Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:plasminogen activation
go back to main search page
Accession:GO:0031639 term browser browse the term
Definition:The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.
Synonyms:exact_synonym: cleavage of plasminogen to plasmin


show annotations for term's descendants           Sort by:
plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H involved_in IEA
ISO		 GO_REF:0000107
(PMID:16480936)		 Ensembl
RGD		 PMID:16480936 GO_REF:0000107 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO MGI:3027024 (MGI:3614236|PMID:16407971) RGD PMID:16407971 MGI:3614236 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G F11 coagulation factor XI involved_in ISO (PMID:89876) RGD PMID:89876 NCBI chr16:46,986,107...47,009,015
Ensembl chr16:46,986,107...47,008,437 		JBrowse link
G Fga fibrinogen alpha chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain involved_in ISO (PMID:16846481) RGD PMID:16846481 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G H2bc1 H2B clustered histone 1 acts_upstream_of_or_within ISO (MGI:3847621|PMID:17690254) RGD PMID:17690254 MGI:3847621 NCBI chr17:41,172,041...41,172,510
Ensembl chr17:41,171,903...41,176,782
Ensembl chr17:41,171,903...41,176,782 		JBrowse link
G Klkb1 kallikrein B1 involved_in ISO
IEA		 (PMID:89876)
GO_REF:0000107		 RGD
Ensembl		 PMID:89876 GO_REF:0000107 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 involved_in ISO (PMID:11130727) RGD PMID:11130727 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Plat plasminogen activator, tissue type involved_in IDA
ISO
IBA
IEA		 (PMID:12694198), (PMID:17849409), (PMID:24196407)
PMID:21873635
GO_REF:0000002		 RGD
InterPro		 PMID:12694198 PMID:17849409 PMID:24196407 PMID:8343497 PMID:21873635 GO_REF:0000002, RGD:11537479, RGD:13792537 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase involved_in ISO
IEA
IBA		 (PMID:25978044)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:25978044 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Tmprss9 transmembrane serine protease 9 acts_upstream_of_or_within ISO (MGI:3694407|PMID:16872279) RGD PMID:16872279 MGI:3694407 NCBI chr 7:8,810,320...8,834,914
Ensembl chr 7:8,810,320...8,831,177 		JBrowse link
negative regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpb2 carboxypeptidase B2 IMP RGD PMID:23369837 RGD:7243115 NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556 		JBrowse link
G Ctsz cathepsin Z involved_in ISO (PMID:19433310) RGD PMID:19433310 NCBI chr 3:163,224,875...163,235,645
Ensembl chr 3:163,224,875...163,235,645 		JBrowse link
G Serpine1 serpin family E member 1 involved_in ISO
IBA
IEA		 (MGI:4418017|PMID:19855083)
PMID:21873635
(PMID:18835034), (PMID:19855083), (PMID:8508955)
GO_REF:0000107		 RGD
Ensembl		 PMID:8508955 PMID:18835034 PMID:19855083 PMID:21873635 GO_REF:0000107 MGI:4418017, RGD:13792537 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpine2 serpin family E member 2 involved_in IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(PMID:19855083)
(MGI:4418017|PMID:19855083)		 Ensembl
RGD		 PMID:19855083 PMID:21873635 GO_REF:0000107 MGI:4418017, RGD:13792537 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:134998) RGD PMID:134998 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:6438154) RGD PMID:6438154 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
positive regulation of plasminogen activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa2 annexin A2 involved_in ISO (PMID:9836589) RGD PMID:9836589 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Clec3b C-type lectin domain family 3, member B involved_in ISS
ISO		 GO_REF:0000024
(MGI:5447625|PMID:12694198)		 UniProt
RGD		 PMID:12694198 GO_REF:0000024 MGI:5447625 NCBI chr 8:122,810,091...122,817,039
Ensembl chr 8:122,810,149...122,815,835 		JBrowse link
G Eno1 enolase 1 involved_in ISO (PMID:12666133) RGD PMID:12666133 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G F12 coagulation factor XII involved_in IEA
ISO		 GO_REF:0000107
(PMID:89876)		 Ensembl
RGD		 PMID:89876 GO_REF:0000107 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Hpn hepsin involved_in ISO
ISS		 (PMID:16908524)
GO_REF:0000024		 RGD
UniProt		 PMID:16908524 GO_REF:0000024 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Meltf melanotransferrin involved_in ISO (PMID:16713448) RGD PMID:16713448 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300 		JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(MGI:4437195|PMID:19897580)		 RGD PMID:19897580 PMID:21873635 MGI:4437195, RGD:13792537 NCBI chr 1:227,099,005...227,111,277
Ensembl chr 1:227,099,015...227,111,194 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 IDA RGD PMID:11027681 RGD:67924 NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384 		JBrowse link
G S100a10 S100 calcium binding protein A10 involved_in ISO (PMID:9836589) RGD PMID:9836589 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      primary metabolic process 10824
        protein metabolic process 5951
          proteolysis 1876
            protein processing 275
              zymogen activation 77
                plasminogen activation 27
                  negative regulation of plasminogen activation 6
                  plasminogen activation in another organism 0
                  positive regulation of plasminogen activation 9
                  regulation of plasminogen activation + 15
Path 2
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      organic substance metabolic process 11597
        macromolecule metabolic process 9959
          protein metabolic process 5951
            proteolysis 1876
              protein processing 275
                zymogen activation 77
                  plasminogen activation 27
                    negative regulation of plasminogen activation 6
                    plasminogen activation in another organism 0
                    positive regulation of plasminogen activation 9
                    regulation of plasminogen activation + 15
paths to the root