RHOB (ras homolog family member B) - Rat Genome Database

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Gene: RHOB (ras homolog family member B) Homo sapiens
Analyze
Symbol: RHOB
Name: ras homolog family member B
RGD ID: 1351195
HGNC Page HGNC
Description: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer; INTERACTS WITH (R)-mevalonic acid; (S)-(-)-perillyl alcohol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Aplysia RAS-related homolog 6; ARH6; ARHB; h6; MST081; MSTP081; oncogene RHO H6; ras homolog gene family, member B; rho cDNA clone 6; rho-related GTP-binding protein RhoB; RHOH6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl220,447,074 - 20,449,440 (+)EnsemblGRCh38hg38GRCh38
GRCh38220,447,074 - 20,449,440 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37220,646,835 - 20,649,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36220,510,316 - 20,512,682 (+)NCBINCBI36hg18NCBI36
Build 34220,568,462 - 20,570,828NCBI
Celera220,509,553 - 20,511,920 (+)NCBI
Cytogenetic Map2p24.1NCBI
HuRef220,404,158 - 20,406,525 (+)NCBIHuRef
CHM1_1220,576,236 - 20,578,603 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-mevalonic acid  (EXP)
(S)-(-)-perillyl alcohol  (EXP,ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-azacytidine  (EXP)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP)
belinostat  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
butan-1-ol  (EXP)
cadmium dichloride  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carveol  (EXP)
carvone  (EXP)
celecoxib  (EXP)
cetrorelix  (EXP)
chloropicrin  (EXP)
chrysene  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
curcumin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
deguelin  (EXP)
desogestrel  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
enzyme inhibitor  (EXP)
ethanol  (EXP)
fipronil  (ISO)
fluoranthene  (ISO)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
gallic acid  (EXP)
gentamycin  (ISO)
glucose  (ISO)
hexadecanoic acid  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
isobutanol  (EXP)
isotretinoin  (EXP)
ivermectin  (EXP)
leflunomide  (EXP,ISO)
lipopolysaccharide  (ISO)
lovastatin  (EXP,ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (ISO)
methylparaben  (EXP)
methylseleninic acid  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
myrtenol  (EXP)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalenes  (ISO)
nefazodone  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
NSC 23766  (ISO)
ochratoxin A  (EXP)
oleic acid  (EXP)
oxaliplatin  (ISO)
p-menthan-3-ol  (EXP)
panobinostat  (EXP)
paracetamol  (ISO)
perillic acid  (EXP)
perillyl alcohol  (EXP,ISO)
perillyl aldehyde  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (EXP)
ranitidine  (ISO)
rotenone  (EXP)
SB 431542  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
temozolomide  (EXP)
terbinafine  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
tetradecane  (ISO)
tetrahydropalmatine  (EXP)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
torcetrapib  (EXP)
triadimefon  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1400319   PMID:2407642   PMID:3283705   PMID:3888408   PMID:7537292   PMID:7713879   PMID:8543060   PMID:8617235   PMID:8621375   PMID:8889548   PMID:8939998   PMID:9478917  
PMID:9734811   PMID:9811589   PMID:10508588   PMID:10713718   PMID:10913192   PMID:11149925   PMID:11353846   PMID:11546812   PMID:11741970   PMID:11786539   PMID:11788600   PMID:11905808  
PMID:12221096   PMID:12473120   PMID:12477932   PMID:12878865   PMID:12939257   PMID:13679852   PMID:13679859   PMID:14647415   PMID:14702039   PMID:15102679   PMID:15226397   PMID:15451670  
PMID:15489334   PMID:15574879   PMID:15642170   PMID:15713677   PMID:15815621   PMID:15944396   PMID:16236794   PMID:16278215   PMID:16642435   PMID:17046241   PMID:17054945   PMID:17096327  
