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ONTOLOGY REPORT - ANNOTATIONS

Term:prostaglandin metabolic process
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Accession:GO:0006693 term browser browse the term
Definition:The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.
Synonyms:exact_synonym: prostaglandin metabolism
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa


show annotations for term's descendants           Sort by:
prostaglandin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:7876265)		 UniProt
Ensembl
RGD		 PMID:7876265 GO_REF:0000024 GO_REF:0000107 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c14 aldo-keto reductase family 1, member C14 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:66,156,286...66,173,277
Ensembl chr17:66,156,288...66,173,277 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 involved_in ISO (PMID:8573067) RGD PMID:8573067 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO
IBA		 (PMID:20036328), (PMID:9792917)
GO_REF:0000033		 RGD
GO_Central		 PMID:9792917 PMID:20036328 GO_REF:0000033 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488 		JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 acts_upstream_of_or_within ISO MGI:2673510 (PMID:24051376) RGD PMID:24051376 NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475 		JBrowse link
G Ces2h carboxylesterase 2H involved_in ISO (PMID:21049984) RGD PMID:21049984 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Comt catechol-O-methyltransferase acts_upstream_of_or_within ISO MGI:2178542 (PMID:19770404) RGD PMID:19770404 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 involved_in ISO (PMID:21068195) RGD PMID:21068195 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 involved_in ISO (PMID:9084911) RGD PMID:9084911 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 involved_in ISO
ISS		 (PMID:9084911)
GO_REF:0000024		 RGD
UniProt		 PMID:9084911 GO_REF:0000024 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:9084911)		 UniProt
RGD		 PMID:9084911 GO_REF:0000024 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase involved_in IDA
IBA
ISS
ISO		 GO_REF:0000033
GO_REF:0000024
(PMID:16828555), (PMID:21072165)		 GO_Central
UniProt
RGD		 PMID:16828555 PMID:21072165 PMID:18058808 GO_REF:0000024 GO_REF:0000033, RGD:11667092 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:12627223)
(PMID:10824118)
GO_REF:0000024		 RGD
UniProt		 PMID:10824118 PMID:12627223 GO_REF:0000024 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883 		JBrowse link
G Pdpn podoplanin acts_upstream_of_or_within ISO MGI:2657021 (PMID:16869965) RGD PMID:16869965 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656 		JBrowse link
G Plaa phospholipase A2, activating protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:28007986)		 UniProt
RGD		 PMID:28007986 GO_REF:0000024 NCBI chr 5:109,428,600...109,460,373
Ensembl chr 5:109,428,265...109,460,282 		JBrowse link
G Ptges prostaglandin E synthase acts_upstream_of_or_within ISO (PMID:10869354) RGD PMID:10869354 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges3 prostaglandin E synthase 3 IMP RGD PMID:21334450 RGD:5688070 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptgr1 prostaglandin reductase 1 involved_in ISO
IEA
IBA		 (PMID:25619643)
GO_REF:0000107
GO_REF:0000033
(PMID:11688989)		 RGD
Ensembl
GO_Central		 PMID:11688989 PMID:25619643 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Ptgr2 prostaglandin reductase 2 involved_in ISO
IEA
IBA
ISS		 (PMID:19000823)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
GO_REF:0000024		 RGD
Ensembl
InterPro
GO_Central
UniProt		 PMID:19000823 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:103,931,367...103,963,113
Ensembl chr 6:103,931,409...103,963,111 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 acts_upstream_of_or_within ISO MGI:1857238 (PMID:10987272) RGD PMID:10987272 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
cyclooxygenase pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 involved_in ISO (PMID:23846981) RGD PMID:23846981 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 involved_in IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:1380156)		 Ensembl
GO_Central
RGD		 PMID:1380156 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA		 GO_REF:0000024
(PMID:12925531)
(PMID:1419907)
GO_REF:0000033
(PMID:1380156), (PMID:7592599), (PMID:7947975)		 UniProt
RGD
GO_Central		 PMID:1380156 PMID:1419907 PMID:7592599 PMID:7947975 PMID:12925531 GO_REF:0000024 GO_REF:0000033 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO MGI:2182095|MGI:5758867 (PMID:28973536) RGD PMID:28973536 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237 		JBrowse link
G Sphk1 sphingosine kinase 1 IDA RGD PMID:18723875 RGD:2311353 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
negative regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir204 microRNA 204 involved_in ISO (PMID:29441883) RGD PMID:29441883 NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040 		JBrowse link
G Pibf1 progesterone immunomodulatory binding factor 1 involved_in ISO (PMID:3863495) RGD PMID:3863495 NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712 		JBrowse link
G Sirt1 sirtuin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20042607)		 Ensembl
RGD		 PMID:20042607 GO_REF:0000107 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
positive regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 IMP RGD PMID:8260938 RGD:2306959 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Avp arginine vasopressin IMP RGD PMID:17254553 RGD:2300349 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:17254553 RGD:2300349 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Cd74 CD74 molecule involved_in ISO
IEA		 (PMID:24569872)
GO_REF:0000107		 RGD
Ensembl		 PMID:24569872 GO_REF:0000107 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO RNAcentral:URS0000424278_9606 (PMID:29384235) RGD PMID:29384235 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:9786861 RGD:2304243 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:23624557) RGD PMID:23624557 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
