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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:non-small cell lung carcinoma pathway
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Accession:PW:0000705 term browser browse the term
Definition:Non-small cell lung carcinoma groups together several non-small cell lung carcinomas. The main types are represented by squamous cell, adeno- and large-cell carcinoma. Alterations in Ras and epidermal growth factor signaling, among others, have been implicated in the condition.
Synonyms:exact_synonym: non-small cell lung cancer pathway
 related_synonym: KEGG:05223;   NSCLC pathway;   non-small cell lung neoplasm pathway
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non-small cell lung carcinoma pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO
IEA 		KEGG
RGD		 PMID:21277552 rno:05223, RGD:5133243 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:05223 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05223 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:05223 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO
IEA 		KEGG
RGD		 PMID:20951313 PMID:21277552 rno:05223, RGD:5133242, RGD:5133243 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05223 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05223 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 IEA KEGG rno:05223 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 IEA KEGG rno:05223 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A IEA KEGG rno:05223 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G E2f1 E2F transcription factor 1 IEA KEGG rno:05223 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f3 E2F transcription factor 3 IEA KEGG rno:05223 NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725 		JBrowse link
G Egf epidermal growth factor IEA KEGG rno:05223 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Egfr epidermal growth factor receptor ISO
IEA 		KEGG
RGD		 PMID:20519133 PMID:20951313 rno:05223, RGD:5133241, RGD:5133242 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO
IEA 		KEGG
RGD		 PMID:21277552 rno:05223, RGD:5133243 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase IEA KEGG rno:05223 NCBI chr15:16,365,401...17,872,901
Ensembl chr15:16,747,338...17,872,621 		JBrowse link
G Foxo3 forkhead box O3 IEA KEGG rno:05223 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG rno:05223 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Hras HRas proto-oncogene, GTPase IEA KEGG rno:05223 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO
IEA 		KEGG
RGD		 PMID:20951313 rno:05223, RGD:5133242 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO
IEA 		KEGG
RGD		 PMID:20951313 PMID:21277552 rno:05223, RGD:5133242, RGD:5133243 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:05223 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:05223 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:05223 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:20519133 PMID:20951313 PMID:21277552 RGD:5133241, RGD:5133242, RGD:5133243 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:05223 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IEA KEGG rno:05223 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,610,063...13,679,181 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA 		KEGG
RGD		 PMID:20951313 PMID:21277552 rno:05223, RGD:5133242, RGD:5133243 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05223 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05223 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05223 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05223 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05223 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05223 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Plcg1 phospholipase C, gamma 1 IEA KEGG rno:05223 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA KEGG rno:05223 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684 		JBrowse link
G Prkca protein kinase C, alpha IEA KEGG rno:05223 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572 		JBrowse link
G Prkcb protein kinase C, beta IEA KEGG rno:05223 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740 		JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:05223 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:20951313 RGD:5133242 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:05223 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rarb retinoic acid receptor, beta IEA KEGG rno:05223 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040 		JBrowse link
G Rassf1 Ras association domain family member 1 IEA KEGG rno:05223 NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805 		JBrowse link
G Rassf5 Ras association domain family member 5 IEA KEGG rno:05223 NCBI chr13:45,189,768...45,255,277
Ensembl chr13:45,189,804...45,255,277 		JBrowse link
G Rb1 RB transcriptional corepressor 1 IEA KEGG rno:05223 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rxra retinoid X receptor alpha IEA KEGG rno:05223 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Rxrb retinoid X receptor beta IEA KEGG rno:05223 NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359 		JBrowse link
G Rxrg retinoid X receptor gamma IEA KEGG rno:05223 NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG rno:05223 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG rno:05223 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811 		JBrowse link
G Stk4 serine/threonine kinase 4 IEA KEGG rno:05223 NCBI chr 3:173,165,238...173,247,135
Ensembl chr 3:173,165,083...173,247,134 		JBrowse link
G Tgfa transforming growth factor alpha IEA KEGG rno:05223 NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:120,175,593...120,258,339 		JBrowse link
G Tp53 tumor protein p53 ISO
IEA 		KEGG
RGD		 PMID:20951313 rno:05223, RGD:5133242 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      cancer pathway 369
        thoracic cancer pathway 104
          respiratory tract cancer pathway 104
            lung cancer pathway 104
              non-small cell lung carcinoma pathway 53
paths to the root