Msh3 (mutS homolog 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Msh3 (mutS homolog 3) Mus musculus
Analyze
Symbol: Msh3
Name: mutS homolog 3
RGD ID: 1557363
MGI Page MGI
Description: Enables centromeric DNA binding activity and damaged DNA binding activity. Acts upstream of or within mismatch repair and somatic recombination of immunoglobulin gene segments. Predicted to be part of MutSbeta complex. Predicted to be active in nucleus. Is expressed in early conceptus; oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D13Em1; DNA mismatch repair protein Msh3; protein repair-1; protein repair-3; Re; Rep; REP-1; Rep-3; Rep3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,348,387 - 92,491,515 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,348,380 - 92,491,511 (-)EnsemblGRCm39 Ensembl
GRCm381392,211,878 - 92,355,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,211,872 - 92,355,003 (-)EnsemblGRCm38mm10GRCm38
MGSCv371392,981,836 - 93,124,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,312,634 - 93,455,756 (-)NCBIMGSCv36mm8
Celera1395,828,509 - 95,961,232 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
MutSbeta complex  (ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
4. Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients. Liu JY, etal., Chin J Cancer. 2017 Jan 16;36(1):12. doi: 10.1186/s40880-016-0175-2.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Risinger JI, etal., Nat Genet. 1996 Sep;14(1):102-5.
14. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
15. Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. Yin J, etal., Hum Mutat. 1997;10(6):474-8.
Additional References at PubMed
PMID:2233729   PMID:2674679   PMID:2722860   PMID:2982814   PMID:7926796   PMID:8889548   PMID:10349636   PMID:10545954   PMID:10662804   PMID:10706084   PMID:11042159   PMID:11076861  
PMID:11223406   PMID:11691815   PMID:11809728   PMID:12477932   PMID:12520002   PMID:12612914   PMID:14610273   PMID:15238604   PMID:15238605   PMID:16141072   PMID:16141073   PMID:16260499  
PMID:16437133   PMID:16552576   PMID:16618598   PMID:16728433   PMID:16964442   PMID:17142234   PMID:18799693   PMID:21344488   PMID:21690297   PMID:21873635   PMID:22174455   PMID:22289650  
PMID:23468640   PMID:24013230   PMID:24457600   PMID:26023099   PMID:26420841   PMID:29178930   PMID:32325033   PMID:37127331   PMID:38267530   PMID:38355793  


Genomics

Comparative Map Data
Msh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,348,387 - 92,491,515 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,348,380 - 92,491,511 (-)EnsemblGRCm39 Ensembl
GRCm381392,211,878 - 92,355,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,211,872 - 92,355,003 (-)EnsemblGRCm38mm10GRCm38
MGSCv371392,981,836 - 93,124,958 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,312,634 - 93,455,756 (-)NCBIMGSCv36mm8
Celera1395,828,509 - 95,961,232 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.63NCBI
MSH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,654,652 - 80,876,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,654,652 - 80,876,815 (+)EnsemblGRCh38hg38GRCh38
GRCh37579,950,471 - 80,172,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,986,050 - 80,208,390 (+)NCBINCBI36Build 36hg18NCBI36
Build 34579,986,294 - 80,208,389NCBI
Celera575,854,379 - 76,076,910 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,159,370 - 75,381,401 (+)NCBIHuRef
CHM1_1579,383,713 - 79,605,325 (+)NCBICHM1_1
T2T-CHM13v2.0581,139,552 - 81,361,456 (+)NCBIT2T-CHM13v2.0
Msh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,179,400 - 25,320,857 (-)NCBIGRCr8
mRatBN7.2223,444,326 - 23,585,777 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx230,479,042 - 30,620,224 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,579,397 - 28,720,585 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,406,403 - 23,548,408 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0221,790,048 - 21,931,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl221,790,044 - 21,931,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0240,996,035 - 41,137,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,462,934 - 22,606,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera219,534,848 - 19,675,746 (-)NCBICelera
Cytogenetic Map2q12NCBI
Msh3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541829,150,085 - 29,274,437 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541829,149,595 - 29,274,067 (-)NCBIChiLan1.0ChiLan1.0
MSH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,432,400 - 34,653,426 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,582,453 - 32,806,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,408,469 - 34,663,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1534,719,261 - 34,938,521 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,719,322 - 34,938,469 (-)Ensemblpanpan1.1panPan2
MSH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,335,788 - 26,520,633 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,336,403 - 26,518,521 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,571,200 - 27,762,336 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,250,075 - 26,441,642 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,250,084 - 26,441,647 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,190,404 - 26,381,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,171,404 - 26,356,535 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,451,047 - 26,636,178 (-)NCBIUU_Cfam_GSD_1.0