G Pla2g4a phospholipase A2 group 4A IMP RGD PMID:16203828 RGD:1642461 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:24287039) RGD PMID:24287039 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO (PMID:21716255) RGD PMID:21716255 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07054614.1 involved_in IEA GO_REF:0000107
GO_REF:0000043		 Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107
G Akr1c15 aldo-keto reductase family 1, member C15 involved_in ISO (PMID:25726376) RGD PMID:25726376 NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061 		JBrowse link
G Cd74 CD74 molecule involved_in ISO
IEA
ISS		 (PMID:12782713)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12782713 GO_REF:0000024 GO_REF:0000107 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Daglb diacylglycerol lipase, beta involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23103940)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23103940 GO_REF:0000024 GO_REF:0000107 NCBI chr12:11,059,732...11,102,170
Ensembl chr12:11,059,732...11,102,154 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:9492062) RGD PMID:9492062 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn2 endothelin 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:9492062)		 Ensembl
RGD		 PMID:9492062 GO_REF:0000107 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase TAS RGD PMID:9323136 RGD:68838 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:12782713) RGD PMID:12782713 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA
ISO		 GO_REF:0000107
(PMID:27292189)		 Ensembl
RGD		 PMID:27292189 GO_REF:0000107 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g2a phospholipase A2 group IIA involved_in ISO (PMID:27292189) RGD PMID:27292189 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g4a phospholipase A2 group 4A involved_in ISO
IEA
ISS		 (PMID:18451993), (PMID:27642067)
(PMID:9403692), (PMID:9403693)
GO_REF:0000043
GO_REF:0000107
GO_REF:0000024
GO_REF:0000041		 RGD
UniProt
Ensembl		 PMID:9403692 PMID:9403693 PMID:18451993 PMID:27642067 GO_REF:0000024 GO_REF:0000041 GO_REF:0000043 GO_REF:0000107 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g4f phospholipase A2, group IVF acts_upstream_of_or_within ISO (PMID:17293613) RGD PMID:17293613 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689 		JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 involved_in ISO (PMID:15695510) RGD PMID:15695510 NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734 		JBrowse link
G Prxl2b peroxiredoxin like 2B involved_in ISS
ISO
IBA		 PMID:18006499
(PMID:18006499)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:18006499 PMID:18006499 GO_REF:0000024 GO_REF:0000033, RGD:8552775 NCBI chr 5:165,462,610...165,465,213 JBrowse link
G Ptgds prostaglandin D2 synthase involved_in IDA
ISO		 PMID:7836410
(PMID:17715133)
(PMID:20347284), (PMID:20667974)		 RGD PMID:17715133 PMID:20347284 PMID:20667974 PMID:7836410 RGD:8553429 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptges prostaglandin E synthase involved_in TAS
ISO
IBA
IEA
IDA		 (PMID:11795891)
GO_REF:0000033
(PMID:25726376)
(PMID:18682561)
GO_REF:0000041		 RGD
GO_Central
UniProt		 PMID:11795891 PMID:18682561 PMID:25726376 PMID:11067848 PMID:11067848 GO_REF:0000033 GO_REF:0000041, RGD:67929, RGD:67929 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptges2 prostaglandin E synthase 2 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688 		JBrowse link
G Ptges3 prostaglandin E synthase 3 acts_upstream_of_or_within
involved_in		 IMP
ISO
IBA
IEA
ISS
IDA		 MGI:3701300 (PMID:17438133)
GO_REF:0000033
GO_REF:0000043
GO_REF:0000041
GO_REF:0000024
(PMID:10922363)		 RGD
GO_Central
UniProt		 PMID:10922363 PMID:17438133 PMID:10922363 PMID:10922363 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000043, RGD:5688071, RGD:5688071 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptges3l1 prostaglandin E synthase 3-like 1 involved_in IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr  X:42,215,200...42,224,472
Ensembl chr  X:42,214,756...42,225,047 		JBrowse link
G Ptgis prostaglandin I2 synthase involved_in IMP
IEA
IBA
ISO
ISS
IDA		 GO_REF:0000043
GO_REF:0000033
GO_REF:0000107
(PMID:15115769), (PMID:20122998), (PMID:21296955)
GO_REF:0000024		 UniProt
GO_Central
Ensembl
RGD		 PMID:15115769 PMID:20122998 PMID:21296955 PMID:10359560 PMID:10536678 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107, RGD:727270, RGD:401959739, RGD:1580695, RGD:8693629 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 acts_upstream_of_or_within
involved_in		 IMP
ISO
ISS		 MGI:1857238 (PMID:12093889)
GO_REF:0000024		 RGD
UniProt		 PMID:12093889 PMID:17673564 GO_REF:0000024, RGD:2300259 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in IMP
ISO		 (PMID:12925531)
(PMID:27642067)		 RGD PMID:12925531 PMID:27642067 PMID:17673564 RGD:2300259 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxas1 thromboxane A synthase 1 involved_in ISO
ISS		 (PMID:11097184)
GO_REF:0000024		 RGD
UniProt		 PMID:11097184 GO_REF:0000024 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
regulation of prostaglandin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp5 fatty acid binding protein 5 involved_in ISO (PMID:29440395) RGD PMID:29440395 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11950
        primary metabolic process 10579
          lipid metabolic process 1452
            fatty acid metabolic process 455
              unsaturated fatty acid metabolic process 141
                prostanoid metabolic process 60
                  prostaglandin metabolic process 59
                    prostaglandin biosynthetic process + 37
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11950
        small molecule metabolic process 1914
          organic acid metabolic process 1044
            oxoacid metabolic process 1031
              carboxylic acid metabolic process 1016
                monocarboxylic acid metabolic process 743
                  fatty acid metabolic process 455
                    unsaturated fatty acid metabolic process 141
                      prostanoid metabolic process 60
                        prostaglandin metabolic process 59
                          prostaglandin biosynthetic process + 37
paths to the root