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ONTOLOGY REPORT - ANNOTATIONS


Term:eluxadoline
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Accession:CHEBI:85980 term browser browse the term
Definition:An amino acid amide obtained by the formal condensation of the carboxy group of 4-carbamoyl-2,6-dimethyl-L-phenylalanine with the secondary amino group of 2-methoxy-5-({[(1S)-1-(4-phenylimidazol-2-yl)ethyl]amino}methyl)benzoic acid. It has mixed opioid receptor activity and is used for treatment of irritable bowel syndrome with diarrhoea.
Synonyms:exact_synonym: 5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid
 related_synonym: Formula=C32H35N5O5;   InChI=1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1;   InChIKey=QFNHIDANIVGXPE-FNZWTVRRSA-N;   SMILES=COc1ccc(CN([C@@H](C)c2nc(c[nH]2)-c2ccccc2)C(=O)[C@@H](N)Cc2c(C)cc(cc2C)C(N)=O)cc1C(O)=O;   Viberzi
 xref: CAS:864821-90-9;   Drug_Central:5001;   KEGG:D10403
 xref_mesh: MESH:C583636
 xref: PMID:23583433;   PMID:25261794;   PMID:25491493;   Reaxys:12390967


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eluxadoline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Oprd1 opioid receptor, delta 1 JBrowse link 5 150,288,126 150,323,063 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      application 19385
        pharmaceutical 19254
          drug 19254
            gastrointestinal drug 316
              eluxadoline 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    main group molecular entity 19674
                      s-block molecular entity 19416
                        hydrogen molecular entity 19407
                          hydrides 18389
                            organic hydride 17747
                              organic fundamental parent 17747
                                hydrocarbon 17255
                                  cyclic hydrocarbon 15317
                                    monocyclic hydrocarbon 5770
                                      annulene 5592
                                        aromatic annulene 5592
                                          benzene 5592
                                            alkylbenzene 3344
                                              methylbenzene 3206
                                                toluene 3069
                                                  benzyl group 2479
                                                    phenylalanine 2479
                                                      L-phenylalanine 2225
                                                        L-phenylalanine derivative 2214
                                                          eluxadoline 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.