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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:actinomycin
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Accession:CHEBI:15369 term browser browse the term
Definition:A large group of antibiotics isolated from various species of Streptomyces and characterised by having a substituted phenoxazine ring linked to two cyclic heterodetic peptides.
Synonyms:related_synonym: actinomycins
 alt_id: CHEBI:13723;   CHEBI:22220;   CHEBI:2445
 xref: CAS:1402-38-6;   KEGG:C01775


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actinomycin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions		 ISO
EXP		 ABCB1 protein results in decreased susceptibility to Dactinomycin
Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of ABCB1 mRNA]
Dactinomycin inhibits the reaction [[Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [[Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1A mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Dactinomycin inhibits the reaction [tetrabromobisphenol A results in increased expression of and results in increased activity of ABCB1A protein]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]		 CTD PMID:1967174 PMID:11455017 PMID:15725475 PMID:18474546 PMID:19813763 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions EXP Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1B mRNA] CTD PMID:20410605 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO
EXP		 ABCC1 protein results in decreased susceptibility to Dactinomycin CTD PMID:11455017 PMID:12067707 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases response to substance
multiple interactions		 EXP
ISO		 ABCC2 protein results in decreased susceptibility to Dactinomycin
Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of ABCC2 mRNA]
Dactinomycin inhibits the reaction [Bucladesine results in increased expression of ABCC2 mRNA]		 CTD PMID:11408547 PMID:11455017 PMID:26049102 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Dactinomycin inhibits the reaction [Daunorubicin results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [Doxorubicin results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [SHH protein alternative form results in increased expression of ABCG2 protein]; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA] CTD PMID:20019844 PMID:21625222 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abhd3 abhydrolase domain containing 3, phospholipase increases expression ISO Dactinomycin results in increased expression of ABHD3 mRNA CTD PMID:21527772 NCBI chr18:1,723,203...1,778,488
Ensembl chr18:1,720,718...1,803,428 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] CTD PMID:15932931 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions EXP Dactinomycin inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA] CTD PMID:10585473 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 multiple interactions ISO Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] CTD PMID:17018608 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of ADRB2 protein]; Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA] CTD PMID:22483689 PMID:24705868 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Agrp agouti related neuropeptide decreases expression
multiple interactions		 ISO Dactinomycin results in decreased expression of AGRP mRNA
Dactinomycin inhibits the reaction [bisphenol A results in increased expression of AGRP mRNA]		 CTD PMID:32575098 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [Amiodarone results in increased expression of AGT mRNA]
Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]		 CTD PMID:16705055 PMID:17214612 PMID:19292980 PMID:23288202 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Dactinomycin inhibits the reaction [TGFB1 protein results in decreased expression of AHR mRNA]
ARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]		 CTD PMID:9145908 PMID:16226227 PMID:25637755 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aicda activation-induced cytidine deaminase multiple interactions ISO [Dactinomycin co-treated with Alpha-Amanitin] inhibits the reaction [Estradiol results in increased expression of AICDA mRNA] CTD PMID:19139166 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased expression of AIFM1 protein CTD PMID:17707539 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases stability		 ISO PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]
PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF1 protein affects the reaction [YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]; YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF2 protein affects the reaction [YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]		 CTD PMID:14640974 PMID:37061066 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions EXP Dactinomycin inhibits the reaction [Fish Oils results in increased activity of ALPI protein] CTD PMID:15599000 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877 		JBrowse link
G Alx3 ALX homeobox 3 multiple interactions EXP Dactinomycin inhibits the reaction [Folic Acid results in increased expression of ALX3 mRNA] CTD PMID:20534379 NCBI chr 2:195,231,197...195,241,609
Ensembl chr 2:195,231,197...195,241,609 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions EXP Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein] CTD PMID:2860926 PMID:6218830 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of AQP1 mRNA] CTD PMID:22415096 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases expression ISO Dactinomycin results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]] CTD PMID:16226227 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]; Dactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein] CTD PMID:20022965 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of ATG7 protein] CTD PMID:24095927 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Dactinomycin results in decreased expression of and results in increased phosphorylation of ATM protein CTD PMID:31226288 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Avp arginine vasopressin multiple interactions EXP Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Dactinomycin results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions ISO Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA] CTD PMID:22020323 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAK1 mRNA]
Dactinomycin promotes the reaction [BAK1 protein binds to BAK1 protein]		 CTD PMID:21281706 PMID:26670606 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 Dactinomycin results in increased expression of BAX mRNA; Dactinomycin results in increased expression of BAX protein
Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]
Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAX mRNA]
Dactinomycin promotes the reaction [BAX protein binds to BAX protein]		 CTD PMID:10760829 PMID:12927789 PMID:21281706 PMID:21527772 PMID:26670606 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Dactinomycin results in increased expression of BBC3 mRNA; Dactinomycin results in increased expression of BBC3 protein CTD PMID:17581298 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO BCL2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [IL1B results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Dactinomycin results in decreased expression of BCL2 mRNA; Dactinomycin results in decreased expression of BCL2 protein		 CTD PMID:11726273 PMID:11880364 PMID:12927789 PMID:16492401 PMID:17581298 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO BCL2A1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
increases expression
multiple interactions		 ISO Dactinomycin results in decreased expression of BCL2L1 protein
