-1 and insulin secretion during pancreatic development in rats. Yuan QX, etal., J Endocrinol Invest. 2008 Jul;31(7):630-5.
Additional References at PubMed
PMID:9195900   PMID:9697857   PMID:9736751   PMID:10440375   PMID:11792326   PMID:11832228   PMID:12163476   PMID:12477932   PMID:12871971   PMID:14734538   PMID:15123597   PMID:15294163  
PMID:15667202   PMID:15988013   PMID:16704978   PMID:17687497   PMID:19558619   PMID:20130189   PMID:20154707   PMID:20375012   PMID:21700703   PMID:21803295   PMID:22000513   PMID:23070049  
PMID:23229896   PMID:23258414   PMID:23658173   PMID:23791195   PMID:23801330   PMID:23999003   PMID:25374362   PMID:25609709   PMID:26030875   PMID:27213521   PMID:28137749   PMID:28177287  
PMID:28477408   PMID:29225210   PMID:29230050   PMID:29244485   PMID:30622273   PMID:32086964   PMID:32643828   PMID:33468652   PMID:34227103  


Genomics

Comparative Map Data
Unc13a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,367,891 - 18,415,808 (-)NCBIGRCr8
mRatBN7.21618,333,910 - 18,381,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,336,229 - 18,381,872 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,384,673 - 18,432,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,516,945 - 19,565,015 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,437,617 - 18,485,341 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,056,398 - 20,103,951 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,056,765 - 20,097,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,917,585 - 19,964,219 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,827,405 - 18,872,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,827,402 - 18,872,453 (-)NCBI
Celera1618,539,912 - 18,584,310 (-)NCBICelera
Cytogenetic Map16p14NCBI
UNC13A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,601,336 - 17,688,354 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,601,336 - 17,688,365 (-)EnsemblGRCh38hg38GRCh38
GRCh371917,712,145 - 17,799,163 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,573,137 - 17,660,401 (-)NCBINCBI36Build 36hg18NCBI36
Celera1917,613,819 - 17,700,754 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,276,161 - 17,362,803 (-)NCBIHuRef
CHM1_11917,711,616 - 17,798,549 (-)NCBICHM1_1
T2T-CHM13v2.01917,735,579 - 17,822,489 (-)NCBIT2T-CHM13v2.0
Unc13a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,079,356 - 72,124,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,077,061 - 72,124,401 (-)EnsemblGRCm39 Ensembl
GRCm38871,624,125 - 71,671,774 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,624,417 - 71,671,757 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,150,611 - 74,195,656 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36874,558,412 - 74,600,636 (-)NCBIMGSCv36mm8
Celera874,140,993 - 74,186,237 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
Unc13a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955524725,353 - 769,745 (+)NCBIChiLan1.0ChiLan1.0
UNC13A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,471,816 - 22,558,672 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,478,384 - 21,565,289 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,088,654 - 17,175,559 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,063,260 - 18,150,713 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,068,006 - 18,150,642 (-)Ensemblpanpan1.1panPan2
UNC13A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,179,275 - 45,237,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,188,750 - 45,238,115 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2045,091,418 - 45,152,586 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,664,551 - 45,729,225 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,664,566 - 45,726,706 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,900,707 - 44,962,114 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,311,011 - 45,375,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,586,777 - 45,648,193 (+)NCBIUU_Cfam_GSD_1.0
Unc13a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,763,514 - 203,824,246 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,312,788 - 3,368,916 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,311,358 - 3,370,833 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UNC13A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1260,057,926 - 60,130,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,626,729 - 59,665,341 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UNC13A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,082,703 - 16,167,165 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,084,168 - 16,154,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660743,233,011 - 3,341,879 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Unc13a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908418,248 - 464,203 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Unc13a
356 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:64
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000011863, ENSRNOT00000025162
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
BF416213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,359,025 - 18,359,139 (+)MAPPERmRatBN7.2
Rnor_6.01620,077,850 - 20,077,963NCBIRnor6.0
Rnor_5.01619,938,598 - 19,938,711UniSTSRnor5.0
RGSC_v3.41618,849,224 - 18,849,337UniSTSRGSC3.4
Celera1618,561,958 - 18,562,071UniSTS
RH 3.4 Map16185.0UniSTS
Cytogenetic Map16p14UniSTS
BE096312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,370,212 - 18,370,431 (+)MAPPERmRatBN7.2
Rnor_6.01620,091,485 - 20,091,703NCBIRnor6.0
Rnor_5.01619,952,233 - 19,952,451UniSTSRnor5.0
RGSC_v3.41618,861,016 - 18,861,234UniSTSRGSC3.4
Celera1618,572,826 - 18,573,044UniSTS
RH 3.4 Map16183.2UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68
Low 3 9 36 20 19 20 6 33 41 11
Below cutoff 34 21 21 21 8 11 2 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC100083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U24070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000025162   ⟹   ENSRNOP00000025162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,336,229 - 18,376,015 (-)Ensembl
