| 621719 | Caly | calcyon neuron-specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding; clathrin light chain binding (ortholog); INVOLVED IN anterograde axonal transport; positive regulation of clathrin coat assembly; positive regulation of retrograde axon cargo transport; ASSOCIATED WITH attention deficit hyperactivit y disorder; Animal Disease Models (ortholog); essential hypertension (ortholog); FOUND IN axon; cytoplasmic vesicle (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 1 | 204292317 | 204303506 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731668 | Caly | calcyon neuron-specific vesicular protein | Predicted to enable clathrin light chain binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse. Is expressed in central nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in attention deficit hyper activity disorder. Orthologous to human CALY (calcyon neuron specific vesicular protein). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 139649793 | 139662485 | Mouse | 109 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1601759 | CALY | calcyon neuron specific vesicular protein | The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA re ceptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008] | 10 | 133324072 | 133336896 | Human | 86 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 9000006 | Caly | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits clathrin light chain binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); clathrin coat assembly (ortholog); positive regulation of clathrin coat assembly (ortholog); ASSOCIATED WITH Animal Disease Mod els (ortholog); attention deficit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog); cytoplasmic vesicle (ortholog); glutamatergic synapse (ortholog) | NW_004955477 | 10983602 | 10993371 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11760360 | CALY | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of retrograde axon cargo transport (ortholog); ASSOCIATED WITH Animal Disease Models (orth olog); attention deficit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog) | | | | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12380019 | CALY | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of endocytosis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); attention def icit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog) | 28 | 40918341 | 40925161 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12550576 | Caly | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of retrograde axon cargo transport (ortholog); ASSOCIATED WITH Animal Disease Models (orth olog); attention deficit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog) | NW_004936486 | 19463989 | 19471976 | Squirrel | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14293967 | CALY | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of retrograde axon cargo transport (ortholog); ASSOCIATED WITH Animal Disease Models (orth olog); attention deficit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18777989 | CALY | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of retrograde axon cargo transport (ortholog); ASSOCIATED WITH Animal Disease Models (orth olog); attention deficit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog) | | | | Green Monkey | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929159 | Caly | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); positive regulation of clathrin coat assembly (ortholog); positive regulation of endocytosis (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); attention def icit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625884845 | Caly | calcyon neuron specific vesicular protein | ENCODES a protein that exhibits clathrin light chain binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); clathrin coat assembly (ortholog); positive regulation of clathrin coat assembly (ortholog); ASSOCIATED WITH Animal Disease Mod els (ortholog); attention deficit hyperactivity disorder (ortholog); essential hypertension (ortholog); FOUND IN axon (ortholog); cytoplasmic vesicle (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14370077 | calypso | | | | | | Fly | | symbol | gene, null |
| 1602121 | NSG2 | neuronal vesicle trafficking associated 2 | Predicted to enable clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly and endosomal transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 174045706 | 174109179 | Human | 96 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1305520 | Aak1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding; protein serine/threonine kinase activity; Notch binding (ortholog); INVOLVED IN presynaptic endocytosis; regulation of clathrin-dependent endocytosis; positive regulation of Notch signaling pathway (ortholog); ASSOCIATED WITH tooth agenes is (ortholog); FOUND IN calyx of Held; cell leading edge; clathrin complex; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 4 | 120845012 | 121009170 | Rat | 158 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1618841 | Aak1 | AP2 associated kinase 1 | Predicted to enable AP-2 adaptor complex binding activity; Notch binding activity; and protein serine/threonine kinase activity. Involved in presynaptic endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; clathrin-coated vesicle; and terminal bouton. P redicted to be part of clathrin complex. Predicted to be active in calyx of Held. Is expressed in cranial ganglion; dorsal root ganglion; retina nuclear layer; and telencephalon. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 86826252 | 86980209 | Mouse | 182 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8853612 | Aak1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); Notch binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN positive regulation of Notch signaling pathway (ortholog); presynaptic endocytosis (ortholog); protein phosphorylation (ortholog); ASSOC IATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leading edge (ortholog); clathrin complex (ortholog) | NW_004955424 | 15480783 | 15640471 | Chinchilla | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 11750528 | AAK1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); ATP binding (inferred); kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leadin g edge (ortholog); clathrin complex (ortholog) | 2A | 69506651 | 69686765 | Bonobo | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12403550 | AAK1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); ATP binding (inferred); kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leadin g edge (ortholog); clathrin complex (ortholog) | 10 | 68181584 | 68336266 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12548208 | Aak1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); ATP binding (inferred); kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leadin g edge (ortholog); clathrin complex (ortholog) | NW_004936491 | 13720687 | 13897899 | Squirrel | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 13888168 | AAK1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); Notch binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN protein phosphorylation; regulation of clathrin-dependent endocytosis; positive regulation of Notch signaling pathway (ortholog); ASSOCI ATED WITH tooth agenesis (ortholog); FOUND IN clathrin-coated vesicle; calyx of Held (ortholog); cell leading edge (ortholog) | | | | Pig | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 18357104 | AAK1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (inferred); ATP binding (inferred); kinase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); ASSOCIATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leadin g edge (ortholog); clathrin complex (ortholog) | | | | Green Monkey | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 18915648 | Aak1 | AP2 associated kinase 1 | ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN positive regulation of Notch signaling pathway (ortholog); presynaptic endocytosis (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leading edge (ortholog); clathrin complex (ortholog) | | | | Naked Mole-Rat | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 626138609 | Aak1 | AP2 associated kinase 1 | ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); Notch binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN positive regulation of Notch signaling pathway (ortholog); presynaptic endocytosis (ortholog); protein phosphorylation (ortholog); ASSOC IATED WITH tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leading edge (ortholog); clathrin complex (ortholog) | | | | Black Rat | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 1550394 | Abhd14b | abhydrolase domain containing 14b | Predicted to enable hydrolase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in epidermis; nose; and renal caly '>calyx. Orthologous to human ABHD14B (abhydrolase domain containing 14B). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 106324936 | 106330122 | Mouse | 117 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605289 | ACTRT1 | actin related protein T1 | This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010] | X | 128050962 | 128052403 | Human | 24 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606455 | ACTRT2 | actin related protein T2 | The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. [provided by RefSeq, Jul 2008] | 1 | 3021467 | 3022903 | Human | 36 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 2169 | Atp1a3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding; D1 dopamine receptor binding; heparan sulfate proteoglycan binding (ortholog); INVOLVED IN cellular response to amyloid-beta; cellular response to retinoic acid; cellular response to thyroid hormone stimulus; PARTICIPATES IN acebutolol pharmacody namics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon; calyx of Held; dendritic spine head; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol | 1 | 89700645 | 89729782 | Rat | 410 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8901313 | Atp1a3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | NW_004955555 | 869508 | 892510 | Chinchilla | 253 | description | gene, protein-coding, MODEL [RefSeq] |
| 11713607 | ATP1A3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 19 | 38854243 | 38882034 | Bonobo | 267 | description | gene, protein-coding, MODEL [RefSeq] |
| 12393741 | ATP1A3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 1 | 112325988 | 112346056 | Dog | 267 | description | gene, protein-coding, MODEL [RefSeq] |
| 12450844 | Atp1a3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | NW_004936706 | 476473 | 494659 | Squirrel | 266 | description | gene, protein-coding, MODEL [RefSeq] |
| 13872924 | ATP1A3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Pig | 273 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18766217 | ATP1A3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Green Monkey | 269 | description | gene, protein-coding, MODEL [RefSeq] |
| 18921466 | Atp1a3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 266 | description | gene, protein-coding, MODEL [RefSeq] |
| 625877857 | Atp1a3 | ATPase Na+/K+ transporting subunit alpha 3 | ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ort holog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Black Rat | 251 | description | gene, protein-coding, MODEL [RefSeq] |
