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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-(6-acetamidohexyl)acetamide
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Accession:CHEBI:125472 term browser browse the term
Definition:An acetamide that has formula C10H20N2O2.
Synonyms:exact_synonym: hexamethylene bisacetamide
 related_synonym: Formula=C10H20N2O2;   InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14);   InChIKey=BNQSTAOJRULKNX-UHFFFAOYSA-N;   SMILES=CC(=O)NCCCCCCNC(=O)C
 alt_id: MESH:C014026
 xref: HMDB:HMDB0041901;   LINCS:LSM-36966
 xref_mesh: MESH:C014026


show annotations for term's descendants           Sort by:
N-(6-acetamidohexyl)acetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO hexamethylene bisacetamide affects the expression of BAX CTD PMID:15543656 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO hexamethylene bisacetamide affects the expression of BCL2 CTD PMID:15543656 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of BCL2A1 mRNA CTD PMID:12130515 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 affects expression ISO hexamethylene bisacetamide affects the expression of BCL2L1 CTD PMID:15543656 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Brd2 bromodomain containing 2 multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter] CTD PMID:26941288 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CCNE1 mRNA CTD PMID:17349212 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd2 Cd2 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD2 mRNA CTD PMID:26941288 NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026 		JBrowse link
G Cd44 CD44 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD44 mRNA CTD PMID:17349212 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd52 CD52 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD52 mRNA CTD PMID:26941288 NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348 		JBrowse link
G Cd69 Cd69 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD69 mRNA CTD PMID:26941288 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO hexamethylene bisacetamide results in decreased expression of CD74 mRNA CTD PMID:26941288 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDC6 mRNA CTD PMID:26941288 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdc7 cell division cycle 7 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDC7 mRNA CTD PMID:26941288 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDK2 mRNA CTD PMID:26941288 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO hexamethylene bisacetamide results in increased expression of CDKN1A mRNA; hexamethylene bisacetamide results in increased expression of CDKN1A protein
[Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CDKN1A mRNA		 CTD PMID:10597302 PMID:12130515 PMID:17349212 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO hexamethylene bisacetamide results in increased expression of CDKN1B mRNA CTD PMID:17349212 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdt1 chromatin licensing and DNA replication factor 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of CDT1 mRNA CTD PMID:26941288 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA; [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of CEBPE mRNA CTD PMID:12130515 NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein]; [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [thiamet G results in increased O-linked glycosylation of CHD4 protein]; [Hemin co-treated with hexamethylene bisacetamide] results in decreased O-linked glycosylation of CHD4 protein CTD PMID:27231347 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression ISO hexamethylene bisacetamide results in increased expression of CSF1R mRNA CTD PMID:8445950 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Dbf4 DBF4-CDC7 kinase regulatory subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of DBF4 mRNA CTD PMID:26941288 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of DUSP6 protein mutant form CTD PMID:17569113 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Eif6 eukaryotic translation initiation factor 6 increases expression ISO hexamethylene bisacetamide results in increased expression of EIF6 protein CTD PMID:17569113 NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression ISO hexamethylene bisacetamide results in increased expression of HBA-A1 mRNA CTD PMID:26941288 NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 increases expression ISO hexamethylene bisacetamide results in increased expression of HEXIM1 mRNA; hexamethylene bisacetamide results in increased expression of HEXIM1 protein CTD PMID:16222702 NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA] CTD PMID:12042074 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hoxa9 homeobox A9 increases expression ISO hexamethylene bisacetamide results in increased expression of HOXA9 protein CTD PMID:16973558 NCBI chr 4:81,323,235...81,329,344
Ensembl chr 4:81,323,382...81,326,358 		JBrowse link
G Hpx hemopexin multiple interactions ISO hexamethylene bisacetamide inhibits the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of HMOX1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased expression of IFIT3 mRNA CTD PMID:12130515 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of IGFBP2 mRNA CTD PMID:26941288 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO hexamethylene bisacetamide results in increased expression of ITGAM protein CTD PMID:10597302 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
increases expression		 ISO hexamethylene bisacetamide results in increased phosphorylation of JUN protein
