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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:733873 | 6480464 | PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]; more ... | CTD | PMID:15210717 | (S)-nicotine | increases expression | ISO | RGD:733873 | 6480464 | Nicotine results in increased expression of PLD2 mRNA | CTD | PMID:18247414 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:736771 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLD2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736771 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLD2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:733873 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLD2 mRNA | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:733873 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLD2 mRNA | CTD | PMID:22574217 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:736771 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLD2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLD2 mRNA | CTD | PMID:22298810 | 2-naphthylamine | increases expression | ISO | RGD:733873 | 6480464 | 2-Naphthylamine results in increased expression of PLD2 mRNA | CTD | PMID:18247414 | 4-hydroxynon-2-enal | increases expression | ISO | RGD:736771 | 6480464 | 4-hydroxy-2-nonenal results in increased expression of PLD2 mRNA | CTD | PMID:19191707 | actinomycin D | multiple interactions | ISO | RGD:736771 | 6480464 | PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; more ... | CTD | PMID:14640974 | aflatoxin B1 | increases expression | ISO | RGD:736771 | 6480464 | Aflatoxin B1 results in increased expression of PLD2 mRNA | CTD | PMID:19770486 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PLD2 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:733873 | 6480464 | Benzo(a)pyrene results in increased expression of PLD2 mRNA | CTD | PMID:18247414 | benzo[a]pyrene | multiple interactions | ISO | RGD:736771 | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PLD2 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:736771 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of PLD2 mRNA | CTD | PMID:21715664 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of PLD2 protein | CTD | PMID:21079920 | butan-1-ol | multiple interactions | ISO | RGD:733873 | 6480464 | 1-Butanol inhibits the reaction [ilimaquinone results in increased activity of PLD2 protein] | CTD | PMID:17897952 | butan-1-ol | decreases activity | EXP | | 6480464 | 1-Butanol results in decreased activity of PLD2 protein | CTD | PMID:18344600 | butan-1-ol | multiple interactions | EXP | | 6480464 | 1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]; more ... | CTD | PMID:14720217 | butan-1-ol | multiple interactions | ISO | RGD:733873 | 6480464 | PLD2 protein affects the reaction [1-Butanol affects the localization of GRM1 protein]; more ... | CTD | PMID:15470141 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PLD2 mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PLD2 mRNA | CTD | PMID:19894126 | calcitriol | multiple interactions | ISO | RGD:733873 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PLD2 mRNA | CTD | PMID:21592394 | calcitriol | increases expression | ISO | RGD:733873 | 6480464 | Calcitriol results in increased expression of PLD2 mRNA | CTD | PMID:21592394 | cholesterol | multiple interactions | ISO | RGD:733873 | 6480464 | PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]; more ... | CTD | PMID:16118212 | cisplatin | increases expression | ISO | RGD:736771 | 6480464 | Cisplatin results in increased expression of PLD2 mRNA | CTD | PMID:21151649 | cobalt dichloride | multiple interactions | ISO | RGD:733873 | 6480464 | Acetylcysteine inhibits the reaction [PLD2 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]; more ... | CTD | PMID:17640750 | cobalt dichloride | increases activity | ISO | RGD:733873 | 6480464 | cobaltous chloride results in increased activity of PLD2 protein | CTD | PMID:17640750 | cocaine | decreases expression | EXP | | 6480464 | Cocaine results in decreased expression of PLD2 mRNA | CTD | PMID:16076954 | dimethylarsinic acid | increases expression | EXP | | 6480464 | Cacodylic Acid results in increased expression of PLD2 mRNA | CTD | PMID:17720352 | Goe 6976 | multiple interactions | ISO | RGD:733873 | 6480464 | Go 6976 inhibits the reaction [PLD2 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein]] | CTD | PMID:15210717 