AGO4 (argonaute RISC component 4) - Rat Genome Database

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Gene: AGO4 (argonaute RISC component 4) Homo sapiens
Analyze
Symbol: AGO4
Name: argonaute RISC component 4
RGD ID: 1312105
HGNC Page HGNC:18424
Description: Enables double-stranded RNA binding activity; miRNA binding activity; and single-stranded RNA binding activity. Involved in RNA secondary structure unwinding and negative regulation of gene expression. Located in cytoplasmic ribonucleoprotein granule and cytosol. Part of RISC complex and RISC-loading complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: argonaute 4; argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; argonaute4; eIF-2C 4; eIF2C 4; EIF2C4; eukaryotic translation initiation factor 2C, 4; hAgo4; protein argonaute-4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,807,636 - 35,857,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,808,016 - 35,857,890 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,273,237 - 36,323,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,046,415 - 36,093,775 (+)NCBINCBI36Build 36hg18NCBI36
Build 34135,942,920 - 35,990,281NCBI
Celera134,548,288 - 34,595,633 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,391,417 - 34,441,140 (+)NCBIHuRef
CHM1_1136,390,239 - 36,439,851 (+)NCBICHM1_1
T2T-CHM13v2.0135,670,525 - 35,720,783 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10997877   PMID:11329013   PMID:12414724   PMID:12477932   PMID:12526743   PMID:12906857   PMID:15260970   PMID:15337849   PMID:15766526   PMID:16094384   PMID:18552826   PMID:18771919  
PMID:19167051   PMID:19324964   PMID:19383768   PMID:19393748   PMID:19470757   PMID:19946268   PMID:19946888   PMID:19966796   PMID:20146808   PMID:20675357   PMID:21244100   PMID:21576459  
PMID:21832049   PMID:21873635   PMID:21878547   PMID:22210886   PMID:22415963   PMID:22505576   PMID:22795694   PMID:23748378   PMID:24778252   PMID:25114291   PMID:28514442   PMID:29395067  
PMID:30021884   PMID:31586073   PMID:33233493   PMID:33961781   PMID:35013429   PMID:35559673   PMID:35803934   PMID:36371565   PMID:36736316  


Genomics

Comparative Map Data
AGO4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,807,636 - 35,857,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,808,016 - 35,857,890 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,273,237 - 36,323,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,046,415 - 36,093,775 (+)NCBINCBI36Build 36hg18NCBI36
Build 34135,942,920 - 35,990,281NCBI
Celera134,548,288 - 34,595,633 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,391,417 - 34,441,140 (+)NCBIHuRef
CHM1_1136,390,239 - 36,439,851 (+)NCBICHM1_1
T2T-CHM13v2.0135,670,525 - 35,720,783 (+)NCBIT2T-CHM13v2.0
Ago4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,383,280 - 126,427,379 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,383,334 - 126,427,265 (-)EnsemblGRCm39 Ensembl
GRCm384126,489,487 - 126,533,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,489,541 - 126,533,472 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,166,785 - 126,210,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,994,456 - 126,035,544 (-)NCBIMGSCv36mm8
Celera4124,826,342 - 124,870,087 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.9NCBI
Ago4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,064,949 - 144,110,422 (-)NCBIGRCr8
mRatBN7.25138,780,446 - 138,825,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,783,069 - 138,825,632 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,477,953 - 141,523,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,247,944 - 143,293,406 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,248,730 - 143,294,206 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,501,875 - 144,557,165 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,504,938 - 144,556,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,269,991 - 148,328,500 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,857,594 - 145,902,950 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,866,645 - 145,932,628 (-)NCBI
Celera5137,279,250 - 137,322,143 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ago4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,882,416 - 13,922,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,882,416 - 13,922,590 (+)NCBIChiLan1.0ChiLan1.0
LOC100977537
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,990,660 - 191,040,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,111,850 - 190,161,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,072,045 - 35,122,418 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,249,040 - 36,299,259 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,249,038 - 36,299,259 (+)Ensemblpanpan1.1panPan2
AGO4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,325,899 - 6,351,748 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,329,413 - 6,356,676 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,569,069 - 6,608,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,462,261 - 6,501,884 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,281,474 - 6,502,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,315,003 - 6,354,575 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,383,741 - 6,423,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,398,098 - 6,437,686 (-)NCBIUU_Cfam_GSD_1.0