Dactinomycin results in increased expression of BCL2L1 protein; Dactinomycin results in increased expression of BCL2L1 protein alternative form
Dexamethasone inhibits the reaction [Dactinomycin results in increased expression of BCL2L1 protein]		 CTD PMID:9326359 PMID:12430140 PMID:15592511 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of BCL2L11 mRNA] CTD PMID:16166651 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of BDNF mRNA]
Dactinomycin results in decreased expression of BDNF mRNA		 CTD PMID:22982731 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of BECN1 protein] CTD PMID:24095927 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Dactinomycin inhibits the reaction [vorinostat results in increased cleavage of BID protein]
Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of BID mRNA]		 CTD PMID:11535817 PMID:16166651 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO BIRC3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Dactinomycin co-treated with TNF protein] results in increased expression of BNIP3 mRNA; Dactinomycin inhibits the reaction [Ethanol results in increased expression of BNIP3 protein]; Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:11592958 PMID:19442826 PMID:24095927 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G Bsdc1 BSD domain containing 1 increases expression ISO Dactinomycin results in increased expression of BSDC1 mRNA CTD PMID:21527772 NCBI chr 5:141,798,918...141,827,091
Ensembl chr 5:141,798,981...141,827,092 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase multiple interactions ISO Dactinomycin promotes the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC mRNA]; Dactinomycin promotes the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC mRNA] CTD PMID:35561756 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G C1qbp complement C1q binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Dactinomycin CTD PMID:25354864 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G multiple interactions EXP Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA] CTD PMID:19292980 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Casp2 caspase 2 increases cleavage ISO Dactinomycin results in increased cleavage of CASP2 protein CTD PMID:10663630 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases activity		 ISO
EXP		 [TNF co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP3 protein; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Dactinomycin inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP3 protein]
Dactinomycin results in decreased expression of CASP3 mRNA
Dactinomycin results in increased activity of CASP3 protein
[Dactinomycin co-treated with TNF protein] results in increased activity of CASP3 protein
Dactinomycin results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:10663630 PMID:16001973 PMID:16492401 PMID:21496118 PMID:22654482 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
decreases expression		 ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP7 protein; [TNF co-treated with Dactinomycin] results in increased activity of CASP7 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP7 protein; Dactinomycin promotes the reaction [TNF results in increased activity of CASP7 protein]
Dactinomycin results in decreased expression of CASP7 mRNA		 CTD PMID:16001973 PMID:16492401 PMID:17707539 PMID:21496118 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 decreases expression ISO Dactinomycin results in decreased expression of CASP8 mRNA CTD PMID:16001973 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP9 protein
Dactinomycin results in increased cleavage of CASP9 protein		 CTD PMID:17707539 PMID:26670606 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Dactinomycin inhibits the reaction [rosiglitazone results in increased expression of CAV1 mRNA] CTD PMID:15314095 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] CTD PMID:15531761 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dactinomycin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:15531761 PMID:16705055 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn4 cellular communication network factor 4 multiple interactions ISO Dactinomycin inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA] CTD PMID:19238344 NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP Dactinomycin inhibits the reaction [Homocysteine results in increased expression of CCNA2 mRNA] CTD PMID:8550827 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnd1 cyclin D1 decreases stability ISO Dactinomycin results in decreased stability of CCND1 mRNA CTD PMID:15610522 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd1d1 CD1d1 molecule multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA] CTD PMID:17392484 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] CTD PMID:11465111 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression		 ISO 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [Dactinomycin results in increased expression of and affects the localization of CDKN1A protein]; Dactinomycin results in increased expression of and affects the localization of CDKN1A protein
Dactinomycin results in decreased expression of CDKN1A protein		 CTD PMID:12807743 PMID:14601052 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO CDKN1B protein affects the reaction [Dactinomycin results in increased degradation of PTGS2 mRNA] CTD PMID:23639288 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Dactinomycin results in decreased expression of CEBPB mRNA CTD PMID:16001973 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cel carboxyl ester lipase increases expression ISO Dactinomycin results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Dactinomycin results in decreased expression of CFLAR protein CTD PMID:11234897 PMID:14601052 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Ckb creatine kinase B multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of CKB protein]; Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of CKB protein] CTD PMID:7839363 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clmn calmin multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CLMN mRNA] CTD PMID:16688769 NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272 		JBrowse link
G Cnmd chondromodulin multiple interactions ISO Dactinomycin inhibits the reaction [hydroquinone results in increased expression of CNMD protein] CTD PMID:19525446 NCBI chr15:55,041,548...55,066,297
Ensembl chr15:55,041,561...55,066,297 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]
Dactinomycin results in decreased expression of COL1A1 mRNA		 CTD PMID:11216681 PMID:18253093 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO Dactinomycin results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Cs citrate synthase multiple interactions EXP Dactinomycin inhibits the reaction [Hydrocortisone results in decreased activity of CS protein] CTD PMID:6476976 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Dactinomycin inhibits the reaction [Reactive Oxygen Species results in increased expression of CSF2 protein]
Dactinomycin inhibits the reaction [IL1B results in increased secretion of CSF2 protein]; Dactinomycin inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein]		 CTD PMID:9606035 PMID:10645887 PMID:11752025 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]] CTD PMID:23288202 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of CYCS mRNA] CTD PMID:21281706 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cygb cytoglobin multiple interactions ISO Dactinomycin inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Lead results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [SB 203580 results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 protein]; Dactinomycin promotes the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; Dactinomycin promotes the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]
