PTX3 (pentraxin 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PTX3 (pentraxin 3) Homo sapiens
Analyze
Symbol: PTX3
Name: pentraxin 3
RGD ID: 1343528
HGNC Page HGNC
Description: Exhibits complement component C1q complex binding activity; identical protein binding activity; and virion binding activity. Involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Localizes to extracellular space. Implicated in cystic fibrosis and invasive aspergillosis. Biomarker of hepatitis C; invasive aspergillosis; pelvic inflammatory disease; pulmonary aspergilloma; and toxic shock syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: long pentraxin 3; pentaxin-related gene, rapidly induced by il-1 beta; pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5; pentaxin-related protein PTX3; pentraxin 3, long; pentraxin-3; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin-related protein PTX3; TNF alpha-induced protein 5; TNFAIP5; TSG-14; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor, alpha-induced protein 5; tumor necrosis factor-inducible gene 14 protein; tumor necrosis factor-inducible protein TSG-14
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3157,436,850 - 157,443,633 (+)EnsemblGRCh38hg38GRCh38
GRCh383157,436,850 - 157,443,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373157,154,639 - 157,161,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363158,637,301 - 158,644,071 (+)NCBINCBI36hg18NCBI36
Build 343158,637,308 - 158,644,078NCBI
Celera3155,578,255 - 155,585,092 (+)NCBI
Cytogenetic Map3q25.32NCBI
HuRef3154,550,694 - 154,557,531 (+)NCBIHuRef
CHM1_13157,117,566 - 157,124,403 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2-naphthylamine  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
belinostat  (EXP)
benzalkonium chloride  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bortezomib  (EXP)
butanal  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chromium(6+)  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (EXP)
crotonaldehyde  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
fenamidone  (ISO)
fluoranthene  (ISO)
fonofos  (EXP)
furan  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflavones  (EXP)
isoprenaline  (ISO)
lithium chloride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
naphthalene  (ISO)
nickel atom  (EXP,ISO)
nicotine  (EXP)
nitrates  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP)
parathion  (EXP)
PD 0325901  (EXP)
pentanal  (EXP)
perfluorononanoic acid  (EXP)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
potassium chromate  (EXP)
progesterone  (EXP)
propanal  (EXP)
protein kinase inhibitor  (EXP)
raloxifene  (EXP)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (EXP)
sulforaphane  (EXP)
tamoxifen  (EXP)
Tanshinone I  (EXP)
terbufos  (EXP)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-caffeic acid  (EXP)
trichostatin A  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

References

Additional References at PubMed
PMID:1429570   PMID:1730767   PMID:7523502   PMID:7679696   PMID:7949102   PMID:8131794   PMID:9119472   PMID:9407058   PMID:9521058   PMID:10931803   PMID:11762945   PMID:12004288  
PMID:12006390   PMID:12006411   PMID:12477932   PMID:12538709   PMID:12611905   PMID:12645945   PMID:12763682   PMID:14515272   PMID:14603263   PMID:15262177   PMID:15308113   PMID:15489334  
PMID:15894273   PMID:16020751   PMID:16166594   PMID:16339571   PMID:16344560   PMID:16380821   PMID:16617159   PMID:16647920   PMID:16769728   PMID:16865225   PMID:16981714   PMID:17095712  
PMID:17277044   PMID:17380301   PMID:17424885   PMID:17441979   PMID:17487767   PMID:17496115   PMID:17611589   PMID:17675295   PMID:17786277   PMID:17947708   PMID:18045580   PMID:18048494  
PMID:18292565   PMID:18417746   PMID:18571180   PMID:18650775   PMID:18676013   PMID:18685085   PMID:18703503   PMID:19014569   PMID:19050261   PMID:19079137   PMID:19131771   PMID:19164811  
PMID:19211665   PMID:19273457   PMID:19327124   PMID:19389798   PMID:19396030   PMID:19565609   PMID:19627396   PMID:19632990   PMID:19718477   PMID:19772962   PMID:19792835   PMID:19794969  
