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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732095
Species: Mus musculus
RGD Object: Gene
Symbol: Pcna
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:83766
Term: olaparib
Definition: A member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine; used to treat advanced ovarian cancer.
Chemical ID: MESH:C531550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcnadecreases expressionISOPCNA (Homo sapiens)6480464CTDolaparib results in decreased expression of PCNA proteinPMID:29567272
Pcnamultiple interactionsISOPCNA (Homo sapiens)6480464CTDINCB054329 promotes the reaction [olaparib results in decreased expression of PCNA protein]PMID:29567272
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