Ago4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505852,510,754 - 52,548,926 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647418,335,531 - 18,370,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647418,335,536 - 18,371,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGO4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,973,119 - 92,012,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,967,499 - 92,013,030 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2685,255,835 - 85,296,920 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGO4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12097,001,484 - 97,056,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2097,003,566 - 97,056,051 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603319,672,650 - 19,725,326 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,838,920 - 18,883,894 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,838,887 - 18,883,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AGO4
21 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.3(chr1:34753938-36055310)x1 copy number loss See cases [RCV000137966] Chr1:34753938..36055310 [GRCh38]
Chr1:35219539..36520911 [GRCh37]
Chr1:34992126..36293498 [NCBI36]
Chr1:1p34.3
likely pathogenic
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2
pathogenic
NM_017629.4(AGO4):c.241C>T (p.Gln81Ter) single nucleotide variant not provided [RCV001194641] Chr1:35822917 [GRCh38]
Chr1:36288518 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p34.3(chr1:34830287-36945093)x1 copy number loss See cases [RCV000448022] Chr1:34830287..36945093 [GRCh37]
Chr1:1p34.3
pathogenic
GRCh37/hg19 1p34.3(chr1:35950860-36465764)x1 copy number loss See cases [RCV000448765] Chr1:35950860..36465764 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease dominant intermediate C [RCV000708276] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p35.2-34.3(chr1:31562164-37421958)x3 copy number gain not provided [RCV000748949] Chr1:31562164..37421958 [GRCh37]
Chr1:1p35.2-34.3
pathogenic
GRCh37/hg19 1p35.1-34.3(chr1:32859415-36454915) copy number loss not provided [RCV000767772] Chr1:32859415..36454915 [GRCh37]
Chr1:1p35.1-34.3
pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NC_000001.10:g.(?_33241563)_(46663513_?)dup duplication Charcot-Marie-Tooth disease, dominant intermediate C [RCV001308684] Chr1:33241563..46663513 [GRCh37]
Chr1:1p35.1-34.1
uncertain significance
GRCh37/hg19 1p34.3(chr1:35950860-36635695) copy number gain not specified [RCV002053225] Chr1:35950860..36635695 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p35.1-33(chr1:33285582-47891811) copy number gain not specified [RCV002052781] Chr1:33285582..47891811 [GRCh37]
Chr1:1p35.1-33
pathogenic
GRCh37/hg19 1p34.3(chr1:36041366-39112237) copy number loss not specified [RCV002053236] Chr1:36041366..39112237 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p34.3(chr1:35950860-36465764) copy number loss not specified [RCV002053205] Chr1:35950860..36465764 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1132A>G (p.Met378Val) single nucleotide variant Inborn genetic diseases [RCV003259292] Chr1:35832072 [GRCh38]
Chr1:36297673 [GRCh37]
Chr1:1p34.3
uncertain significance
GRCh37/hg19 1p34.3(chr1:35104233-37357913)x1 copy number loss not provided [RCV002474552] Chr1:35104233..37357913 [GRCh37]
Chr1:1p34.3
pathogenic
NM_017629.4(AGO4):c.203T>C (p.Met68Thr) single nucleotide variant Inborn genetic diseases [RCV002778451] Chr1:35822879 [GRCh38]
Chr1:36288480 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1880G>A (p.Arg627Gln) single nucleotide variant Inborn genetic diseases [RCV002997865] Chr1:35841320 [GRCh38]
Chr1:36306921 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.251A>G (p.Tyr84Cys) single nucleotide variant Inborn genetic diseases [RCV002818629] Chr1:35822927 [GRCh38]
Chr1:36288528 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.829C>T (p.Arg277Trp) single nucleotide variant AGO4-related condition [RCV003420453]|Inborn genetic diseases [RCV002860114] Chr1:35826816 [GRCh38]
Chr1:36292417 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1531G>A (p.Val511Met) single nucleotide variant Inborn genetic diseases [RCV002905136] Chr1:35834141 [GRCh38]
Chr1:36299742 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1591C>G (p.Leu531Val) single nucleotide variant Inborn genetic diseases [RCV002887191] Chr1:35835860 [GRCh38]
Chr1:36301461 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.2128C>A (p.Gln710Lys) single nucleotide variant Inborn genetic diseases [RCV002821717] Chr1:35841703 [GRCh38]
Chr1:36307304 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.314T>C (p.Met105Thr) single nucleotide variant Inborn genetic diseases [RCV002984899] Chr1:35825320 [GRCh38]
Chr1:36290921 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1979G>A (p.Arg660His) single nucleotide variant Inborn genetic diseases [RCV002956494] Chr1:35841419 [GRCh38]
