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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of SMPD1 mRNA | CTD | PMID:17108234 | 2,3,7,8-tetrachlorodibenzodioxine | decreases activity | ISO | RGD:1349414 | 6480464 | Tetrachlorodibenzodioxin results in decreased activity of SMPD1 protein | CTD | PMID:19131362 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1349414 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMPD1 mRNA | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557572 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMPD1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1557572 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMPD1 mRNA | CTD | PMID:19770486 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:1557572 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SMPD1 mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1557572 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of SMPD1 mRNA | CTD | PMID:18648102 | afimoxifene | multiple interactions | ISO | RGD:1349414 | 6480464 | 4-hydroxytamoxifen inhibits the reaction [Estrogens results in decreased expression of SMPD1 mRNA] | CTD | PMID:21233418 | all-trans-retinoic acid | increases expression | ISO | RGD:1349414 | 6480464 | Tretinoin results in increased expression of SMPD1 mRNA | CTD | PMID:15498508 | bezafibrate | increases activity | EXP | | 6480464 | [Bezafibrate results in increased activity of PPARA protein] which results in increased activity of SMPD1 protein | CTD | PMID:18024222 | bisphenol A | increases expression | ISO | RGD:1557572 | 6480464 | bisphenol A results in increased expression of SMPD1 mRNA | CTD | PMID:22687993 | clofibrate | decreases expression | ISO | RGD:1557572 | 6480464 | Clofibrate results in decreased expression of SMPD1 mRNA | CTD | PMID:17585979 | clofibric acid | affects expression | EXP | | 6480464 | Clofibric Acid affects the expression of SMPD1 mRNA | CTD | PMID:17602206 | copper(2+) sulfate | decreases expression | ISO | RGD:1349414 | 6480464 | Copper Sulfate results in decreased expression of SMPD1 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1349414 | 6480464 | Cyclosporine results in decreased expression of SMPD1 mRNA | CTD | PMID:20106945 | daunorubicin | increases expression | ISO | RGD:1349414 | 6480464 | Daunorubicin results in increased expression of SMPD1 mRNA | CTD | PMID:19698806 | daunorubicin | increases activity | ISO | RGD:1349414 | 6480464 | Daunorubicin results in increased activity of SMPD1 protein | CTD | PMID:19698806 | desipramine | decreases activity | ISO | RGD:1349414 | 6480464 | Desipramine results in decreased activity of SMPD1 protein | CTD | PMID:15781658 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of SMPD1 mRNA | CTD | PMID:21266533 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of SMPD1 mRNA | CTD | PMID:21551480 | doxorubicin | increases activity | ISO | RGD:1557572 | 6480464 | Doxorubicin results in increased activity of SMPD1 protein | CTD | PMID:17520194 | doxorubicin | increases uptake | ISO | RGD:1557572 | 6480464 | SMPD1 gene mutant form results in increased uptake of Doxorubicin | CTD | PMID:16439991 | doxorubicin | multiple interactions | ISO | RGD:1557572 | 6480464 | [Doxorubicin results in increased activity of SMPD1 protein] promotes the reaction [TNFSF10 protein binds to TNFSF10 protein] | CTD | PMID:17520194 | folic acid | increases expression | ISO | RGD:1557572 | 6480464 | Folic Acid deficiency results in increased expression of SMPD1 mRNA | CTD | PMID:21893018 | folic acid | affects response to substance | ISO | RGD:1557572 | 6480464 | SMPD1 protein affects the susceptibility to Folic Acid deficiency | CTD | PMID:21893018 | hydrogen peroxide | affects expression | ISO | RGD:1349414 | 6480464 | Hydrogen Peroxide affects the expression of SMPD1 mRNA | CTD | PMID:20044591 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of SMPD1 mRNA | CTD | PMID:20387270 | paracetamol | affects expression | ISO | RGD:1557572 | 6480464 | Acetaminophen affects the expression of SMPD1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1349414 | 6480464 | Acetaminophen results in increased expression of SMPD1 mRNA | CTD | PMID:22230336 | peroxynitrous acid | increases activity | ISO | RGD:1349414 | 6480464 | Peroxynitrous Acid results in increased activity of SMPD1 protein | CTD | PMID:17498692 | pirinixic acid | decreases expression | ISO | RGD:1557572 | 6480464 | pirinixic acid results in decreased expression of SMPD1 mRNA | CTD | PMID:20059764 | pirinixic acid | multiple interactions | ISO | RGD:1557572 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SMPD1 mRNA] | CTD | PMID:20059764 | sevoflurane | decreases activity | ISO | RGD:1349414 | 6480464 | sevoflurane results in decreased activity of SMPD1 protein | CTD | PMID:19572936 | tamibarotene | increases expression | ISO | RGD:1349414 | 6480464 | Am 80 results in increased expression of SMPD1 mRNA; more ... | CTD | PMID:15498508 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Lysosome |