| 1557933 | C1s1 | complement component 1, s subcomponent 1 | Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Predicted to be involved in complement activation, classical pathway; innate immune response; and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space . Is expressed in chondrocranium; liver lobe; renal calyx; and urogenital ridge. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 2. Orthologous to human C1S (complement C1s). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 124507303 | 124519340 | Mouse | 280 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 10258 | C4bp | complement component 4 binding protein | Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membran e. Is expressed in foregut-midgut junction; midgut; midgut loop; renal calyx; and renal pelvis. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 130562510 | 130589365 | Mouse | 70 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2244 | Cacna1a | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding; high voltage-gated calcium channel activity; voltage-gated calcium channel activity; INVOLVED IN calcium ion import; calcium ion transport; chemical synaptic transmission; PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodyn amics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH abnormal gait; decreased spike-wave discharge type I; ASSOCIATED WITH childhood absence epilepsy; temporal lobe epilepsy; Alternating Hemiplegia of Childhood 1 (ortholog); FOUND IN calyx of Held; neuronal cell body; perikaryon; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide | 19 | 40425560 | 40724810 | Rat | 389 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8866424 | Cacna1a | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); syntaxin binding (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmac odynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN dendrite; neuronal cell body; calyx of Held (ortholog) | NW_004955415 | 32182536 | 32457511 | Chinchilla | 239 | description | gene, protein-coding, MODEL [RefSeq] |
| 11813415 | CACNA1A | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 19 | 12769586 | 13189022 | Bonobo | 240 | description | gene, protein-coding, MODEL [RefSeq] |
| 12383950 | CACNA1A | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 20 | 48747087 | 49036627 | Dog | 242 | description | gene, protein-coding, MODEL [RefSeq] |
| 14040283 | CACNA1A | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 243 | description | gene, protein-coding, MODEL [RefSeq] |
| 18737833 | CACNA1A | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); syntaxin binding (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmac odynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); cell projection (ortholog); cytoplasm (ortholog) | | | | Green Monkey | 237 | description | gene, protein-coding, MODEL [RefSeq] |
| 18910585 | Cacna1a | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); syntaxin binding (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmac odynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); cell projection (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 238 | description | gene, protein-coding, MODEL [RefSeq] |
| 625842600 | Cacna1a | calcium voltage-gated channel subunit alpha1 A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); syntaxin binding (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmac odynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); cell projection (ortholog); cytoplasm (ortholog) | | | | Black Rat | 231 | description | gene, protein-coding, MODEL [RefSeq] |
| 69340 | Calb1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding; calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN cochlea development; l earning or memory; regulation of synaptic plasticity; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder; bilirubin metabolic disorder; Hearing Loss, Noise-Induced; FOUND IN axon; calyx of Held; cuticular plate; INTERACTS WITH (S)-nicotine; 3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid; 3H-1,2-dithiole-3-thione | 5 | 34172612 | 34199555 | Rat | 239 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11906641 | CALB1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cochlea development (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog) | 8 | 86747702 | 86771995 | Bonobo | 66 | description | gene, protein-coding, MODEL [RefSeq] |
| 12176425 | CALB1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cochlea development (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog) | 29 | 35551836 | 35572985 | Dog | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 12725932 | Calb1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cochlea development (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog) | NW_004936544 | 3858344 | 3881985 | Squirrel | 66 | description | gene, protein-coding, MODEL [RefSeq] |
| 13953219 | CALB1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cochlea development (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog) | | | | Pig | 64 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18473599 | CALB1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cochlea development (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 66 | description | gene, protein-coding, MODEL [RefSeq] |
| 18906522 | Calb1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN cochlea dev elopment (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN calyx of Held (ortholog); cell body (ortholog); cuticular plate (ortholog) | | | | Naked Mole-Rat | 58 | description | gene, protein-coding, MODEL [RefSeq] |
| 626090987 | Calb1 | calbindin 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration (ortholog); calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN cochlea dev elopment (ortholog); learning or memory (ortholog); locomotory behavior (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); bilirubin metabolic disorder (ortholog); gestational diabetes (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell body (ortholog) | | | | Black Rat | 54 | description | gene, protein-coding, MODEL [RefSeq] |
| 8775056 | Calb2 | calbindin 2 | ENCODES a protein that exhibits calcium ion binding (ortholog); calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); regulation of synaptic plasticity (ortholog); synaptic signaling (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Endometrial Neoplasms (ortholog); malignant mesothelioma (ortholog); FOUND IN neuronal cell body; vestibular calyx terminal; cuticular plate (ortholog) | NW_004955484 | 4075103 | 4103509 | Chinchilla | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 8824130 | Calm1 | calmodulin 1 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | NW_004955438 | 12842437 | 12854028 | Chinchilla | 163 | description | gene, protein-coding, MODEL [RefSeq] |
| 12359409 | CALM1 | calmodulin 1 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Alzheimer's disease (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | 8 | 61398231 | 61408874 | Dog | 164 | description | gene, protein-coding, MODEL [RefSeq] |
| 10278 | Calm2 | calmodulin 2 | Enables calcium-dependent protein binding activity. Involved in negative regulation of calcium ion export across plasma membrane; negative regulation of calcium ion transmembrane transporter activity; and presynaptic endocytosis. Acts upstream of or within G2/M transition of mitotic cell cycle and r egulation of calcium-mediated signaling. Located in membrane; myelin sheath; and vesicle. Part of voltage-gated potassium channel complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in long QT syndrome 15. Orthologous to human CALM2 (calmodulin 2). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 87740829 | 87754363 | Mouse | 328 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8966209 | Calm2 | calmodulin 2 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); cannabis abuse (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | NW_004955441 | 13973147 | 13988665 | Chinchilla | 122 | description | gene, protein-coding, MODEL [RefSeq] |
| 625910075 | Calm2 | calmodulin 2 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); cannabis abuse (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | | | | Black Rat | 118 | description | gene, protein-coding, MODEL [RefSeq] |
| 10282 | Calm3 | calmodulin 3 | Predicted to enable several functions, including enzyme activator activity; enzyme binding activity; and titin binding activity. Involved in presynaptic endocytosis. Acts upstream of or within G2/M transition of mitotic cell cycle. Located in myelin sheath. Part of voltage-gated potassium channel co mplex. Is active in calyx of Held. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and long QT syndrome 16. Orthologous to human CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 16649304 | 16657957 | Mouse | 314 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9050103 | Calm3 | calmodulin 3 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | NW_004955574 | 672441 | 680924 | Chinchilla | 106 | description | gene, protein-coding, MODEL [RefSeq] |
| 12283682 | CALM3 | calmodulin 3 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | 1 | 109284729 | 109294491 | Dog | 109 | description | gene, protein-coding, MODEL [RefSeq] |
| 626138309 | Calm3 | calmodulin 3 | ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); Cardiac Arrhythmias (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog) | | | | Black Rat | 102 | description | gene, protein-coding, MODEL [RefSeq] |
| 736979 | Capn10 | calpain 10 | Predicted to enable SNARE binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including cellular response to insulin stimulus; positive regulation of transport; and type B pancreatic cell apoptotic proces s. Acts upstream of or within positive regulation of type B pancreatic cell apoptotic process. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and mitochondrion. Predicted to be active in cytoplasm. Is expressed in dorsal root ganglion and renal calyx. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; polycystic ovary syndrome; and type 2 diabetes mellitus. Orthologous to human CAPN10 (calpain 10). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 92862130 | 92875670 | Mouse | 164 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314006 | Casp8ap2 | caspase 8 associated protein 2 | Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm and nucleus. Pred icted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 32615462 | 32653271 | Mouse | 138 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1359369 | Ccin | calicin | INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog); INTERACTS WITH bisphenol A; cadm ium dichloride; gentamycin | 5 | 63002427 | 63004314 | Rat | 44 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1617144 | Ccin | calicin | Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in spermatogenesis. Located in cytoskeletal calyx. Human ortholog(s) of this gene implicated in spermatogenic failure 91. Orthologous to human CCIN (calicin). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 43983504 | 43985533 | Mouse | 44 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8990865 | Ccin | calicin | INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | NW_004958151 | 6 | 1111 | Chinchilla | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 11901849 | CCIN | calicin | INVOLVED IN cell differentiation (inferred); spermatogenesis (inferred); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (inferred); perinuclear theca (inferred); sperm glycocalyx (inferred) | 9 | 36014394 | 36021056 | Bonobo | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 12301895 | CCIN | calicin | INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | 11 | 52637580 | 52640121 | Dog | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 12615498 | Ccin | calicin | INVOLVED IN cell differentiation (inferred); spermatogenesis (inferred); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (inferred); perinuclear theca (inferred); sperm glycocalyx (inferred) | NW_004936524 | 4143238 | 4145183 | Squirrel | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 13984561 | CCIN | calicin | INVOLVED IN cell differentiation (inferred); spermatogenesis (inferred); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (inferred); cytoskeleton (inferred); perinuclear theca (inferred) | | | | Pig | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 18695865 | CCIN | calicin | INVOLVED IN cell differentiation (inferred); spermatogenesis (inferred); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (inferred); perinuclear theca (inferred); sperm glycocalyx (inferred) | | | | Green Monkey | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 18936647 | Ccin | calicin | INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | | | | Naked Mole-Rat | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 625872045 | Ccin | calicin | INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH spermatogenic failure 91 (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | | | | Black Rat | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 1312900 | Cdkl1 | cyclin dependent kinase like 1 | Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cilium assembly. Predicted to be located in ciliary transition zone and nucleoplasm. Predicted to be active in nucleus. Is expressed in renal calyx and rest o f cerebellum mantle layer. Orthologous to human CDKL1 (cyclin dependent kinase like 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 69791944 | 69838057 | Mouse | 85 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1558033 | Chchd10 | coiled-coil-helix-coiled-coil-helix domain containing 10 | Predicted to be involved in several processes, including mitochondrial nucleoid organization; oxidative phosphorylation; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in several structures, including brain ventricle and choroid plexus; early embryo; hypothalamu s mantle layer; renal calyx; and ventral grey horn. Used to study isolated mitochondrial myopathy. Human ortholog(s) of this gene implicated in frontotemporal dementia and/or amyotrophic lateral sclerosis 2; isolated mitochondrial myopathy; and spinal muscular atrophy, Jokela type. Orthologous to human CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 75768964 | 75773584 | Mouse | 187 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 733328 | Cplx1 | complexin 1 | Enables lipid binding activity. Involved in regulation of vesicle-mediated transport and signal release. Part of SNARE complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; calyx of Held; and glutamatergic synapse. Is ex pressed in nervous system; retina; and tongue. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 108666420 | 108697893 | Mouse | 165 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8743540 | Cplx1 | complexin 1 | ENCODES a protein that exhibits lipid binding (ortholog); SNARE binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN insulin secretion (ortholog); regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane (ortholog); regulation of synaptic vesicle fusion to pre synaptic active zone membrane (ortholog); ASSOCIATED WITH Ataxia (ortholog); bipolar disorder (ortholog); developmental and epileptic encephalopathy 63 (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | NW_004955514 | 359174 | 376916 | Chinchilla | 35 | description | gene, protein-coding, MODEL [RefSeq] |
| 12420241 | CPLX1 | complexin 1 | ENCODES a protein that exhibits lipid binding (ortholog); SNARE binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN insulin secretion (ortholog); regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane (ortholog); synaptic vesicle exocytosis (ortholog); ASSO CIATED WITH Ataxia (ortholog); bipolar disorder (ortholog); developmental and epileptic encephalopathy 63 (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | 3 | 91635953 | 91658084 | Dog | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 625987581 | Cplx1 | complexin 1 | ENCODES a protein that exhibits lipid binding (ortholog); SNARE binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN insulin secretion (ortholog); regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane (ortholog); regulation of synaptic vesicle fusion to pre synaptic active zone membrane (ortholog); ASSOCIATED WITH Ataxia (ortholog); bipolar disorder (ortholog); developmental and epileptic encephalopathy 63 (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 35 | description | gene, protein-coding, MODEL [RefSeq] |
| 732284 | Cplx2 | complexin 2 | Predicted to enable calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in positive regulation of synaptic plasticity and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Is active in calyx of Held and g lutamatergic synapse. Is expressed in nervous system; retina layer; and skeletal muscle. Used to study schizophrenia. Orthologous to human CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 54455447 | 54531736 | Mouse | 187 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8847074 | Cplx2 | complexin 2 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); SNARE binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN positive regulation of synaptic plasticity (ortholog); regulation of synaptic vesicle fusion to presynaptic active zone membrane (ortholog); synaptic ves icle exocytosis (ortholog); ASSOCIATED WITH bipolar disorder (ortholog); psychotic disorder (ortholog); schizophrenia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | NW_004955408 | 28308807 | 28388650 | Chinchilla | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 150657537 | CPLX2 | histamine receptor H2 | ENCODES a protein that exhibits syntaxin binding (inferred); INVOLVED IN exocytosis (inferred); neurotransmitter transport (inferred); positive regulation of synaptic plasticity (inferred); FOUND IN calyx of Held (inferred); cytosol (inferred); glutamatergic syn apse (inferred) | | | | Dog | 13 | description | gene, protein-coding |
| 625881505 | Cplx2 | complexin 2 | ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); SNARE binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN positive regulation of synaptic plasticity (ortholog); regulation of synaptic vesicle fusion to presynaptic active zone membrane (ortholog); synaptic ves icle exocytosis (ortholog); ASSOCIATED WITH bipolar disorder (ortholog); psychotic disorder (ortholog); schizophrenia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 1348149 | CYLC1 | cylicin 1 | This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] | X | 83861146 | 83886698 | Human | 46 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1344761 | CYLC2 | cylicin 2 | Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008] | 9 | 102995333 | 103018488 | Human | 23 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1562799 | Cylc2 | cylicin 2 | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog ); sperm glycocalyx (ortholog); INTERACTS WITH 2-palmitoylglycerol (ortholog); aflatoxin B1 (ortholog); raloxifene (ortholog) | 5 | 70349791 | 70384673 | Rat | 22 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9000713 | Cylc2 | cylicin 2 | INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | NW_004955419 | 23183700 | 23218555 | Chinchilla | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 11667972 | CYLC2 | cylicin 2 | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (inferred); nucleus (inferred); perinuc lear theca (inferred) | 9 | 74188934 | 74208842 | Bonobo | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 13997349 | CYLC2 | cylicin 2 | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (inferred); perinuclear theca (inferred ); sperm glycocalyx (inferred) | | | | Pig | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 18344034 | CYLC2 | cylicin 2 | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (inferred); nucleus (inferred); perinuc lear theca (inferred) | | | | Green Monkey | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 124883114 | Cylc2 | cylicin 2 | INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | | | | Squirrel | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 626107792 | Cylc2 | cylicin 2 | INVOLVED IN acrosome assembly (ortholog); maintenance of cell number (ortholog); manchette assembly (ortholog); FOUND IN cytoskeletal calyx (ortholog); perinuclear theca (ortholog); sperm glycocalyx (ortholog) | | | | Black Rat | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 1618148 | Eva1a | eva-1 homolog A, regulator of programmed cell death | Acts upstream of or within several processes, including TOR signaling; cardiac left ventricle morphogenesis; and connective tissue replacement. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in foot; hand; left lung; renal caly ht:700;'>calyx; and right lung. Orthologous to human EVA1A (eva-1 homolog A, regulator of programmed cell death). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 82018058 | 82070079 | Mouse | 140 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 62100 | Faah | fatty acid amide hydrolase | Enables monoacylglycerol lipase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Is active in glutamatergic synapse. Is expressed in several structures, including brain; ganglia; gut; olfactory epithelium; and renal caly weight:700;'>calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 115853866 | 115876034 | Mouse | 288 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315506 | Fam149a | family with sequence similarity 149, member A | Is expressed in renal calyx. Orthologous to human FAM149A (family with sequence similarity 149 member A). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 45789752 | 45835328 | Mouse | 104 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737425 | Git1 | GIT ArfGAP 1 | Predicted to enable several functions, including GTPase activator activity; enzyme binding activity; and gamma-tubulin binding activity. Predicted to be a structural constituent of postsynaptic specialization. Involved in several processes, including modulation of chemical synaptic transmission; neg ative regulation of metabolic process; and nervous system development. Acts upstream of or within ephrin receptor signaling pathway. Located in postsynapse. Is active in calyx of Held. Is expressed in embryo. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 77384114 | 77398600 | Mouse | 242 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8816544 | Git1 | GIT ArfGAP 1 | ENCODES a protein that exhibits gamma-tubulin binding (ortholog); GTPase activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN brain development (ortholog); cell redox homeostasis (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); genetic disease (ortholog); Huntington's disease (ortholog); FOUND IN calyx of Held (ortholog); centrosome (ortholog); cytosol (ortholog) | NW_004955481 | 3671728 | 3681279 | Chinchilla | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 18924020 | Git1 | GIT ArfGAP 1 | ENCODES a protein that exhibits gamma-tubulin binding (ortholog); GTPase activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN cell redox homeostasis (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to lipopolysaccharide (orth olog); PARTICIPATES IN Arf family mediated signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); genetic disease (ortholog); Huntington's disease (ortholog); FOUND IN calyx of Held (ortholog); centrosome (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 625948992 | Git1 | GIT ArfGAP 1 | ENCODES a protein that exhibits gamma-tubulin binding (ortholog); GTPase activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN brain development (ortholog); cell redox homeostasis (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); genetic disease (ortholog); Huntington's disease (ortholog); FOUND IN calyx of Held (ortholog); centrosome (ortholog); cytosol (ortholog) | | | | Black Rat | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 1359708 | Git2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); PARTICIPATES IN endocytosis pathway; ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN caly ont-weight:700;'>calyx of Held (ortholog); nucleoplasm (ortholog); presynapse (ortholog); INTERACTS WITH 2,4,6-trinitrotoluene; 2,6-dinitrotoluene; atrazine | 12 | 47490350 | 47531232 | Rat | 105 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550927 | Git2 | GIT ArfGAP 2 | Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral response to pain. Is active in caly yx of Held. Is expressed in genitourinary system. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 114865469 | 114912647 | Mouse | 121 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9033175 | Git2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); nucleoplasm (ortholog); presynapse (ortholog) | NW_004955455 | 8611218 | 8669527 | Chinchilla | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 11838896 | GIT2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | 12 | 107505791 | 107572641 | Bonobo | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 12160116 | GIT2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | 26 | 17170651 | 17217634 | Dog | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 12575582 | Git2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | NW_004936769 | 1529983 | 1574805 | Squirrel | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 14182966 | GIT2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | | | | Pig | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 18606161 | GIT2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | | | | Green Monkey | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 18924962 | Git2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); nucleoplasm (ortholog); presynapse (ortholog) | | | | Naked Mole-Rat | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 626057684 | Git2 | GIT ArfGAP 2 | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); regulation of synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH inflammatory bowel disease (ortholog); FOUND IN calyx of Held (ortholog); nucleoplasm (ortholog); presynapse (ortholog) | | | | Black Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 2704 | Glra1 | glycine receptor, alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity; extracellularly glycine-gated ion channel activity; glycine binding; INVOLVED IN chloride transport; monoatomic anion transport; synaptic transmission, glycinergic; PARTICIPATES IN Inhibitory synaptic transmissi on pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held; endoplasmic reticulum; external side of plasma membrane; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; atrazine | 10 | 40128284 | 40228612 | Rat | 257 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9049429 | Glra1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); external side of plasma membrane (ortholog) | NW_004955408 | 6236092 | 6333166 | Chinchilla | 87 | description | gene, protein-coding, MODEL [RefSeq] |
| 11814475 | GLRA1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); postsynaptic specialization membrane (ortholog) | 5 | 147245741 | 147348555 | Bonobo | 100 | description | gene, protein-coding, MODEL [RefSeq] |
| 12304129 | GLRA1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); postsynaptic specialization membrane (ortholog); INTERACTS WITH digoxin; Doramectin; ivermectin | 4 | 57443094 | 57541494 | Dog | 106 | description | gene, protein-coding, MODEL [RefSeq] |
| 12534711 | Glra1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); postsynaptic specialization membrane (ortholog) | NW_004936515 | 10816712 | 10896958 | Squirrel | 99 | description | gene, protein-coding, MODEL [RefSeq] |
| 14244029 | GLRA1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); postsynaptic specialization membrane (ortholog) | | | | Pig | 103 | description | gene, protein-coding, MODEL [RefSeq] |
| 18490699 | GLRA1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); postsynaptic specialization membrane (ortholog) | | | | Green Monkey | 100 | description | gene, protein-coding, MODEL [RefSeq] |
| 18922802 | Glra1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); external side of plasma membrane (ortholog) | | | | Naked Mole-Rat | 93 | description | gene, protein-coding, MODEL [RefSeq] |
| 625929896 | Glra1 | glycine receptor alpha 1 | ENCODES a protein that exhibits extracellularly glycine-gated chloride channel activity (ortholog); extracellularly glycine-gated ion channel activity (ortholog); glycine binding (ortholog); INVOLVED IN acrosome reaction (ortholog); action potential (ortholog); adult walking behavior (ortholog); PAR TICIPATES IN Inhibitory synaptic transmission pathway; ASSOCIATED WITH dystonia (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); endoplasmic reticulum (ortholog); external side of plasma membrane (ortholog) | | | | Black Rat | 87 | description | gene, protein-coding, MODEL [RefSeq] |
| 1623058 | Gpn2 | GPN-loop GTPase 2 | Predicted to enable GTPase activity. Is expressed in collecting duct; liver; renal calyx; and ureter. Orthologous to human GPN2 (GPN-loop GTPase 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 133311684 | 133319046 | Mouse | 58 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2846 | Htr1b | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity; heterocyclic compound binding; voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels; INVOLVED IN chemical synaptic transmission; drinking behavior; feeding behavior; ASSOCI ATED WITH abnormal fear/anxiety-related behavior; ASSOCIATED WITH Anorexia; anxiety disorder; Dyskinesias; FOUND IN calyx of Held; cytoplasm (ortholog); G protein-coupled serotonin receptor complex (ortholog); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine | 8 | 91395405 | 91414815 | Rat | 200 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8943561 | Htr1b | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gi/o-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase -inhibiting serotonin receptor signaling pathway (ortholog); bone remodeling (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amphetamine abuse (ortholog); FOUND IN calyx of Held (ortholog); cytoplasm (ortholog); G protein-coupled serotonin receptor complex (ortholog) | NW_004955502 | 5640919 | 5646899 | Chinchilla | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 11994364 | HTR1B | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN bone remodeling (ortholog); chemical synap tic transmission (ortholog); drinking behavior (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog) | 6 | 75309078 | 75313747 | Bonobo | 99 | description | gene, protein-coding, MODEL [RefSeq] |
| 12408957 | HTR1B | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN adenylate cyclase-inhibiting serotonin rec eptor signaling pathway (ortholog); bone remodeling (ortholog); cellular response to alkaloid (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amphetamine abuse (ortholog); FOUND IN calyx of Held (ortholog); plasma membrane (ortholog); INTERACTS WITH capsaicin | 12 | 38659088 | 38659546 | Dog | 98 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12502545 | Htr1b | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN bone remodeling (ortholog); chemical synap tic transmission (ortholog); drinking behavior (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog) | NW_004936890 | 154252 | 157044 | Squirrel | 96 | description | gene, protein-coding, MODEL [RefSeq] |
| 14262186 | HTR1B | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN adenylate cyclase-inhibiting serotonin rec eptor signaling pathway (ortholog); bone remodeling (ortholog); cellular response to alkaloid (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog); plasma membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 107 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18606788 | HTR1B | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN bone remodeling (ortholog); chemical synap tic transmission (ortholog); drinking behavior (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog) | | | | Green Monkey | 99 | description | gene, protein-coding, MODEL [RefSeq] |
| 18920462 | Htr1b | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN bone remodeling (ortholog); chemical synap tic transmission (ortholog); drinking behavior (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog) | | | | Naked Mole-Rat | 96 | description | gene, protein-coding, MODEL [RefSeq] |
| 626087666 | Htr1b | 5-hydroxytryptamine receptor 1B | ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); Gi/o-coupled serotonin receptor activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase -inhibiting serotonin receptor signaling pathway (ortholog); bone remodeling (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); Anorexia (ortholog); FOUND IN calyx of Held (ortholog); cytoplasm (ortholog); G protein-coupled serotonin receptor complex (ortholog) | | | | Black Rat | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 10791 | Il1rap | interleukin 1 receptor accessory protein | Enables interleukin-1 receptor activity and interleukin-33 receptor activity. Involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Acts upstream of or within cytokine-mediated signaling pat hway. Is active in glutamatergic synapse. Is expressed in several structures, including aorta-gonad-mesonephros; brain ventricle and choroid plexus; forebrain; renal calyx; and ventral grey horn. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 26400259 | 26548878 | Mouse | 229 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1332367 | Itsn1 | intersectin 1 (SH3 domain protein 1A) | Enables kinase activator activity. Involved in synaptic vesicle endocytosis. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and small GTPase-mediated s ignal transduction. Located in clathrin-coated pit; endocytic vesicle; and lamellipodium. Is active in calyx of Held; cytosol; and presynaptic endocytic zone. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 91526198 | 91717479 | Mouse | 247 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8873193 | Itsn1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); molecular adaptor activity (ortholog); proline-rich region binding (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); intracellular protein localization (ortholog); PARTICIPATES IN clathrin-dependent s ynaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | NW_004955407 | 33056004 | 33275681 | Chinchilla | 68 | description | gene, protein-coding, MODEL [RefSeq] |
| 11751332 | ITSN1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectiona l signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | 21 | 20009385 | 20266835 | Bonobo | 94 | description | gene, protein-coding, MODEL [RefSeq] |
| 12224546 | ITSN1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); molecular adaptor activity (ortholog); proline-rich region binding (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); intracellular protein localization (ortholog); PARTICIPATES IN clathrin-dependent s ynaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | 31 | 29144754 | 29360134 | Dog | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 12472728 | Itsn1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectiona l signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | NW_004936500 | 8490514 | 8678127 | Squirrel | 93 | description | gene, protein-coding, MODEL [RefSeq] |
| 14123880 | ITSN1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectiona l signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | | | | Pig | 91 | description | gene, protein-coding, MODEL [RefSeq] |
| 18724488 | ITSN1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; ephrin - ephrin receptor bidirectiona l signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | | | | Green Monkey | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 18917005 | Itsn1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); molecular adaptor activity (ortholog); proline-rich region binding (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); intracellular protein localization (ortholog); PARTICIPATES IN clathrin-dependent s ynaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | | | | Naked Mole-Rat | 82 | description | gene, protein-coding, MODEL [RefSeq] |
| 625990520 | Itsn1 | intersectin 1 | ENCODES a protein that exhibits kinase activator activity (ortholog); molecular adaptor activity (ortholog); proline-rich region binding (ortholog); INVOLVED IN cell-cell signaling (ortholog); endocytosis (ortholog); intracellular protein localization (ortholog); PARTICIPATES IN clathrin-dependent s ynaptic vesicle endocytosis; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); esophageal atresia/tracheoesophageal fistula (ortholog); FOUND IN apical dendrite (ortholog); calyx of Held (ortholog); clathrin-coated pit (ortholog) | | | | Black Rat | 68 | description | gene, protein-coding, MODEL [RefSeq] |