PMID:19811281   PMID:19846603   PMID:19900712   PMID:19913121   PMID:19917159   PMID:20022320   PMID:20121391   PMID:20134101   PMID:20356766   PMID:20363749   PMID:20378410   PMID:20391484  
PMID:20399512   PMID:20430947   PMID:20508541   PMID:20515753   PMID:20628086   PMID:20640440   PMID:20683616   PMID:21072498   PMID:21072499   PMID:21106539   PMID:21112127   PMID:21173097  
PMID:21257721   PMID:21330486   PMID:21388349   PMID:21389698   PMID:21391986   PMID:21423699   PMID:21465531   PMID:21490156   PMID:21501295   PMID:21529268   PMID:21677138   PMID:21716666  
PMID:21764903   PMID:21796992   PMID:21873635   PMID:21880642   PMID:21883907   PMID:21900125   PMID:21914683   PMID:21915248   PMID:21920889   PMID:21933102   PMID:21948359   PMID:21953577  
PMID:21989653   PMID:22053612   PMID:22072855   PMID:22123215   PMID:22178425   PMID:22267482   PMID:22278372   PMID:22304663   PMID:22309253   PMID:22319633   PMID:22447522   PMID:22529962  
PMID:22546644   PMID:22577258   PMID:22617341   PMID:22687644   PMID:22714118   PMID:22747472   PMID:22785134   PMID:22822025   PMID:22834944   PMID:22847671   PMID:22883522   PMID:22889492  
PMID:23012252   PMID:23062219   PMID:23100088   PMID:23169308   PMID:23182717   PMID:23235124   PMID:23237880   PMID:23245734   PMID:23284306   PMID:23285251   PMID:23341967   PMID:23401658  
PMID:23424081   PMID:23434196   PMID:23443958   PMID:23475792   PMID:23527487   PMID:23544079   PMID:23579776   PMID:23609129   PMID:23625866   PMID:23643952   PMID:23658833   PMID:23664694  
PMID:23690668   PMID:23735470   PMID:23771016   PMID:23817411   PMID:23863905   PMID:23954061   PMID:23979265   PMID:23991979   PMID:24012697   PMID:24039869   PMID:24060373   PMID:24132243  
PMID:24215445   PMID:24261762   PMID:24273922   PMID:24279306   PMID:24333560   PMID:24347428   PMID:24350299   PMID:24457902   PMID:24462365   PMID:24474442   PMID:24476432   PMID:24503185  
PMID:24568622   PMID:24613562   PMID:24628740   PMID:24652286   PMID:24664887   PMID:24675235   PMID:24705587   PMID:24709882   PMID:24724970   PMID:24745336   PMID:24936646   PMID:24950910  
PMID:24958171   PMID:24979323   PMID:25048680   PMID:25049357   PMID:25131923   PMID:25148605   PMID:25159210   PMID:25178940   PMID:25190808   PMID:25237185   PMID:25303877   PMID:25323314  
PMID:25344970   PMID:25373851   PMID:25385504   PMID:25394473   PMID:25401491   PMID:25412085   PMID:25435748   PMID:25447599   PMID:25467846   PMID:25491620   PMID:25496843   PMID:25530683  
PMID:25538378   PMID:25543194   PMID:25550806   PMID:25553422   PMID:25604633   PMID:25620175   PMID:25641196   PMID:25664655   PMID:25679762   PMID:25695775   PMID:25732129   PMID:25747934  
PMID:25760650   PMID:25774777   PMID:25797258   PMID:25805362   PMID:25814534   PMID:25832310   PMID:25854969   PMID:25855355   PMID:25867925   PMID:25912421   PMID:25920034   PMID:25964543  
PMID:25977268   PMID:25982553   PMID:25993733   PMID:26040439   PMID:26054123   PMID:26070095   PMID:26124179   PMID:26138903   PMID:26176960   PMID:26186194   PMID:26267536   PMID:26276571  
PMID:26348770   PMID:26356573   PMID:26367098   PMID:26434104   PMID:26457877   PMID:26467819   PMID:26485684   PMID:26508705   PMID:26514267   PMID:26546709   PMID:26563370   PMID:26576501  
PMID:26650391   PMID:26738395   PMID:26763449   PMID:26836044   PMID:26842615   PMID:26921689   PMID:27152709   PMID:27179743   PMID:27233528   PMID:27255354   PMID:27278519   PMID:27309736  
PMID:27377307   PMID:27403446   PMID:27403536   PMID:27404695   PMID:27421969   PMID:27450429   PMID:27538101   PMID:27553858   PMID:27567326   PMID:27568661   PMID:27605038   PMID:27621420  
PMID:27659714   PMID:27779166   PMID:27838407   PMID:27838804   PMID:27878407   PMID:27893415   PMID:27915246   PMID:27941350   PMID:27980366   PMID:28043168   PMID:28119515   PMID:28216633  
PMID:28223411   PMID:28225768   PMID:28228104   PMID:28257596   PMID:28327132   PMID:28332877   PMID:28359407   PMID:28377191   PMID:28377558   PMID:28420068   PMID:28421853   PMID:28440716  
