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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of SCNN1B mRNA | CTD | PMID:17557909 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | affects expression | EXP | | 6480464 | Puromycin Aminonucleoside affects the expression of SCNN1B mRNA | CTD | PMID:12653683 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | increases expression | EXP | | 6480464 | Puromycin Aminonucleoside results in increased expression of SCNN1B mRNA | CTD | PMID:16267158 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | EXP | | 6480464 | Puromycin Aminonucleoside results in decreased expression of SCNN1B mRNA | CTD | PMID:16020936 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | multiple interactions | EXP | | 6480464 | Puromycin Aminonucleoside results in increased expression of and results in increased localization of SCNN1B protein | CTD | PMID:15075188 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | affects localization | EXP | | 6480464 | Puromycin Aminonucleoside affects the localization of SCNN1B protein | CTD | PMID:16267158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] | CTD | PMID:15161604 | 3-isobutyl-1-methyl-7H-xanthine | increases expression | ISO | RGD:11272 | 6480464 | 1-Methyl-3-isobutylxanthine results in increased expression of SCNN1B protein | CTD | PMID:20613715 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:11272 | 6480464 | [1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of SCNN1B protein | CTD | PMID:20613715 | 5-fluorouracil | affects expression | ISO | RGD:734263 | 6480464 | Fluorouracil affects the expression of SCNN1B mRNA | CTD | PMID:16584549 | 8-bromo-3',5'-cyclic GMP | multiple interactions | ISO | RGD:11272 | 6480464 | [1-Methyl-3-isobutylxanthine co-treated with 8-bromocyclic GMP] results in increased expression of SCNN1B protein | CTD | PMID:20613715 | actinomycin D | multiple interactions | ISO | RGD:734263 | 6480464 | Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1B mRNA] | CTD | PMID:10942727 | aldosterone | increases expression | ISO | RGD:734263 | 6480464 | Aldosterone results in increased expression of SCNN1B mRNA; more ... | CTD | PMID:18665318 | amiloride | multiple interactions | ISO | RGD:734263 | 6480464 | Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium] | CTD | PMID:18665318 | amiloride | multiple interactions | ISO | RGD:734263 | 6480464 | Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] | CTD | PMID:18665318 PMID:18398334 | amiloride | affects activity | ISO | RGD:11272 | 6480464 | Amiloride affects the activity of SCNN1B protein | CTD | PMID:8617496 | amiloride | multiple interactions | ISO | RGD:734263 | 6480464 | Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] | CTD | PMID:18398334 PMID:18665318 | amiloride | multiple interactions | ISO | RGD:734263 | 6480464 | Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D] | CTD | PMID:19359370 | brefeldin A | multiple interactions | EXP | | 6480464 | Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]] | CTD | PMID:12608646 | cortisol | increases expression | ISO | RGD:734263 | 6480464 | Hydrocortisone results in increased expression of SCNN1B mRNA | CTD | PMID:17715387 | desmopressin | increases expression | EXP | | 6480464 | Deamino Arginine Vasopressin results in increased expression of SCNN1B mRNA | CTD | PMID:11711512 | dexamethasone | multiple interactions | ISO | RGD:734263 | 6480464 | Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1B mRNA] | CTD | PMID:10942727 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of SCNN1B mRNA | CTD | PMID:12682491 | dexamethasone | increases expression | ISO | RGD:11272 | 6480464 | Dexamethasone results in increased expression of SCNN1B mRNA | CTD | PMID:19344079 | dexamethasone | increases expression | ISO | RGD:734263 | 6480464 | Dexamethasone results in increased expression of SCNN1B mRNA; more ... | CTD | PMID:10942727 | dioxygen | multiple interactions | EXP | | 6480464 | Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]] | CTD | PMID:12608646 | dioxygen | multiple interactions | EXP | | 6480464 | Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein] | CTD | PMID:12372821 | dioxygen | decreases expression | EXP | | 6480464 | Oxygen deficiency results in decreased expression of SCNN1B protein | CTD | PMID:12372821 | hydralazine | multiple interactions | ISO | RGD:734263 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SCNN1B mRNA | CTD | PMID:17183730 | lithium atom | multiple interactions | ISO | RGD:734263 | 6480464 | [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Lithium | CTD | PMID:18665318 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of SCNN1B mRNA | CTD | PMID:19162173 | pirinixic acid | multiple interactions | ISO | RGD:734263 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SCNN1B mRNA | CTD | PMID:19710929 | potassium atom | multiple interactions | ISO | RGD:734263 | 6480464 | [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Potassium | CTD | PMID:18665318 | progesterone | multiple interactions | EXP | | 6480464 | Progesterone affects the activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] | CTD | PMID:17939260 | progesterone | multiple interactions | EXP | | 6480464 | Progesterone results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] | CTD | PMID:16172119 | progesterone | affects expression | EXP | | 6480464 | Progesterone affects the expression of SCNN1B protein; more ... | CTD | PMID:17939260 | sodium atom | multiple interactions | ISO | RGD:734263 | 6480464 | Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium] | CTD | PMID:18665318 | sodium atom | affects transport | ISO | RGD:11272 | 6480464 | SCNN1B protein affects the transport of Sodium | CTD | PMID:8617496 | sodium atom | multiple interactions | ISO | RGD:734263 | 6480464 | [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which affects the transport of Sodium; more ... | CTD | PMID:18398334 | sodium atom | multiple interactions | ISO | RGD:734263 | 6480464 | [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein binds to SCNN1D protein] which results in increased transport of Sodium | CTD | PMID:19359370 | terbutaline | multiple interactions | EXP | | 6480464 | Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]] | CTD | PMID:12608646 | terbutaline | multiple interactions | EXP | | 6480464 | Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein] | CTD | PMID:12372821 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SCNN1B mRNA | CTD | PMID:16644059 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SCNN1B protein | CTD | PMID:16192424 | thiourea | decreases expression | EXP | | 6480464 | Thiourea results in decreased expression of SCNN1B mRNA | CTD | PMID:15248066 | valproic acid | multiple interactions | ISO | RGD:734263 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SCNN1B mRNA | CTD | PMID:17183730 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Aldosterone-regulated sodium reabsorption |
| Taste transduction | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Aldosterone-regulated sodium reabsorption |
| Taste transduction | |
References - curated| 1. |
Asher C, etal., Biochem Biophys Res Commun. 2001 Sep 7;286(5):1228-31. |
| 2. |
Bachhuber T, etal., J Biol Chem. 2005 Sep 9;280(36):31587-94. Epub 2005 Jul 18. |
| 3. |
Canessa CM, etal., Nature 1994 Feb 3;367(6462):463-7. |
| 4. |
Chang SS, etal., Nat Genet. 1996 Mar;12(3):248-53. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Grifoni SC, etal., Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3076-86. Epub 2006 Jul 14. |
| 7. |
Hanwell D, etal., J Biol Chem 2002 Mar 22;277(12):9772-9. |
| 8. |
Kanelis V, etal., Biochem Cell Biol. 1998;76(2-3):341-50. |
| 9. |
Kim SW, etal., Am J Physiol Renal Physiol. 2004 May;286(5):F922-35. Epub 2004 Jan 6. |
| 10. |
Kreutz R, etal., Hypertension 1997 Jan;29(1 Pt 1):131-6. |
| 11. |
Mazzochi C, etal., J Biol Chem. 2006 Mar 10;281(10):6528-38. Epub 2005 Dec 14. |
| 12. |
MGD data from the GO Consortium |
| 13. |
Michlig S, etal., J Biol Chem. 2005 Nov 18;280(46):38264-70. Epub 2005 Sep 19. |
| 14. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 15. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 16. |
Planes C, etal., J Biol Chem 2002 Dec 6;277(49):47318-24. |
| 17. |
Pradervand S, etal., J Am Soc Nephrol 1999 Dec;10(12):2527-33. |
| 18. |
RGD automated data pipeline |
| 19. |
RGD automated import pipeline for gene-chemical interactions |
| 20. |
RGD Automated Pipelines |
| 21. |
Shi H, etal., J Biol Chem 2002 Apr 19;277(16):13539-47. |
| 22. |
Shimkets RA, etal., Cell. 1994 Nov 4;79(3):407-14. |
| 23. |
Staub O, etal., EMBO J 1996 May 15;15(10):2371-80. |
| 24. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 25. |