| 2949 | Kcna1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN a xon development; cell communication by electrical coupling; cerebral cortex development; ASSOCIATED WITH convulsive seizures; environmentally induced seizures; ASSOCIATED WITH epilepsy with generalized tonic-clonic seizures; episodic ataxia type 1; Myokymia; FOUND IN apical plasma membrane; calyx of Held; cell surface; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acrylamide | 4 | 161150378 | 161160051 | Rat | 236 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12041426 | KCNA1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane po tential (ortholog); INVOLVED IN axon development (ortholog); cell communication by electrical coupling (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH epilepsy (ortholog); epilepsy with generalized tonic-clonic seizures (ortholog); episodic ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 12 | 5027333 | 5037136 | Bonobo | 101 | description | gene, protein-coding, MODEL [RefSeq] |
| 12105823 | KCNA1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane po tential (ortholog); INVOLVED IN axon development (ortholog); cell communication by electrical coupling (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH epilepsy (ortholog); epilepsy with generalized tonic-clonic seizures (ortholog); episodic ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 27 | 39928347 | 39936753 | Dog | 100 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 14086529 | KCNA1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane po tential (ortholog); INVOLVED IN axon development (ortholog); cell communication by electrical coupling (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH epilepsy (ortholog); epilepsy with generalized tonic-clonic seizures (ortholog); episodic ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Pig | 102 | description | gene, protein-coding, MODEL [RefSeq] |
| 18493660 | KCNA1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane po tential (ortholog); INVOLVED IN axon development (ortholog); cell communication by electrical coupling (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH epilepsy (ortholog); epilepsy with generalized tonic-clonic seizures (ortholog); episodic ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Green Monkey | 101 | description | gene, protein-coding, MODEL [RefSeq] |
| 18936822 | Kcna1 | potassium voltage-gated channel subfamily A member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane po tential (ortholog); INVOLVED IN axon development (ortholog); cell communication by electrical coupling (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH epilepsy (ortholog); epilepsy with generalized tonic-clonic seizures (ortholog); episodic ataxia (ortholog); FOUND IN apical plasma membrane (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 102 | description | gene, protein-coding, MODEL [RefSeq] |
| 2950 | Kcna2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; kinesin binding; outward rectifier potassium channel activity; INVOLVED IN cerebral cortex development; corpus callosum development; neuronal action potential; ASSOCIATED WITH Experimental Diabetes Mellitus; autism spectru m disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN calyx of Held; glutamatergic synapse; juxtaparanode region of axon; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil | 2 | 197392746 | 197406606 | Rat | 214 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 11771955 | KCNA2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits kinesin binding (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | 1 | 113187158 | 113256260 | Bonobo | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 12235737 | KCNA2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits voltage-gated potassium channel activity; delayed rectifier potassium channel activity (ortholog); kinesin binding (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 6 | 41405453 | 41415727 | Dog | 102 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12692265 | Kcna2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits kinesin binding (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | NW_004936704 | 2007577 | 2019520 | Squirrel | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 14184349 | KCNA2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits kinesin binding (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | | | | Pig | 85 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18426534 | KCNA2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits kinesin binding (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | | | | Green Monkey | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 18912801 | Kcna2 | potassium voltage-gated channel subfamily A member 2 | ENCODES a protein that exhibits kinesin binding (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN axon (ortholog); axon initial segment (ortholog); calyx of Held (ortholog) | | | | Naked Mole-Rat | 81 | description | gene, protein-coding, MODEL [RefSeq] |
| 2951 | Kcna3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; outward rectifier potassium channel activity; voltage-gated potassium channel activity; INVOLVED IN corpus callosum development; optic nerve development; potassium ion transmembrane transport; ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held; glutamatergic synapse; membrane raft; INTERACTS WITH acetamide; ammonium chloride; bisphenol A | 2 | 197320324 | 197322277 | Rat | 129 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8944773 | Kcna3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); glutamatergic synapse (ortholog) | NW_004955435 | 14132877 | 14148911 | Chinchilla | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 11690385 | KCNA3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); glutamatergic synapse (ortholog) | 1 | 113304340 | 113323367 | Bonobo | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 12193857 | KCNA3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); ASSOCIATED WI TH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | 6 | 41343613 | 41363076 | Dog | 51 | description | gene, protein-coding, MODEL [RefSeq] |
| 12550874 | Kcna3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); ASSOCIATED WI TH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | NW_004936704 | 2083037 | 2085917 | Squirrel | 53 | description | gene, protein-coding, MODEL [RefSeq] |
| 14139434 | KCNA3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); ASSOCIATED WI TH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | | | | Pig | 51 | description | gene, protein-coding, MODEL [RefSeq] |
| 18754524 | KCNA3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); ASSOCIATED WI TH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | | | | Green Monkey | 52 | description | gene, protein-coding, MODEL [RefSeq] |
| 18923176 | Kcna3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); ASSOCIATED WI TH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); membrane raft (ortholog) | | | | Naked Mole-Rat | 50 | description | gene, protein-coding, MODEL [RefSeq] |
| 625978768 | Kcna3 | potassium voltage-gated channel subfamily A member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); genetic disease (ortholog); hypertension (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 2955 | Kcnc1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity; transmembrane transporter binding; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN cellular response to xenobiotic stimulus; cerebellum development; corpu s callosum development; ASSOCIATED WITH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held; cell surface; dendrite; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; Ampullosporin | 1 | 106039247 | 106081034 | Rat | 171 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8952193 | Kcnc1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); kinesin binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholog); corpus callosum development (ortholog ); ASSOCIATED WITH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axolemma (ortholog); calyx of Held (ortholog); cell surface (ortholog) | NW_004955414 | 32538968 | 32580370 | Chinchilla | 57 | description | gene, protein-coding, MODEL [RefSeq] |
| 11952710 | KCNC1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholog); corpus callosum development (ortholog); ASSOCIATED WI TH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); cell surface (ortholog); dendrite (ortholog) | 11 | 17788010 | 17936591 | Bonobo | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 12378292 | KCNC1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholo g); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); cell surface (ortholog); dendrite (ortholog) | 21 | 40273366 | 40315189 | Dog | 69 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12691441 | Kcnc1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholog); corpus callosum development (ortholog); ASSOCIATED WI TH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); cell surface (ortholog); dendrite (ortholog) | NW_004936528 | 1351687 | 1393926 | Squirrel | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 14269855 | KCNC1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholog); corpus callosum development (ortholog); ASSOCIATED WI TH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); cell surface (ortholog); dendrite (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 84 | description | gene, protein-coding, MODEL [RefSeq] |
| 18778865 | KCNC1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholog); corpus callosum development (ortholog); ASSOCIATED WI TH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN calyx of Held (ortholog); cell surface (ortholog); dendrite (ortholog) | | | | Green Monkey | 79 | description | gene, protein-coding, MODEL [RefSeq] |
| 18904668 | Kcnc1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits kinesin binding (ortholog); transmembrane transporter binding (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum dev elopment (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axolemma (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 77 | description | gene, protein-coding, MODEL [RefSeq] |
| 625913151 | Kcnc1 | potassium voltage-gated channel subfamily C member 1 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (ortholog); kinesin binding (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); cerebellum development (ortholog); corpus callosum development (ortholog ); ASSOCIATED WITH Alzheimer's disease (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN axolemma (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Black Rat | 56 | description | gene, protein-coding, MODEL [RefSeq] |
| 733064 | Kcnc3 | potassium voltage gated channel, Shaw-related subfamily, member 3 | Enables voltage-gated potassium channel activity. Involved in regulation of synaptic vesicle endocytosis. Acts upstream of or within regulation of neurotransmitter secretion. Located in several cellular components, including neuromuscular junction; neuron projection membrane; and neuronal cell body membrane. Is active in calyx of Held. Is expressed in aorta; aortic valve; and brain. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 44236405 | 44254175 | Mouse | 168 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8745766 | Kcnc3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); cortical actin cytoskeleton organization (ortholog); optic nerve development (ortholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ort holog); FOUND IN axolemma (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | NW_004955559 | 782842 | 795455 | Chinchilla | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 11680584 | KCNC3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); cortical actin cytoskeleton organization (ortholog); optic nerve development (ortholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ort holog); FOUND IN axolemma (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 19 | 47275213 | 47296809 | Bonobo | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 12249363 | KCNC3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits monoatomic ion channel activity (inferred); potassium channel activity (inferred); voltage-gated potassium channel activity (inferred); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); regulation of neurotransmitter secretion (or tholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ortholog); FOUND IN axolemma (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 1 | 106366657 | 106371062 | Dog | 49 | description | gene, protein-coding, MODEL [RefSeq] |
