Gene: Nlrc4 (NLR family, CARD domain containing 4) Rattus norvegicus
Symbol: Nlrc4
Name: NLR family, CARD domain containing 4
Description: ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); activation of innate immune response (ortholog); defense response to bacterium (ortholog); ASSOCIATED WITH Autoinflammation with Infantile Enterocolitis (ortholog); Cryopyrin-Associated Periodic Syndromes (ortholog); Enterocolitis (ortholog); FOUND IN cytosol (ortholog); IPAF inflammasome complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; endosulfan
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Card12; caspase recruitment domain family, member 12; ice protease-activating factor; ipaf; LOC298784; NLR family CARD domain-containing protein 4
Homo sapiens (human) : NLRC4 (NLR family CARD domain containing 4)  HGNC  Alliance
Mus musculus (house mouse) : Nlrc4 (NLR family, CARD domain containing 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nlrc4 (NLR family CARD domain containing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NLRC4 (NLR family CARD domain containing 4)
Canis lupus familiaris (dog) : NLRC4 (NLR family CARD domain containing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nlrc4 (NLR family CARD domain containing 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0622,167,874 - 22,194,755 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0632,058,459 - 32,081,799 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4620,934,595 - 20,953,654 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1620,933,896 - 20,956,415 (+)NCBI
Celera620,554,800 - 20,577,780 (+)NCBICelera
Cytogenetic Map6q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Nlrc4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309831
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2018-10-09
Status: ACTIVE