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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:10307 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CD28 mRNA | CTD | PMID:16102516 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:10307 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CD28 mRNA | CTD | PMID:18684927 | 2-amino-2-deoxy-D-glucopyranose | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of CD28 mRNA | CTD | PMID:17109745 | acetohydrazide | decreases expression | ISO | RGD:10307 | 6480464 | acetylhydrazine results in decreased expression of CD28 mRNA | CTD | PMID:15282401 | acrolein | increases expression | ISO | RGD:10307 | 6480464 | Acrolein results in increased expression of CD28 mRNA | CTD | PMID:18515264 | actinomycin D | multiple interactions | ISO | RGD:735932 | 6480464 | Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] | CTD | PMID:11465111 | aldehydo-D-glucosamine | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of CD28 mRNA | CTD | PMID:17109745 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CD28 mRNA | CTD | PMID:16483693 | atrazine | multiple interactions | ISO | RGD:735932 | 6480464 | [Atrazine co-treated with Arsenates] results in increased expression of CD28 mRNA | CTD | PMID:18585445 | benzo[a]pyrene | decreases expression | ISO | RGD:10307 | 6480464 | Benzo(a)pyrene results in decreased expression of CD28 mRNA | CTD | PMID:21569818 | beta-D-glucosamine | increases expression | EXP | | 6480464 | Glucosamine results in increased expression of CD28 mRNA | CTD | PMID:17109745 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:10307 | 6480464 | Mustard Gas results in increased expression of CD28 mRNA | CTD | PMID:15674844 | calcium atom | multiple interactions | ISO | RGD:735932 | 6480464 | 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Calcium]; more ... | CTD | PMID:14607919 | calcium atom | increases abundance | ISO | RGD:735932 | 6480464 | CD28 protein results in increased abundance of Calcium | CTD | PMID:14607919 | calcium(0) | multiple interactions | ISO | RGD:735932 | 6480464 | 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Calcium]; more ... | CTD | PMID:14607919 | calcium(0) | increases abundance | ISO | RGD:735932 | 6480464 | CD28 protein results in increased abundance of Calcium | CTD | PMID:14607919 | cyclophosphamide | decreases expression | ISO | RGD:10307 | 6480464 | Cyclophosphamide results in decreased expression of CD28 mRNA | CTD | PMID:21041162 | dexamethasone | multiple interactions | ISO | RGD:735932 | 6480464 | [Dexamethasone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA; more ... | CTD | PMID:20363256 | dexamethasone | decreases expression | ISO | RGD:10307 | 6480464 | Dexamethasone results in decreased expression of CD28 mRNA | CTD | PMID:21041162 | diethylstilbestrol | decreases expression | ISO | RGD:10307 | 6480464 | Diethylstilbestrol results in decreased expression of CD28 mRNA | CTD | PMID:21041162 | hydrazine | decreases expression | ISO | RGD:10307 | 6480464 | hydrazine results in decreased expression of CD28 mRNA | CTD | PMID:15282401 | mercaptopurine | multiple interactions | ISO | RGD:735932 | 6480464 | 6-Mercaptopurine inhibits the reaction [CD28 protein results in increased activity of [NFKB1 protein binds to RELA protein]] | CTD | PMID:12697733 | mercury dichloride | affects response to substance | ISO | RGD:10307 | 6480464 | CD28 protein affects the susceptibility to Mercuric Chloride | CTD | PMID:19077085 | mercury dichloride | multiple interactions | ISO | RGD:10307 | 6480464 | CD28 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein] | CTD | PMID:19077085 | methotrexate | decreases expression | ISO | RGD:735932 | 6480464 | Methotrexate results in decreased expression of CD28 mRNA | CTD | PMID:17400583 | mifepristone | multiple interactions | ISO | RGD:735932 | 6480464 | Mifepristone inhibits the reaction [[Dexamethasone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]; more ... | CTD | PMID:20363256 | nitric oxide | multiple interactions | ISO | RGD:735932 | 6480464 | 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; more ... | CTD | PMID:14607919 | nitric oxide | increases abundance | ISO | RGD:735932 | 6480464 | CD28 protein results in increased abundance of Nitric Oxide | CTD | PMID:14607919 | paracetamol | affects expression | ISO | RGD:10307 | 6480464 | Acetaminophen affects the expression of CD28 mRNA | CTD | PMID:17562736 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:735932 | 6480464 | Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein]; more ... | CTD | PMID:11465111 | phorbol 13-acetate 12-myristate | increases expression | ISO | RGD:735932 | 6480464 | Tetradecanoylphorbol Acetate results in increased expression of CD28 protein | CTD | PMID:11465111 | pirinixic acid | multiple interactions | ISO | RGD:10307 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD28 mRNA | CTD | PMID:19710929 | purine-6-thiol | multiple interactions | ISO | RGD:735932 | 6480464 | 6-Mercaptopurine inhibits the reaction [CD28 protein results in increased activity of [NFKB1 protein binds to RELA protein]] | CTD | PMID:12697733 | silver(1+) nitrate | multiple interactions | ISO | RGD:10307 | 6480464 | CD28 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein] | CTD | PMID:19077085 | silver(1+) nitrate | affects response to substance | ISO | RGD:10307 | 6480464 | CD28 protein affects the susceptibility to Silver Nitrate | CTD | PMID:19077085 | sodium aurothiomalate | multiple interactions | ISO | RGD:10307 | 6480464 | CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein] | CTD | PMID:19077085 | sodium aurothiomalate | affects response to substance | ISO | RGD:10307 | 6480464 | CD28 protein affects the susceptibility to Gold Sodium Thiomalate | CTD | PMID:19077085 | staurosporine | multiple interactions | ISO | RGD:735932 | 6480464 | Staurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] | CTD | PMID:11465111 | thimerosal | affects response to substance | ISO | RGD:10307 | 6480464 | CD28 affects the susceptibility to Thimerosal | CTD | PMID:15808517 | trimellitic anhydride | increases expression | ISO | RGD:10307 | 6480464 | trimellitic anhydride results in increased expression of CD28 mRNA | CTD | PMID:19042947 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Allograft rejection |
| Autoimmune thyroid disease | |
| Cell adhesion molecules (CAMs) | |
| Graft-versus-host disease | |
| Intestinal immune network for IgA production | |
| Measles | |
| Rheumatoid arthritis | |
| Systemic lupus erythematosus | |
| T cell receptor signaling pathway | |
| Type I diabetes mellitus | |
| Viral myocarditis | |
| Pathway Interaction Database | IL12 signaling mediated by STAT4 (PID:200229) |
| TCR signaling in naïve CD4+ T cells (PID:200027) | |
| TCR signaling in naïve CD8+ T cells (PID:200075) | |
References - curated| 1. |
Arreaza GA, etal., J Clin Invest. 1997 Nov 1;100(9):2243-53. |
| 2. |
Bantsimba-Malanda C, etal., Am J Respir Crit Care Med. 2010 Aug 1;182(3):385-95. Epub 2010 Apr 15. |
| 3. |
Barcelo B, etal., Eur Respir J. 2008 Mar;31(3):555-62. Epub 2007 Dec 5. |
| 4. |
Beyersdorf N, etal., J Exp Med. 2005 Aug 1;202(3):445-55. |
| 5. |
Botturi K, etal., Respir Res. 2011 Feb 28;12:25. |
| 6. |
Chen X, etal., Blood. 2009 Apr 2;113(14):3226-34. Epub 2008 Dec 15. |
| 7. |
Dolfi DV, etal., J Immunol. 2011 Apr 15;186(8):4599-608. Epub 2011 Mar 9. |
| 8. |
Elflein K, etal., Blood. 2003 Sep 1;102(5):1764-70. Epub 2003 May 15. |
| 9. |
Felonato M, etal., Infect Immun. 2010 Nov;78(11):4922-35. Epub 2010 Aug 16. |
| 10. |
GOA data from the GO Consortium |
| 11. |
Haspot F, etal., Blood 2002 Mar 15;99(6):2228-34. |
| 12. |
Heidema J, etal., J Immunol. 2007 Dec 15;179(12):8410-7. |
| 13. |
Heron M, etal., Clin Exp Immunol. 2010 May;160(2):256-65. Epub 2009 Dec 17. |
| 14. |
Ihara K, etal., Immunogenetics. 2001 Aug;53(6):447-54. |
| 15. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 16. |
Lambers C, etal., Clin Exp Immunol. 2009 Mar;155(3):466-75. |