| 12633285 | Kcnc3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (inferred); monoatomic ion channel activity (inferred); potassium channel activity (inferred); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); regulation of neurotransmitter secretion (ortholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ortholog); FOUND IN axolemma (ortholog); calyx of Held (ortholog); glutamatergic synapse (ortholog) | NW_004936889 | 185349 | 203847 | Squirrel | 48 | description | gene, protein-coding, MODEL [RefSeq] |
| 13897791 | KCNC3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits monoatomic ion channel activity (inferred); potassium channel activity (inferred); voltage-gated potassium channel activity (inferred); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); regulation of neurotransmitter secretion (or tholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ortholog); FOUND IN axolemma (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | | | | Pig | 49 | description | gene, protein-coding, MODEL [RefSeq] |
| 18695892 | KCNC3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (inferred); monoatomic ion channel activity (inferred); potassium channel activity (inferred); INVOLVED IN corpus callosum development (ortholog); optic nerve development (ortholog); regulation of neurotransmitter secretion (ortholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ortholog); FOUND IN axolemma (ortholog); calyx of Held (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 50 | description | gene, protein-coding, MODEL [RefSeq] |
| 18922114 | Kcnc3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits delayed rectifier potassium channel activity (inferred); monoatomic ion channel activity (inferred); potassium channel activity (inferred); INVOLVED IN corpus callosum development (ortholog); cortical actin cytoskeleton organization (ortholog); optic nerve development (ortholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ortholog); FOUND IN axolemma (ortholog); calyx of Held (ortholog); cell cortex (ortholog) | | | | Naked Mole-Rat | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 626133988 | Kcnc3 | potassium voltage-gated channel subfamily C member 3 | ENCODES a protein that exhibits voltage-gated potassium channel activity (ortholog); INVOLVED IN corpus callosum development (ortholog); cortical actin cytoskeleton organization (ortholog); optic nerve development (ortholog); ASSOCIATED WITH genetic disease (ortholog); spinocerebellar ataxia 13 (ort holog); FOUND IN axolemma (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | | | | Black Rat | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 1589169 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity; INVOLVED IN axon development; cerebral cortex development; corpus callosum development; ASSOCIATED WITH Hyperalgesia; sciatic neuropathy; status epilepticus; FOUND IN axon; calyx of Held; cell surface; INTERACTS WITH (+)-pilocarpine; (5Z,8Z,11Z,13E)-15-HETE; 2,3,7,8-tetrachlorodibenzodioxine | 2 | 197747095 | 197788467 | Rat | 130 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8975539 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activ ity (ortholog); INVOLVED IN axon development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | NW_004955435 | 13728272 | 13750420 | Chinchilla | 38 | description | gene, protein-coding, MODEL [RefSeq] |
| 12018879 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | 1 | 112860887 | 112884687 | Bonobo | 60 | description | gene, protein-coding, MODEL [RefSeq] |
| 12056086 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | 6 | 41743214 | 41764572 | Dog | 58 | description | gene, protein-coding, MODEL [RefSeq] |
| 12439346 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | NW_004936704 | 1667387 | 1689337 | Squirrel | 62 | description | gene, protein-coding, MODEL [RefSeq] |
| 14170346 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | | | | Pig | 58 | description | gene, protein-coding, MODEL [RefSeq] |
| 18676144 | KCNC4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Green Monkey | 63 | description | gene, protein-coding, MODEL [RefSeq] |
| 18904921 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN axon development (ortholo g); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 66 | description | gene, protein-coding, MODEL [RefSeq] |
| 626135712 | Kcnc4 | potassium voltage-gated channel subfamily C member 4 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activ ity (ortholog); INVOLVED IN axon development (ortholog); cerebral cortex development (ortholog); corpus callosum development (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Hyperalgesia (ortholog); sciatic neuropathy (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); calyx of Held (ortholog) | | | | Black Rat | 38 | description | gene, protein-coding, MODEL [RefSeq] |
| 628848 | Kcnq5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; voltage-gated potassium channel activity; INVOLVED IN potassium ion transport; potassium ion transmembrane transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held; presynaptic membrane; clathrin coat (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; ammonium chloride | 9 | 31326595 | 31892399 | Rat | 124 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550963 | Kcnq5 | potassium voltage-gated channel, subfamily Q, member 5 | Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of clathrin coat and voltage-gated potassium channel complex. Predicted to be active in calyx o f Held and presynaptic membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 21468623 | 22032874 | Mouse | 123 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8836666 | Kcnq5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); AS SOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); clathrin coat (ortholog); plasma membrane (ortholog) | NW_004955488 | 7406633 | 7928526 | Chinchilla | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 11723174 | KCNQ5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); presynaptic membrane (ortholog) | 6 | 70448161 | 71025173 | Bonobo | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 12309802 | KCNQ5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); presynaptic membrane (ortholog) | 12 | 34872514 | 35364794 | Dog | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 12457498 | Kcnq5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); presynaptic membrane (ortholog) | NW_004936618 | 4283240 | 4815571 | Squirrel | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 14000434 | KCNQ5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); presynaptic membrane (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 45 | description | gene, protein-coding, MODEL [RefSeq] |
| 18346180 | KCNQ5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); presynaptic membrane (ortholog) | | | | Green Monkey | 42 | description | gene, protein-coding, MODEL [RefSeq] |
| 18904094 | Kcnq5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transport (ortholog); ASSOCIATED WITH autosomal dominant intellectual deve lopmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); clathrin coat (ortholog); presynaptic membrane (ortholog) | | | | Naked Mole-Rat | 38 | description | gene, protein-coding, MODEL [RefSeq] |
| 625875003 | Kcnq5 | potassium voltage-gated channel subfamily Q member 5 | ENCODES a protein that exhibits voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated potassium channel activity (ortholog); INVOLVED IN potassium ion transmembrane transport (ortholog); potassium ion transport (ortholog); AS SOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 46 (ortholog); congenital diaphragmatic hernia (ortholog); FOUND IN calyx of Held (ortholog); clathrin coat (ortholog); plasma membrane (ortholog) | | | | Black Rat | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 1623931 | Krt80 | keratin 80 | Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in keratin filament. Is expressed in molar; naris; renal caly font-weight:700;'>calyx; submandibular gland primordium; and vibrissa. Orthologous to human KRT80 (keratin 80). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 101246196 | 101268043 | Mouse | 115 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1347368 | LCN10 | lipocalin 10 | Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specifi c cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009] | 9 | 136738170 | 136742940 | Human | 20 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1350830 | LCN12 | lipocalin 12 | Members of the lipocalin family, such as LCN12, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specifi c cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009] | 9 | 136949197 | 136956538 | Human | 49 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1343207 | LCN8 | lipocalin 8 | Members of the lipocalin family, such as LCN8, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009] | 9 | 136754386 | 136758543 | Human | 23 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1345733 | LCN9 | lipocalin 9 | Members of the lipocalin family, such as LCN9, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009] | 9 | 135663309 | 135666961 | Human | 15 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18926087 | LOC101701409 | cylicin-1-like | ENCODES a protein that exhibits structural constituent of cytoskeleton (inferred); INVOLVED IN cell differentiation (inferred); cytoskeleton organization (inferred); spermatogenesis (inferred); FOUND IN acrosomal matrix (inferred); cytoskeletal calyx (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 7 | description | gene, protein-coding, MODEL [RefSeq] |
| 12446997 | LOC101960999 | voltage-dependent P/Q-type calcium channel subunit alpha-1A | ENCODES a protein that exhibits calmodulin binding (ortholog); high voltage-gated calcium channel activity (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); behavioral response to pain (ortholog); calcium ion import (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH Alternating Hemiplegia of Childhood 1 (ortholog); amyotrophic lateral sclerosis (ortholog); Ataxia (ortholog); FOUND IN calyx of Held (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog) | NW_004936659 | 2201606 | 2269625 | Squirrel | 241 | description | gene, protein-coding, MODEL [RefSeq] |