Dactinomycin inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [NSC 674495 results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Sunitinib results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [T-2 Toxin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]
Dactinomycin results in decreased expression of CYP1A1 mRNA		 CTD PMID:1934297 PMID:10359656 PMID:11577022 PMID:11752201 PMID:16093525 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]; Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA] CTD PMID:21262253 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [NSC 674495 results in increased expression of CYP1B1 mRNA]
Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
Dactinomycin results in decreased expression of CYP1B1 mRNA
Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of CYP1B1 protein]		 CTD PMID:11577022 PMID:11752201 PMID:21867498 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA] CTD PMID:9007836 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 multiple interactions ISO Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] CTD PMID:20187624 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA] CTD PMID:17277313 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]
Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]; Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A4 mRNA]		 CTD PMID:11181506 PMID:15795092 PMID:24819614 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP3A23-3A1 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:11181506 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A5 mRNA] CTD PMID:24819614 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions ISO Dactinomycin inhibits the reaction [Nebivolol results in increased expression of DDAH2 mRNA] CTD PMID:17977009 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Dio3 iodothyronine deiodinase 3 multiple interactions EXP Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein] CTD PMID:18420745 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Dactinomycin results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA; [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein] CTD PMID:20561571 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Dactinomycin inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA] CTD PMID:20561571 PMID:20716444 PMID:22207076 PMID:25772258 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Efnb2 ephrin B2 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of EFNB2 mRNA] CTD PMID:16688769 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of EGFR protein]; Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of EGFR protein] CTD PMID:8888411 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of EGR1 mRNA] CTD PMID:1717835 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 multiple interactions ISO Dactinomycin inhibits the reaction [Norepinephrine results in increased expression of ELOVL3 mRNA]; Dactinomycin inhibits the reaction [rosiglitazone results in increased expression of ELOVL3 mRNA] CTD PMID:17726147 NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Dactinomycin results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904 		JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Dactinomycin results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988 		JBrowse link
G Epas1 endothelial PAS domain protein 1 increases stability EXP Dactinomycin results in increased stability of EPAS1 protein CTD PMID:23545307 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions		 ISO Dactinomycin results in decreased expression of F3 mRNA
Dactinomycin inhibits the reaction [indoleacetic acid results in increased expression of F3 mRNA]		 CTD PMID:30324315 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fadd Fas associated via death domain decreases expression ISO Dactinomycin results in decreased expression of FADD mRNA CTD PMID:16001973 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fads3 fatty acid desaturase 3 increases expression ISO Dactinomycin results in increased expression of FADS3 mRNA CTD PMID:21527772 NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769 		JBrowse link
G Fbl fibrillarin affects localization ISO Dactinomycin analog affects the localization of FBL protein CTD PMID:10942594 NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932 		JBrowse link
G Fcar Fc alpha receptor multiple interactions ISO Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of FCAR mRNA] CTD PMID:21911031 NCBI chr 1:69,626,458...69,660,558 JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
Dactinomycin results in decreased expression of FGF2 mRNA
Dactinomycin inhibits the reaction [FGF2 protein results in increased expression of SNCA protein]		 CTD PMID:12562524 PMID:26800359 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 multiple interactions EXP Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA] CTD PMID:12805413 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fhl1 four and a half LIM domains 1 multiple interactions EXP Dactinomycin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] CTD PMID:17161435 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928 		JBrowse link
G Flnc filamin C increases expression ISO Dactinomycin results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA] CTD PMID:18253093 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Dactinomycin inhibits the reaction [[Cycloheximide co-treated with Cadmium] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [IL1A protein results in increased expression of FOS mRNA]
Dactinomycin results in decreased expression of FOS mRNA
Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]		 CTD PMID:1696944 PMID:7564102 PMID:10381381 PMID:11123204 PMID:11353138 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of FOSL1 mRNA]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of FOSL1 mRNA]
Dactinomycin results in decreased expression of FOSL1 mRNA		 CTD PMID:14565943 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression		 ISO Dactinomycin inhibits the reaction [arsenite results in increased expression of GADD45A mRNA]
Dactinomycin results in increased expression of GADD45A mRNA		 CTD PMID:17616671 PMID:21527772 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Galm galactose mutarotase multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of GALM mRNA] CTD PMID:18052213 NCBI chr 6:14,837,540...14,889,484
Ensembl chr 6:14,837,548...14,889,310 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Dactinomycin results in increased expression of GAPDH mRNA CTD PMID:16001973 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gas6 growth arrest specific 6 multiple interactions
increases degradation		 ISO Phosphates promotes the reaction [Dactinomycin results in increased degradation of GAS6 mRNA] CTD PMID:20048160 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA]
Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]		 CTD PMID:11972604 PMID:24437944 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO Dactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA] CTD PMID:17257620 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of GDNF mRNA]
Dactinomycin results in decreased expression of GDNF mRNA		 CTD PMID:22982731 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration increases secretion
multiple interactions		 EXP Dactinomycin results in increased secretion of GFER protein