PMID:28458531   PMID:28489600   PMID:28514442   PMID:28569615   PMID:28601054   PMID:28664745   PMID:28778748   PMID:28793880   PMID:28809733   PMID:29022895   PMID:29120574   PMID:29174966  
PMID:29272525   PMID:29374201   PMID:29573785   PMID:29675428   PMID:29715313   PMID:29738271   PMID:29880612   PMID:29945330   PMID:29949524   PMID:29990442   PMID:30036122   PMID:30105036  
PMID:30129088   PMID:30232004   PMID:30243000   PMID:30319631   PMID:30349543   PMID:30411809   PMID:30477668   PMID:30483742   PMID:30555480   PMID:30572222   PMID:30628067   PMID:30658876  
PMID:30718300   PMID:30740098   PMID:30766534   PMID:30796272   PMID:30903769   PMID:30923526   PMID:30942197   PMID:31019517   PMID:31057548   PMID:31061822   PMID:31066256   PMID:31071711  
PMID:31111284   PMID:31147578   PMID:31191526   PMID:31253871   PMID:31316299   PMID:31405644   PMID:31446881   PMID:31489646   PMID:31492148   PMID:31594258   PMID:31599644   PMID:31703088  
PMID:31721795   PMID:31744201   PMID:31785215   PMID:31795454   PMID:31798002   PMID:31799884   PMID:31813079   PMID:31828271   PMID:31922501   PMID:31942733   PMID:31994174   PMID:32011454  
PMID:32078718   PMID:32239253   PMID:32300954   PMID:32345771   PMID:32427938   PMID:32587638   PMID:32791527   PMID:33080253   PMID:33110136   PMID:33208929   PMID:33219288   PMID:33301518  
PMID:33472324   PMID:33617838   PMID:33660256  


Genomics

Comparative Map Data
PTX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3157,436,850 - 157,443,633 (+)EnsemblGRCh38hg38GRCh38
GRCh383157,436,850 - 157,443,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373157,154,639 - 157,161,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363158,637,301 - 158,644,071 (+)NCBINCBI36hg18NCBI36
Build 343158,637,308 - 158,644,078NCBI
Celera3155,578,255 - 155,585,092 (+)NCBI
Cytogenetic Map3q25.32NCBI
HuRef3154,550,694 - 154,557,531 (+)NCBIHuRef
CHM1_13157,117,566 - 157,124,403 (+)NCBICHM1_1
Ptx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39366,127,308 - 66,133,227 (+)NCBIGRCm39mm39
GRCm39 Ensembl366,127,331 - 66,133,226 (+)Ensembl
GRCm38366,219,887 - 66,225,806 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl366,219,910 - 66,225,805 (+)EnsemblGRCm38mm10GRCm38
MGSCv37366,023,809 - 66,029,728 (+)NCBIGRCm37mm9NCBIm37
MGSCv36366,307,812 - 66,313,734 (+)NCBImm8
Celera366,363,920 - 66,369,839 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.25NCBI
Ptx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22150,487,513 - 150,493,323 (+)NCBI
Rnor_6.0 Ensembl2158,097,843 - 158,103,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02158,097,843 - 158,103,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02177,457,263 - 177,463,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42156,089,917 - 156,095,726 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2144,894,946 - 144,900,755 (+)NCBICelera
Cytogenetic Map2q31NCBI
Ptx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554488,366,925 - 8,372,411 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554488,366,795 - 8,373,010 (+)NCBIChiLan1.0ChiLan1.0
PTX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13162,537,440 - 162,544,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3162,537,577 - 162,543,652 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03154,485,470 - 154,492,293 (+)NCBIMhudiblu_PPA_v0panPan3
PTX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12350,952,835 - 50,958,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2350,952,885 - 50,958,167 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2350,825,322 - 50,831,079 (+)NCBI
ROS_Cfam_1.02351,586,874 - 51,592,673 (+)NCBI
UMICH_Zoey_3.12351,169,291 - 51,175,068 (+)NCBI
UNSW_CanFamBas_1.02351,222,224 - 51,228,028 (+)NCBI
UU_Cfam_GSD_1.02351,507,584 - 51,513,394 (+)NCBI
Ptx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560285,424,779 - 85,430,719 (-)NCBI
SpeTri2.0NW_0049365194,303,549 - 4,309,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1397,273,594 - 97,279,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11397,273,594 - 97,279,570 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213105,440,917 - 105,446,892 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11533,320,592 - 33,327,236 (-)NCBI
