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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:olaparib
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Accession:CHEBI:83766 term browser browse the term
Definition:A member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine; used to treat advanced ovarian cancer.
Synonyms:exact_synonym: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one
 related_synonym: AZD-2281;   AZD2281;   Formula=C24H23FN4O3;   InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30);   InChIKey=FDLYAMZZIXQODN-UHFFFAOYSA-N;   KU59436;   Lynparza;   SMILES=Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1
 xref: CAS:763113-22-0;   Drug_Central:4907;   KEGG:D09730;   LINCS:LSM-1145
 xref_mesh: MESH:C531550
 xref: PDBeChem:09L;   PMID:18800822;   PMID:22454224;   PMID:24038812;   PMID:24356813;   PMID:24534203;   PMID:24577941;   PMID:24631446;   PMID:24694947;   PMID:24700236;   PMID:24817481;   PMID:24826054;   PMID:24827126;   PMID:25025963;   PMID:25072752;   PMID:25139258;   PMID:25218906;   PMID:25275045;   PMID:25404465;   PMID:25483710;   PMID:25531448;   PMID:25566684;   PMID:25573533;   Reaxys:12051534;   Wikipedia:Olaparib


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olaparib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions EXP [Dietary Fats co-treated with olaparib] results in decreased expression of ACACA mRNA CTD PMID:27984176 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta multiple interactions EXP [Dietary Fats co-treated with olaparib] results in decreased expression of ACACB mRNA CTD PMID:27984176 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP [Dietary Fats co-treated with olaparib] results in decreased expression of ACOX1 mRNA CTD PMID:27984176 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions EXP olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 mRNA] CTD PMID:27984176 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions EXP olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ADGRE1 mRNA] CTD PMID:27984176 NCBI chr17:57,665,650...57,790,527
Ensembl chr17:57,665,691...57,790,527 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO olaparib inhibits the reaction [Methylmercury Compounds results in increased expression of AIFM1 protein] CTD PMID:35396826 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO olaparib promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; olaparib promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:30296409 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bap1 Brca1 associated protein 1 increases response to substance ISO BAP1 gene mutant form results in increased susceptibility to olaparib CTD PMID:22683710 NCBI chr14:30,973,358...30,981,887
Ensembl chr14:30,973,407...30,981,901 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO olaparib results in increased expression of BAX protein
INCB054329 promotes the reaction [olaparib results in increased expression of BAX protein]		 CTD PMID:29567272 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO olaparib results in decreased expression of BCL2 protein CTD PMID:25531448 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO olaparib results in decreased expression of BIRC5 protein CTD PMID:25531448 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Brca1 breast cancer 1, early onset affects response to substance
multiple interactions		 ISO BRCA1 affects the susceptibility to olaparib
[BRD4 protein affects the susceptibility to olaparib] which affects the expression of BRCA1 protein; [olaparib co-treated with INCB054329] results in decreased expression of BRCA1 protein; olaparib promotes the reaction [INCB054329 results in decreased expression of BRCA1 protein]		 CTD PMID:21633166 PMID:29567272 NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781 		JBrowse link
G Brca2 breast cancer 2, early onset affects response to substance ISO BRCA2 affects the susceptibility to olaparib CTD PMID:21633166 NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions
affects response to substance		 ISO [BRD4 protein affects the susceptibility to olaparib] which affects the cleavage of PARP1 protein; [BRD4 protein affects the susceptibility to olaparib] which affects the expression of BRCA1 protein; [BRD4 protein affects the susceptibility to olaparib] which affects the expression of H2AX protein CTD PMID:29567272 NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Fluorouracil co-treated with olaparib] results in increased cleavage of CASP3 protein; [olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP3 protein]; CASP8 protein affects the reaction [[olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; olaparib inhibits the reaction [Methylmercury Compounds results in increased cleavage of CASP3 protein] CTD PMID:25531448 PMID:26544897 PMID:35396826 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein; [olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased cleavage of CASP8 protein]; CASP8 protein affects the reaction [[olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein] CTD PMID:25531448 PMID:26544897 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP9 protein; olaparib inhibits the reaction [Methylmercury Compounds results in increased expression of CASP9 protein] CTD PMID:25531448 PMID:35396826 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP olaparib inhibits the reaction [Ethanol results in increased expression of CCL2 