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lupeol - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lupeol
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Accession:CHEBI:6570 term browser browse the term
Definition:A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables.
Synonyms:exact_synonym: (3beta)-lup-20(29)-en-3-ol
 related_synonym: Formula=C30H50O;   InChI=1S/C30H50O/c1-19(2)20-11-14-27(5)17-18-29(7)21(25(20)27)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3/t20-,21+,22-,23+,24-,25+,27+,28-,29+,30+/m0/s1;   InChIKey=MQYXUWHLBZFQQO-QGTGJCAVSA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]1(C)CC[C@@H](C(C)=C)[C@]21[H];   beta-viscol;   fagarasterol;   monogynol B
 alt_id: CHEBI:132397
 xref: CAS:545-47-1;   KEGG:C08628;   KNApSAcK:C00003749
 xref_mesh: MESH:C010480
 xref: MetaCyc:CPD-90;   PMID:10930257;   PMID:16445885;   PMID:17107079;   PMID:21118697;   PMID:21467639;   PMID:21712449;   PMID:9883589;   Pubchem:259846;   Reaxys:2063497

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lupeol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO lupeol results in decreased expression of ABCG2 protein CTD PMID:20979057 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO		 lupeol inhibits the reaction [COL2A1 results in increased expression of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein]]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein]		 CTD PMID:35446470 PMID:39067743 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions EXP lupeol inhibits the reaction [COL2A1 results in increased activity of ALOX5 protein] CTD PMID:35446470 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
lupeol results in increased expression of BAX mRNA; lupeol results in increased expression of BAX protein
lupeol inhibits the reaction [COL2A1 results in decreased expression of BAX protein]		 CTD PMID:27235710 PMID:30506710 PMID:31112703 PMID:35446470 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
lupeol results in decreased expression of BCL2 mRNA; lupeol results in decreased expression of BCL2 protein
lupeol inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]		 CTD PMID:27235710 PMID:30506710 PMID:31112703 PMID:35446470 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of BECN1 protein]]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of BECN1 protein] CTD PMID:39067743 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO
EXP		 lupeol results in increased expression of CASP3 mRNA; lupeol results in increased expression of CASP3 protein
lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP3 protein]		 CTD PMID:30506710 PMID:35446470 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression ISO lupeol results in increased expression of CASP8 mRNA; lupeol results in increased expression of CASP8 protein CTD PMID:30506710 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions		 ISO
EXP		 lupeol results in increased expression of CASP9 mRNA; lupeol results in increased expression of CASP9 protein
lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP9 protein]		 CTD PMID:30506710 PMID:35446470 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions EXP
ISO		 lupeol inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased activity of CAT protein]; lupeol inhibits the reaction [Sodium Selenite results in decreased activity of CAT protein]
lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]		 CTD PMID:16933029 PMID:26697995 PMID:27235710 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO lupeol results in decreased expression of CCND1 mRNA CTD PMID:20732907 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 increases expression ISO lupeol results in increased expression of CDH1 mRNA; lupeol results in increased expression of CDH1 protein CTD PMID:31112703 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases activity
multiple interactions		 ISO lupeol results in decreased activity of CFLAR protein
enzalutamide promotes the reaction [lupeol results in decreased activity of CFLAR protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of CFLAR protein]		 CTD PMID:37777120 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP lupeol inhibits the reaction [COL2A1 protein results in increased secretion of Dinoprostone]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of IL6 protein]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of TNF protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of BAX protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP3 protein]; lupeol inhibits the reaction [COL2A1 results in decreased expression of CASP9 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of ALOX5 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of MPO protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of PTGS2 protein]; lupeol inhibits the reaction [COL2A1 results in increased expression of AKT1 protein]; lupeol inhibits the reaction [COL2A1 results in increased expression of BCL2 protein]; lupeol inhibits the reaction [COL2A1 results in increased secretion of CP protein]; lupeol inhibits the reaction [COL2A1 results in increased secretion of CRP protein] CTD PMID:35446470 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cp ceruloplasmin multiple interactions EXP lupeol inhibits the reaction [COL2A1 results in increased secretion of CP protein] CTD PMID:35446470 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Crp C-reactive protein multiple interactions EXP lupeol inhibits the reaction [COL2A1 results in increased secretion of CRP protein] CTD PMID:35446470 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cryz crystallin zeta multiple interactions ISO lupeol inhibits the reaction [Benzoyl Peroxide affects the activity of CRYZ protein] CTD PMID:15248479 NCBI chr 2:246,211,707...246,239,472
