GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MIR21 | increases expression | EXP | | 6480464 | CTD | arsenite results in increased expression of MIR21 mRNA | PMID:22387281 PMID:22728250 PMID:23469214 | MIR21 | multiple interactions | EXP | | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [arsenite promotes the reaction [RELA protein binds to MIR21 promoter]]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [arsenite results in increased expression of MIR21 mRNA]; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of MIR21 mRNA; arsenite promotes the reaction [RELA protein binds to MIR21 promoter]; CAT protein inhibits the reaction [arsenite results in increased expression of MIR21 mRNA]; IL6 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of MIR21 mRNA]; RELA mutant form inhibits the reaction [arsenite results in increased expression of MIR21 mRNA]; STAT3 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of MIR21 mRNA]; U 0126 inhibits the reaction [arsenite results in increased expression of MIR21 mRNA] | PMID:22387281 PMID:24004609 | MIR21 | increases expression | ISO | Mir21a (Mus musculus) | 6480464 | CTD | arsenite results in increased expression of MIR21 mRNA | PMID:22387281 | MIR21 | multiple interactions | ISO | Mir21a (Mus musculus) | 6480464 | CTD | CAT protein inhibits the reaction [arsenite results in increased expression of MIR21 mRNA] | PMID:22387281 | | ||||||||||||||||||||||
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