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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200 Species: Rattus norvegicus RGD Object: Gene Symbol: Bcl2l1 Name: Bcl2-like 1

Acc ID: CHEBI:27666 Term: actinomycin D Definition: An actinomycin that has formula C62H86N12O16. CasRN: 50-76-0 Chemical ID: MESH:D003609

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:735516	6480464	CTD	Dactinomycin results in decreased expression of BCL2L1 protein	PMID:15592511
increases expression	ISO	RGD:735516	6480464	CTD	Dactinomycin results in increased expression of BCL2L1 protein	PMID:9326359
increases expression	ISO	RGD:735516	6480464	CTD	Dactinomycin results in increased expression of BCL2L1 protein alternative form	PMID:12430140
multiple interactions	ISO	RGD:735516	6480464	CTD	Dexamethasone inhibits the reaction [Dactinomycin results in increased expression of BCL2L1 protein]	PMID:9326359