Chr1:36307020 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1135G>A (p.Val379Met) single nucleotide variant Inborn genetic diseases [RCV002763081] Chr1:35832075 [GRCh38]
Chr1:36297676 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1768G>A (p.Val590Ile) single nucleotide variant Inborn genetic diseases [RCV002954609] Chr1:35841208 [GRCh38]
Chr1:36306809 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.2219G>A (p.Ser740Asn) single nucleotide variant Inborn genetic diseases [RCV002897384] Chr1:35850200 [GRCh38]
Chr1:36315801 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1399C>T (p.Arg467Cys) single nucleotide variant Inborn genetic diseases [RCV002831531] Chr1:35834009 [GRCh38]
Chr1:36299610 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1508C>T (p.Thr503Ile) single nucleotide variant Inborn genetic diseases [RCV002678420] Chr1:35834118 [GRCh38]
Chr1:36299719 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.46C>G (p.Pro16Ala) single nucleotide variant Inborn genetic diseases [RCV003193771] Chr1:35816908 [GRCh38]
Chr1:36282509 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1393C>G (p.Gln465Glu) single nucleotide variant Inborn genetic diseases [RCV003200199] Chr1:35834003 [GRCh38]
Chr1:36299604 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.540C>A (p.His180Gln) single nucleotide variant Inborn genetic diseases [RCV003207696] Chr1:35825730 [GRCh38]
Chr1:36291331 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.298C>G (p.Arg100Gly) single nucleotide variant Inborn genetic diseases [RCV003201293] Chr1:35822974 [GRCh38]
Chr1:36288575 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.419A>G (p.His140Arg) single nucleotide variant Inborn genetic diseases [RCV003371829] Chr1:35825425 [GRCh38]
Chr1:36291026 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.482C>A (p.Ser161Tyr) single nucleotide variant AGO4-related condition [RCV003419060] Chr1:35825488 [GRCh38]
Chr1:36291089 [GRCh37]
Chr1:1p34.3
uncertain significance
NM_017629.4(AGO4):c.1225A>G (p.Met409Val) single nucleotide variant Inborn genetic diseases [RCV003362437] Chr1:35832165 [GRCh38]
Chr1:36297766 [GRCh37]
Chr1:1p34.3
uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3
likely pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR21hsa-miR-21-5pTarbaseexternal_infoMicroarrayPOSITIVE
MIRLET7A2hsa-let-7a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20144220
MIRLET7A1hsa-let-7a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20144220

Predicted Target Of
Summary Value
Count of predictions:1782
Count of miRNA genes:982
Interacting mature miRNAs:1160
Transcripts:ENST00000373210, ENST00000488778, ENST00000496257
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
AL010009  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37136,299,104 - 36,299,183UniSTSGRCh37
Build 36136,071,691 - 36,071,770RGDNCBI36
Celera134,573,555 - 34,573,634RGD
Cytogenetic Map1p34UniSTS
HuRef134,416,760 - 34,416,839UniSTS
RH80595  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37136,317,561 - 36,317,788UniSTSGRCh37
Build 36136,090,148 - 36,090,375RGDNCBI36
Celera134,592,006 - 34,592,233RGD
Cytogenetic Map1p34UniSTS
HuRef134,435,212 - 34,435,439UniSTS
GeneMap99-GB4 RH Map1108.21UniSTS
SHGC-74548  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37136,323,330 - 36,323,432UniSTSGRCh37
Build 36136,095,917 - 36,096,019RGDNCBI36
Celera134,597,773 - 34,597,875RGD
Cytogenetic Map1p34UniSTS
HuRef134,440,979 - 34,441,081UniSTS
TNG Radiation Hybrid Map117094.0UniSTS
GeneMap99-GB4 RH Map1102.93UniSTS
GeneMap99-GB4 RH Map1111.15UniSTS
Whitehead-RH Map1114.8UniSTS
NCBI RH Map1220.6UniSTS
A009K46  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37136,323,276 - 36,323,408UniSTSGRCh37
Build 36136,095,863 - 36,095,995RGDNCBI36
Celera134,597,719 - 34,597,851RGD
Cytogenetic Map1p34UniSTS
HuRef134,440,925 - 34,441,057UniSTS
GeneMap99-GB4 RH Map1108.11UniSTS
NCBI RH Map1230.0UniSTS
D11S2560  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10p12.1-p11.2UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map8q21.13UniSTS
Cytogenetic Map18p11.22UniSTS
Cytogenetic Map9p13.3-p12UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map8p22-p21UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map9q22.33UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map12p13.33UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q23UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map3p21.2UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map6q27UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map2q12.1UniSTS
Cytogenetic Map9q13-q21UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map8q11.21UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map12q23-q24.1UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map10q23.2UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map12p13.2UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q26.2-q27UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic MapXp11.2UniSTS
Cytogenetic Map20q11.2UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map4p15.32UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map1p36.11-p34.2UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map18p11.32UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic Map14q13.2UniSTS
