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ONTOLOGY REPORT - ANNOTATIONS

Term:zymogen activation
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Accession:GO:0031638 term browser browse the term
Definition:The proteolytic processing of an inactive enzyme to an active form.
Synonyms:exact_synonym: zymogen activation by proteolytic cleavage


show annotations for term's descendants           Sort by:
zymogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1r complement C1r involved_in ISO
IBA		 (PMID:20178990)
GO_REF:0000033		 RGD
GO_Central		 PMID:20178990 GO_REF:0000033 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1rl complement C1r subcomponent like involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134 		JBrowse link
G Cd163 CD163 molecule involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd5l Cd5 molecule-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Cd6 Cd6 molecule involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634 		JBrowse link
G Ctsh cathepsin H involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:20435891)
(MGI:4838939|PMID:20435891)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:20435891 GO_REF:0000024 GO_REF:0000107 MGI:4838939 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Ctsl cathepsin L involved_in ISO
ISS		 (PMID:9468501)
GO_REF:0000024		 RGD
UniProt		 PMID:9468501 GO_REF:0000024 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Dmbt1l1 deleted in malignant brain tumors 1 like 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 1:185,949,897...186,084,340
Ensembl chr 1:185,949,881...186,084,338 		JBrowse link
G ENSRNOG00000066972 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:94,518,965...94,532,051 JBrowse link
G ENSRNOG00000067174 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:94,557,968...94,568,968 JBrowse link
G ENSRNOG00000068886 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:94,651,856...94,654,712 JBrowse link
G ENSRNOG00000069479 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:94,459,406...94,464,664 JBrowse link
G ENSRNOG00000071144 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 Ensembl chr 1:94,395,534...94,397,417 JBrowse link
G F12 coagulation factor XII involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000118
GO_REF:0000033
(PMID:18725990), (PMID:6793628), (PMID:89876)		 Ensembl
TreeGrafter
GO_Central
RGD		 PMID:89876 PMID:6793628 PMID:18725990 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G F9 coagulation factor IX involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:2592373)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:2592373 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Fcrl1 Fc receptor-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:172,809,442...172,829,780
Ensembl chr 2:172,790,934...172,829,753 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
IEA		 (PMID:11799113), (PMID:9130696)
GO_REF:0000107		 RGD
Ensembl		 PMID:9130696 PMID:11799113 GO_REF:0000107 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23682772)		 UniProt
RGD		 PMID:23682772 GO_REF:0000024 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Hgfac HGF activator involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:75,707,588...75,714,182
Ensembl chr14:75,707,591...75,714,278 		JBrowse link
G Hp haptoglobin involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Klk1 kallikrein 1 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754 		JBrowse link
G Klk1b3 kallikrein 1-related peptidase B3 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Klk1c12 kallikrein 1-related peptidase C12 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:94,378,103...94,382,140
Ensembl chr 1:94,378,054...94,382,176 		JBrowse link
G Klk1c2 kallikrein 1-related peptidase C2 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:94,492,332...94,496,480
Ensembl chr 1:94,492,332...94,496,481 		JBrowse link
G Klk1c3 kallikrein 1-related peptidase C3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,671,636...94,675,417
Ensembl chr 1:94,671,618...94,675,417 		JBrowse link
G Klk1c4 kallikrein 1-related peptidase C4 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 1:94,434,574...94,438,678
Ensembl chr 1:94,434,534...94,438,709 		JBrowse link
G Klk1c6 kallikrein 1-related peptidase C6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:94,467,626...94,475,842
Ensembl chr 1:94,467,672...94,475,806 		JBrowse link
G Klk1c8 kallikrein 1-related peptidase C8 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:94,547,774...94,552,287
Ensembl chr 1:94,547,774...94,551,636 		JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245 		JBrowse link
G LOC120093064 scavenger receptor cysteine-rich domain-containing protein SCART1-like involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 1:195,080,285...195,136,263
Ensembl chr 1:195,039,123...195,136,263 		JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974 		JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:20666777)
MGI:2386246 (PMID:15572153)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:15572153 PMID:20666777 GO_REF:0000033 GO_REF:0000118 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5560823|PMID:24550258), (MGI:6436376|PMID:24719224)		 UniProt
Ensembl
RGD		 PMID:24550258 PMID:24719224 GO_REF:0000024 GO_REF:0000107 MGI:5560823 MGI:6436376 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980 		JBrowse link
G Or12j2 olfactory receptor family 12 subfamily J member 2 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:195,209,804...195,210,721
Ensembl chr 1:195,208,141...195,212,120 		JBrowse link
G Prss12 serine protease 12 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:17223089)		 GO_Central
RGD		 PMID:17223089 GO_REF:0000033 NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126 		JBrowse link
G Prss3 serine protease 3 involved_in ISO (PMID:6698368) RGD PMID:6698368 NCBI chr 4:70,203,088...70,206,562
Ensembl chr 4:70,203,088...70,206,562 		JBrowse link
G Prss3b protease, serine, 3B involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:69,871,810...69,875,518
Ensembl chr 4:69,871,797...69,875,549 		JBrowse link