Rnor_6.0 Ensembl1620,056,765 - 20,097,287 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095596   ⟹   ENSRNOP00000089726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,336,229 - 18,381,811 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098794   ⟹   ENSRNOP00000083088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,336,229 - 18,381,811 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099242   ⟹   ENSRNOP00000086767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,336,229 - 18,376,018 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103348   ⟹   ENSRNOP00000088082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,336,229 - 18,381,872 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118574   ⟹   ENSRNOP00000083638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,336,229 - 18,376,015 (-)Ensembl
RefSeq Acc Id: NM_022861   ⟹   NP_074052
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,786 (-)NCBI
mRatBN7.21618,333,910 - 18,381,813 (-)NCBI
Rnor_6.01620,056,398 - 20,103,951 (-)NCBI
Rnor_5.01619,917,585 - 19,964,219 (-)NCBI
RGSC_v3.41618,827,405 - 18,872,461 (-)RGD
Celera1618,539,912 - 18,584,310 (-)RGD
Sequence:
RefSeq Acc Id: XM_063275694   ⟹   XP_063131764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,807 (-)NCBI
RefSeq Acc Id: XM_063275695   ⟹   XP_063131765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,807 (-)NCBI
RefSeq Acc Id: XM_063275696   ⟹   XP_063131766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,808 (-)NCBI
RefSeq Acc Id: XM_063275697   ⟹   XP_063131767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,806 (-)NCBI
RefSeq Acc Id: XM_063275698   ⟹   XP_063131768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,807 (-)NCBI
RefSeq Acc Id: XM_063275700   ⟹   XP_063131770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,807 (-)NCBI
RefSeq Acc Id: XM_063275701   ⟹   XP_063131771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,808 (-)NCBI
RefSeq Acc Id: XM_063275702   ⟹   XP_063131772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,415,806 (-)NCBI
RefSeq Acc Id: XM_063275703   ⟹   XP_063131773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,378,559 - 18,415,807 (-)NCBI
RefSeq Acc Id: XM_063275704   ⟹   XP_063131774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,403,802 (-)NCBI
RefSeq Acc Id: XM_063275705   ⟹   XP_063131775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,397,660 (-)NCBI
RefSeq Acc Id: XM_063275706   ⟹   XP_063131776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,367,891 - 18,395,673 (-)NCBI
RefSeq Acc Id: XR_010058317
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,370,750 - 18,415,807 (-)NCBI
RefSeq Acc Id: NP_074052   ⟸   NM_022861
- UniProtKB: Q62768 (UniProtKB/Swiss-Prot),   A0A8I5ZWH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025162   ⟸   ENSRNOT00000025162
RefSeq Acc Id: ENSRNOP00000083088   ⟸   ENSRNOT00000098794
RefSeq Acc Id: ENSRNOP00000083638   ⟸   ENSRNOT00000118574
RefSeq Acc Id: ENSRNOP00000089726   ⟸   ENSRNOT00000095596
RefSeq Acc Id: ENSRNOP00000088082   ⟸   ENSRNOT00000103348
RefSeq Acc Id: ENSRNOP00000086767   ⟸   ENSRNOT00000099242
RefSeq Acc Id: XP_063131771   ⟸   XM_063275701
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A8K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131766   ⟸   XM_063275696
- Peptide Label: isoform X3
- UniProtKB: Q62768 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131768   ⟸   XM_063275698
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A9C4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131765   ⟸   XM_063275695
- Peptide Label: isoform X2
- UniProtKB: Q62768 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131770   ⟸   XM_063275700
- Peptide Label: isoform X6
- UniProtKB: Q62768 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131764   ⟸   XM_063275694
- Peptide Label: isoform X1
- UniProtKB: Q62768 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131772   ⟸   XM_063275702
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A8K9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131767   ⟸   XM_063275697
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A9C4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131774   ⟸   XM_063275704
- Peptide Label: isoform X10
- UniProtKB: Q62768 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063131775   ⟸   XM_063275705
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063131776   ⟸   XM_063275706
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063131773   ⟸   XM_063275703
- Peptide Label: isoform X9
- UniProtKB: A0A8I6A8K9 (UniProtKB/TrEMBL)
Protein Domains
C2   MHD1   MHD2   Phorbol-ester/DAG-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62768-F1-model_v2 AlphaFold Q62768 1-1735 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619722 AgrOrtholog
BioCyc Gene G2FUF-11830 BioCyc
Ensembl Genes ENSRNOG00000018452 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025162.9 UniProtKB/TrEMBL
  ENSRNOT00000095596.1 UniProtKB/TrEMBL
  ENSRNOT00000098794.1 UniProtKB/TrEMBL
  ENSRNOT00000099242.1 UniProtKB/TrEMBL
  ENSRNOT00000103348.1 UniProtKB/TrEMBL
  ENSRNOT00000118574.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.357.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.1100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAPS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Munc13_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Munc13_dom-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Unc-13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Unc-13_C2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64829 UniProtKB/Swiss-Prot
NCBI Gene 64829 ENTREZGENE
PANTHER PTHR10480 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10480:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Unc13a PhenoGen
PRINTS C2DOMAIN UniProtKB/TrEMBL
PROSITE MHD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018452 RatGTEx
SMART DUF1041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZWH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXL5_RAT UniProtKB/TrEMBL
  A0A8I6A1W4_RAT UniProtKB/TrEMBL
  A0A8I6A8K9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9C4 ENTREZGENE, UniProtKB/TrEMBL
  A6K9X2_RAT UniProtKB/TrEMBL
  F1M378_RAT UniProtKB/TrEMBL
  Q62768 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Unc13a  unc-13 homolog A  Unc13a  unc-13 homolog A (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Unc13a  unc-13 homolog A (C. elegans)  Unc13h1  Munc13-1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Unc13h1  Munc13-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membranes in synaptosomes 634400