RGD Reference Report - Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. - Rat Genome Database
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Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming.

Authors: Betz, A  Thakur, P  Junge, HJ  Ashery, U  Rhee, JS  Scheuss, V  Rosenmund, C  Rettig, J  Brose, N 
Citation: Betz A, etal., Neuron 2001 Apr;30(1):183-96.
RGD ID: 634478
Pubmed: (View Article at PubMed) PMID:11343654

Synaptic neurotransmitter release is restricted to active zones, where the processes of synaptic vesicle tethering, priming to fusion competence, and Ca2+-triggered fusion are taking place in a highly coordinated manner. We show that the active zone components Munc13-1, an essential vesicle priming protein, and RIM1, a Rab3 effector with a putative role in vesicle tethering, interact functionally. Disruption of this interaction causes a loss of fusion-competent synaptic vesicles, creating a phenocopy of Munc13-1-deficient neurons. RIM1 binding and vesicle priming are mediated by two distinct structural modules of Munc13-1. The Munc13-1/RIM1 interaction may create a functional link between synaptic vesicle tethering and priming, or it may regulate the priming reaction itself, thereby determining the number of fusion-competent vesicles.

Annotation

Gene Ontology Annotations    

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Rims1  (regulating synaptic membrane exocytosis 1)
Unc13a  (unc-13 homolog A)
Unc13b  (unc-13 homolog B)


Additional Information