MIR21 (microRNA 21) - Rat Genome Database

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Gene: MIR21 (microRNA 21) Homo sapiens
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Symbol: MIR21
Name: microRNA 21
RGD ID: 1349265
HGNC Page HGNC:31586
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and regulation of signal transduction. Acts upstream of or within negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm and extracellular exosome. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); liver disease (multiple); lung cancer (multiple); and uterine disease (multiple).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-21; miR-21; MIRN21; miRNA21
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,841,266 - 59,841,337 (+)Ensemblhg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
acute myocardial infarction  (IEP)
alcohol use disorder  (ISO)
Alcoholic Intoxication  (IEP)
allergic contact dermatitis  (ISO)
anaplastic thyroid carcinoma  (IEP)
Angina Pectoris  (IEP)
atherosclerosis  (IEP)
Atrial Remodeling  (ISO)
autoimmune uveitis  (ISO)
brain glioma  (IEP)
breast cancer  (HEP,IEP,ISO)
Burkitt lymphoma  (IEP)
Cardio-Renal Syndrome  (ISO)
Cardiomegaly  (EXP,ISO)
cerebral infarction  (ISO)
cervical cancer  (IEP)
cervical squamous cell carcinoma  (IEP)
cervicitis  (IEP)
cervix uteri carcinoma in situ  (IEP)
Chemical and Drug Induced Liver Injury  (EXP)
chlamydia  (ISO)
cholangiocarcinoma  (IEP)
Cholangiofibrosis  (IEP)
Chronic Hepatitis  (IEP)
chronic lymphocytic leukemia  (IEP)
colon cancer  (IEP)
colorectal cancer  (IEP,ISO)
congestive heart failure  (EXP,IEP,ISO)
coronary artery disease  (IEP)
Crohn's disease  (IEP)
cryptosporidiosis  (ISO)
dengue disease  (IEP)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (EXP)
endometrial cancer  (IEP)
endometriosis  (EXP)
esophageal cancer  (IEP)
Esophageal Neoplasms  (EXP)
esophagus adenocarcinoma  (IEP)
Experimental Colitis  (ISO)
Fibrosis  (EXP)
Fusobacterium Infections  (IEP)
glioblastoma  (ISO)
Haemophilus Infections  (ISO)
heart disease  (EXP)
hepatitis C  (IEP)
hepatoblastoma  (IEP)
hepatocellular carcinoma  (IEP)
Hyperoxic Lung Injury  (ISO)
hypertensive heart disease  (IEP)
Inflammation  (EXP)
influenza  (ISO)
intermediate coronary syndrome  (IEP)
intestinal obstruction  (IEP)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (IEP)
irritable bowel syndrome  (IEP)
kidney disease  (EXP)
laryngeal squamous cell carcinoma  (HEP)
listeriosis  (ISO)
liver cirrhosis  (IEP,ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (IEP,ISO)
lung adenoma  (ISO)
lung cancer  (IEP,ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IEP)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
Microsatellite Instability  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP,IMP)
Neoplastic Cell Transformation  (EXP)
obesity  (EXP)
papillomavirus infectious disease  (IEP)
Parkinson's disease  (ISO)
Peritoneal Fibrosis  (ISO)
peritonitis  (ISO)
primary biliary cholangitis  (IEP)
Prostatic Neoplasms  (EXP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (ISO)
skin melanoma  (IEP)
skin papilloma  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
stomach cancer  (IEP)
thyroid cancer  (ISO)
toxic shock syndrome  (ISO)
Varicose Ulcer  (IEP)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (EXP)
(R)-lipoic acid  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,5-hexanedione  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (ISO)
acetic acid  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (ISO)
alcohol  (EXP,ISO)
all-trans-retinoic acid  (EXP)
Allylamine  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antigen  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
baicalein  (EXP)
Bandrowski's base  (EXP)
benomyl  (ISO)
benzene-1,2,4-triol  (EXP)
berberine  (EXP)
bicalutamide  (EXP)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (EXP)
bortezomib  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (EXP)
carbon atom  (EXP)
carbon monoxide  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (EXP)
curcumin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dapagliflozin  (ISO)
daunorubicin  (EXP)
DDT  (EXP,ISO)
dehydroepiandrosterone  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental carbon  (EXP)
Enterolactone  (EXP)
fenhexamid  (EXP)
ferulic acid  (ISO)
fludioxonil  (EXP)
formaldehyde  (EXP)
fulvestrant  (EXP)
fumonisin B1  (EXP)
gallic acid  (ISO)
geldanamycin  (EXP)
gentamycin  (ISO)
glycidol  (ISO)
graphene oxide  (EXP)
halothane  (ISO)
hydrogen peroxide  (EXP)
icariin  (ISO)
isoprenaline  (ISO)
lamotrigine  (EXP)
lipoic acid  (ISO)
lithium atom  (ISO)
lithium carbonate  (ISO)
lithium hydride  (ISO)
LY294002  (EXP)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
mercaptopurine  (ISO)
methanol  (ISO)
methapyrilene  (ISO)
methyl beta-cyclodextrin  (EXP)
methylmercury chloride  (EXP)
morphine  (EXP)