Msh3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,351,062 - 182,542,651 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646983,285 - 273,561 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646982,967 - 275,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,250,003 - 89,453,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,255,647 - 89,456,102 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,102,138 - 91,281,732 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,811,181 - 75,032,067 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl474,811,198 - 75,032,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,674,149 - 23,899,258 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msh3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,461,077 - 1,581,180 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,461,952 - 1,581,524 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Msh3
4983 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:115
Interacting mature miRNAs:123
Transcripts:ENSMUST00000022220
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
12879495Fexq1_mfear expression QTL 1 (mouse)137826885895836553Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
12880402Emlq1_memotional learning QTL 1 (mouse)137810885896866553Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
1301610Dps1_mdelta power in slow-wave sleep 1 (mouse)Not determined137719586295730894Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse

Markers in Region
Msh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371393,121,206 - 93,121,391UniSTSGRCm37
Celera1395,957,447 - 95,957,632UniSTS
Cytogenetic Map13C3UniSTS
cM Map1351.0UniSTS
cM Map1351.0UniSTS
M80360  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,212,171 - 92,212,342UniSTSGRCm38
MGSCv371392,982,126 - 92,982,297UniSTSGRCm37
Celera1395,828,799 - 95,828,970UniSTS
Cytogenetic Map13C3UniSTS
cM Map1351.0UniSTS
Whitehead_YAC13 UniSTS
PMC138237P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,355,155 - 92,355,324UniSTSGRCm38
MGSCv371393,125,110 - 93,125,279UniSTSGRCm37
Celera1395,961,384 - 95,961,553UniSTS
Cytogenetic Map13C3UniSTS
cM Map1351.0UniSTS
cM Map1343.0UniSTS
Msh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381392,351,251 - 92,351,436UniSTSGRCm38
MGSCv371393,121,206 - 93,121,391UniSTSGRCm37
Celera1395,957,447 - 95,957,632UniSTS
Cytogenetic Map13C3UniSTS
cM Map1351.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001311120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004937944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC155263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM900100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ571929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY710130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01059462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK022909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000022220   ⟹   ENSMUSP00000022220
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,348,394 - 92,491,511 (-)Ensembl
GRCm38.p6 Ensembl1392,211,886 - 92,355,003 (-)Ensembl
Ensembl Acc Id: ENSMUST00000185852   ⟹   ENSMUSP00000140002
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,348,380 - 92,491,503 (-)Ensembl
GRCm38.p6 Ensembl1392,211,872 - 92,354,995 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186392
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,348,394 - 92,386,581 (-)Ensembl
GRCm38.p6 Ensembl1392,211,886 - 92,250,073 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186878
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,482,377 - 92,491,461 (-)Ensembl
GRCm38.p6 Ensembl1392,345,869 - 92,354,953 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187424   ⟹   ENSMUSP00000139622
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,487,635 - 92,491,493 (-)Ensembl
GRCm38.p6 Ensembl1392,351,127 - 92,354,985 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187831
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,477,180 - 92,491,023 (-)Ensembl
GRCm38.p6 Ensembl1392,340,672 - 92,354,515 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187874   ⟹   ENSMUSP00000139620
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,386,362 - 92,491,493 (-)Ensembl
GRCm38.p6 Ensembl1392,249,854 - 92,354,985 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189376
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,449,160 - 92,481,886 (-)Ensembl
GRCm38.p6 Ensembl1392,312,652 - 92,345,378 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190393   ⟹   ENSMUSP00000141163
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,483,028 - 92,491,493 (-)Ensembl
GRCm38.p6 Ensembl1392,346,520 - 92,354,985 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190462
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,444,005 - 92,445,965 (-)Ensembl
GRCm38.p6 Ensembl1392,307,497 - 92,309,457 (-)Ensembl
Ensembl Acc Id: ENSMUST00000190761   ⟹   ENSMUSP00000140402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,348,765 - 92,372,107 (-)Ensembl
GRCm38.p6 Ensembl1392,212,257 - 92,235,599 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191242
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,348,388 - 92,377,638 (-)Ensembl
GRCm38.p6 Ensembl1392,211,880 - 92,241,130 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191304
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,348,389 - 92,402,580 (-)Ensembl
GRCm38.p6 Ensembl1392,211,881 - 92,266,072 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191509   ⟹   ENSMUSP00000141158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,445,688 - 92,491,504 (-)Ensembl
GRCm38.p6 Ensembl1392,309,180 - 92,354,996 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191550   ⟹   ENSMUSP00000140659
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1392,348,390 - 92,491,507 (-)Ensembl
GRCm38.p6 Ensembl1392,211,882 - 92,354,999 (-)Ensembl
RefSeq Acc Id: NM_001311120   ⟹   NP_001298049
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,394 - 92,491,515 (-)NCBI
GRCm381392,211,878 - 92,355,003 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010829   ⟹   NP_034959
