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Gene: TIAM1 (TIAM Rac1 associated GEF 1) Homo sapiens
Symbol: TIAM1
Name: TIAM Rac1 associated GEF 1
RGD ID: 1316657
Description: Exhibits Rac guanyl-nucleotide exchange factor activity and kinase binding activity. Involved in several processes, including Rac protein signal transduction; activation of GTPase activity; and regulation of epithelial to mesenchymal transition. Localizes to cell-cell contact zone; cytosol; and extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with microtubule.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ36302; human T-lymphoma invasion and metastasis inducing TIAM1 protein; T cell lymphoma invasion and metastasis 1; T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1; TIAM-1
Mus musculus (house mouse) : Tiam1 (T cell lymphoma invasion and metastasis 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tiam1 (TIAM Rac1 associated GEF 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tiam1 (TIAM Rac1 associated GEF 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TIAM1 (TIAM Rac1 associated GEF 1)
Canis lupus familiaris (dog) : TIAM1 (TIAM Rac1 associated GEF 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tiam1 (TIAM Rac1 associated GEF 1)
Sus scrofa (pig) : TIAM1 (TIAM Rac1 associated GEF 1)
Chlorocebus sabaeus (African green monkey) : TIAM1 (TIAM Rac1 associated GEF 1)
Heterocephalus glaber (naked mole-rat) : Tiam1 (TIAM Rac1 associated GEF 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2131,118,416 - 31,559,977 (-)EnsemblGRCh38hg38GRCh38
GRCh382131,118,418 - 31,559,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372132,490,736 - 32,931,290 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,412,607 - 31,853,161 (-)NCBINCBI36hg18NCBI36
Build 342131,238,437 - 31,853,161NCBI
Celera2117,673,700 - 18,114,602 (-)NCBI
Cytogenetic Map21q22.11ENTREZGENE
HuRef2117,900,683 - 18,341,390 (-)NCBIHuRef
CHM1_12132,052,512 - 32,493,303 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TIAM1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316657
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.