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | PLD2 protein affects the reaction [Hydrogen Peroxide promotes the reaction [PTK2B protein binds to SRC protein]]; more ... | CTD | PMID:15705590 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | PLD2 protein inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein] | CTD | PMID:10936186 | ionomycin | multiple interactions | ISO | RGD:736771 | 6480464 | PLD2 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... | CTD | PMID:18423386 | ionomycin | multiple interactions | ISO | RGD:733873 | 6480464 | PLD2 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; more ... | CTD | PMID:18423386 | N-acetyl-L-cysteine | multiple interactions | ISO | RGD:733873 | 6480464 | Acetylcysteine inhibits the reaction [PLD2 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] | CTD | PMID:17640750 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PLD2 mRNA | CTD | PMID:18164116 | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of PLD2 mRNA | CTD | PMID:23358140 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:733873 | 6480464 | PLD2 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; more ... | CTD | PMID:18423386 | phorbol 13-acetate 12-myristate | increases activity | EXP | | 6480464 | Tetradecanoylphorbol Acetate results in increased activity of PLD2 protein | CTD | PMID:15067002 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:736771 | 6480464 | PLD2 protein promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; more ... | CTD | PMID:18423386 | potassium chloride | multiple interactions | EXP | | 6480464 | PLD2 protein affects the reaction [Potassium Chloride results in increased expression of GAP43 mRNA]; more ... | CTD | PMID:18004999 | prostaglandin E2 | multiple interactions | ISO | RGD:733873 | 6480464 | PLD2 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone] | CTD | PMID:17640750 | testosterone | multiple interactions | ISO | RGD:733873 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PLD2 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | RGD:733873 | 6480464 | Testosterone results in increased expression of PLD2 mRNA | CTD | PMID:21592394 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsPhenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Endocytosis |
| Ether lipid metabolism | |
| Fc gamma R-mediated phagocytosis | |
| Glutamatergic synapse | |
| Glycerophospholipid metabolism | |
| GnRH signaling pathway | |
| Metabolic pathways | |
| Pathway Interaction Database | Alpha-synuclein signaling (PID:200219) |
| Angiopoietin receptor Tie2-mediated signaling (PID:200079) | |
| Arf1 pathway (PID:200195) | |
| Arf6 downstream pathway (PID:200095) | |
| Arf6 trafficking events (PID:200057) | |
| ErbB1 downstream signaling (PID:200133) | |
| Fc-epsilon receptor I signaling in mast cells (PID:200004) | |
| IL8- and CXCR2-mediated signaling events (PID:200167) | |
| LPA receptor mediated events (PID:200013) | |
| mTOR signaling pathway (PID:200096) | |
| RhoA signaling pathway (PID:200009) | |
Phenotype AnnotationsReferences - curated| 1. |
Asemu G, etal., Arch Biochem Biophys. 2005 Apr 1;436(1):136-44. |
| 2. |
Banno Y, etal., J Biol Chem. 2005 Apr 22;280(16):16319-24. Epub 2005 Feb 10. |
| 3. |
Banno Y, etal., J Neurochem. 2008 Mar;104(5):1372-86. Epub 2007 Nov 14. |
| 4. |
Bhattacharya M, etal., J Neurosci. 2004 Oct 6;24(40):8752-61. |
| 5. |
Dent MR, etal., J Cell Mol Med. 2004 Oct-Dec;8(4):526-36. |
| 6. |
Freyberg Z, etal., Mol Biol Cell. 2002 Nov;13(11):3930-42. |
| 7. |
GOA data from the GO Consortium |
| 8. |
Jin S, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):545-51. |
| 9. |
KEGG |
| 10. |
Kim JH, etal., Biochemistry. 2002 Mar 12;41(10):3414-21. |
| 11. |
Kim SY, etal., J Neuropathol Exp Neurol. 2004 Aug;63(8):812-20. |
| 12. |
Kodaki T and Yamashita S, J Biol Chem 1997 Apr 25;272(17):11408-13. |
| 13. |
Lee JH, etal., Blood. 2006 Aug 1;108(3):956-64. |
| 14. |
MGD data from the GO Consortium |
| 15. |
Min do S, etal., Acta Neuropathol. 2007 Aug;114(2):157-62. Epub 2007 Mar 29. |
| 16. |
Nagasaki A, etal., Cell Struct Funct. 2008;33(1):27-33. Epub 2008 Mar 13. |
| 17. |
Nakashima S, etal., Cytogenet Cell Genet 1997;79(1-2):109-13. |
| 18. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 19. |
Park JB, etal., J Biol Chem. 2000 Jul 14;275(28):21295-301. |
| 20. |
Parmentier JH, etal., Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H46-54. Epub 2005 Aug 19. |
| 21. |