Dactinomycin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of GFER protein]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Dactinomycin results in increased secretion of GFER protein]		 CTD PMID:23073658 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Dactinomycin promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 mRNA] CTD PMID:36863560 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpr137b G protein-coupled receptor 137B increases expression ISO Dactinomycin results in increased expression of GPR137B mRNA CTD PMID:21527772 NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Dactinomycin inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions EXP Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]; Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein] CTD PMID:11665859 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of GSTA1 mRNA] CTD PMID:28483492 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases response to substance EXP GSTP1 protein results in decreased susceptibility to Dactinomycin CTD PMID:11455017 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO Dactinomycin results in increased expression of H2AX protein CTD PMID:31226288 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]
Dactinomycin results in decreased expression of HBEGF mRNA		 CTD PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein] CTD PMID:29408570 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:12479793 PMID:19958256 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Lipid Peroxides results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Resveratrol results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]; Dactinomycin results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]]
Dactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 protein]
Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]
Dactinomycin results in decreased expression of HMOX1 protein		 CTD PMID:8764571 PMID:9747510 PMID:9808084 PMID:11880364 PMID:12763371 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions
affects localization		 ISO Dactinomycin affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]
Dactinomycin affects the localization of HNRNPA1 protein		 CTD PMID:12754101 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Homer3 homer scaffold protein 3 increases expression ISO Dactinomycin results in increased expression of HOMER3 mRNA CTD PMID:21527772 NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene] CTD PMID:9345283 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Dactinomycin inhibits the reaction [Bexarotene results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA] CTD PMID:31927052 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 protein] CTD PMID:30309986 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Dithiothreitol results in increased expression of HSP90B1 mRNA] CTD PMID:34244458 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
decreases expression		 EXP
ISO		 Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]
[Arsenic Trioxide co-treated with Dactinomycin] results in decreased expression of HSPA5 mRNA; [Arsenic Trioxide co-treated with Dactinomycin] results in increased expression of HSPA5 protein
Dactinomycin results in decreased expression of HSPA5 mRNA		 CTD PMID:17915553 PMID:34560123 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO Dactinomycin promotes the reaction [Dronabinol results in decreased activity of HTR3A protein] CTD PMID:20800662 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Id1 inhibitor of DNA binding 1 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of ID1 mRNA] CTD PMID:16494909 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO Dactinomycin inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA] CTD PMID:16849584 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ier5 immediate early response 5 increases expression ISO Dactinomycin results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227 		JBrowse link
G Ifna1 interferon, alpha 1 multiple interactions ISO Dactinomycin inhibits the reaction [IFNA1 protein results in increased expression of TYMP mRNA] CTD PMID:15937643 NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Dactinomycin inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA] CTD PMID:15937643 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dactinomycin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA]; Dactinomycin inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]] CTD PMID:15937643 PMID:16085646 PMID:26278786 PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO IGF1 protein results in decreased susceptibility to Dactinomycin CTD PMID:9525472 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Dactinomycin inhibits the reaction [Zymosan results in increased expression of IL10 mRNA] CTD PMID:17458858 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il11 interleukin 11 multiple interactions ISO Dactinomycin inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Dactinomycin inhibits the reaction [Glucose results in increased secretion of IL17A protein] CTD PMID:18310510 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Dactinomycin inhibits the reaction [IL1A protein results in increased expression of FOS mRNA] CTD PMID:7564102 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Nitric Oxide]; Dactinomycin inhibits the reaction [IL1B results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [IL1B results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [IL1B results in increased secretion of CSF2 protein]
Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA]
Dactinomycin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]		 CTD PMID:9606035 PMID:11286988 PMID:12512699 PMID:16338976 PMID:16365456 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Dactinomycin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha increases expression ISO Dactinomycin results in increased expression of IL27RA mRNA CTD PMID:21527772 NCBI chr19:24,109,963...24,121,977
Ensembl chr19:24,109,972...24,121,938 		JBrowse link
G Il6 interleukin 6 decreases secretion ISO Dactinomycin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Dactinomycin inhibits the reaction [bisphenol A results in increased secretion of INS1 protein]; Dactinomycin inhibits the reaction [nonylphenol results in increased secretion of INS1 protein] CTD PMID:15778011 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with alitretinoin] results in increased expression of SLC27A1 mRNA] CTD PMID:10777552 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of IRF1 mRNA] CTD PMID:16085646 PMID:16636311 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Itga2b integrin subunit alpha 2b increases expression ISO Dactinomycin results in increased expression of ITGA2B mRNA CTD PMID:21527772 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA] CTD PMID:17241155 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Dactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] CTD PMID:15932931 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Dactinomycin inhibits the reaction [Cadmium results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of JUN mRNA]
Dactinomycin results in decreased expression of JUN mRNA		 CTD PMID:1696944 PMID:11123204 PMID:11353138 PMID:11568973 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kif1a kinesin family member 1A increases expression ISO Dactinomycin results in increased expression of KIF1A mRNA CTD PMID:21527772 NCBI chr 9:93,563,033...93,647,412
Ensembl chr 9:93,563,045...93,647,480 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Dactinomycin inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased expression of TNFRSF10B mRNA] CTD PMID:27222248 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt80 keratin 80 increases expression ISO Dactinomycin results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr 7:132,463,216...132,485,134