Ensembl chr 2:243,552,119...243,579,758 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions		 ISO lupeol results in decreased expression of CTNNB1 protein
lupeol results in decreased localization of and results in decreased activity of CTNNB1 protein		 CTD PMID:20732907 PMID:20979057 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA] CTD PMID:27235710 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects binding EXP lupeol binds to GSK3B protein CTD PMID:18222664 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP lupeol inhibits the reaction [Sodium Selenite results in decreased activity of GSR protein] CTD PMID:26697995 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il10 interleukin 10 decreases expression
increases expression		 ISO lupeol results in decreased expression of IL10 mRNA
lupeol results in increased expression of IL10 protein		 CTD PMID:31112703 PMID:39067743 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO lupeol results in decreased expression of IL1B mRNA
lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of IL1B protein]		 CTD PMID:31112703 PMID:39067743 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO
EXP		 lupeol results in decreased expression of IL6 mRNA
lupeol inhibits the reaction [COL2A1 protein results in increased secretion of IL6 protein]		 CTD PMID:31112703 PMID:35446470 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO lupeol results in decreased expression of MKI67 mRNA CTD PMID:20732907 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP		 [lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased activity of MPO protein]
lupeol inhibits the reaction [COL2A1 results in increased activity of MPO protein]		 CTD PMID:32006539 PMID:35446470 PMID:39067743 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of MTOR protein]]; lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of MTOR protein] CTD PMID:39067743 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
decreases activity		 ISO lupeol results in decreased expression of MYC mRNA
enzalutamide promotes the reaction [lupeol results in decreased activity of MYC protein]; lupeol promotes the reaction [enzalutamide results in decreased activity of MYC protein]		 CTD PMID:20732907 PMID:37777120 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO lupeol results in decreased expression of NANOG protein CTD PMID:20979057 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Nes nestin decreases expression ISO lupeol results in decreased expression of NES protein CTD PMID:20979057 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Numa1 nuclear mitotic apparatus protein 1 multiple interactions EXP lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of NUMA1 protein] CTD PMID:26251508 NCBI chr 1:165,709,893...165,784,848
Ensembl chr 1:156,326,259...156,372,855 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA] CTD PMID:27235710 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO lupeol results in decreased expression of PCNA mRNA CTD PMID:20732907 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO lupeol results in decreased expression of POU5F1 protein CTD PMID:20979057 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Prom1 prominin 1 decreases expression ISO lupeol results in decreased expression of PROM1 protein CTD PMID:20979057 NCBI chr14:71,202,303...71,307,008
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
increases response to substance
multiple interactions		 ISO
EXP		 lupeol results in increased expression of PTEN protein
PTEN protein results in increased susceptibility to lupeol
lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in decreased expression of PTEN protein]		 CTD PMID:20979057 PMID:26251508 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA] CTD PMID:27235710 NCBI chr 3:34,575,643...34,586,987 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of PTGS2 protein]; lupeol inhibits the reaction [COL2A1 results in increased activity of PTGS2 protein] CTD PMID:26251508 PMID:35446470 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]
lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased phosphorylation of RELA protein]		 CTD PMID:26251508 PMID:27235710 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO lupeol results in decreased expression of SOX2 protein CTD PMID:20979057 NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TLR4 protein] CTD PMID:39067743 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 lupeol results in decreased expression of TNF mRNA
lupeol inhibits the reaction [[Butylhydroxybutylnitrosamine co-treated with Cacodylic Acid] results in increased expression of TNF protein]; lupeol inhibits the reaction [COL2A1 protein results in increased secretion of TNF protein]
lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]		 CTD PMID:26251508 PMID:31112703 PMID:35446470 PMID:39067743 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA] CTD PMID:27235710 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO lupeol inhibits the reaction [Benzoyl Peroxide affects the activity of XDH protein] CTD PMID:15248479 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA] CTD PMID:27235710 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        anti-inflammatory agent 16678
          anti-inflammatory drug 14962
            lupeol 47
              3-(Z)-caffeoyllupeol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            organic hydride 18698
                              organic fundamental parent 18698
                                hydrocarbon 18446
                                  terpene 14074
                                    triterpene 1268
                                      triterpenoid 1264
                                        pentacyclic triterpenoid 526
                                          lupeol 47
                                            3-(Z)-caffeoyllupeol 0
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