myo-inositol hexakisphosphate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nitrofen  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
PhIP  (EXP)
piperacillin  (EXP)
potassium bromate  (EXP)
progesterone  (EXP)
purine-6-thiol  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
SB 431542  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
solasodine  (EXP)
sporidesmin A  (EXP)
stattic  (EXP)
streptozocin  (ISO)
sulfamethoxazole  (EXP)
sulfur dioxide  (EXP)
tacrolimus hydrate  (ISO)
Tanshinone I  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
Tungsten carbide  (ISO)
tyrphostin AG 1478  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP)
wortmannin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (ISS)
BMP signaling pathway  (IMP)
cellular response to angiotensin  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to gamma radiation  (IMP)
cellular response to glucose stimulus  (ISO)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to ionizing radiation  (IDA)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IDA,IMP,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to resveratrol  (ISS)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen metabolic process  (ISS)
embryo implantation  (NAS)
endothelial tube morphogenesis  (IMP)
epithelial to mesenchymal transition involved in cardiac fibroblast development  (IDA)
female pregnancy  (ISO)
inflammatory response to antigenic stimulus  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (IDA,IMP)
miRNA-mediated post-transcriptional gene silencing  (IDA,IMP,ISO)
negative regulation of angiogenesis  (IC,ISO,ISS)
negative regulation of aortic smooth muscle cell differentiation  (IDA)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of arginine catabolic process  (ISS)
negative regulation of canonical NF-kappaB signal transduction  (IGI)
negative regulation of cardiac muscle cell apoptotic process  (ISO,ISS)
negative regulation of cardiac muscle hypertrophy  (ISS)
negative regulation of cartilage development  (IDA)
negative regulation of cell migration  (IDA)
negative regulation of cell population proliferation  (IDA)
negative regulation of chondrocyte proliferation  (IDA)
negative regulation of cytokine-mediated signaling pathway  (IDA)
negative regulation of endothelial cell migration  (IDA)
negative regulation of endothelial cell proliferation  (IDA)
negative regulation of endothelial tube morphogenesis  (ISS)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of fibroblast apoptotic process  (ISO)
negative regulation of gene expression  (IDA,IGI,IMP,ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (ISO,ISS)
negative regulation of hydrogen sulfide biosynthetic process  (IDA)
negative regulation of innate immune response  (IMP)
negative regulation of interleukin-1-mediated signaling pathway  (IGI)
negative regulation of interleukin-12 production  (IDA)
negative regulation of interleukin-21 production  (IDA)
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (IDA)
negative regulation of MAPK cascade  (ISS)
negative regulation of mitotic cell cycle  (IMP)
negative regulation of myofibroblast cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (IMP,ISS)
negative regulation of Rac protein signal transduction  (IDA)
negative regulation of reactive oxygen species biosynthetic process  (ISS)
negative regulation of regulatory T cell differentiation  (IGI)
negative regulation of Rho protein signal transduction  (IDA)
negative regulation of smooth muscle cell apoptotic process  (ISS)
negative regulation of stress fiber assembly  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISS)
negative regulation of type I interferon production  (IDA)
negative regulation of type I interferon-mediated signaling pathway  (IDA)
negative regulation of vascular associated smooth muscle cell apoptotic process  (IDA)
negative regulation of vascular associated smooth muscle cell migration  (IDA)
phenotypic switching  (IDA)
positive regulation of activated T cell proliferation  (IGI)
positive regulation of angiogenesis  (IDA)
positive regulation of apoptotic process  (IDA)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA)
positive regulation of cardiac muscle hypertrophy  (ISS)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (IDA,IMP)
positive regulation of cell population proliferation  (IDA,IMP)
positive regulation of cell projection organization  (ISS)
positive regulation of cellular response to hypoxia  (ISS)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cytokine production  (IDA)
positive regulation of cytokine production involved in inflammatory response  (ISS)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell differentiation  (IDA)
positive regulation of endothelial cell migration  (IDA)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of epithelial to mesenchymal transition  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISS)
positive regulation of fat cell differentiation  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of inflammatory response  (IMP,ISS)