protein] CTD PMID:29317476 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCN2 mRNA] CTD PMID:27984176 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO [olaparib co-treated with INCB054329] results in decreased expression of CCNE1 protein; olaparib promotes the reaction [INCB054329 results in decreased expression of CCNE1 protein] CTD PMID:29567272 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of CCR2 mRNA CTD PMID:27984176 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO INCB054329 promotes the reaction [olaparib results in increased expression of CDKN1A protein]; olaparib promotes the reaction [INCB054329 results in increased expression of CDKN1A protein] CTD PMID:29567272 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO olaparib results in increased phosphorylation of CHEK1 protein CTD PMID:25531448 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions EXP olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA] CTD PMID:27984176 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Ctcf CCCTC-binding factor decreases binding ISO olaparib decreases binding of CTCF to Cp promoter region in human lymphoblastoid cell lines RGD PMID:29976663 RGD:151356754 NCBI chr 8:106,351,135...106,409,554
Ensembl chr 8:106,363,200...106,409,554 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of CXCL2 mRNA; olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CXCL2 mRNA] CTD PMID:27984176 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO olaparib inhibits the reaction [Methylmercury Compounds results in increased expression of CYCS protein] CTD PMID:35396826 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO olaparib results in increased expression of DDIT3 protein
DDIT3 protein affects the reaction [[TNFSF10 protein co-treated with olaparib] results in increased expression of TNFRSF10B protein]		 CTD PMID:25531448 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Dietary Fats co-treated with olaparib] results in decreased expression of FASN mRNA CTD PMID:27984176 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fh1 fumarate hydratase 1 increases response to substance ISO FH mutant form results in increased susceptibility to olaparib CTD PMID:30013182 NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of GPT protein; olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of GPT protein] CTD PMID:27984176 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
increases expression		 ISO (+)-JQ1 compound promotes the reaction [olaparib results in increased expression of H2AX protein]; [BRD4 protein affects the susceptibility to olaparib] which affects the expression of H2AX protein; [Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein]; INCB054329 promotes the reaction [olaparib results in increased expression of H2AX protein]; olaparib promotes the reaction [(+)-JQ1 compound results in increased expression of H2AX protein]; olaparib promotes the reaction [INCB054329 results in increased expression of H2AX protein]; TP53 gene mutant form affects the reaction [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein]]
olaparib results in increased phosphorylation of H2AX protein		 CTD PMID:25531448 PMID:26544897 PMID:29567272 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO olaparib inhibits the reaction [Ethanol results in increased expression of HMGB1 protein] CTD PMID:29339456 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of ICAM1 mRNA CTD PMID:27984176 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of IL1B mRNA CTD PMID:27984176 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP olaparib inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:29317476 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ly6g lymphocyte antigen 6 family member G multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of LY6G mRNA; olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of LY6G mRNA] CTD PMID:27984176 NCBI chr15:75,027,110...75,030,977
Ensembl chr15:75,027,089...75,030,975 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]
bafilomycin A1 inhibits the reaction [olaparib inhibits the reaction [Hydrogen Peroxide results in increased lipidation of MAP1LC3B protein]]; olaparib inhibits the reaction [Hydrogen Peroxide results in increased lipidation of MAP1LC3B protein]		 CTD PMID:34826546 PMID:36639873 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression
multiple interactions		 ISO olaparib results in decreased expression of MKI67 protein
INCB054329 promotes the reaction [olaparib results in decreased expression of MKI67 protein]; olaparib promotes the reaction [INCB054329 results in decreased expression of MKI67 protein]		 CTD PMID:29567272 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mlh1 mutL homolog 1 multiple interactions ISO olaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of MPO protein CTD PMID:27984176 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Msh2 mutS homolog 2 multiple interactions ISO olaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141 		JBrowse link
G Msh3 mutS homolog 3 decreases response to substance ISO MSH3 protein results in decreased susceptibility to olaparib CTD PMID:21285347 NCBI chr13:92,348,387...92,491,515
Ensembl chr13:92,348,380...92,491,511 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions
decreases activity
decreases binding
increases cleavage		 EXP
ISO		 olaparib inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]