PMID:17163575   PMID:17198702   PMID:17304710   PMID:17405813   PMID:17728102   PMID:18047684   PMID:18056259   PMID:18212741   PMID:18464290   PMID:18471322   PMID:18524772   PMID:18590726  
PMID:18694745   PMID:19056867   PMID:19208833   PMID:19322201   PMID:19477269   PMID:19637314   PMID:19782069   PMID:19889053   PMID:19911011   PMID:19995557   PMID:19997872   PMID:20237151  
PMID:20460403   PMID:20473933   PMID:20717930   PMID:20810568   PMID:21347332   PMID:21373644   PMID:21423176   PMID:21565167   PMID:21750679   PMID:21872591   PMID:21873635   PMID:22092654  
PMID:22227305   PMID:22366462   PMID:22539766   PMID:22673745   PMID:22724071   PMID:22896740   PMID:22939629   PMID:22992742   PMID:23135917   PMID:23339407   PMID:23420497   PMID:23488932  
PMID:23583411   PMID:23792460   PMID:24086429   PMID:24223801   PMID:24321314   PMID:24636898   PMID:24984542   PMID:25207810   PMID:25216671   PMID:25249323   PMID:25301945   PMID:25320360  
PMID:25454559   PMID:25470816   PMID:25486363   PMID:25540389   PMID:25630770   PMID:26148238   PMID:26186194   PMID:26496610   PMID:26741994   PMID:26759237   PMID:26760575   PMID:26949039  
PMID:27121468   PMID:27138256   PMID:27147504   PMID:27210746   PMID:27324125   PMID:27342126   PMID:27384222   PMID:27807006   PMID:27832197   PMID:28212429   PMID:28949796   PMID:28960175  
PMID:29059167   PMID:29233918   PMID:29358211   PMID:29474434   PMID:29500478   PMID:29509190   PMID:29660302   PMID:29702193   PMID:29705334   PMID:29791485   PMID:30024968   PMID:30049714  
PMID:30206932   PMID:30297842   PMID:30587574   PMID:30601691   PMID:30652415   PMID:30747229   PMID:31011573   PMID:31128038   PMID:31148579   PMID:31182584   PMID:31591185   PMID:32203420  
PMID:32460013   PMID:33162807   PMID:33845483   PMID:33961781   PMID:33972537   PMID:34079125  


Genomics

Comparative Map Data
RHOB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl220,447,074 - 20,449,440 (+)EnsemblGRCh38hg38GRCh38
GRCh38220,447,074 - 20,449,440 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37220,646,835 - 20,649,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36220,510,316 - 20,512,682 (+)NCBINCBI36hg18NCBI36
Build 34220,568,462 - 20,570,828NCBI
Celera220,509,553 - 20,511,920 (+)NCBI
Cytogenetic Map2p24.1NCBI
HuRef220,404,158 - 20,406,525 (+)NCBIHuRef
CHM1_1220,576,236 - 20,578,603 (+)NCBICHM1_1
Rhob
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39128,547,661 - 8,550,009 (-)NCBIGRCm39mm39
GRCm39 Ensembl128,547,661 - 8,550,009 (-)Ensembl
GRCm38128,497,661 - 8,500,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl128,497,661 - 8,500,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37128,504,564 - 8,506,791 (-)NCBIGRCm37mm9NCBIm37
MGSCv36128,523,766 - 8,525,993 (-)NCBImm8
Celera128,887,131 - 8,889,358 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
Rhob
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2631,363,752 - 31,365,926 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl631,363,548 - 31,366,108 (+)Ensembl
Rnor_6.0633,689,127 - 33,691,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,689,127 - 33,691,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,472,691 - 43,474,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4632,052,333 - 32,054,507 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1632,055,314 - 32,057,457 (-)NCBI
Celera630,812,638 - 30,814,812 (-)NCBICelera
Cytogenetic Map6q14NCBI
Rhob
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554692,965,041 - 2,965,631 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554692,964,968 - 2,966,998 (+)NCBIChiLan1.0ChiLan1.0
RHOB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A20,548,853 - 20,551,243 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A20,549,254 - 20,549,844 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A20,433,576 - 20,435,986 (+)NCBIMhudiblu_PPA_v0panPan3