| Metabolic pathways | |
| Sphingolipid metabolism | |
| Pathway Interaction Database | Ceramide signaling pathway (PID:200119) |
| FAS (CD95) signaling pathway (PID:200080) | |
| IL2 signaling events mediated by PI3K (PID:200118) | |
| TNF receptor signaling pathway (PID:200102) | |
| TRAIL signaling pathway (PID:200068) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Lysosome |
| Metabolic pathways | |
| Sphingolipid metabolism | |
| Pathway Interaction Database | Ceramide signaling pathway (PID:200119) |
| FAS (CD95) signaling pathway (PID:200080) | |
| IL2 signaling events mediated by PI3K (PID:200118) | |
| TNF receptor signaling pathway (PID:200102) | |
| TRAIL signaling pathway (PID:200068) | |
References - curated| 1. |
Baranowski M, etal., Prostaglandins Other Lipid Mediat. 2007 Feb;83(1-2):99-111. Epub 2006 Nov 16. |
| 2. |
Becker S, etal., Biol Chem. 2007 Feb;388(2):185-96. |
| 3. |
Gorska M, etal., Horm Metab Res. 2004 Jan;36(1):14-21. |
| 4. |
Lang PA, etal., Nat Med. 2007 Feb;13(2):164-70. Epub 2007 Jan 28. |
| 5. |
Loidl A, etal., J Biol Chem. 2003 Aug 29;278(35):32921-8. Epub 2003 Jun 19. |
| 6. |
Nassogne MC, etal., Toxicol Appl Pharmacol. 2004 Jan 15;194(2):101-10. |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD Automated Pipelines |
| 12. |
RGD comprehensive gene curation |
| 13. |
Sikora J, etal., Ann Hum Genet. 2003 Jan;67(Pt 1):63-70. |
| 14. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
RGD Disease Portals| Smpd1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Smpd1 (Rattus norvegicus) |
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| SMPD1 (Homo sapiens) |
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| Smpd1 (Mus musculus) |
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Position Markers| AF206720 |
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| RH130448 |
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| Smpd1 |
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| RH134756 |
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| UniSTS:235734 |
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| SMPD1_855 |
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| Smpd1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001006997 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06007653 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01007681 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC083780 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473956 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001006997 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001006998 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001006998 | (Get FASTA) |
| GenBank Protein | AAH83780 | (Get FASTA) |
| EDM18044 | (Get FASTA) | |
| EDM18045 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000017977 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000024224 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000024224 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 308909 | ENTREZGENE |
| HomoloGene Group ID | 457 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7096039 | IMAGE-MGC_LOAD |
| InterPro | M-pesterase | UniProtKB/TrEMBL |
| Saposin-like | UniProtKB/TrEMBL | |
| SaposinB | UniProtKB/TrEMBL | |
| Sphingomy_PDE | UniProtKB/TrEMBL | |
| IPI | IPI00189029 | UniProtKB/TrEMBL |
| KEGG Report | rno:308909 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:94748 | IMAGE-MGC_LOAD |
| Pfam | Metallophos | UniProtKB/TrEMBL |
| PharmGKB | SMPD1 | RGD |
| PIRSF | Sphingomy_PDE | UniProtKB/TrEMBL |
| PROSITE | SAP_B | UniProtKB/TrEMBL |
| SMART | SapB | UniProtKB/TrEMBL |
| Superfamily-SCOP | Saposin_like | UniProtKB/TrEMBL |
| UniGene | Rn.18277 | ENTREZGENE |
| UniProt | Q5XIA6_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2006-03-30 | Smpd1 | sphingomyelin phosphodiesterase 1, acid lysosomal | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2005-09-15 | Smpd1 | sphingomyelin phosphodiesterase 1, acid lysosomal | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Smpd1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1549719 |
| Created: | 2005-09-15 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.