Peng JH, etal., Neurochem Res. 2006 Oct;31(10):1191-6. Epub 2006 Oct 6. |
| 22. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 23. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 24. |
Powner DJ, etal., J Cell Sci. 2005 Jul 1;118(Pt 13):2975-86. |
| 25. |
RGD automated import pipeline for gene-chemical interactions |
| 26. |
Singh AT, etal., Lipids. 2005 Nov;40(11):1135-40. |
| 27. |
Sumara I, etal., Curr Biol. 2004 Oct 5;14(19):1712-22. |
| 28. |
Xie Z, etal., Biochim Biophys Acta. 2002 Jan 30;1580(1):9-21. |
| 29. |
Yamakawa H, etal., Neuroreport. 2000 Nov 9;11(16):3647-50. |
| 30. |
Yoshimura S, etal., Biochem Biophys Res Commun 1996 Aug 14;225(2):494-9. |
| 31. |
Zhao Y, etal., Biochem Biophys Res Commun. 2000 Nov 11;278(1):140-3. |
| 32. |
Zhong M, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):615-9. |
References - uncurated| PubMed | 11373276 |
| 11672434 | |
| 11744693 | |
| 12036299 | |
| 12054584 | |
| 12388770 | |
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| 15036596 | |
| 15210717 | |
| 15581494 | |
| 15616193 | |
| 16024570 | |
| 17110338 | |
| 19010519 | |
| 19666113 | |
| 19794068 | |
| 20664530 | |
| 20705243 | |
| 21414324 | |
| 21525000 | |
| 22344748 |
RGD Disease Portals| Pld2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pld2 (Rattus norvegicus) |
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| PLD2 (Homo sapiens) |
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| Pld2 (Mus musculus) |
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Position Markers| D10Wox42 |
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| D10Wox41 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_033299 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06064420 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06064421 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06064422 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01064636 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01064637 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01064638 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB003172 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF449445 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D88672 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_033299 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_150641 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_150641 | (Get FASTA) |
| GenBank Protein | AAM48521 | (Get FASTA) |
| BAA19882 | (Get FASTA) | |
| BAA24078 | (Get FASTA) | |
| EDM05018 | (Get FASTA) | |
| EDM05019 | (Get FASTA) | |
| P70498 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000019604 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000053831 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000056998 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 25097 | ENTREZGENE |
| Gene3D-CATH | 520.10 | UniProtKB/Swiss-Prot |
| PH_type | UniProtKB/Swiss-Prot | |
| HomoloGene Group ID | 55672 | ENTREZGENE |
| InterPro | IPR001683 | UniProtKB/Swiss-Prot |
| PH_type | UniProtKB/Swiss-Prot | |
| Phospholipase_D | UniProtKB/Swiss-Prot | |
| PLD-like_dom | UniProtKB/Swiss-Prot | |
| Pleckstrin_homology | UniProtKB/Swiss-Prot | |
| PLipase_D/transphosphatidylase | UniProtKB/Swiss-Prot | |
| PLipase_D_euk | UniProtKB/Swiss-Prot | |
| IPI | IPI00188899 | UniProtKB/Swiss-Prot |
| IPI00778735 | UniProtKB/TrEMBL | |
| IPI00782571 | UniProtKB/TrEMBL | |
| KEGG Report | rno:25097 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Phospholipase_D | UniProtKB/Swiss-Prot |
| Pfam | PF00787 | UniProtKB/Swiss-Prot |
| PLDc | UniProtKB/Swiss-Prot | |
| PLDc_2 | UniProtKB/Swiss-Prot | |
| PIRSF | Phospholipase_D_euk | UniProtKB/Swiss-Prot |
| PROSITE | PH_DOMAIN; FALSE_NEG | UniProtKB/Swiss-Prot |
| PLD | UniProtKB/Swiss-Prot | |
| PS50195 | UniProtKB/Swiss-Prot | |
| SMART | PLDc | UniProtKB/Swiss-Prot |
| SM00233 | UniProtKB/Swiss-Prot | |
| SM00312 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | 64268 | UniProtKB/Swiss-Prot |
| UniGene | Rn.9798 | ENTREZGENE |
| UniProt | F1LPQ4_RAT | UniProtKB/TrEMBL |
| PLD2_RAT | UniProtKB/Swiss-Prot | |
| Q8K4D5_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Pld2 | Phoshpolipase D gene 2 | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_regulation | stimulated by PIP2, inhibited by oleate; not affected by ARF1 or RhoA | 729617 |
| More on Pld2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3350 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.