Yang LM, etal., J Biol Chem. 2006 Apr 14;281(15):9859-68. Epub 2006 Feb 13. |
References - uncurated| PubMed | 11323714 |
| 12548398 | |
| 12654927 | |
| 12759227 | |
| 12876281 | |
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| 16020936 | |
| 16554417 | |
| 17200158 | |
| 17605762 | |
| 17724164 | |
| 17926064 | |
| 18024548 | |
| 18504317 | |
| 18806814 | |
| 18990692 | |
| 19202345 | |
| 19224431 | |
| 19420735 | |
| 19426735 | |
| 21423289 | |
| 22045317 | |
| 22090066 | |
| 22830999 | |
| 9501257 |
RGD Disease Portals| Scnn1b has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Scnn1b (Rattus norvegicus) |
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| SCNN1B (Homo sapiens) |
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| Scnn1b (Mus musculus) |
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Position Markers| D1Smu8 |
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| D1Smu7 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Related Rat Strains
Nucleotide Sequences| Nucleotide RefSeqs | NM_012648 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06008637 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06008638 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008639 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008330 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008331 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008332 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008333 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008334 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473956 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU627516 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U35174 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U35175 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U35176 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U35177 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X77932 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012648 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036780 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_036780 | (Get FASTA) |
| GenBank Protein | AAB58457 | (Get FASTA) |
| AAB58458 | (Get FASTA) | |
| AAD10397 | (Get FASTA) | |
| AAD10398 | (Get FASTA) | |
| ACG70177 | (Get FASTA) | |
| CAA54904 | (Get FASTA) | |
| EDM17579 | (Get FASTA) | |
| P37090 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000030981 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000063755 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000067138 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 24767 | ENTREZGENE |
| Germonline | ENSRNOG00000030981 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20280 | ENTREZGENE |
| InterPro | EnaC | UniProtKB/Swiss-Prot |
| Na+channel_ASC | UniProtKB/Swiss-Prot | |
| Na+channel_ASC_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00325744 | UniProtKB/Swiss-Prot |
| IPI00950970 | UniProtKB/TrEMBL | |
| KEGG Report | rno:24767 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Na+channel_ASC | UniProtKB/Swiss-Prot |
| Pfam | ASC | UniProtKB/Swiss-Prot |
| PharmGKB | SCNN1B | RGD |
| PRINTS | AMINACHANNEL | UniProtKB/Swiss-Prot |
| PROSITE | ASC | UniProtKB/Swiss-Prot |
| TIGR | TC236653 | |
| TIGRFAMs | ENaC | UniProtKB/Swiss-Prot |
| UniGene | Rn.9807 | ENTREZGENE |
| UniProt | B8QP48_RAT | UniProtKB/TrEMBL |
| Q9QUI8_RAT | UniProtKB/TrEMBL | |
| SCNNB_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-05-07 | Scnn1b | sodium channel, nonvoltage-gated 1, beta | Scnn1b | sodium channel, nonvoltage-gated, type I, beta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2010-05-07 | Scnn1b | sodium channel, nonvoltage-gated 1, beta | Scnn1b | sodium channel, nonvoltage-gated 1, beta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2009-12-15 | Scnn1b | sodium channel, nonvoltage-gated, type I, beta | Scnn1b | sodium channel, nonvoltage-gated 1 beta | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Scnn1b | Sodium channel, nonvoltage-gated 1, beta (epithelial) | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | beta subunit, with alpha and gamma subunits forms the amiloride-sensitive epithelial Na+ channel | 729911 |
| More on Scnn1b | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3640 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