Ensembl chr 7:132,463,218...132,485,508 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO Dactinomycin results in increased expression of LAMC2 mRNA CTD PMID:21527772 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
decreases expression		 ISO Ascorbic Acid inhibits the reaction [Dactinomycin results in decreased expression of LDLR mRNA] CTD PMID:32913121 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin multiple interactions EXP Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lgals3 galectin 3 multiple interactions ISO Dactinomycin inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein] CTD PMID:21821001 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lgals7 galectin 7 increases expression ISO Dactinomycin results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015 		JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Dactinomycin results in decreased expression of LMNB1 mRNA CTD PMID:16001973 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of MAP1LC3B protein] CTD PMID:24095927 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 decreases expression ISO Dactinomycin results in decreased expression of MAP2K4 mRNA CTD PMID:16001973 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO Dactinomycin results in decreased expression of MAP3K7 mRNA CTD PMID:16001973 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression		 ISO
EXP		 PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Dactinomycin results in increased expression of MAPK1 protein
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]		 CTD PMID:14640974 PMID:15959627 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression		 ISO
EXP		 PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Dactinomycin results in increased expression of MAPK3 protein		 CTD PMID:14640974 PMID:15959627 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO Dactinomycin results in decreased expression of MCL1 mRNA
Dactinomycin inhibits the reaction [IL1B results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of MCL1 protein]; Quercetin promotes the reaction [Dactinomycin results in decreased expression of MCL1 mRNA]		 CTD PMID:16492401 PMID:21750559 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mir21 microRNA 21 multiple interactions ISO Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:19264808 PMID:23052036 PMID:25969534 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir22 microRNA 22 multiple interactions ISO [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] CTD PMID:25969534 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor increases expression ISO Dactinomycin results in increased expression of MLLT11 mRNA CTD PMID:21527772 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein] CTD PMID:19136476 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of MMP9 mRNA]
Dactinomycin results in decreased expression of MMP9 mRNA		 CTD PMID:24956101 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator multiple interactions ISO Dactinomycin inhibits the reaction [Calcitriol results in increased expression of MN1 mRNA] CTD PMID:15890672 NCBI chr12:45,181,794...45,220,959
Ensembl chr12:45,183,085...45,221,651 		JBrowse link
G Mrpl41 mitochondrial ribosomal protein L41 multiple interactions ISO Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein] CTD PMID:16024796 NCBI chr 3:7,780,658...7,781,576
Ensembl chr 3:7,779,143...7,782,818 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA] CTD PMID:17234632 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Dactinomycin inhibits the reaction [pirinixic acid results in increased expression of MTTP mRNA] CTD PMID:15537571 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions		 ISO
EXP		 Dactinomycin results in decreased expression of MYC mRNA
Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of MYC mRNA]
Dactinomycin inhibits the reaction [Cadmium results in increased expression of MYC mRNA]		 CTD PMID:1696944 PMID:11353138 PMID:16001973 PMID:21527772 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mylk myosin light chain kinase multiple interactions ISO Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK protein] CTD PMID:15701621 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Nav2 neuron navigator 2 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of NAV2 mRNA] CTD PMID:16688769 NCBI chr 1:98,957,629...99,322,339
Ensembl chr 1:98,663,759...99,322,337 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA] CTD PMID:19559082 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO [nickel chloride co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA; [Oxygen deficiency co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA CTD PMID:10646848 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of NEDD9 mRNA] CTD PMID:16688769 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Neto2 neuropilin and tolloid like 2 increases expression ISO Dactinomycin results in increased expression of NETO2 mRNA CTD PMID:21527772 NCBI chr19:21,344,299...21,415,524
Ensembl chr19:21,344,289...21,417,023 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Dactinomycin inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFE2L2 mRNA] CTD PMID:22019695 PMID:24632381 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression
multiple interactions		 ISO Dactinomycin results in decreased expression of NFKB1 mRNA
[RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]		 CTD PMID:11880364 PMID:16001973 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of NGF mRNA]
Dactinomycin results in decreased expression of NGF mRNA		 CTD PMID:22982731 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Dactinomycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA] CTD PMID:23937860 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]
Dactinomycin inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]		 CTD PMID:11286988 PMID:28138957 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppc natriuretic peptide C multiple interactions ISO Dactinomycin inhibits the reaction [Estradiol results in increased expression of NPPC mRNA] CTD PMID:9435603 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Biological Products results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Lead results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Dactinomycin promotes the reaction [Chromium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]
Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]		 CTD PMID:16243960 PMID:17923278 PMID:18474416 PMID:22570534 PMID:24437944 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Bucladesine results in decreased expression of NR0B1 mRNA]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of NR0B1 mRNA] CTD PMID:18787026 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO Dactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA] CTD PMID:19593819 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Dactinomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [Clofibrate results in increased expression of NR1I2 protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of NR1I2 mRNA]; Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]
Dactinomycin inhibits the reaction [ochratoxin A results in decreased expression of NR1I2 mRNA]		 CTD PMID:15826607 PMID:20599767 PMID:26341324 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein]; Dactinomycin inhibits the reaction [Dexamethasone binds to NR3C1 protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased degradation of NR3C1 protein] CTD PMID:21569845 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nthl1 nth-like DNA glycosylase 1 decreases expression ISO Dactinomycin results in decreased expression of NTHL1 mRNA CTD PMID:21527772 NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Dactinomycin inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form] CTD PMID:20678484 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pappa pappalysin multiple interactions ISO Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA] CTD PMID:16338976 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [TNF co-treated with Dactinomycin] results in increased cleavage of PARP1 protein; Dactinomycin promotes the reaction [TNF results in increased cleavage of PARP1 protein]; PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]
PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]		 CTD PMID:14640974 PMID:16492401 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP Dactinomycin inhibits the reaction [Hydrocortisone results in increased activity of PCK1 protein] CTD PMID:6476976 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions		 EXP
ISO		 Dactinomycin results in decreased expression of PCNA protein
Dactinomycin inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein]		 CTD PMID:15959627 PMID:21533478 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of PLAT mRNA]; Dactinomycin inhibits the reaction [Resveratrol results in increased expression of PLAT mRNA] CTD PMID:11236827 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression		 ISO Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAU mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of PLAU mRNA]; Dactinomycin inhibits the reaction [resveratrol results in increased expression of PLAU mRNA]
Dactinomycin results in increased expression of PLAU mRNA		 CTD PMID:11236827 PMID:21527772 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]; PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:14640974 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]; PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:14640974 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Polh DNA polymerase eta multiple interactions ISO Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA] CTD PMID:25125662 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723 		JBrowse link
G Polr2a RNA polymerase II subunit A decreases phosphorylation
multiple interactions
increases phosphorylation		 ISO Dactinomycin results in decreased phosphorylation of POLR2A protein
[Dactinomycin co-treated with sodium arsenite] results in increased phosphorylation of POLR2A protein
Dactinomycin results in increased phosphorylation of POLR2A protein		 CTD PMID:8126066 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455 		JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 increases expression ISO Dactinomycin results in increased expression of POMT1 mRNA CTD PMID:21527772 NCBI chr 3:15,520,717...15,538,579
Ensembl chr 3:15,520,481...15,538,581 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of PRDX6 mRNA]; Dactinomycin inhibits the reaction [Paraquat results in increased expression of PRDX6 mRNA] CTD PMID:12851211 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]
PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]		 CTD PMID:14640974 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prl prolactin multiple interactions ISO Dactinomycin inhibits the reaction [PRL protein results in increased expression of SLC30A2 mRNA] CTD PMID:19494234 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Procr protein C receptor increases expression ISO Dactinomycin results in increased expression of PROCR mRNA CTD PMID:21527772 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903 		JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions		 ISO Dactinomycin results in decreased expression of PROM1 mRNA
Dactinomycin results in decreased expression of and affects the localization of PROM1 protein		 CTD PMID:31226288 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases degradation		 ISO
EXP		 Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Sodium Fluoride results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]
Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Dactinomycin results in decreased expression of PTGS2 mRNA
CDKN1B protein affects the reaction [Dactinomycin results in increased degradation of PTGS2 mRNA]; Dactinomycin inhibits the reaction [nickel chloride results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [nickel sulfide results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]		 CTD PMID:9576062 PMID:11286988 PMID:16894348 PMID:17065197 PMID:18513776 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression EXP Dactinomycin results in decreased expression of PTK2 protein CTD PMID:15959627 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression		 ISO tetrachlorobenzoquinone promotes the reaction [Dactinomycin results in decreased expression of RAD51 mRNA] CTD PMID:27989139 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression EXP Dactinomycin results in decreased expression of RAF1 protein CTD PMID:15959627 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; RELA protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions ISO Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein] CTD PMID:9203624 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Retsat retinol saturase increases expression ISO Dactinomycin results in increased expression of RETSAT mRNA CTD PMID:21527772 NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310 		JBrowse link
G Rhob ras homolog family member B multiple interactions ISO Dactinomycin inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB mRNA]; Dactinomycin inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB protein] CTD PMID:23732113 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Ripply3 ripply transcriptional repressor 3 increases expression ISO Dactinomycin results in increased expression of RIPPLY3 mRNA CTD PMID:21527772 NCBI chr11:33,648,471...33,656,587
Ensembl chr11:33,648,486...33,656,584 		JBrowse link
G Rnf213 ring finger protein 213 multiple interactions ISO Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA] CTD PMID:26278786 NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression ISO Dactinomycin results in increased expression of ROS1 mRNA CTD PMID:16001973 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865 		JBrowse link
G Rpl34 ribosomal protein L34 increases expression ISO Dactinomycin results in increased expression of RPL34 mRNA CTD PMID:21527772 NCBI chr 2:219,284,373...219,288,108
Ensembl chr 2:219,284,382...219,288,111 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]		 CTD PMID:14640974 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rras RAS related increases expression ISO Dactinomycin results in increased expression of RRAS mRNA CTD PMID:21527772 NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions ISO Dactinomycin inhibits the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA] CTD PMID:16637064 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Dactinomycin inhibits the reaction [ciprofibrate results in increased expression of SCD1 mRNA] CTD PMID:11172741 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1B mRNA] CTD PMID:10942727 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1G mRNA] CTD PMID:10942727 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816 		JBrowse link
G Sdc3 syndecan 3 multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of SDC3 mRNA] CTD PMID:11024013 NCBI chr 5:142,965,659...142,998,390
Ensembl chr 5:142,965,591...142,996,480 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA] CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Sfn stratifin increases expression ISO Dactinomycin results in increased expression of SFN mRNA CTD PMID:21527772 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 protein] CTD PMID:25128767 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO Dactinomycin inhibits the reaction [SHH protein alternative form results in increased expression of ABCG2 protein] CTD PMID:21625222 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Dactinomycin affects the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA]