positive regulation of inflammatory response to wounding  (ISS)
positive regulation of keratinocyte proliferation  (IDA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IMP)
positive regulation of myofibroblast differentiation  (IMP,ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of osteoblast differentiation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IMP,ISO)
positive regulation of potassium ion export across plasma membrane  (IDA)
positive regulation of replicative senescence  (IDA)
positive regulation of T-helper 17 cell differentiation  (ISS)
positive regulation of T-helper 17 type immune response  (ISS)
positive regulation of transforming growth factor beta receptor signaling pathway  (IMP,ISS)
positive regulation of type II interferon production  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (IMP)
positive regulation of vascular associated smooth muscle cell migration  (IMP,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA,IMP,ISS)
positive regulation of vascular associated smooth muscle contraction  (IDA)
positive regulation of vascular endothelial cell proliferation  (IDA)
positive regulation of vascular endothelial growth factor signaling pathway  (IDA)
positive regulation of wound healing  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (IDA)
regulation of cell migration  (IGI)
regulation of cell shape  (IMP)
regulation of epidermal growth factor receptor signaling pathway  (IMP)
regulation of extracellular matrix organization  (IDA)
regulation of gene expression  (ISO)
regulation of mesenchymal stem cell differentiation  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISS)
regulation of reactive oxygen species metabolic process  (IDA,ISS)
response to bacterium  (ISO)
response to hypoxia  (ISO)
response to muscle activity  (ISO)
response to oxygen levels  (ISO)
retinal cell apoptotic process  (ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Adams AT, etal., Inflamm Bowel Dis. 2014 Oct;20(10):1784-93. doi: 10.1097/MIB.0000000000000179.
2. Anti-inflammatory effects of miR-21 in the macrophage response to peritonitis. Barnett RE, etal., J Leukoc Biol. 2016 Feb;99(2):361-71. doi: 10.1189/jlb.4A1014-489R. Epub 2015 Sep 17.
3. MicroRNA-21 protects neurons from ischemic death. Buller B, etal., FEBS J. 2010 Oct;277(20):4299-307. doi: 10.1111/j.1742-4658.2010.07818.x. Epub 2010 Sep 14.
4. Up-Regulation of miR-21 Is Associated with Cervicitis and Human Papillomavirus Infection in Cervical Tissues. Bumrungthai S, etal., PLoS One. 2015 May 26;10(5):e0127109. doi: 10.1371/journal.pone.0127109. eCollection 2015.
5. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
6. Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia. Chen N, etal., Oncol Rep. 2018 Jun;39(6):3064-3072. doi: 10.3892/or.2018.6367. Epub 2018 Apr 12.
7. MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Chuppa S, etal., Kidney Int. 2018 Feb;93(2):375-389. doi: 10.1016/j.kint.2017.05.014. Epub 2017 Jul 29.
8. Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein. Clément S, etal., Liver Int. 2019 Jul;39(7):1226-1236. doi: 10.1111/liv.14112. Epub 2019 Apr 16.
9. Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. Correa-Gallego C, etal., PLoS One. 2016 Sep 29;11(9):e0163699. doi: 10.1371/journal.pone.0163699. eCollection 2016.
10. Upregulation of miR-21 by Ras in vivo and its role in tumor growth. Frezzetti D, etal., Oncogene. 2011 Jan 20;30(3):275-86. doi: 10.1038/onc.2010.416. Epub 2010 Oct 18.
11. miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen-/- Immunization. Gannavaram S, etal., Front Immunol. 2019 Sep 24;10:2273. doi: 10.3389/fimmu.2019.02273. eCollection 2019.
12. MicroRNA-21 contributes to high glucose-induced fibrosis in peritoneal mesothelial cells in rat models by activation of the Ras-MAPK signaling pathway via Sprouty-1. Gao Q, etal., J Cell Physiol. 2019 May;234(5):5915-5925. doi: 10.1002/jcp.26941. Epub 2018 Dec 4.
13. Serum levels of microRNA-21 and microRNA-10a can predict long-term prognosis in laryngeal cancer patients: a multicenter study. Gao S, etal., Transl Cancer Res. 2020 May;9(5):3680-3690. doi: 10.21037/tcr-20-1758.
14. CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice. Guesdon W, etal., J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.
15. MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis. He J, etal., Clin Invest Med. 2013 Apr 1;36(2):E103-11. doi: 10.25011/cim.v36i2.19573.
16. Methyl helicterte ameliorates liver fibrosis by regulating miR-21-mediated ERK and TGF-β1/Smads pathways. Huang Q, etal., Int Immunopharmacol. 2019 Jan;66:41-51. doi: 10.1016/j.intimp.2018.11.006. Epub 2018 Nov 9.
17. Circulating MicroRNAs in Extracellular Vesicles as Potential Biomarkers of Alcohol-Induced Neuroinflammation in Adolescence: Gender Differences. Ibáñez F, etal., Int J Mol Sci. 2020 Sep 14;21(18):6730. doi: 10.3390/ijms21186730.
