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ONTOLOGY REPORT - ANNOTATIONS

Term:zymogen activation
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Accession:GO:0031638 term browser browse the term
Definition:The proteolytic processing of an inactive enzyme to an active form.
Synonyms:exact_synonym: zymogen activation by proteolytic cleavage


show annotations for term's descendants           Sort by:
zymogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1r complement C1r involved_in ISO
IBA		 (PMID:20178990)
GO_REF:0000033		 RGD
GO_Central		 PMID:20178990 GO_REF:0000033 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1rl complement C1r subcomponent like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134 		JBrowse link
G Cd5l Cd5 molecule-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Ctsh cathepsin H involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:20435891)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:20435891 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Ctsl cathepsin L involved_in ISO
ISS		 (PMID:9468501)
GO_REF:0000024		 RGD
UniProt		 PMID:9468501 GO_REF:0000024 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G F12 coagulation factor XII involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:18725990), (PMID:6793628), (PMID:89876)		 Ensembl
GO_Central
RGD		 PMID:89876 PMID:6793628 PMID:18725990 GO_REF:0000033 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G F9 coagulation factor IX involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:2592373)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:2592373 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fcrl1 Fc receptor-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:172,809,442...172,829,780
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
IEA		 (PMID:11799113), (PMID:9130696)
GO_REF:0000107		 RGD
Ensembl		 PMID:9130696 PMID:11799113 GO_REF:0000107 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23682772)		 UniProt
RGD		 PMID:23682772 GO_REF:0000024 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Hgfac HGF activator involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:75,707,588...75,714,182
Ensembl chr14:75,707,591...75,714,278 		JBrowse link
G Klk1 kallikrein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Klk1b3 kallikrein 1-related peptidase B3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Klk1c12 kallikrein 1-related peptidase C12 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,378,103...94,382,140
Ensembl chr 1:94,378,054...94,382,176 		JBrowse link
G Klk1c2 kallikrein 1-related peptidase C2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,492,332...94,496,480
Ensembl chr 1:94,492,332...94,496,481 		JBrowse link
G Klk1c3 kallikrein 1-related peptidase C3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,671,636...94,675,417
Ensembl chr 1:94,671,618...94,675,417 		JBrowse link
G Klk1c6 kallikrein 1-related peptidase C6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,467,626...94,475,842
Ensembl chr 1:94,467,672...94,475,806 		JBrowse link
G Klk1c8 kallikrein 1-related peptidase C8 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,547,774...94,552,287
Ensembl chr 1:94,547,774...94,551,636 		JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:20666777)
MGI:2386246 (PMID:15572153)
GO_REF:0000033		 RGD
GO_Central		 PMID:15572153 PMID:20666777 GO_REF:0000033 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:24550258), (PMID:24719224)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:24550258 PMID:24719224 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980 		JBrowse link
G Or12j2 olfactory receptor family 12 subfamily J member 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:195,209,804...195,210,721
Ensembl chr 1:195,208,141...195,212,120 		JBrowse link
G Prss12 serine protease 12 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:17223089)		 GO_Central
RGD		 PMID:17223089 GO_REF:0000033 NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126 		JBrowse link
G Prss3 serine protease 3 involved_in ISO (PMID:6698368) RGD PMID:6698368 NCBI chr 4:70,203,088...70,206,562
Ensembl chr 4:70,203,088...70,206,562 		JBrowse link
G Prss3b protease, serine, 3B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:69,871,810...69,875,518
Ensembl chr 4:69,871,797...69,875,549 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:20666777) RGD PMID:20666777 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878 		JBrowse link
activation of cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asph aspartate-beta-hydroxylase involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876 		JBrowse link
G Bad BCL2-associated agonist of cell death involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Casp8 caspase 8 involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113 		JBrowse link
G Fadd Fas associated via death domain involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Lgmn legumain involved_in ISO (PMID:9821970) RGD PMID:9821970 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 involved_in ISO UniProtKB:P10749|UniProtKB:P29466 (PMID:15882992) RGD PMID:15882992 NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248 		JBrowse link
G Nlrp6 NLR family, pyrin domain containing 6 acts_upstream_of_or_within ISO (PMID:30248149) RGD PMID:30248149 NCBI chr 1:196,004,854...196,011,615
Ensembl chr 1:196,004,953...196,011,113 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:23302887) RGD PMID:23302887 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 involved_in ISO (PMID:11821383) RGD PMID:11821383 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Tbc1d10a TBC1 domain family, member 10a involved_in ISO (PMID:18387192) RGD PMID:18387192 NCBI chr14:79,051,822...79,083,603