Cytogenetic Map8q12.1UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map14q31.1UniSTS
Cytogenetic Map21q22.2UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map8q24.21UniSTS
Cytogenetic Map12q22-q23.1UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map7p14-p13UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map19p13.3-p13.2UniSTS
Cytogenetic Map6q22-q23UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map11q13.1-q13.3UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map6p24UniSTS
Cytogenetic Map10q25UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map9q31.1UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic MapXq28UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map3p26.1-p25.1UniSTS
Cytogenetic Map6q16.3UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic MapXq27.1UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map3q25.31UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map14q32.32UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map6q14.1UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map1p32-p31UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map5q11UniSTS
G32631  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37136,323,276 - 36,323,408UniSTSGRCh37
Celera134,597,719 - 34,597,851UniSTS
Cytogenetic Map1p34UniSTS
HuRef134,440,925 - 34,441,057UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2003 1983 872 179 1236 57 3766 1293 1567 126 1282 1371 129 1029 2308 2
Low 433 1008 854 445 714 408 591 904 2167 293 178 241 46 1 175 480 4 2
Below cutoff 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_146062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011540883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011540884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047448151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047448156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054334831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008485947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008485948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008485949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008485950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_246243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_246244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_946567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB046787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL354864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG186585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA419947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000373210   ⟹   ENSP00000362306
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl135,808,016 - 35,857,890 (+)Ensembl
RefSeq Acc Id: ENST00000488778
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl135,841,673 - 35,851,195 (+)Ensembl
RefSeq Acc Id: ENST00000496257
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl135,853,488 - 35,854,758 (+)Ensembl
RefSeq Acc Id: NM_017629   ⟹   NP_060099
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,016 - 35,857,890 (+)NCBI
GRCh37136,273,231 - 36,323,491 (+)NCBI
Build 36136,046,415 - 36,093,775 (+)NCBI Archive
Celera134,548,288 - 34,595,633 (+)RGD
HuRef134,391,417 - 34,441,140 (+)ENTREZGENE
CHM1_1136,390,239 - 36,439,851 (+)NCBI
T2T-CHM13v2.0135,670,905 - 35,720,783 (+)NCBI
Sequence:
RefSeq Acc Id: NR_146062
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,807,636 - 35,857,890 (+)NCBI
T2T-CHM13v2.0135,670,525 - 35,720,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005270578   ⟹   XP_005270635
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,807,636 - 35,857,890 (+)NCBI
GRCh37136,273,231 - 36,323,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005270579   ⟹   XP_005270636
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,816,982 - 35,857,890 (+)NCBI
GRCh37136,273,231 - 36,323,491 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011540883   ⟹   XP_011539185
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,825,402 - 35,857,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011540884   ⟹   XP_011539186
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,825,402 - 35,857,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047448151   ⟹   XP_047304107
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,016 - 35,834,110 (+)NCBI
RefSeq Acc Id: XM_047448156   ⟹   XP_047304112
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,016 - 35,832,185 (+)NCBI
RefSeq Acc Id: XM_054334826   ⟹   XP_054190801
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,670,525 - 35,720,783 (+)NCBI
RefSeq Acc Id: XM_054334827   ⟹   XP_054190802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,679,871 - 35,720,783 (+)NCBI
RefSeq Acc Id: XM_054334828   ⟹   XP_054190803
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,688,311 - 35,720,783 (+)NCBI
RefSeq Acc Id: XM_054334829   ⟹   XP_054190804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,688,311 - 35,720,783 (+)NCBI
RefSeq Acc Id: XM_054334830   ⟹   XP_054190805
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,670,905 - 35,697,016 (+)NCBI