18. Prognostic Significance of MicroRNA-21 Expression in Patients with Unresectable Metastatic Colon Cancer. Iseki Y, etal., Anticancer Res. 2016 Oct;36(10):5145-5151. doi: 10.21873/anticanres.11084.
19. MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis. Jia P, etal., Crit Care Med. 2017 Jul;45(7):e703-e710. doi: 10.1097/CCM.0000000000002363.
20. Serum miR-21 and miR-26a Levels Negatively Correlate with Severity of Cirrhosis in Patients with Chronic Hepatitis B. Jiang S, etal., Microrna. 2019;8(1):86-92. doi: 10.2174/2211536607666180821162850.
21. Expression and clinicopathological significance of microRNA-21 and programmed cell death 4 in malignant melanoma. Jiao J, etal., J Int Med Res. 2015 Oct;43(5):672-8. doi: 10.1177/0300060515583707. Epub 2015 Jul 6.
22. MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection. Johnston DGW, etal., Front Cell Infect Microbiol. 2017 May 23;7:201. doi: 10.3389/fcimb.2017.00201. eCollection 2017.
23. Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer. Kabakov AV, etal., Bull Exp Biol Med. 2020 Feb;168(4):500-502. doi: 10.1007/s10517-020-04740-w. Epub 2020 Mar 10.
24. Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes. Kim G, etal., J Control Release. 2020 Jan 10;317:273-281. doi: 10.1016/j.jconrel.2019.11.009. Epub 2019 Nov 12.
25. Therapeutic efficacy of modified anti-miR21 in metastatic prostate cancer. Kim K, etal., Biochem Biophys Res Commun. 2020 Aug 27;529(3):707-713. doi: 10.1016/j.bbrc.2020.05.215. Epub 2020 Jul 18.
26. MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2. Kim RY, etal., J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10.
27. Associations Between miRNAs and Two Different Cancers: Breast and Colon. Kundaktepe BP, etal., Cancer Manag Res. 2020 Feb 7;12:871-879. doi: 10.2147/CMAR.S227628. eCollection 2020.
28. MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression. Kunita A, etal., Sci Rep. 2018 Jun 11;8(1):8838. doi: 10.1038/s41598-018-27128-3.
29. Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children. Li J, etal., Med Sci Monit. 2016 Dec 19;22:4992-5002. doi: 10.12659/msm.897417.
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PMID:38192185   PMID:38218039   PMID:38262269   PMID:38277748   PMID:38287200   PMID:38299392   PMID:38302783   PMID:38409136   PMID:38446251   PMID:38457157   PMID:38470169   PMID:38516774  
PMID:38530760   PMID:38542098   PMID:38602536   PMID:38612895   PMID:38708494   PMID:38742566   PMID:38750066   PMID:38766781   PMID:38817823   PMID:38874783   PMID:38926950   PMID:39042337  
PMID:39111613   PMID:39201680   PMID:39226804  


Genomics

Comparative Map Data
MIR21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,841,266 - 59,841,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,841,266 - 59,841,337 (+)Ensemblhg38GRCh38
GRCh371757,918,627 - 57,918,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,273,408 - 55,273,479 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1754,382,140 - 54,382,211 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,291,116 - 53,291,187 (+)NCBIHuRef
CHM1_11757,982,648 - 57,982,719 (+)NCBICHM1_1
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBIT2T-CHM13v2.0
Mir21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,474,893 - 86,474,984 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,474,893 - 86,474,984 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381186,584,067 - 86,584,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,584,067 - 86,584,158 (-)Ensemblmm10GRCm38
MGSCv371186,397,569 - 86,397,660 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1196,199,974 - 96,200,065 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.82NCBI
Mir21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,902,600 - 71,902,691 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21071,405,257 - 71,405,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1071,405,257 - 71,405,348 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1076,026,707 - 76,026,798 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01075,531,582 - 75,531,673 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01070,996,132 - 70,996,223 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01073,902,210 - 73,902,301 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,902,210 - 73,902,301 (-)Ensemblrn6Rnor6.0
Rnor_5.01076,197,081 - 76,197,172 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1070,326,375 - 70,326,466 (-)NCBICelera
Cytogenetic Map10q26NCBI
MIR21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,340,550 - 34,340,609 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,340,533 - 34,340,624 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha933,572,293 - 33,572,352 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0935,150,885 - 35,150,944 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,150,868 - 35,150,959 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1933,934,637 - 33,934,696 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,220,122 - 34,220,181 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,306,261 - 34,306,320 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,065,267 - 36,065,358 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11236,065,267 - 36,065,358 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,340,385 - 37,340,476 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh37/hg19 17q22-23.3(chr17:56321134-62080001)x3 copy number gain See cases [RCV000240364] Chr17:56321134..62080001 [GRCh37]
Chr17:17q22-23.3		 pathogenic