olaparib results in decreased activity of PARP1 protein
olaparib decreases binding of PARP1 to Cp promoter region in human lymphoblastoid cell lines
(+)-JQ1 compound promotes the reaction [olaparib results in increased cleavage of PARP1 protein]; [BRD4 protein affects the susceptibility to olaparib] which affects the cleavage of PARP1 protein; INCB054329 promotes the reaction [olaparib results in increased cleavage of PARP1 protein]; olaparib inhibits the reaction [Methylmercury Compounds results in increased cleavage of PARP1 protein]; olaparib promotes the reaction [INCB054329 results in increased cleavage of PARP1 protein]		 CTD
RGD		 PMID:24814482 PMID:28001384 PMID:29567272 PMID:35396826 PMID:29976663 RGD:151356754 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Parp2 poly (ADP-ribose) polymerase family, member 2 multiple interactions ISO olaparib binds to and results in decreased activity of PARP2 protein CTD PMID:28001384 NCBI chr14:51,045,347...51,058,758
Ensembl chr14:51,045,298...51,058,758 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions		 ISO olaparib results in decreased expression of PCNA protein
INCB054329 promotes the reaction [olaparib results in decreased expression of PCNA protein]		 CTD PMID:29567272 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) multiple interactions ISO olaparib inhibits the reaction [Ethanol results in increased expression of PLA2G2A protein] CTD PMID:29339456 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) multiple interactions ISO olaparib inhibits the reaction [Ethanol results in increased expression of PLA2G4A protein] CTD PMID:29339456 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Dietary Fats co-treated with olaparib] results in decreased expression of PPARA mRNA CTD PMID:27984176 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO [olaparib co-treated with INCB054329] results in decreased expression of RAD51 protein CTD PMID:29567272 NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926 		JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) increases response to substance ISO SDHB mutant form results in increased susceptibility to olaparib CTD PMID:30013182 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression		 ISO olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]
olaparib results in increased expression of SIRT1 protein		 CTD PMID:34826546 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO olaparib inhibits the reaction [Hydrogen Peroxide results in decreased expression of SQSTM1 protein] CTD PMID:36639873 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Dietary Fats co-treated with olaparib] results in decreased expression of SREBF1 mRNA CTD PMID:27984176 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA] CTD PMID:27984176 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of TNF mRNA; olaparib inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; olaparib inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:27984176 PMID:29317476 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO [olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein; [olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein; [olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP9 protein; [TNFSF10 protein co-treated with olaparib] results in increased expression of TNFRSF10B protein; CASP8 protein affects the reaction [[olaparib co-treated with TNFSF10 protein] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [[TNFSF10 protein co-treated with olaparib] results in increased expression of TNFRSF10B protein] CTD PMID:25531448 NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases phosphorylation		 ISO [Fluorouracil co-treated with olaparib] results in increased expression of TP53 protein; TP53 gene mutant form affects the reaction [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein]]
olaparib results in increased phosphorylation of TP53 protein		 CTD PMID:25531448 PMID:26544897 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 multiple interactions ISO olaparib affects the reaction [[XRCC1 protein affects the susceptibility to Camptothecin] which affects the abundance of NAD] CTD PMID:35778544 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865 		JBrowse link
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  CHEBI ontology 22192
    role 22177
      biological role 22176
        biochemical role 21448
          apoptosis inducer 13771
            olaparib 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 22192
    subatomic particle 22184
      composite particle 22184
        hadron 22184
          baryon 22184
            nucleon 22184
              atomic nucleus 22184
                atom 22184
                  main group element atom 22118
                    p-block element atom 22118
                      carbon group element atom 21918
                        carbon atom 21844
                          organic molecular entity 21844
                            organic molecule 21660
                              organic cyclic compound 21266
                                carbocyclic compound 19699
                                  benzenoid aromatic compound 18846
                                    benzenes 18648
                                      fluorobenzenes 6675
                                        monofluorobenzenes 5316
                                          olaparib 59
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