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,394 - 92,491,515 (-)NCBI
GRCm381392,211,881 - 92,355,003 (-)NCBI
MGSCv371392,981,836 - 93,124,958 (-)RGD
Celera1395,828,509 - 95,961,232 (-)ENTREZGENE
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517542   ⟹   XP_006517605
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,389 - 92,491,359 (-)NCBI
GRCm381392,211,881 - 92,354,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006517543   ⟹   XP_006517606
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,389 - 92,491,360 (-)NCBI
GRCm381392,211,881 - 92,354,852 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315412   ⟹   XP_017170901
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,387 - 92,483,215 (-)NCBI
GRCm381392,211,881 - 92,354,852 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017315413   ⟹   XP_017170902
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,389 - 92,491,359 (-)NCBI
GRCm381392,211,881 - 92,354,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157896   ⟹   XP_036013789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,387 - 92,491,509 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157897   ⟹   XP_036013790
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,387 - 92,483,953 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004937944
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391392,348,389 - 92,491,513 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034959   ⟸   NM_010829
- Peptide Label: isoform 1
- UniProtKB: A0A087WQ16 (UniProtKB/TrEMBL),   B2RWY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517606   ⟸   XM_006517543
- Peptide Label: isoform X1
- UniProtKB: B2RWY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517605   ⟸   XM_006517542
- Peptide Label: isoform X1
- UniProtKB: B2RWY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001298049   ⟸   NM_001311120
- Peptide Label: isoform 2
- UniProtKB: E9QPY6 (UniProtKB/TrEMBL),   B2RWY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017170902   ⟸   XM_017315413
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017170901   ⟸   XM_017315412
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000140659   ⟸   ENSMUST00000191550
Ensembl Acc Id: ENSMUSP00000141158   ⟸   ENSMUST00000191509
Ensembl Acc Id: ENSMUSP00000140002   ⟸   ENSMUST00000185852
Ensembl Acc Id: ENSMUSP00000140402   ⟸   ENSMUST00000190761
Ensembl Acc Id: ENSMUSP00000141163   ⟸   ENSMUST00000190393
Ensembl Acc Id: ENSMUSP00000022220   ⟸   ENSMUST00000022220
Ensembl Acc Id: ENSMUSP00000139620   ⟸   ENSMUST00000187874
Ensembl Acc Id: ENSMUSP00000139622   ⟸   ENSMUST00000187424
RefSeq Acc Id: XP_036013789   ⟸   XM_036157896
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036013790   ⟸   XM_036157897
- Peptide Label: isoform X2
Protein Domains
DNA mismatch repair protein MutS-like N-terminal   DNA mismatch repair proteins mutS family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13705-F1-model_v2 AlphaFold P13705 1-1091 view protein structure

Promoters
RGD ID:8680978
Promoter ID:EPDNEW_M18520
Type:initiation region
Name:Msh3_1
Description:Mus musculus mutS homolog 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381392,354,975 - 92,355,035EPDNEW
RGD ID:6824168
Promoter ID:MM_KWN:14883
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:ENSMUST00000109520
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361393,011,426 - 93,011,926 (-)MPROMDB
RGD ID:6824165
Promoter ID:MM_KWN:14888
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   MEF_B6,   Spleen
Transcripts:ENSMUST00000022219
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361393,124,261 - 93,124,761 (-)MPROMDB
RGD ID:6824167
Promoter ID:MM_KWN:14889
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   Brain,   Kidney
Transcripts:NM_010829,   UC007RKJ.1,   UC007RKK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361393,124,646 - 93,125,146 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109519 AgrOrtholog
Ensembl Genes ENSMUSG00000014850 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022220 ENTREZGENE
  ENSMUST00000022220.13 UniProtKB/TrEMBL
  ENSMUST00000185852 ENTREZGENE
  ENSMUST00000185852.7 UniProtKB/TrEMBL
  ENSMUST00000187424.2 UniProtKB/TrEMBL
  ENSMUST00000187874.7 UniProtKB/TrEMBL
  ENSMUST00000190393.7 UniProtKB/TrEMBL
  ENSMUST00000190761.2 UniProtKB/TrEMBL
  ENSMUST00000191509.7 UniProtKB/TrEMBL
  ENSMUST00000191550 ENTREZGENE
  ENSMUST00000191550.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_MutS-lik_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS/MSH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mmatch_repair_MutS_con_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_con_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109519 ENTREZGENE
NCBI Gene 17686 ENTREZGENE
PANTHER DNA MISMATCH REPAIR PROTEIN MSH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11361 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MutS_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_V UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Msh3 PhenoGen
PIRSF DNA_mis_repair_Msh6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MUTSac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUTSd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WP43_MOUSE UniProtKB/TrEMBL
  A0A087WP45_MOUSE UniProtKB/TrEMBL
  A0A087WQ16 ENTREZGENE, UniProtKB/TrEMBL
  A0A087WQZ2_MOUSE UniProtKB/TrEMBL
  A0A087WRJ5_MOUSE UniProtKB/TrEMBL
  A0A087WSR8_MOUSE UniProtKB/TrEMBL
  A0A087WSS2_MOUSE UniProtKB/TrEMBL
  B2RWY6 ENTREZGENE, UniProtKB/TrEMBL
  E9QPY6 ENTREZGENE, UniProtKB/TrEMBL
  MSH3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TTD3_MOUSE UniProtKB/TrEMBL
  Q8CGC9_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Msh3  mutS homolog 3    mutS homolog 3 (E. coli)  Symbol and/or name change 5135510 APPROVED