GRCh37/hg19 17q21.33-23.2(chr17:49076980-58740945)x3 copy number gain See cases [RCV000448805] Chr17:49076980..58740945 [GRCh37]
Chr17:17q21.33-23.2		 pathogenic
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q22-23.2(chr17:56623275-60285107)x1 copy number loss See cases [RCV000511292] Chr17:56623275..60285107 [GRCh37]
Chr17:17q22-23.2		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q23.1(chr17:57817697-57955754)x3 copy number gain not provided [RCV000739625] Chr17:57817697..57955754 [GRCh37]
Chr17:17q23.1		 benign
GRCh37/hg19 17q22-23.1(chr17:57582867-58080569)x3 copy number gain not provided [RCV000752157] Chr17:57582867..58080569 [GRCh37]
Chr17:17q22-23.1		 benign
GRCh37/hg19 17q23.1(chr17:57616400-57986918)x1 copy number loss not provided [RCV001006908] Chr17:57616400..57986918 [GRCh37]
Chr17:17q23.1		 likely pathogenic
GRCh37/hg19 17q22-24.2(chr17:57357088-66306668) copy number gain not provided [RCV000767764] Chr17:57357088..66306668 [GRCh37]
Chr17:17q22-24.2		 pathogenic
GRCh37/hg19 17q23.1-24.2(chr17:57869604-67078443)x3 copy number gain not provided [RCV000845965] Chr17:57869604..67078443 [GRCh37]
Chr17:17q23.1-24.2		 pathogenic
GRCh37/hg19 17q23.1-23.2(chr17:57605300-59389547)x1 copy number loss not provided [RCV001827980] Chr17:57605300..59389547 [GRCh37]
Chr17:17q23.1-23.2		 pathogenic
NC_000017.10:g.(?_54671585)_(59938900_?)dup duplication Joubert syndrome [RCV001923071] Chr17:54671585..59938900 [GRCh37]
Chr17:17q22-23.2		 uncertain significance
GRCh37/hg19 17q22-23.2(chr17:56587609-59483412)x1 copy number loss not provided [RCV005430869] Chr17:56587609..59483412 [GRCh37]
Chr17:17q22-23.2		 likely pathogenic
miRNA Target Status (No longer updated)

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
LRRFIP1hsa-miR-21-5pMirtarbaseexternal_infosemi-qRT-PCR//Luciferase reporter assay//Western bFunctional MTI19559015
MARCKShsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19302977
SP1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22034194
CCL20hsa-miR-21-5pMirtarbaseexternal_infoELISA//Immunofluorescence//Luciferase reporter assFunctional MTI22001440
TPM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18270520
TPM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot;qRT-PCRFunctional MTI17363372
NFIBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18384814
CDK6hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
BTG2hsa-miR-21-5pMirtarbaseexternal_infosemi-qRT-PCR//GFP reporter assay//Western blot//LuFunctional MTI19546886
FAShsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20048743
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Westren blot//Reporter Functional MTI17968323
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19509156
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19682430
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI18270520
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20143188
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19836969
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19419954
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayFunctional MTI18372920
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19133651
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19264808
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20056717
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI20831814
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Quantitative pFunctional MTI19253296
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19276261
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI18829576
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunofluorescence//Luciferase reporteFunctional MTI20533548
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)16966691
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21469086
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistryFunctional MTI (WeaK)19473551
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20219857
PDCD4hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI17991735
PTENhsa-miR-21-5pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCR//WesternFunctional MTI19167416
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20460403
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21347332
RHOBhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21872591
RHOBhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23313253
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18270520
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI21636785
SERPINB5hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI20693317
BMPR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19578724
ERBB2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19419954
PTENhsa-miR-21-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI20827319
TGFBR3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19253296
MSH2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21078976
MSH2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21047769
TIAM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI20826792
TIAM1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23442323
ISCUhsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//Luciferase reporFunctional MTI20480266
MEF2Chsa-miR-21-5pMirtarbaseexternal_infoImmunofluorescence//In situ hybridization//LuciferFunctional MTI21170291
EIF4A2hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//Luciferase reporFunctional MTI21219636
EGFRhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