TAF15 mRNA inhibits the reaction [Dactinomycin results in decreased expression of SIRT1 mRNA]		 CTD PMID:30055241 PMID:35307376 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc25a14 solute carrier family 25 member 14 multiple interactions ISO Dactinomycin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA]; Dactinomycin inhibits the reaction [Dopamine results in increased expression of SLC25A14 mRNA] CTD PMID:20600837 NCBI chr  X:127,807,630...127,845,823
Ensembl chr  X:127,807,449...127,845,823 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with alitretinoin] results in increased expression of SLC27A1 mRNA]
Dactinomycin inhibits the reaction [alitretinoin results in increased expression of SLC27A1 mRNA]		 CTD PMID:10777552 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of SLC2A2 mRNA] CTD PMID:12787936 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions EXP Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA] CTD PMID:11123204 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106 		JBrowse link
G Slc30a2 solute carrier family 30 member 2 multiple interactions ISO Dactinomycin inhibits the reaction [PRL protein results in increased expression of SLC30A2 mRNA] CTD PMID:19494234 NCBI chr 5:146,559,733...146,571,957
Ensembl chr 5:146,559,733...146,571,956 		JBrowse link
G Slc30a5 solute carrier family 30 member 5 multiple interactions ISO Dactinomycin inhibits the reaction [zinc chloride results in decreased expression of SLC30A5 mRNA] CTD PMID:17234632 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934 		JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions ISO Dactinomycin inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA] CTD PMID:21738690 NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325 		JBrowse link
G Slc39a4 solute carrier family 39 member 4 multiple interactions ISO Dactinomycin inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA] CTD PMID:18020946 NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of SLC3A2 mRNA] CTD PMID:26621329 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA] CTD PMID:20090884 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Dactinomycin results in decreased expression of SLC7A11 protein CTD PMID:31226288 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 multiple interactions ISO Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of SLC7A5 mRNA] CTD PMID:26621329 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO Dactinomycin inhibits the reaction [diethyl maleate results in increased expression of SMPD1 mRNA] CTD PMID:25762726 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Snca synuclein alpha multiple interactions EXP Dactinomycin inhibits the reaction [FGF2 protein results in increased expression of SNCA protein] CTD PMID:12562524 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of SOCS3 mRNA] CTD PMID:23237828 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [SOD2 protein results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; SOD2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]
Dactinomycin inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]
Dactinomycin inhibits the reaction [polysaccharide-K results in increased expression of SOD2]		 CTD PMID:9852137 PMID:11154046 PMID:11880364 PMID:12031898 PMID:14996425 More... NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO Dactinomycin results in decreased expression of SOS1 mRNA CTD PMID:16001973 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Dactinomycin results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Spata18 spermatogenesis associated 18 increases expression ISO Dactinomycin results in increased expression of SPATA18 mRNA CTD PMID:21527772 NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in decreased expression of SQSTM1 protein]
Dactinomycin inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of SQSTM1 mRNA]		 CTD PMID:24095927 PMID:25301941 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO Dactinomycin results in increased expression of STAT1 mRNA CTD PMID:16001973 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stmn3 stathmin 3 increases expression ISO Dactinomycin results in increased expression of STMN3 mRNA CTD PMID:21527772 NCBI chr 3:168,416,810...168,424,946
Ensembl chr 3:168,416,810...168,425,056 		JBrowse link
G Stom stomatin increases expression ISO Dactinomycin results in increased expression of STOM mRNA CTD PMID:21527772 NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 mRNA] CTD PMID:16308312 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Taf15 TATA-box binding protein associated factor 15 multiple interactions ISO TAF15 mRNA inhibits the reaction [Dactinomycin results in decreased expression of SIRT1 mRNA] CTD PMID:35307376 NCBI chr10:68,272,921...68,304,951
Ensembl chr10:68,272,969...68,304,949 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Dactinomycin results in increased expression of TAP1 mRNA CTD PMID:21527772 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [Dexamethasone results in increased activity of TAT protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]] CTD PMID:9398635 PMID:20599767 PMID:28483492 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tbx3 T-box transcription factor 3 multiple interactions ISO actinomycin D inhibits the reaction [all-trans-retinoic acid increases expression of TBX3 mRNA in melanoma cells] RGD PMID:22535523 RGD:151361117 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tcf4 transcription factor 4 multiple interactions EXP Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of TCF4 mRNA] CTD PMID:20459685 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects activity EXP Dactinomycin affects the activity of TDO2 protein CTD PMID:7306070 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Testin testin gene multiple interactions
decreases secretion		 EXP Dactinomycin inhibits the reaction [Bucladesine results in decreased expression of TESTIN mRNA]; Dactinomycin inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Dactinomycin inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]
Dactinomycin results in decreased secretion of TESTIN protein		 CTD PMID:11090432 NCBI chr17:3,824,222...3,859,385
Ensembl chr17:3,846,899...3,859,385 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dactinomycin inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; Dactinomycin inhibits the reaction [TGFB1 protein results in decreased expression of AHR mRNA] CTD PMID:9145908 PMID:16365456 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]; Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA] CTD PMID:18253093 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA] CTD PMID:17641275 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions ISO Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 multiple interactions ISO Dactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 mRNA] CTD PMID:23405127 NCBI chr 9:50,445,947...50,733,473
Ensembl chr 9:50,436,079...50,733,475 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance		 ISO
EXP		 [Dactinomycin co-treated with TNF protein] results in increased expression of BNIP3 mRNA; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Dactinomycin promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]]
Dactinomycin results in increased susceptibility to TNF protein
[RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [TNF co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF co-treated with Dactinomycin] results in increased activity of CASP7 protein; [TNF co-treated with Dactinomycin] results in increased cleavage of PARP1 protein; [TNF protein co-treated with Dactinomycin] results in decreased expression of TP53 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP7 protein; BCL2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; BCL2A1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; BIRC3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Dactinomycin inhibits the reaction [TNF results in increased abundance of Nitric Oxide]; Dactinomycin inhibits the reaction [TNF results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [Zinc deficiency promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP3 protein]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP7 protein]; Dactinomycin promotes the reaction [TNF results in increased cleavage of PARP1 protein]; HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]]; RELA protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; SOD2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; TNFAIP3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]
[Dactinomycin co-treated with TNF protein] results in increased activity of CASP3 protein; Dactinomycin inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]		 CTD PMID:9576062 PMID:10100995 PMID:11592958 PMID:11880364 PMID:12479793 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO TNFAIP3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf22 tumor necrosis factor receptor superfamily, member 22 multiple interactions EXP Dactinomycin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNFRSF10B mRNA] CTD PMID:27484784 NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP7 protein; [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP9 protein; [Dactinomycin co-treated with TNFSF10 protein] results in increased expression of AIFM1 protein CTD PMID:17707539 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Dactinomycin results in increased expression of TNFSF9 mRNA CTD PMID:21527772 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Top1 DNA topoisomerase I increases activity ISO Dactinomycin results in increased activity of TOP1 protein CTD PMID:2164630 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
increases activity		 ISO [TNF protein co-treated with Dactinomycin] results in decreased expression of TP53 protein; Cadmium Chloride inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Cadmium inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein]; Dactinomycin results in increased expression of and affects the localization of TP53 protein; Dactinomycin results in increased expression of and results in increased activity of TP53 protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]
Dactinomycin results in increased expression of TP53 protein; Dactinomycin results in increased expression of TP53 protein modified form
Dactinomycin results in increased activity of TP53 protein
Actinomycin D inhibits the reaction [Sunitinib increases expression of TP53 mRNA and protein in breast epithelium]		 CTD
RGD		 PMID:10531375 PMID:12807743 PMID:12869419 PMID:12927789 PMID:16024796 More... RGD:150537096 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i11 tumor protein p53 inducible protein 11 multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of TP53I11 mRNA]
Dactinomycin results in decreased expression of TP53I11 mRNA		 CTD PMID:19333544 NCBI chr 3:79,144,824...79,160,056
Ensembl chr 3:79,144,895...79,160,050 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 multiple interactions ISO Dactinomycin inhibits the reaction [1,25-dihydroxyvitamin D results in increased expression of TRPV6 mRNA] CTD PMID:16362534 NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017 		JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Dactinomycin results in increased expression of TUBA4A mRNA CTD PMID:21527772 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO Dactinomycin inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]; Dactinomycin inhibits the reaction [sulforaphane results in increased expression of TXNRD1 mRNA] CTD PMID:12663510 PMID:15652504 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO Dactinomycin inhibits the reaction [IFNA1 protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]; Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]] CTD PMID:15937643 PMID:30796972 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Tyr tyrosinase multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein]
Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]		 CTD PMID:14717847 PMID:15278367 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 multiple interactions ISO Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of UBE2L3 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UBE2L3 mRNA] CTD PMID:26318284 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein] CTD PMID:15545831 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]
Dactinomycin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]		 CTD PMID:10100995 PMID:12892526 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Oxaliplatin results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of VEGFA mRNA]
Dactinomycin inhibits the reaction [Cobalt results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA alternative form]; Dactinomycin inhibits the reaction [Nickel results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]		 CTD PMID:8344219 PMID:10751333 PMID:11641398 PMID:16386082 PMID:18790786 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of VIM mRNA] CTD PMID:9044050 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions
decreases expression		 ISO [Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of VMP1 mRNA]
Dactinomycin results in decreased expression of VMP1 mRNA		 CTD PMID:23052036 PMID:25969534 NCBI chr10:71,405,058...71,505,045
Ensembl chr10:71,405,452...71,505,007 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Dactinomycin results in decreased expression of XIAP protein CTD PMID:12430140 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Ythdf1 YTH N6-methyladenosine RNA binding protein F1 multiple interactions ISO YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF1 protein affects the reaction [YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]; YTHDF2 protein affects the reaction [YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]] CTD PMID:37061066 NCBI chr 3:168,024,660...168,040,172
Ensembl chr 3:168,024,663...168,040,172 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 multiple interactions ISO YTHDF1 protein affects the reaction [YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]; YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF2 protein affects the reaction [YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]] CTD PMID:37061066 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        antimicrobial agent 18166
          peptide antibiotic 1816
            chromopeptide 307
              actinomycin 307
                actinomycin D 307
                actinomycinic monolactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      carboacyl group 17698
                                        univalent carboacyl group 17698
                                          carbamoyl group 17548
                                            carboxamide 17548
                                              peptide 11126
                                                peptide antibiotic 1816
                                                  chromopeptide 307
                                                    actinomycin 307
                                                      actinomycin D 307
                                                      actinomycinic monolactone 0
paths to the root