ChlSab1.1 Ensembl1533,321,208 - 33,327,268 (-)Ensembl
Vero_WHO_p1.0NW_0236660415,897,822 - 5,904,486 (-)NCBI
Ptx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473035,125,536 - 35,131,645 (+)NCBI

Position Markers
SHGC-77488  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373157,160,816 - 157,161,031UniSTSGRCh37
Build 363158,643,510 - 158,643,725RGDNCBI36
Celera3155,584,491 - 155,584,706RGD
Cytogenetic Map3q25UniSTS
Cytogenetic Map3q24-q25UniSTS
HuRef3154,556,930 - 154,557,145UniSTS
TNG Radiation Hybrid Map388665.0UniSTS
GeneMap99-GB4 RH Map3581.44UniSTS
WI-7070  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373157,160,773 - 157,161,112UniSTSGRCh37
Build 363158,643,467 - 158,643,806RGDNCBI36
Celera3155,584,448 - 155,584,787RGD
Cytogenetic Map3q25UniSTS
Cytogenetic Map3q24-q25UniSTS
HuRef3154,556,887 - 154,557,226UniSTS
Whitehead-YAC Contig Map3 UniSTS
GDB:252088  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373157,160,774 - 157,160,865UniSTSGRCh37
Build 363158,643,468 - 158,643,559RGDNCBI36
Celera3155,584,449 - 155,584,540RGD
Cytogenetic Map3q25UniSTS
Cytogenetic Map3q24-q25UniSTS
HuRef3154,556,888 - 154,556,979UniSTS
PTX3_470  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373157,160,762 - 157,161,548UniSTSGRCh37
Build 363158,643,456 - 158,644,242RGDNCBI36
Celera3155,584,437 - 155,585,223RGD
HuRef3154,556,876 - 154,557,662UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI21131358

Predicted Target Of
Summary Value
Count of predictions:227
Count of miRNA genes:184
Interacting mature miRNAs:205
Transcripts:ENST00000295927
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 8 55 5 2 17 99 12
Medium 702 1134 313 56 432 19 1757 443 537 68 223 711 43 877 1080
Low 1602 1723 1140 310 973 187 2191 1368 2224 244 1130 809 126 228 1395 1
Below cutoff 67 114 255 242 307 243 346 371 940 102 76 58 2 298 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000295927   ⟹   ENSP00000295927
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3157,436,850 - 157,443,633 (+)Ensembl
RefSeq Acc Id: NM_002852   ⟹   NP_002843
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383157,436,850 - 157,443,633 (+)NCBI
GRCh373157,154,580 - 157,161,417 (+)ENTREZGENE
Build 363158,637,301 - 158,644,071 (+)NCBI Archive
HuRef3154,550,694 - 154,557,531 (+)ENTREZGENE
CHM1_13157,117,566 - 157,124,403 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002843   ⟸   NM_002852
- Peptide Label: precursor
- UniProtKB: P26022 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000295927   ⟸   ENST00000295927
Protein Domains
Pentraxin (PTX)

Promoters
RGD ID:6866094
Promoter ID:EPDNEW_H6212
Type:initiation region
Name:PTX3_1
Description:pentraxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383157,436,850 - 157,436,910EPDNEW
RGD ID:6801488
Promoter ID:HG_KWN:46555
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:NM_002852
Position:
Human AssemblyChrPosition (strand)Source
Build 363158,637,106 - 158,637,606 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q24-26.32(chr3:147442566-178522531)x3 copy number gain See cases [RCV000051724] Chr3:147442566..178522531 [GRCh38]
Chr3:147160353..178240319 [GRCh37]
Chr3:148643043..179723013 [NCBI36]
Chr3:3q24-26.32
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:157293378-198134727)x3 copy number gain See cases [RCV000051726] Chr3:157293378..198134727 [GRCh38]
Chr3:157011167..197861598 [GRCh37]
Chr3:158493861..199345995 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
NM_002852.4(PTX3):c.108T>C (p.Asn36=) single nucleotide variant not provided [RCV000122503] Chr3:157437041 [GRCh38]
Chr3:157154830 [GRCh37]
Chr3:3q25.32
uncertain significance
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q25.1-29(chr3:152100512-198118383)x3 copy number gain See cases [RCV000139435] Chr3:152100512..198118383 [GRCh38]
Chr3:151818301..197845254 [GRCh37]
Chr3:153300991..199329651 [NCBI36]
