humulene - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	humulene	go back to main search page
Accession:	CHEBI:49289	browse the term
Synonyms:	related_synonym:	Formula=C15H24; Humulen

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Genes (52)

(1E,4E,8E)-alpha-humulene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

humulene results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

zerumbone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

zerumbone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

zerumbone promotes the reaction [[2-aminofluorene co-treated with Diethylnitrosamine] results in increased expression of BAX protein]
zerumbone analog results in increased expression of BAX protein

PMID:20452335 PMID:28987329

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

zerumbone results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

zerumbone analog results in decreased expression of BCL2 protein; zerumbone results in decreased expression of BCL2 mRNA
zerumbone inhibits the reaction [[2-aminofluorene co-treated with Diethylnitrosamine] results in increased expression of BCL2 protein]

PMID:16007145 PMID:20452335 PMID:28987329

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

decreases expression

zerumbone results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

decreases expression

zerumbone results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 2

decreases expression

zerumbone results in decreased expression of BIRC2 mRNA

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

decreases expression

zerumbone results in decreased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

zerumbone results in decreased expression of BIRC5 mRNA

PMID:16007145 PMID:36122806

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions

zerumbone analog results in increased activity of and results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin D1

decreases expression

zerumbone results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

increases expression

zerumbone results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CASP8 and FADD-like apoptosis regulator

decreases expression

zerumbone results in decreased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

zerumbone inhibits the reaction [CHUK protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression

zerumbone results in decreased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

zerumbone results in increased expression of CYP1A2 mRNA

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

zerumbone results in increased expression of CYP2C19 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases expression

zerumbone results in decreased expression of CYP2D6 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

endoplasmic reticulum to nucleus signaling 1

increases expression

zerumbone results in increased expression of ERN1 mRNA

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

growth arrest and DNA-damage-inducible, alpha

increases expression

zerumbone results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glutathione peroxidase 1

increases expression

zerumbone results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione S-transferase pi 1

increases expression

zerumbone results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

intercellular adhesion molecule 1

decreases expression

zerumbone results in decreased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor 1

decreases expression

zerumbone results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

zerumbone inhibits the reaction [TNF protein results in increased activity of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 beta

decreases expression
multiple interactions
decreases secretion

zerumbone results in decreased expression of IL1B mRNA
zerumbone inhibits the reaction [IL1B protein results in increased expression of IL1B mRNA]; zerumbone inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]
zerumbone results in decreased secretion of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

zerumbone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

microtubule-associated protein 1 light chain 3 alpha

decreases expression

zerumbone results in decreased expression of MAP1LC3A mRNA

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

mitogen-activated protein kinase kinase kinase 14

multiple interactions

zerumbone inhibits the reaction [MAP3K14 protein results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523

G

mitogen activated protein kinase 1

multiple interactions

zerumbone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

zerumbone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 2

multiple interactions

zerumbone analog results in decreased expression of and results in decreased secretion of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

zerumbone inhibits the reaction [DDT results in increased expression of MMP3 mRNA]; zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

decreases expression
multiple interactions

zerumbone results in decreased expression of MMP9 mRNA
zerumbone analog results in decreased expression of and results in decreased secretion of MMP9 protein

PMID:16007145 PMID:28987329

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

zerumbone results in decreased expression of MYC mRNA

PMID:16007145 PMID:36122806

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression

zerumbone inhibits the reaction [CHUK protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [MAP3K14 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNFRSF1A protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TRADD protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TRAF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone results in decreased activity of [NFKB1 protein binds to RELA protein]
zerumbone results in decreased expression of NFKB1 mRNA

PMID:16007145 PMID:36122806

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

zerumbone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; zerumbone inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

zerumbone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases expression

zerumbone results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

poly (ADP-ribose) polymerase 1

increases cleavage
decreases expression

zerumbone analog results in increased cleavage of PARP1 protein; zerumbone results in increased cleavage of PARP1 protein
zerumbone results in decreased expression of PARP1 mRNA

PMID:16007145 PMID:28987329 PMID:36122806

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

zerumbone inhibits the reaction [[2-aminofluorene co-treated with Diethylnitrosamine] results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

zerumbone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; zerumbone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
zerumbone results in decreased expression of PTGS2 mRNA
zerumbone inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

PMID:15122579 PMID:16007145 PMID:20865247 PMID:28442377

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases phosphorylation

zerumbone inhibits the reaction [CHUK protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; zerumbone inhibits the reaction [MAP3K14 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; zerumbone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; zerumbone inhibits the reaction [TNFRSF1A protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TRADD protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TRAF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone results in decreased activity of [NFKB1 protein binds to RELA protein]
zerumbone results in decreased phosphorylation of RELA protein

PMID:16007145 PMID:27567548

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

superoxide dismutase 2

increases expression

zerumbone results in increased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

tumor necrosis factor

multiple interactions

zerumbone inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; zerumbone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNF protein results in increased activity of CHUK protein]; zerumbone inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; zerumbone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; zerumbone inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; zerumbone inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
zerumbone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

PMID:16007145 PMID:28442377

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

zerumbone inhibits the reaction [TNFRSF1A protein results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

decreases expression

zerumbone results in decreased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

zerumbone inhibits the reaction [TRADD protein results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

TNF receptor-associated factor 1

decreases expression

zerumbone results in decreased expression of TRAF1 mRNA

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

Tnf receptor-associated factor 2

multiple interactions

zerumbone inhibits the reaction [TRAF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538

G

vascular endothelial growth factor A

multiple interactions
decreases expression

zerumbone inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]
zerumbone analog results in decreased expression of VEGFA protein

PMID:20865247 PMID:28987329

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-linked inhibitor of apoptosis

decreases expression

zerumbone results in decreased expression of XIAP mRNA

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19898
chemical entity	19896
atom	19896
nonmetal atom	19818
carbon atom	19771
organic molecular entity	19771
isoprenoid	14074
terpene	14074
sesquiterpene	3289
humulene	52
alpha-humulene +	52
beta-humulene +	0
gamma-humulene +	0
Path 2
Term	Annotations
CHEBI ontology	19898
subatomic particle	19896
composite particle	19896
hadron	19896
baryon	19896
nucleon	19896
atomic nucleus	19896
atom	19896
main group element atom	19835
main group molecular entity	19835
s-block molecular entity	19670
hydrogen molecular entity	19651
hydrides	19158
organic hydride	18704
organic fundamental parent	18704
hydrocarbon	18452
terpene	14074
sesquiterpene	3289
humulane	52
humulene	52
alpha-humulene +	52
beta-humulene +	0
gamma-humulene +	0

paths to the root