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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
mebeverine results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
mebeverine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Acox1 |
acyl-CoA oxidase 1 |
increases activity |
EXP |
Dicamba results in increased activity of ACOX1 protein |
CTD |
PMID:7657066 |
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NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
Dicamba inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] |
CTD |
PMID:29782964 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Alb |
albumin |
multiple interactions |
EXP |
[bentazone co-treated with Dicamba] results in increased secretion of ALB protein |
CTD |
PMID:25863332 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Ebf2 |
EBF transcription factor 2 |
multiple interactions |
ISO |
[Herbicides results in increased abundance of Dicamba] which affects the methylation of EBF2 gene |
CTD |
PMID:34516295 |
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NCBI chr15:41,435,509...41,634,403
Ensembl chr15:41,435,509...41,634,403
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Dicamba inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] |
CTD |
PMID:29782964 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
Dicamba results in increased expression of SRXN1 mRNA |
CTD |
PMID:34626751 |
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NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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G |
Oprd1 |
opioid receptor, delta 1 |
affects response to substance |
ISO |
OPRD1 protein affects the susceptibility to eluxadoline |
CTD |
PMID:25261794 |
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NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
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G |
Duox2 |
dual oxidase 2 |
increases expression |
ISO |
methyl vanillate results in increased expression of DUOX2 mRNA |
CTD |
PMID:35523312 |
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NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902
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G |
Nox4 |
NADPH oxidase 4 |
decreases expression |
ISO |
methyl vanillate results in decreased expression of NOX4 mRNA |
CTD |
PMID:35523312 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases activity |
ISO |
2-methoxybenzoic acid inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid] 2-methoxybenzoic acid results in decreased activity of PTGS2 protein |
CTD |
PMID:12538810 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein] |
CTD |
PMID:36764371 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:36764371 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of BAD protein] |
CTD |
PMID:33651899 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP3 mRNA] |
CTD |
PMID:25794854 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP8 mRNA] |
CTD |
PMID:25794854 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of CASP9 mRNA] |
CTD |
PMID:25794854 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of DDIT3 protein] |
CTD |
PMID:36764371 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased activity of DGAT2 protein] |
CTD |
PMID:36764371 |
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NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:36764371 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:36764371 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:36764371 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
EXP |
Vanillic Acid inhibits the reaction [Isoproterenol results in increased expression of FAS mRNA] |
CTD |
PMID:25794854 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of FASN protein] |
CTD |
PMID:36764371 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of FGF21 protein] |
CTD |
PMID:36764371 |
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NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of G6PC1 protein] |
CTD |
PMID:33651899 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Gck |
glucokinase |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased activity of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GCK protein] |
CTD |
PMID:33651899 |
|
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Gckr |
glucokinase regulator |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of GCKR protein] |
CTD |
PMID:33651899 |
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NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of GSK3B protein] |
CTD |
PMID:33651899 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gys1 |
glycogen synthase 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GYS1 protein] |
CTD |
PMID:33651899 |
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NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of HSPA5 protein] |
CTD |
PMID:36764371 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of HSPA9 protein] |
CTD |
PMID:36764371 |
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NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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G |
Ide |
insulin degrading enzyme |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of IDE protein] |
CTD |
PMID:36764371 |
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NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Vanillic Acid affects the reaction [INS protein results in increased expression of PRKCB protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased activity of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of ATP6 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of BAD protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of FGF21 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GCK protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GYS1 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of HSPA9 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of IDE protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of IRS2 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of MFN2 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Vanillic Acid inhibits the reaction [INS protein results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]; Vanillic Acid inhibits the reaction [INS protein results in increased activity of DGAT2 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of DDIT3 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of FASN protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of G6PC1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of GCKR protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of HSPA5 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of IRS1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of ITPR1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of MAPK8 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of PPARG protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of SCD protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of SREBF1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased expression of XBP1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein]; Vanillic Acid inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:33651899 PMID:36764371 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of IRS1 protein] |
CTD |
PMID:36764371 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irs2 |
insulin receptor substrate 2 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of IRS2 protein] |
CTD |
PMID:36764371 |
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NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of ITPR1 protein] |
CTD |
PMID:36764371 |
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NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of MAPK8 protein] |
CTD |
PMID:36764371 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mfn2 |
mitofusin 2 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of MFN2 protein] |
CTD |
PMID:36764371 |
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NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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G |
Mir122 |
microRNA 122 |
decreases expression |
ISO |
Vanillic Acid results in decreased expression of MIR122 mRNA |
CTD |
PMID:24165878 |
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NCBI chr18:58,758,703...58,758,787
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of ATP6 protein] |
CTD |
PMID:36764371 |
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NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Nos3 |
nitric oxide synthase 3 |
increases expression |
ISO |
Vanillic Acid results in increased expression of NOS3 mRNA |
CTD |
PMID:15740983 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Or5d18 |
olfactory receptor family 5 subfamily D member 18 |
multiple interactions |
ISO |
Vanillic Acid analog binds to and results in increased activity of OR5D18 protein |
CTD |
PMID:21142015 |
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NCBI chr 3:73,516,522...73,517,463
Ensembl chr 3:73,516,364...73,519,858 Ensembl chr 3:73,516,364...73,519,858
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of PPARG protein] |
CTD |
PMID:36764371 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkcb |
protein kinase C, beta |
multiple interactions |
ISO |
Vanillic Acid affects the reaction [INS protein results in increased expression of PRKCB protein] |
CTD |
PMID:36764371 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of SCD protein] |
CTD |
PMID:36764371 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Slc2a2 |
solute carrier family 2 member 2 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein] |
CTD |
PMID:36764371 |
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NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of SREBF1 protein] |
CTD |
PMID:36764371 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of Vanillic Acid |
CTD |
PMID:15117964 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Xbp1 |
X-box binding protein 1 |
multiple interactions |
ISO |
Vanillic Acid inhibits the reaction [INS protein results in increased expression of XBP1 protein] |
CTD |
PMID:36764371 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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