Chr3:3q25.1-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156321878-198113452)x3 copy number gain See cases [RCV000140849] Chr3:156321878..198113452 [GRCh38]
Chr3:156039667..197840323 [GRCh37]
Chr3:157522361..199324720 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156118441-198125115)x3 copy number gain See cases [RCV000142310] Chr3:156118441..198125115 [GRCh38]
Chr3:155836230..197851986 [GRCh37]
Chr3:157318924..199336383 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh37/hg19 3q24-29(chr3:142995020-192997215)x4 copy number gain See cases [RCV000240256] Chr3:142995020..192997215 [GRCh37]
Chr3:3q24-29
pathogenic
GRCh37/hg19 3q25.32-26.33(chr3:157128738-181637333)x3 copy number gain See cases [RCV000446611] Chr3:157128738..181637333 [GRCh37]
Chr3:3q25.32-26.33
pathogenic
GRCh37/hg19 3q25.2-29(chr3:152356847-197851986)x3 copy number gain See cases [RCV000448608] Chr3:152356847..197851986 [GRCh37]
Chr3:3q25.2-29
pathogenic
GRCh37/hg19 3q24-26.2(chr3:147180945-168415875)x1 copy number loss See cases [RCV000448130] Chr3:147180945..168415875 [GRCh37]
Chr3:3q24-26.2
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_002852.4(PTX3):c.919A>G (p.Ile307Val) single nucleotide variant not provided [RCV000660499] Chr3:157442752 [GRCh38]
Chr3:157160541 [GRCh37]
Chr3:3q25.32
uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_002852.4(PTX3):c.500A>G (p.Gln167Arg) single nucleotide variant not provided [RCV000950113] Chr3:157437882 [GRCh38]
Chr3:157155671 [GRCh37]
Chr3:3q25.32
benign
NM_002852.4(PTX3):c.795A>T (p.Gly265=) single nucleotide variant not provided [RCV000886488] Chr3:157442628 [GRCh38]
Chr3:157160417 [GRCh37]
Chr3:3q25.32
benign
NM_002852.4(PTX3):c.46T>C (p.Leu16=) single nucleotide variant not provided [RCV000949703] Chr3:157436979 [GRCh38]
Chr3:157154768 [GRCh37]
Chr3:3q25.32
benign
NM_002852.4(PTX3):c.1079G>A (p.Arg360Gln) single nucleotide variant not provided [RCV000905979] Chr3:157442912 [GRCh38]
Chr3:157160701 [GRCh37]
Chr3:3q25.32
benign
NM_002852.4(PTX3):c.117T>G (p.His39Gln) single nucleotide variant not provided [RCV000965660] Chr3:157437050 [GRCh38]
Chr3:157154839 [GRCh37]
Chr3:3q25.32
benign
GRCh37/hg19 3q25.31-25.33(chr3:156812581-160154747)x3 copy number gain See cases [RCV001194528] Chr3:156812581..160154747 [GRCh37]
Chr3:3q25.31-25.33
uncertain significance
GRCh37/hg19 3q22.3-26.1(chr3:138145289-162275610)x3 copy number gain See cases [RCV001194586] Chr3:138145289..162275610 [GRCh37]
Chr3:3q22.3-26.1
pathogenic
GRCh37/hg19 3q22.3-26.1(chr3:138173683-162494699) copy number gain Global developmental delay [RCV001352648] Chr3:138173683..162494699 [GRCh37]
Chr3:3q22.3-26.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9692 AgrOrtholog
COSMIC PTX3 COSMIC
Ensembl Genes ENSG00000163661 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000295927 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000295927 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000163661 GTEx
HGNC ID HGNC:9692 ENTREZGENE
Human Proteome Map PTX3 Human Proteome Map
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  LamG-like UniProtKB/Swiss-Prot
  Pentaxin_CS UniProtKB/Swiss-Prot
  Pentraxin-related UniProtKB/Swiss-Prot
  PTX3 UniProtKB/Swiss-Prot
KEGG Report hsa:5806 UniProtKB/Swiss-Prot
NCBI Gene 5806 ENTREZGENE
OMIM 602492 OMIM
PANTHER PTHR46943 UniProtKB/Swiss-Prot
Pfam Pentaxin UniProtKB/Swiss-Prot
PharmGKB PA34036 PharmGKB
PRINTS PENTAXIN UniProtKB/Swiss-Prot
PROSITE PTX_1 UniProtKB/Swiss-Prot
  PTX_2 UniProtKB/Swiss-Prot
SMART LamGL UniProtKB/Swiss-Prot
  PTX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt P26022 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2R6T6 UniProtKB/Swiss-Prot
  Q38M82 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 PTX3  pentraxin 3  TNFAIP5  tumor necrosis factor, alpha-induced protein 5  Data Merged 737654 PROVISIONAL
2015-11-24 PTX3  pentraxin 3    pentraxin 3, long  Symbol and/or name change 5135510 APPROVED
2011-07-27 PTX3  pentraxin 3, long  PTX3  pentraxin-related gene, rapidly induced by IL-1 beta  Symbol and/or name change 5135510 APPROVED