hexamethylene bisacetamide results in increased expression of JUN protein		 CTD PMID:10597302 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM10 mRNA CTD PMID:26941288 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM2 mRNA CTD PMID:26941288 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM3 mRNA CTD PMID:26941288 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM4 mRNA CTD PMID:26941288 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM5 mRNA CTD PMID:26941288 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM6 mRNA CTD PMID:26941288 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO hexamethylene bisacetamide results in decreased expression of MCM7 mRNA CTD PMID:26941288 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Tretinoin co-treated with arsenic trioxide co-treated with hexamethylene bisacetamide] results in decreased expression of MPO mRNA CTD PMID:12130515 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT1 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT1 mRNA] CTD PMID:12042074 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO hexamethylene bisacetamide promotes the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased expression of MT2 mRNA]; hexamethylene bisacetamide promotes the reaction [[mesoporphyrin IX binds to HPX protein] which results in increased expression of MT2 mRNA] CTD PMID:12042074 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MYB protein CTD PMID:10597302 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO hexamethylene bisacetamide results in decreased expression of MYC protein CTD PMID:10597302 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of NPM1 protein CTD PMID:17569113 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO [Hemin co-treated with hexamethylene bisacetamide] inhibits the reaction [CHD4 protein binds to OGT protein] CTD PMID:27231347 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of PML protein mutant form CTD PMID:12130515 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of POLA2 mRNA CTD PMID:26941288 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348 		JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit decreases expression ISO hexamethylene bisacetamide results in decreased expression of POLE mRNA CTD PMID:26941288 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939 		JBrowse link
G Prim1 DNA primase subunit 1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of PRIM1 mRNA CTD PMID:26941288 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526 		JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of PRIM2 mRNA CTD PMID:26941288 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Tretinoin co-treated with hexamethylene bisacetamide] results in increased cleavage of RARA protein mutant form CTD PMID:12130515 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO hexamethylene bisacetamide results in decreased phosphorylation of RB1 protein CTD PMID:10597302 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rpa1 replication protein A1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA1 mRNA CTD PMID:26941288 NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949 		JBrowse link
G Rpa2 replication protein A2 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA2 mRNA CTD PMID:26941288 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rpa3 replication protein A3 decreases expression ISO hexamethylene bisacetamide results in decreased expression of RPA3 mRNA CTD PMID:26941288 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709 		JBrowse link
G RT1-Ba RT1 class II, locus Ba decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-AA mRNA CTD PMID:26941288 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-AB1 mRNA CTD PMID:26941288 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 decreases expression ISO hexamethylene bisacetamide results in decreased expression of H2-EB1 mRNA CTD PMID:26941288 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Sin3b SIN3 transcription regulator family member B increases expression ISO hexamethylene bisacetamide results in increased expression of SIN3B protein CTD PMID:17569113 NCBI chr16:17,123,277...17,159,978
Ensembl chr16:17,123,434...17,159,978 		JBrowse link
G Sla src-like adaptor decreases expression ISO hexamethylene bisacetamide results in decreased expression of SLA mRNA CTD PMID:26941288 NCBI chr 7:98,534,431...98,584,810
Ensembl chr 7:98,535,368...98,584,648 		JBrowse link
G Slamf9 SLAM family member 9 decreases expression ISO hexamethylene bisacetamide results in decreased expression of SLAMF9 mRNA CTD PMID:26941288 NCBI chr13:84,941,896...84,944,749
Ensembl chr13:84,941,982...84,944,748 		JBrowse link
G Srm spermidine synthase multiple interactions
decreases expression		 ISO hexamethylene bisacetamide inhibits the reaction [BRD2 protein binds to SRM promoter]
hexamethylene bisacetamide results in decreased expression of SRM mRNA		 CTD PMID:26941288 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405 		JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 increases expression ISO hexamethylene bisacetamide results in increased expression of SRSF1 protein CTD PMID:17569113 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression ISO hexamethylene bisacetamide results in increased expression of TUBB4B protein CTD PMID:17569113 NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    chemical entity 19867
      atom 19888
        nonmetal atom 19789
          nitrogen atom 18971
            nitrogen molecular entity 18971
              organonitrogen compound 18845
                carboxamide 17566
                  acetamides 14620
                    N-(6-acetamidohexyl)acetamide 65
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbon oxoacid 18666
                                    carboxylic acid 18663
                                      carboacyl group 17715
                                        univalent carboacyl group 17690
                                          carbamoyl group 17566
                                            carboxamide 17566
                                              acetamides 14620
                                                N-(6-acetamidohexyl)acetamide 65
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