NFKB1hsa-miR-21-5pMirtarbaseexternal_infoChIP-seqFunctional MTI (Weak)21081469
IL1Bhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCRFunctional MTI21131358
CDK2AP1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21191961
PTX3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI21131358
CDK2AP1hsa-miR-21-5pMirtarbaseexternal_infoReporter assayFunctional MTI21328460
PPARAhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Flow//ImmunoprecipitaioFunctional MTI21636785
FASLGhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23177026
FASLGhsa-miR-21-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI20371612
SOD3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22836756
TCF21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23206776
SMAD7hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23292313
MMP2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19435867
VEGFAhsa-miR-21-5pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI21544242
ELAVL4hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986
AKAP9hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19242418
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17072344
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21826097
MGAhsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17478730
WNK3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21544242
NSD3hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19398721
DCP1Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18372920
DCP1Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17968323
RDH11hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17363372
BCL6hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23416424
OTUD1hsa-miR-21-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TPM1hsa-miR-21-5pTarbaseexternal_infoWesternblitPOSITIVE
PDCD4hsa-miR-21-5pTarbaseexternal_infoReporter GenePOSITIVE
TPM1hsa-miR-21-5pTarbaseexternal_infoqPCRNEGATIVE
AGO4hsa-miR-21-5pTarbaseexternal_infoMicroarrayPOSITIVE
RECKhsa-miR-21-5pTarbaseexternal_infoqPCRPOSITIVE
EGFRhsa-miR-21-5pTarbaseexternal_infoOtherPOSITIVE
TIMP3hsa-miR-21-5pTarbaseexternal_infoMicroarrayNEGATIVE
GRPEL2hsa-miR-21-5pTarbaseexternal_infoSequencingPOSITIVE
TPM1hsa-miR-21-5pMirecordsexternal_infoNANA17363372
NFIBhsa-miR-21-5pMirecordsexternal_info{unchanged}NA18384814
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}NA18372920
PDCD4hsa-miR-21-5pMirecordsexternal_infoNANA18270520
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}{unchanged}NA17968323
CDKN1Ahsa-miR-21-5pMirecordsexternal_info{changed}NA17991735
PDCD4hsa-miR-21-5pMirecordsexternal_info{changed}{changed}NA17991735
RECKhsa-miR-21-5pMirecordsexternal_infoNANA18794849
TIMP3hsa-miR-21-5pMirecordsexternal_info{changed}NA18591254
MTAPhsa-miR-21-5pMirecordsexternal_infoNANA19013014
JMYhsa-miR-21-5pMirecordsexternal_infoNANA18829576
TGFBR3hsa-miR-21-5pMirecordsexternal_infoNANA11829576
PDCD4hsa-miR-21-5pMirecordsexternal_infoNANA18850008
RB1hsa-miR-21-5pMirecordsexternal_infoNANA19175831
TGFB1hsa-miR-21-5pMirecordsexternal_infoNANA19264808
PDCD4hsa-miR-21-5pMirecordsexternal_info{unchanged}NA19276261
PTENhsa-miR-21-5pMirecordsexternal_info{changed}NA19906824
CDC25Ahsa-miR-21-5pMirecordsexternal_info{changed}NA19826040
BMPR2hsa-miR-21-5pMirecordsexternal_infoNANA19578724
LRRFIP1hsa-miR-21-5pMirecordsexternal_infoNANA19559015
BTG2hsa-miR-21-5pMirecordsexternal_info{changed}NA19546886
RECKhsa-miR-21-5pMirecordsexternal_info{unchanged}NA20154725
JAG1hsa-miR-21-5pMirecordsexternal_infoNANA19398721
MARCKShsa-miR-21-5pMirecordsexternal_infoNANA19302977
PELI1hsa-miR-21-5pMirecordsexternal_infoNANA20167875
PPARAhsa-miR-21-5pMirecordsexternal_infoNANA20693317
STAT3hsa-miR-21-5pMirecordsexternal_info{changed}NA21381024
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23466500
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23226804
TCF21hsa-miR-21-5pOncomiRDBexternal_infoNANA23206776
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA23174819
CASP3hsa-miR-21-5pOncomiRDBexternal_infoNANA22964638
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22956424
SOD3hsa-miR-21-5pOncomiRDBexternal_infoNANA22836756
MSH2hsa-miR-21-5pOncomiRDBexternal_infoNANA22806311
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22770403
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA22761427
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22685542
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22678116
BTG2hsa-miR-21-5pOncomiRDBexternal_infoNANA22614007
SERPINI1hsa-miR-21-5pOncomiRDBexternal_infoNANA22464652
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22335905
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA22322403
PIAS3hsa-miR-21-5pOncomiRDBexternal_infoNANA22316494
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA22267008
CCL20hsa-miR-21-5pOncomiRDBexternal_infoNANA22099878
JAG1hsa-miR-21-5pOncomiRDBexternal_infoNANA22618231
GRHL3hsa-miR-21-5pOncomiRDBexternal_infoNANA22094257
TGFBR2hsa-miR-21-5pOncomiRDBexternal_infoNANA22072622
CCL20hsa-miR-21-5pOncomiRDBexternal_infoNANA22001440
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21940630
RHOBhsa-miR-21-5pOncomiRDBexternal_infoNANA21872591
TIMP3hsa-miR-21-5pOncomiRDBexternal_infoNANA21820586
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21806946
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21471222
CDK2AP1hsa-miR-21-5pOncomiRDBexternal_infoNANA21328460
ANP32Ahsa-miR-21-5pOncomiRDBexternal_infoNANA21317927
SPRY2hsa-miR-21-5pOncomiRDBexternal_infoNANA21278789