RHOB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11715,438,744 - 15,439,793 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1715,439,143 - 15,441,136 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1715,403,411 - 15,404,475 (+)NCBI
ROS_Cfam_1.01715,590,936 - 15,592,006 (+)NCBI
UMICH_Zoey_3.11715,444,980 - 15,446,038 (+)NCBI
UNSW_CanFamBas_1.01715,451,597 - 15,452,660 (+)NCBI
UU_Cfam_GSD_1.01715,483,858 - 15,484,931 (+)NCBI
Rhob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629259,849,358 - 59,851,760 (+)NCBI
SpeTri2.0NW_00493649310,987,801 - 10,990,207 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3117,773,405 - 117,777,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13117,773,400 - 117,777,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23125,747,271 - 125,747,861 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11487,247,615 - 87,249,984 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1487,249,005 - 87,249,592 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604524,967,249 - 24,969,623 (+)NCBIVero_WHO_p1.0
Rhob
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247383,115,840 - 3,117,719 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH44304  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37220,648,992 - 20,649,120UniSTSGRCh37
Build 36220,512,473 - 20,512,601RGDNCBI36
Celera220,511,711 - 20,511,839RGD
Cytogenetic Map2p24UniSTS
HuRef220,406,316 - 20,406,444UniSTS
GeneMap99-GB4 RH Map270.91UniSTS
RH66820  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37220,647,679 - 20,647,800UniSTSGRCh37
Build 36220,511,160 - 20,511,281RGDNCBI36
Celera220,510,397 - 20,510,518RGD
Cytogenetic Map2p24UniSTS
HuRef220,405,002 - 20,405,123UniSTS
GeneMap99-GB4 RH Map270.73UniSTS
NCBI RH Map298.2UniSTS
RH16017  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37220,649,344 - 20,649,481UniSTSGRCh37
Build 36220,512,825 - 20,512,962RGDNCBI36
Celera220,512,063 - 20,512,200RGD
Cytogenetic Map2p24UniSTS
HuRef220,406,668 - 20,406,805UniSTS
GeneMap99-GB4 RH Map276.38UniSTS
NCBI RH Map299.9UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20460403
MIR21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21347332
MIR21hsa-miR-21-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21872591
MIR21hsa-miR-21-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23313253
MIR21hsa-miR-21-5pOncomiRDBexternal_infoNANA21872591
MIR21hsa-miR-21-5pOncomiRDBexternal_infoNANA20460403
MIR223hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19850724
MIR223hsa-miR-223-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22080513
MIR223hsa-miR-223-5pMirecordsexternal_infoNANA19850724

Predicted Target Of
Summary Value
Count of predictions:1184
Count of miRNA genes:472
Interacting mature miRNAs:504
Transcripts:ENST00000272233
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 971 1195 84 14 83 14 1438 558 328 47 224 169 550 1037
Medium 1466 1780 1641 610 1708 451 2919 1638 3406 371 1233 1440 175 1 654 1751 6 2
Low 2 16 1 96 1 1 4
Below cutoff 40 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC023137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF171089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BK001671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM669284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA443347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X06820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000272233   ⟹   ENSP00000272233
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl220,447,074 - 20,449,440 (+)Ensembl
RefSeq Acc Id: NM_004040   ⟹   NP_004031
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38220,447,074 - 20,449,440 (+)NCBI
GRCh37220,646,835 - 20,649,201 (+)ENTREZGENE
Build 36220,510,316 - 20,512,682 (+)NCBI Archive
HuRef220,404,158 - 20,406,525 (+)ENTREZGENE
CHM1_1220,576,233 - 20,578,608 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004031   ⟸   NM_004040
- UniProtKB: P62745 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000272233   ⟸   ENST00000272233