Ensembl chr14:79,055,432...79,083,600 		JBrowse link
negative regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpb2 carboxypeptidase B2 IMP RGD PMID:23369837 RGD:7243115 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Ctsz cathepsin Z involved_in ISO
IEA		 (PMID:19433310)
GO_REF:0000107		 RGD
Ensembl		 PMID:19433310 GO_REF:0000107 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Serpine1 serpin family E member 1 involved_in IEA
ISO
IBA		 GO_REF:0000107
(PMID:19855083)
GO_REF:0000033
(PMID:18835034), (PMID:19855083), (PMID:8508955)		 Ensembl
RGD
GO_Central		 PMID:8508955 PMID:18835034 PMID:19855083 GO_REF:0000033 GO_REF:0000107 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 involved_in ISO
IBA
IEA		 (PMID:19855083)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:19855083 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:134998) RGD PMID:134998 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:6438154) RGD PMID:6438154 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H involved_in ISO
IEA		 (PMID:16480936)
GO_REF:0000107		 RGD
Ensembl		 PMID:16480936 GO_REF:0000107 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:3027024 (PMID:16407971) RGD PMID:16407971 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G F11 coagulation factor XI involved_in ISO (PMID:89876) RGD PMID:89876 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G Fga fibrinogen alpha chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G H2bc1 H2B clustered histone 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17690254)		 Ensembl
RGD		 PMID:17690254 GO_REF:0000107 NCBI chr17:41,172,041...41,172,510
Ensembl chr17:41,171,903...41,176,782
Ensembl chr17:41,171,903...41,176,782 		JBrowse link
G Klkb1 kallikrein B1 involved_in ISO
IEA		 (PMID:89876)
GO_REF:0000107		 RGD
Ensembl		 PMID:89876 GO_REF:0000107 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 involved_in ISO (PMID:11130727) RGD PMID:11130727 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Plat plasminogen activator, tissue type involved_in IDA
ISO
IEA
IBA		 (PMID:12694198), (PMID:17849409), (PMID:24196407)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033		 RGD
InterPro
Ensembl
GO_Central		 PMID:12694198 PMID:17849409 PMID:24196407 PMID:8343497 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:11537479 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase involved_in ISO
IBA
IEA		 (PMID:25978044)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25978044 GO_REF:0000033 GO_REF:0000107 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Tmprss9 transmembrane serine protease 9 acts_upstream_of_or_within ISO (PMID:16872279) RGD PMID:16872279 NCBI chr 7:8,810,321...8,831,177
Ensembl chr 7:8,810,320...8,831,177 		JBrowse link
positive regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:9836589) RGD PMID:9836589 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Clec3b C-type lectin domain family 3, member B involved_in ISS
ISO		 GO_REF:0000024
(PMID:12694198)		 UniProt
RGD		 PMID:12694198 GO_REF:0000024 NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835 		JBrowse link
G Eno1 enolase 1 involved_in ISO (PMID:12666133) RGD PMID:12666133 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G F12 coagulation factor XII involved_in ISO
IEA		 (PMID:89876)
GO_REF:0000107		 RGD
Ensembl		 PMID:89876 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Hpn hepsin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16908524)		 UniProt
Ensembl
RGD		 PMID:16908524 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Meltf melanotransferrin involved_in ISO (PMID:16713448) RGD PMID:16713448 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300 		JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:19897580)		 GO_Central
RGD		 PMID:19897580 GO_REF:0000033 NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 IDA RGD PMID:11027681 RGD:67924 NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384 		JBrowse link
G S100a10 S100 calcium binding protein A10 involved_in ISO
IEA		 (PMID:9836589)
GO_REF:0000107		 RGD
Ensembl		 PMID:9836589 GO_REF:0000107 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661 		JBrowse link
trypsinogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cuzd1 CUB and zona pellucida-like domains 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:12401800)		 UniProt
Ensembl
RGD		 PMID:12401800 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:186,089,422...186,130,536
Ensembl chr 1:186,089,423...186,102,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        macromolecule metabolic process 9808
          protein metabolic process 5296
            protein maturation 643
              protein processing 269
                zymogen activation 68
                  activation of cysteine-type endopeptidase activity 13
                  plasminogen activation + 27
                  trypsinogen activation 1
                  zymogen activation in another organism 0
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        biosynthetic process 8469
          macromolecule biosynthetic process 7494
            gene expression 7050
              protein maturation 643
                protein processing 269
                  zymogen activation 68
                    activation of cysteine-type endopeptidase activity 13
                    plasminogen activation + 27
                    trypsinogen activation 1
                    zymogen activation in another organism 0
paths to the root