ANKRD46hsa-miR-21-5pOncomiRDBexternal_infoNANA21219636
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA21820606
THRBhsa-miR-21-5pOncomiRDBexternal_infoNANA21159845
PLAThsa-miR-21-5pOncomiRDBexternal_infoNANA21131358
MSH2hsa-miR-21-5pOncomiRDBexternal_infoNANA21078976
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20831814
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20581857
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA20480266
TIAM1hsa-miR-21-5pOncomiRDBexternal_infoNANA20826792
RHOBhsa-miR-21-5pOncomiRDBexternal_infoNANA20460403
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA20447717
TIMP3hsa-miR-21-5pOncomiRDBexternal_infoNANA20346171
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA20223231
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20148895
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20143188
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20141427
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA20670480
CDC25Ahsa-miR-21-5pOncomiRDBexternal_infoNANA19826040
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19682430
BMPR2hsa-miR-21-5pOncomiRDBexternal_infoNANA19578724
LRRFIP1hsa-miR-21-5pOncomiRDBexternal_infoNANA19559015
BTG2hsa-miR-21-5pOncomiRDBexternal_infoNANA19546886
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19308091
MARCKShsa-miR-21-5pOncomiRDBexternal_infoNANA19302977
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19276261
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19264808
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19013014
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA18850008
HNRNPKhsa-miR-21-5pOncomiRDBexternal_infoNANA18829576
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA18794849
RECKhsa-miR-21-5pOncomiRDBexternal_infoNANA18591254
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA18372920
TPM1hsa-miR-21-5pOncomiRDBexternal_infoNANA18270520
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA17991735
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA17968323
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA16762633
PTENhsa-miR-21-5pOncomiRDBexternal_infoNANA17681183
TPM1hsa-miR-21-5pOncomiRDBexternal_infoNANA17363372
BCL2hsa-miR-21-5pOncomiRDBexternal_infoNANA17072344
PDCD4hsa-miR-21-5pOncomiRDBexternal_infoNANA19296468
CDC25Ahsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Northern blot//qRT-PCRFunctional MTI (Weak)19826040
CDC25Ahsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23496142
BCL2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17072344
BCL2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotNon-Functional MTI22528454
BCL2hsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI21468550
BCL2hsa-miR-21-5pMirtarbaseexternal_infoWestern blot;OtherFunctional MTI20048743
PYM1hsa-miR-21-5pMirtarbaseexternal_infoQuantitative proteomic approachFunctional MTI (Weak)19253296
TM9SF3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19253296
RTN4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Quantitative proteomic Functional MTI19253296
RPS7hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Quantitative proteomic approachFunctional MTI (Weak)19253296
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20371350
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarray//Western blotFunctional MTI17968323
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17991735
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19682430
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19276261
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19419954
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18850008
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16966691
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21069438
KMT5Bhsa-miR-21-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
RASGRP1hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20483747
RASGRP1hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18591254
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19672202
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19342589
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18270520
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19836969
RPS7hsa-miR-21-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)19133651
RPS7hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)18372920
RPS7hsa-miR-21-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)18591254
JAG1hsa-miR-21-5pMirtarbaseexternal_infoFlow//Immunoblot//Luciferase reporter assay//MicroFunctional MTI19398721
JAG1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22618231
RESThsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19242418
SMARCA4hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21317927
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18508928
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI21278789
SPRY2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23239100
DUSP10hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22387553
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//qRT-PCR//Functional MTI18591254
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20346171
TIMP3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21820586
SOX5hsa-miR-21-5pMirtarbaseexternal_infoWestern blot//Northern blot//qRT-PCR//Luciferase rFunctional MTI19013014
DOCK7hsa-miR-21-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22158624
RECKhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20480266
RECKhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI18794849
RECKhsa-miR-21-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assay//Functional MTI18591254
RECKhsa-miR-21-5pMirtarbaseexternal_infoWestern blot//qRT-PCR//Luciferase reporter assayFunctional MTI20154725
RECKhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22630347
PIAS3hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22316494
E2F2hsa-miR-21-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//ChIPFunctional MTI (Weak)19528081
FMODhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19906824
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19906824
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI19816956
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18829576
TGFBR2hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22072622
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI19672202
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19072831
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18850008
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI20216554
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20223231
PTENhsa-miR-21-5pMirtarbaseexternal_infoMicroarray//immunohistochemistryFunctional MTI (Weak)19175831
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI20048743
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20813833
PTENhsa-miR-21-5pMirtarbaseexternal_infoGFP reporter assay//Northern blot//qRT-PCR//WesterFunctional MTI19641183
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunocytochemistry//Luciferase reporter assay//NoFunctional MTI17681183
PTENhsa-miR-21-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blot//Reporter assFunctional MTI16762633
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI20797623
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//qRT-PCR//Western blotFunctional MTI20978511
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22267008
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistryNon-Functional MTI (Weak)19473551
PTENhsa-miR-21-5pMirtarbaseexternal_infoELISA//Immunoblot//qRT-PCRFunctional MTI (Weak)22678116
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22956424
PTENhsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22761812
PTENhsa-miR-21-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI22770403
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22879939
PTENhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23226804
PTENhsa-miR-21-5pMirtarbaseexternal_infoWestern blotFunctional MTI21544242
E2F1hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI19528081
TGFBIhsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19136465

Predicted Targets
Summary Value
Count of predictions:19209
Count of gene targets:7868
Count of transcripts:15128
Interacting mature miRNAs:hsa-miR-21-3p, hsa-miR-21-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-64257  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,735 - 57,917,824UniSTSGRCh37
Build 361755,272,517 - 55,272,606RGDNCBI36
Celera1754,381,248 - 54,381,337RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,224 - 53,290,313UniSTS
TNG Radiation Hybrid Map1726111.0UniSTS
RH91780  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,917,788 - 57,917,888UniSTSGRCh37
Build 361755,272,570 - 55,272,670RGDNCBI36
Celera1754,381,301 - 54,381,401RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,277 - 53,290,377UniSTS
GeneMap99-GB4 RH Map17372.1UniSTS
RH102091  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,919,341 - 57,919,465UniSTSGRCh37
GRCh37994,913,462 - 94,913,586UniSTSGRCh37
Build 36993,953,283 - 93,953,407RGDNCBI36
Celera1754,382,854 - 54,382,978UniSTS
Celera965,349,755 - 65,349,879RGD
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map17q23.1UniSTS
HuRef1753,291,830 - 53,291,954UniSTS
HuRef964,591,395 - 64,591,519UniSTS
D17F294S2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37994,913,534 - 94,913,699UniSTSGRCh37
GRCh371757,919,413 - 57,919,578UniSTSGRCh37
Build 36993,953,355 - 93,953,520RGDNCBI36
Celera965,349,827 - 65,349,992RGD
Celera1754,382,926 - 54,383,091UniSTS
Cytogenetic Map17q23.1UniSTS
Cytogenetic Map9q22.31UniSTS
HuRef1753,291,902 - 53,292,067UniSTS
HuRef964,591,467 - 64,591,632UniSTS
RH46129  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371757,918,157 - 57,918,341UniSTSGRCh37
Build 361755,272,939 - 55,273,123RGDNCBI36
Celera1754,381,670 - 54,381,854RGD
Cytogenetic Map17q23.1UniSTS
HuRef1753,290,646 - 53,290,830UniSTS
GeneMap99-GB4 RH Map17377.81UniSTS
NCBI RH Map17665.5UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
30 32 16 21 61 23 40 2 31 1 21 77 94 46 11 20 33 1

Sequence


Ensembl Acc Id: ENST00000362134
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1759,841,266 - 59,841,337 (+)Ensembl
RefSeq Acc Id: NR_029493
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381759,841,266 - 59,841,337 (+)NCBI
GRCh371757,918,627 - 57,918,698 (+)ENTREZGENE
HuRef1753,291,116 - 53,291,187 (+)ENTREZGENE
CHM1_11757,982,648 - 57,982,719 (+)NCBI
T2T-CHM13v2.01760,710,020 - 60,710,091 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31586 AgrOrtholog
COSMIC MIR21 COSMIC
Ensembl Genes ENSG00000284190 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362134 ENTREZGENE
GTEx ENSG00000284190 GTEx
HGNC ID HGNC:31586 ENTREZGENE
Human Proteome Map MIR21 Human Proteome Map
miRBase MI0000077 ENTREZGENE
NCBI Gene 406991 ENTREZGENE
OMIM 611020 OMIM
PharmGKB PA164722590 PharmGKB
RNAcentral URS000009262D RNACentral
  URS00000AF93C RNACentral
  URS000039ED8D RNACentral