| 1623807 | Ly6g2 | lymphocyte antigen 6 family member G2 | Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in midgut; renal calyx; and r enal pelvis. [provided by Alliance of Genome Resources, Jul 2025] | 15 | 75088227 | 75094510 | Mouse | 12 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552593 | Marveld3 | MARVEL (membrane-associating) domain containing 3 | Predicted to enable mitogen-activated protein kinase kinase kinase binding activity. Acts upstream of or within cell-cell junction organization; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Located in bicellular tight junction. Is expres sed in brain ventricle and choroid plexus; foregut; renal calyx; retina; and trachea. Orthologous to human MARVELD3 (MARVEL domain containing 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 110674541 | 110688837 | Mouse | 119 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319560 | Nacc2 | nucleus accumbens associated 2, BEN and BTB (POZ) domain containing | Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Predicted to be located in chromatin; mitochondrion; and nucleolus. Is expressed in several structures, including brain; limb; renal calyx; submandibular gland primordium; and tooth. Orthologous to human NACC2 (NACC family member 2). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 25945547 | 26012823 | Mouse | 150 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68417 | Ncs1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding; magnesium ion binding; protein kinase binding; INVOLVED IN positive regulation of calcium-mediated signaling; positive regulation of exocytosis; regulation of neuron projection development; PARTICIPATES IN calcium/calcium-mediated signaling pathwa y; FOUND IN calyx of Held; dense core granule; glutamatergic synapse; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; amitrole | 3 | 34920949 | 34966554 | Rat | 132 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8924004 | Ncs1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN axon (ortholog); calyx of Held (ortholog); cytoplasm (ortholog) | NW_004955513 | 268979 | 289385 | Chinchilla | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 11992394 | NCS1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN calyx of Held (ortholog); dense core granule (ortholog); glutamatergic synapse (ortholog) | 9 | 101299724 | 101364897 | Bonobo | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 12088742 | NCS1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN axon (ortholog); calyx of Held (ortholog); cytoplasm (ortholog) | 9 | 53661361 | 53676925 | Dog | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 14027794 | NCS1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN calyx of Held (ortholog); dense core granule (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18511796 | NCS1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN axon (ortholog); calyx of Held (ortholog); cytoplasm (ortholog) | | | | Green Monkey | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 18906554 | Ncs1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN calyx of Held (ortholog); dense core granule (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 125021173 | Ncs1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN axon (ortholog); calyx of Held (ortholog); cytoplasm (ortholog) | | | | Squirrel | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 626057247 | Ncs1 | neuronal calcium sensor 1 | ENCODES a protein that exhibits calcium ion binding (ortholog); magnesium ion binding (ortholog); protein kinase binding (ortholog); INVOLVED IN positive regulation of calcium-mediated signaling (ortholog); positive regulation of exocytosis (ortholog); regulation of neuron projection development (or tholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; FOUND IN axon (ortholog); calyx of Held (ortholog); cytoplasm (ortholog) | | | | Black Rat | 28 | description | gene, protein-coding, MODEL [RefSeq] |
| 10991 | Nos1 | nitric oxide synthase 1, neuronal | Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 118004904 | 118096905 | Mouse | 902 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18789965 | NOS1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to growth factor stimulus (ortholog) ; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); calyx of Held (ortholog); caveola (ortholog) | | | | Green Monkey | 254 | description | gene, protein-coding, MODEL [RefSeq] |
| 18928719 | Nos1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to growth factor stimulus (ortholog) ; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); calyx of Held (ortholog); caveola (ortholog) | | | | Naked Mole-Rat | 259 | description | gene, protein-coding, MODEL [RefSeq] |
| 20865819 | NOS1 | nitric oxide synthase 1 | ENCODES a protein that exhibits arginine binding (inferred); calmodulin binding (inferred); FMN binding (inferred); INVOLVED IN cellular response to growth factor stimulus (inferred); multicellular organismal response to stress (inferred); negative regulation of serotonin uptake (inferred); FOUND IN calyx of Held (inferred); caveola (inferred); cell projection (inferred) | | | | Green Monkey | 40 | description | gene, protein-coding |
| 626049975 | Nos1 | nitric oxide synthase 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cadmium ion binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN behavioral response to cocaine (ortholog); cellular response to epinephrine stimulus (ortholog); cellular response to growth factor stimulus (ortholog) ; PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH achalasia (ortholog); acute kidney failure (ortholog); acute necrotizing pancreatitis (ortholog); FOUND IN azurophil granule (ortholog); calyx of Held (ortholog); caveola (ortholog) | | | | Black Rat | 254 | description | gene, protein-coding, MODEL [RefSeq] |
| 1615897 | Pbld2 | phenazine biosynthesis-like protein domain containing 2 | Predicted to enable identical protein binding activity and isomerase activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to act upstream of or within with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. P redicted to be active in cytoplasm. Is expressed in pancreas epithelium and renal calyx. Orthologous to human PBLD (phenazine biosynthesis like protein domain containing). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 62858319 | 62894592 | Mouse | 40 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 731879 | Plscr1 | phospholipid scramblase 1 | Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to lipopolysaccharide; negative regulation of vir al genome replication; and phosphatidylserine biosynthetic process. Acts upstream of or within myeloid cell differentiation; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Located in cytosol; nucleus; and plasma membrane. Is expressed in hindgut; midgut; renal calyx; and renal pelvis. Orthologous to human PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 92132265 | 92154034 | Mouse | 280 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 737063 | Prkca | protein kinase C, alpha | Enables calcium,diacylglycerol-dependent serine/threonine kinase activity; integrin binding activity; and lipid binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of cytokine production involved in inflammatory response; and p ositive regulation of bone resorption. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including cone photoreceptor outer segment; intercalated disc; and ooplasm. Part of alphav-beta3 integrin-PKCalpha complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 107824213 | 108237360 | Mouse | 696 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550017 | Prkcb | protein kinase C, beta | Enables calcium channel regulator activity and calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; and positive regulation of cell communication. Acts upstream of or within several processes, including cellular response to carbohydrate stimulus; intracellular calcium ion homeostasis; and protein phosphorylation. Located in cytoplasm and nucleus. Part of spectrin. Is active in calyx of Held; plasma membrane; and presynaptic cytosol. Is expressed in several structures, including central nervous system; exocrine system; genitourinary system; heart ventricle; and retina. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 121888327 | 122233625 | Mouse | 521 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8758313 | Prkcb | protein kinase C beta | ENCODES a protein that exhibits calcium channel regulator activity (ortholog); calcium,diacylglycerol-dependent serine/threonine kinase activity (ortholog); chromatin binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell receptor signaling pathway (ortholog); calcium ion transport (or tholog); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); Alzheimer's disease (ortholog); autistic disorder (ortholog); FOUND IN brush border membrane (ortholog); calyx of Held (ortholog); centrosome (ortholog) | NW_004955493 | 2395494 | 2710522 | Chinchilla | 102 | description | gene, protein-coding, MODEL [RefSeq] |
| 18922389 | Prkcb | protein kinase C beta | ENCODES a protein that exhibits calcium channel regulator activity (ortholog); chromatin binding (ortholog); histone binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell receptor signaling pathway (ortholog); calcium ion transport (ortholog); PARTICIPATES IN insulin signaling pathway ; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); Alzheimer's disease (ortholog); autistic disorder (ortholog); FOUND IN brush border membrane (ortholog); calyx of Held (ortholog); centrosome (ortholog) | | | | Naked Mole-Rat | 120 | description | gene, protein-coding, MODEL [RefSeq] |
| 625977199 | Prkcb | protein kinase C beta | ENCODES a protein that exhibits calcium channel regulator activity (ortholog); calcium,diacylglycerol-dependent serine/threonine kinase activity (ortholog); chromatin binding (ortholog); INVOLVED IN B cell activation (ortholog); B cell receptor signaling pathway (ortholog); calcium ion transport (or tholog); PARTICIPATES IN insulin signaling pathway; interleukin-2 signaling pathway; protein kinase C (PKC) signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); Alzheimer's disease (ortholog); autistic disorder (ortholog); FOUND IN brush border membrane (ortholog); calyx of Held (ortholog); centrosome (ortholog) | | | | Black Rat | 102 | description | gene, protein-coding, MODEL [RefSeq] |
| 11147 | Prkcg | protein kinase C, gamma | Enables calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and response to morphine. Acts upstream of or within chemosensory behavior; regulation o f phagocytosis; and synaptic signaling via neuropeptide. Located in several cellular components, including dendrite; postsynaptic density; and synaptic membrane. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Used to study spinocerebellar ataxia type 14. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 14. Orthologous to human PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 3352038 | 3379615 | Mouse | 261 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8857853 | Prkcg | protein kinase C gamma | ENCODES a protein that exhibits calcium,diacylglycerol-dependent serine/threonine kinase activity (ortholog); protein kinase activity (ortholog); protein serine/threonine/tyrosine kinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); chemosensory behavior (ortholog); inn ervation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 14 (ortholog); FOUND IN calyx of Held (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog) | NW_004955604 | 262182 | 279259 | Chinchilla | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 18914314 | Prkcg | protein kinase C gamma | ENCODES a protein that exhibits calcium,diacylglycerol-dependent serine/threonine kinase activity (ortholog); protein serine/threonine/tyrosine kinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); chemosensory behavior (ortholog); innervation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 14 (ortholog); FOUND IN calyx of Held (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog) | | | | Naked Mole-Rat | 89 | description | gene, protein-coding, MODEL [RefSeq] |