G Ssc5d scavenger receptor cysteine rich family member with 5 domains involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 1:68,891,942...68,910,462
Ensembl chr 1:68,891,949...68,909,743 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:20666777) RGD PMID:20666777 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878 		JBrowse link
activation of cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pawr pro-apoptotic WT1 regulator IMP RGD PMID:10349840 RGD:9835366 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
negative regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpb2 carboxypeptidase B2 IMP RGD PMID:23369837 RGD:7243115 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Ctsz cathepsin Z involved_in ISO
IEA		 (PMID:19433310)
GO_REF:0000107		 RGD
Ensembl		 PMID:19433310 GO_REF:0000107 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Serpine1 serpin family E member 1 involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(MGI:4418017|PMID:19855083)
(PMID:18835034), (PMID:19855083), (PMID:8508955)		 Ensembl
GO_Central
RGD		 PMID:8508955 PMID:18835034 PMID:19855083 GO_REF:0000033 GO_REF:0000107 MGI:4418017 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 involved_in ISO
IBA
IEA		 (PMID:19855083)
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
(MGI:4418017|PMID:19855083)		 RGD
GO_Central
TreeGrafter
Ensembl		 PMID:19855083 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:4418017 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:134998) RGD PMID:134998 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:6438154) RGD PMID:6438154 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H involved_in ISO (PMID:16480936) RGD PMID:16480936 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:3027024 (PMID:16407971) RGD PMID:16407971 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G F11 coagulation factor XI involved_in ISO (PMID:89876) RGD PMID:89876 NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G Fga fibrinogen alpha chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G H2bc1 H2B clustered histone 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17690254)		 Ensembl
RGD		 PMID:17690254 GO_REF:0000107 NCBI chr17:41,172,041...41,172,510
Ensembl chr17:41,171,903...41,176,782
Ensembl chr17:41,171,903...41,176,782 		JBrowse link
G Klkb1 kallikrein B1 involved_in ISO (PMID:89876) RGD PMID:89876 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 involved_in ISO (PMID:11130727) RGD PMID:11130727 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Plat plasminogen activator, tissue type involved_in IDA
ISO
IEA
IBA		 (PMID:12694198), (PMID:17849409), (PMID:24196407)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118		 RGD
InterPro
Ensembl
GO_Central
TreeGrafter		 PMID:12694198 PMID:17849409 PMID:24196407 PMID:8343497 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:11537479 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase involved_in ISO
IEA
IBA		 (PMID:25978044)
GO_REF:0000118
GO_REF:0000033		 RGD
TreeGrafter
GO_Central		 PMID:25978044 GO_REF:0000033 GO_REF:0000118 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Tmprss9 transmembrane serine protease 9 acts_upstream_of_or_within ISO (PMID:16872279) RGD PMID:16872279 NCBI chr 7:8,810,321...8,831,177
Ensembl chr 7:8,810,320...8,831,177 		JBrowse link
positive regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:9836589) RGD PMID:9836589 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Clec3b C-type lectin domain family 3, member B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5447625|PMID:12694198)		 UniProt
RGD		 PMID:12694198 GO_REF:0000024 MGI:5447625 NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835 		JBrowse link
G Eno1 enolase 1 involved_in ISO (PMID:12666133) RGD PMID:12666133 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G F12 coagulation factor XII involved_in ISO
IEA		 (PMID:89876)
GO_REF:0000107		 RGD
Ensembl		 PMID:89876 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Hpn hepsin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:16908524)		 UniProt
Ensembl
RGD		 PMID:16908524 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Meltf melanotransferrin involved_in ISO (PMID:16713448) RGD PMID:16713448 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300 		JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:19897580)		 GO_Central
RGD		 PMID:19897580 GO_REF:0000033 NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 IDA RGD PMID:11027681 RGD:67924 NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384 		JBrowse link
G S100a10 S100 calcium binding protein A10 involved_in ISO
IEA		 (PMID:9836589)
GO_REF:0000107		 RGD
Ensembl		 PMID:9836589 GO_REF:0000107 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661 		JBrowse link
trypsinogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cuzd1 CUB and zona pellucida-like domains 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:2447912|PMID:12401800)		 UniProt
Ensembl
RGD		 PMID:12401800 GO_REF:0000024 GO_REF:0000107 MGI:2447912 NCBI chr 1:186,089,422...186,130,536
Ensembl chr 1:186,089,423...186,102,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    metabolic process 11720
      primary metabolic process 10271
        protein metabolic process 4698
          protein maturation 558
            protein processing 264
              zymogen activation 68
                activation of cysteine-type endopeptidase activity 1
                plasminogen activation + 27
                trypsinogen activation 1
                zymogen activation in another organism + 0
Path 2
Term Annotations click to browse term
  biological_process 20292
    metabolic process 11720
      cellular metabolic process 10279
        cellular biosynthetic process 8211
          macromolecule biosynthetic process 7370
            gene expression 6922
              protein maturation 558
                protein processing 264
                  zymogen activation 68
                    activation of cysteine-type endopeptidase activity 1
                    plasminogen activation + 27
                    trypsinogen activation 1
                    zymogen activation in another organism + 0
paths to the root