Promoters
RGD ID:6798083
Promoter ID:HG_KWN:31684
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:ENST00000405629,   OTTHUMT00000207500
Position:
Human AssemblyChrPosition (strand)Source
Build 36220,510,044 - 20,510,544 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-23.1(chr2:30141-31766749)x3 copy number gain See cases [RCV000052929] Chr2:30141..31766749 [GRCh38]
Chr2:30141..31991818 [GRCh37]
Chr2:20141..31845322 [NCBI36]
Chr2:2p25.3-23.1
pathogenic
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1
pathogenic
GRCh38/hg38 2p25.3-23.2(chr2:30341-28419664)x3 copy number gain See cases [RCV000135398] Chr2:30341..28419664 [GRCh38]
Chr2:30341..28642531 [GRCh37]
Chr2:20341..28496035 [NCBI36]
Chr2:2p25.3-23.2
pathogenic
GRCh38/hg38 2p25.3-23.3(chr2:17019-26318846)x3 copy number gain See cases [RCV000137344] Chr2:17019..26318846 [GRCh38]
Chr2:17019..26541714 [GRCh37]
Chr2:7019..26395218 [NCBI36]
Chr2:2p25.3-23.3
pathogenic
GRCh38/hg38 2p25.3-24.1(chr2:1664615-23664142)x3 copy number gain See cases [RCV000137913] Chr2:1664615..23664142 [GRCh38]
Chr2:1668387..23887012 [GRCh37]
Chr2:1647394..23740517 [NCBI36]
Chr2:2p25.3-24.1
pathogenic|likely pathogenic
GRCh38/hg38 2p24.2-24.1(chr2:16723596-21600734)x1 copy number loss See cases [RCV000139451] Chr2:16723596..21600734 [GRCh38]
Chr2:16904863..21823606 [GRCh37]
Chr2:16768344..21677111 [NCBI36]
Chr2:2p24.2-24.1
pathogenic|likely pathogenic
GRCh38/hg38 2p25.3-22.3(chr2:12770-33711509)x3 copy number gain See cases [RCV000141829] Chr2:12770..33711509 [GRCh38]
Chr2:12770..33936576 [GRCh37]
Chr2:2770..33790080 [NCBI36]
Chr2:2p25.3-22.3
pathogenic
GRCh38/hg38 2p25.3-23.3(chr2:12770-25039694)x3 copy number gain See cases [RCV000141877] Chr2:12770..25039694 [GRCh38]
Chr2:12770..25262563 [GRCh37]
Chr2:2770..25116067 [NCBI36]
Chr2:2p25.3-23.3
pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh38/hg38 2p25.3-21(chr2:236816-45983232)x3 copy number gain See cases [RCV000143682] Chr2:236816..45983232 [GRCh38]
Chr2:236816..46210371 [GRCh37]
Chr2:226816..46063875 [NCBI36]
Chr2:2p25.3-21
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p24.1-23.3(chr2:19905995-24762790)x1 copy number loss not provided [RCV000682157] Chr2:19905995..24762790 [GRCh37]
Chr2:2p24.1-23.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p24.3-24.1(chr2:15631145-21729493)x1 copy number loss not provided [RCV000847885] Chr2:15631145..21729493 [GRCh37]
Chr2:2p24.3-24.1
pathogenic
NM_000085.5(CLCNKB):c.101-50G>C single nucleotide variant not provided [RCV001684363] Chr2:20446871 [GRCh38]
Chr2:20646632 [GRCh37]
Chr2:2p24.1
benign
GRCh37/hg19 2p24.1(chr2:20576216-20684239)x1 copy number loss not provided [RCV001005235] Chr2:20576216..20684239 [GRCh37]
Chr2:2p24.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:668 AgrOrtholog
COSMIC RHOB COSMIC
Ensembl Genes ENSG00000143878 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000272233 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000272233 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
GTEx ENSG00000143878 GTEx
HGNC ID HGNC:668 ENTREZGENE
Human Proteome Map RHOB Human Proteome Map
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rho UniProtKB/Swiss-Prot
KEGG Report hsa:388 UniProtKB/Swiss-Prot
NCBI Gene 388 ENTREZGENE
OMIM 165370 OMIM
PANTHER PTHR24072 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PharmGKB PA24950 PharmGKB
PROSITE RHO UniProtKB/Swiss-Prot
SMART RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
TIGRFAMs small_GTP UniProtKB/Swiss-Prot
UniProt P62745 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2R692 UniProtKB/Swiss-Prot
  P01121 UniProtKB/Swiss-Prot
  Q5U0H6 UniProtKB/Swiss-Prot
  Q7RTN5 UniProtKB/Swiss-Prot
  Q7RTR9 UniProtKB/Swiss-Prot
  Q9CUV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-03-01 RHOB  ras homolog family member B  RHOB  ras homolog gene family, member B  Symbol and/or name change 5135510 APPROVED