| 17. |
Liu H, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Jul;6(7):744-7. |
| 18. |
Lorusso L, etal., Autoimmun Rev. 2009 Feb;8(4):287-91. Epub 2008 Sep 16. |
| 19. |
Macphee IA, etal., Clin Exp Immunol 2002 Sep;129(3):405-10. |
| 20. |
MGD data from the GO Consortium |
| 21. |
Muller N, etal., J Clin Invest. 2008 Apr;118(4):1405-16. |
| 22. |
Nakatsuji T Tohoku J Exp Med. 1999 Mar;187(3):215-25. |
| 23. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 24. |
Nolan A, etal., Am J Respir Crit Care Med. 2008 Feb 1;177(3):301-8. Epub 2007 Nov 7. |
| 25. |
Pawlowski P, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2004;10(2):81-5. |
| 26. |
Pechhold K, etal., J Immunol. 2001 Feb 15;166(4):2531-9. |
| 27. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 28. |
RGD automated data pipeline |
| 29. |
RGD automated import pipeline for gene-chemical interactions |
| 30. |
Sadra A, etal., Proc Natl Acad Sci U S A 2004 Aug 3;101(31):11422-7. Epub 2004 Jul 27. |
| 31. |
Schmidt J, etal., J Neuroimmunol. 2003 Jul;140(1-2):143-52. |
| 32. |
Tacke M, etal., J Immunol. 1995 May 15;154(10):5121-7. |
| 33. |
Teutsch SM, etal., J Neuroimmunol 2004 Mar;148(1-2):218-30. |
References - uncurated
RGD Disease Portals| Cd28 has been annotated in the following RGD Disease Portals. |
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Candidate Gene Status
Comparative Map Data| Cd28 (Rattus norvegicus) |
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| CD28 (Homo sapiens) |
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| Cd28 (Mus musculus) |
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Position Markers| RH94659 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013121 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06060638 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01060325 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01060326 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473965 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X55288 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013121 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037253 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037253 | (Get FASTA) |
| GenBank Protein | CAA39003 | (Get FASTA) |
| EDL98926 | (Get FASTA) | |
| P31042 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000010283 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000013701 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000013701 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 25660 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000010283 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 4473 | ENTREZGENE |
| InterPro | CD28 | UniProtKB/Swiss-Prot |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_sub | UniProtKB/Swiss-Prot | |
| Ig_V-set | UniProtKB/Swiss-Prot | |
| IPI | IPI00208889 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25660 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | V-set | UniProtKB/Swiss-Prot |
| PRINTS | CD28ANTIGEN | UniProtKB/Swiss-Prot |
| PROSITE | IG_LIKE; FALSE_NEG | UniProtKB/Swiss-Prot |
| SMART | SM00409 | UniProtKB/Swiss-Prot |
| UniGene | Rn.10327 | ENTREZGENE |
| UniProt | CD28_RAT | UniProtKB/Swiss-Prot |
| G3V7C2_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-06-27 | Cd28 | Cd28 molecule | Cd28 | CD28 antigen | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Cd28 | CD28 antigen | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | binds to B7-1 or B7-2 on Antigen Presenting Cells | 634714 |
| gene_process | involved in initiation of the Th2-response; may be required to maintain basal IgE production during mercuric chloride (HgCl2)-induced autoimmunity | 634715 |
| gene_process | costimulatory molecule for T-cell proliferation, particularly during T-cell mediated allograft responses | 634714 |
| More on Cd28 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2299 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