RefSeq Acc Id: XM_054334831   ⟹   XP_054190806
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,670,905 - 35,695,091 (+)NCBI
RefSeq Acc Id: XR_001737019
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,016 - 35,857,890 (+)NCBI
Sequence:
RefSeq Acc Id: XR_008485947
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,670,905 - 35,720,783 (+)NCBI
RefSeq Acc Id: XR_008485948
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,670,905 - 35,720,783 (+)NCBI
RefSeq Acc Id: XR_008485949
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,670,905 - 35,720,564 (+)NCBI
RefSeq Acc Id: XR_008485950
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0135,670,905 - 35,704,134 (+)NCBI
RefSeq Acc Id: XR_246243
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,016 - 35,857,890 (+)NCBI
GRCh37136,273,231 - 36,323,491 (+)NCBI
Sequence:
RefSeq Acc Id: XR_246244
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,016 - 35,857,890 (+)NCBI
GRCh37136,273,231 - 36,323,491 (+)NCBI
Sequence:
RefSeq Acc Id: XR_946567
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,016 - 35,841,231 (+)NCBI
Sequence:
RefSeq Acc Id: NP_060099   ⟸   NM_017629
- UniProtKB: A7MD27 (UniProtKB/Swiss-Prot),   Q9HCK5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005270635   ⟸   XM_005270578
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005270636   ⟸   XM_005270579
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011539185   ⟸   XM_011540883
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011539186   ⟸   XM_011540884
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000362306   ⟸   ENST00000373210
RefSeq Acc Id: XP_047304107   ⟸   XM_047448151
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047304112   ⟸   XM_047448156
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054190801   ⟸   XM_054334826
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054190805   ⟸   XM_054334830
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054190806   ⟸   XM_054334831
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054190802   ⟸   XM_054334827
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054190803   ⟸   XM_054334828
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054190804   ⟸   XM_054334829
- Peptide Label: isoform X3
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HCK5-F1-model_v2 AlphaFold Q9HCK5 1-861 view protein structure

Promoters
RGD ID:6854952
Promoter ID:EPDNEW_H641
Type:initiation region
Name:AGO4_2
Description:argonaute 4, RISC catalytic component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H631  EPDNEW_H642  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,807,636 - 35,807,696EPDNEW
RGD ID:6854954
Promoter ID:EPDNEW_H642
Type:initiation region
Name:AGO4_3
Description:argonaute 4, RISC catalytic component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H631  EPDNEW_H641  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38135,808,150 - 35,808,210EPDNEW
RGD ID:6785109
Promoter ID:HG_KWN:1982
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000012213
Position:
Human AssemblyChrPosition (strand)Source
Build 36136,046,071 - 36,046,772 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18424 AgrOrtholog
COSMIC AGO4 COSMIC
Ensembl Genes ENSG00000134698 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373210 ENTREZGENE
  ENST00000373210.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  paz domain UniProtKB/Swiss-Prot
GTEx ENSG00000134698 GTEx
HGNC ID HGNC:18424 ENTREZGENE
Human Proteome Map AGO4 Human Proteome Map
InterPro AGO4 UniProtKB/Swiss-Prot
  ArgoL1 UniProtKB/Swiss-Prot
  ArgoL2 UniProtKB/Swiss-Prot
  Argonaute_Mid_dom UniProtKB/Swiss-Prot
  Argonaute_N UniProtKB/Swiss-Prot
  PAZ_dom UniProtKB/Swiss-Prot
  PAZ_dom_sf UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
  Piwi_ago-like UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
  RNaseH_sf UniProtKB/Swiss-Prot
KEGG Report hsa:192670 UniProtKB/Swiss-Prot
NCBI Gene 192670 ENTREZGENE
OMIM 607356 OMIM
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/Swiss-Prot
  PROTEIN ARGONAUTE-4 UniProtKB/Swiss-Prot
Pfam ArgoL1 UniProtKB/Swiss-Prot
  ArgoL2 UniProtKB/Swiss-Prot
  ArgoMid UniProtKB/Swiss-Prot
  ArgoN UniProtKB/Swiss-Prot
  PAZ UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
PharmGKB PA38330 PharmGKB
PROSITE PAZ UniProtKB/Swiss-Prot
  PIWI UniProtKB/Swiss-Prot
SMART DUF1785 UniProtKB/Swiss-Prot
  PAZ UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot
  SSF53098 UniProtKB/Swiss-Prot
UniProt A7MD27 ENTREZGENE
  AGO4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A7MD27 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 AGO4  argonaute RISC component 4  AGO4  argonaute RISC catalytic component 4  Symbol and/or name change 5135510 APPROVED
2018-11-29 AGO4  argonaute RISC catalytic component 4  AGO4  argonaute 4, RISC catalytic component  Symbol and/or name change 5135510 APPROVED
2015-12-01 AGO4  argonaute 4, RISC catalytic component  AGO4  argonaute RISC catalytic component 4  Symbol and/or name change 5135510 APPROVED
2013-02-20 AGO4  argonaute RISC catalytic component 4  EIF2C4  eukaryotic translation initiation factor 2C, 4  Symbol and/or name change 5135510 APPROVED