| 626010545 | Prkcg | protein kinase C gamma | ENCODES a protein that exhibits calcium,diacylglycerol-dependent serine/threonine kinase activity (ortholog); protein kinase activity (ortholog); protein serine/threonine/tyrosine kinase activity (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); chemosensory behavior (ortholog); inn ervation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; insulin signaling pathway; ASSOCIATED WITH Animal Disease Models (ortholog); autosomal dominant cerebellar ataxia (ortholog); autosomal recessive spinocerebellar ataxia 14 (ortholog); FOUND IN calyx of Held (ortholog); cell-cell junction (ortholog); cytoplasm (ortholog) | | | | Black Rat | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 736434 | Ptprj | protein tyrosine phosphatase receptor type J | Enables protein tyrosine phosphatase activity. Involved in several processes, including peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; regulation of cell migration; and regulation of signal transduction. Acts upstream of or within heart development; oligoden drocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung squamous cell carcinoma; and thrombocytopenia. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 90260100 | 90411102 | Mouse | 308 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552784 | Rhcg | Rhesus blood group-associated C glycoprotein | Enables ammonium channel activity. Involved in ammonium transmembrane transport and regulation of pH. Located in apical plasma membrane. Is expressed in medulla oblongata basal plate ventricular layer; renal calyx; spinal cord ventricular layer; and telencephalo n. Orthologous to human RHCG (Rh family C glycoprotein). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 79243111 | 79267405 | Mouse | 129 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319813 | Rigi | RNA sensor RIG-I | Enables double-stranded DNA binding activity; double-stranded RNA binding activity; and single-stranded RNA binding activity. Involved in several processes, including innate immune response; positive regulation of cytokine production; and response to virus. Acts upstream of or within response to exo genous dsRNA. Predicted to be located in actin cytoskeleton; bicellular tight junction; and ruffle membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including foregut; olfactory epithelium; ovary; renal calyx; and submandibular gland primordium. Orthologous to human RIGI (RNA sensor RIG-I). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 40203775 | 40239843 | Mouse | 331 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 708533 | Rimbp2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity; structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-dependent activati on of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil | 12 | 33383646 | 33582259 | Rat | 86 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 733346 | Rimbp2 | RIMS binding protein 2 | Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. A structural constituent of presynaptic active zone. Involved in regulation of cal cium-dependent activation of synaptic vesicle fusion and regulation of presynaptic membrane potential. Is active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Orthologous to human RIMBP2 (RIMS binding protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 128834852 | 129030636 | Mouse | 101 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606822 | RIMBP2 | RIMS binding protein 2 | Predicted to enable voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be a structural constituent of presynaptic active zone. P redicted to be involved in neuromuscular synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of presynaptic membrane potential. Predicted to be located in plasma membrane and synapse. Predicted to be active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 130396133 | 130716299 | Human | 82 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9033587 | Rimbp2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | NW_004955482 | 1326628 | 1431358 | Chinchilla | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12041736 | RIMBP2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | 12 | 128009575 | 128338009 | Bonobo | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 12138247 | RIMBP2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | 26 | 1519489 | 1744011 | Dog | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 12587899 | Rimbp2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN regulation of calcium-depend ent activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | NW_004936660 | 1433535 | 1601912 | Squirrel | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 14196103 | RIMBP2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | | | | Pig | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 18692806 | RIMBP2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | | | | Green Monkey | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 18931651 | Rimbp2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); INVOLVED IN regulation of calcium-depend ent activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | | | | Naked Mole-Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 626125690 | Rimbp2 | RIMS binding protein 2 | ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); structural constituent of presynaptic active zone (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of calcium-depende nt activation of synaptic vesicle fusion (ortholog); regulation of presynaptic membrane potential (ortholog); FOUND IN calyx of Held (ortholog); glutamatergic synapse (ortholog); presynaptic active zone cytoplasmic component (ortholog) | | | | Black Rat | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 1316538 | Rprd1a | regulation of nuclear pre-mRNA domain containing 1A | Predicted to enable RNA polymerase II complex binding activity and identical protein binding activity. Predicted to be involved in RNA polymerase II promoter clearance and mRNA 3'-end processing. Predicted to be located in nucleus. Predicted to be part of transcription preinitiation complex. Is expr essed in dorsal root ganglion; renal calyx; and submandibular gland primordium. Orthologous to human RPRD1A (regulation of nuclear pre-mRNA domain containing 1A). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 24618017 | 24663306 | Mouse | 89 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550240 | Septin5 | septin 5 | Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and protein homodimerization activity. Involved in adult behavior; regulation of synaptic vesicle docking; and social behavior. Located in cell cortex; synaptic vesicle; and terminal bouton. Par t of septin complex. Is active in calyx of Held. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human SEPTIN5 (septin 5). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 18440561 | 18448688 | Mouse | 143 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12330700 | SEPTIN5 | septin 5 | ENCODES a protein that exhibits GDP binding (ortholog); phosphatidylinositol binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN adult behavior (ortholog); negative regulation of regulated secretory pathway (ortholog); regulation of synaptic vesicle docking (ortholog); ASSO CIATED WITH adult respiratory distress syndrome (ortholog); Polyarteritis Nodosa, Childhood-Onset (ortholog); FOUND IN axon terminus (ortholog); calyx of Held (ortholog); cell cortex (ortholog) | 26 | 29568776 | 29573837 | Dog | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 14139964 | SEPTIN5 | septin 5 | ENCODES a protein that exhibits GDP binding (ortholog); phosphatidylinositol binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN adult behavior (ortholog); negative regulation of regulated secretory pathway (ortholog); regulation of synaptic vesicle docking (ortholog); ASSO CIATED WITH adult respiratory distress syndrome (ortholog); Polyarteritis Nodosa, Childhood-Onset (ortholog); FOUND IN axon terminus (ortholog); calyx of Held (ortholog); cell cortex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 68 | description | gene, protein-coding, MODEL [RefSeq] |
| 625875336 | Septin5 | septin 5 | ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); identical protein binding (ortholog); INVOLVED IN adult behavior (ortholog); negative regulation of regulated secretory pathway (ortholog); regulation of exocytosis (ortholog); ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Polyarteritis Nodosa, Childhood-Onset (ortholog); FOUND IN axon terminus (ortholog); calyx of Held (ortholog); cell cortex (ortholog) | | | | Black Rat | 51 | description | gene, protein-coding, MODEL [RefSeq] |
| 1614439 | Serpina1a | serine (or cysteine) peptidase inhibitor, clade A, member 1A | Predicted to enable identical protein binding activity; protease binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within protein N-linked glycosylation; response to cytokine; and response to peptide hormone. Located in extracellular region. Is expressed in gut; liver lobe; and renal calyx. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 103819554 | 103829878 | Mouse | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614438 | Serpina1b | serine (or cysteine) preptidase inhibitor, clade A, member 1B | Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including in utero embryonic development; protein N-linked glycosylation; and response to peptide hormone. Located in extracellular region. Is expressed in gut; liver lobe; nucleus pulposus; and renal calyx. Human ortholog(s) of this gene implicated in several diseases, including alpha 1-antitrypsin deficiency; artery disease (multiple); chronic obstructive pulmonary disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to human SERPINA1 (serpin family A member 1). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 103694415 | 103704448 | Mouse | 72 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8768375 | Syp | synaptophysin | ENCODES a protein that exhibits cholesterol binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN endocytosis (ortholog); modulation of chemical synaptic transmission (ortholog); protein homooligomerization (ortholog); ASSOCIATED WITH cochl ear disease; alcohol use disorder (ortholog); Alzheimer's disease (ortholog); FOUND IN basal part of cell; vestibular calyx terminal; excitatory synapse (ortholog) | NW_004955543 | 675294 | 689579 | Chinchilla | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 1615771 | Tbc1d10a | TBC1 domain family, member 10a | Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in positive regulation of proteolysis and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Is expressed in renal calyx and vibrissa. Orthologous to human TBC1D10A (TBC1 domain family member 10A). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 4136852 | 4167407 | Mouse | 96 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319322 | Thnsl2 | threonine synthase-like 2 (bacterial) | Enables pyridoxal phosphate binding activity and serine binding activity. Involved in 2-oxobutyrate biosynthetic process; dephosphorylation; and serine family amino acid catabolic process. Is expressed in renal calyx. Orthologous to human THNSL2 (threonine synth ase like 2). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 71105150 | 71121364 | Mouse | 110 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614939 | Tmem252 | transmembrane protein 252 | Predicted to be located in membrane. Is expressed in brain; renal calyx; and spinal cord. Orthologous to human TMEM252 (transmembrane protein 252). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 24651372 | 24657025 | Mouse | 73 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1590079 | Tprg1l | tumor protein p63 regulated 1-like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle exocytosis; calcineurin-NFAT signaling cascade (ortholog); FOUND IN caly /span>x of Held; extrinsic component of synaptic vesicle membrane; glutamatergic synapse; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil | 5 | 170004577 | 170007784 | Rat | 82 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8843577 | Tprg1l | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | NW_004955486 | 8007678 | 8013996 | Chinchilla | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 11714436 | TPRG1L | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | 1 | 2296601 | 2301687 | Bonobo | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 12223499 | TPRG1L | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (inferred); identical protein binding (inferred); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | 5 | 58155178 | 58159880 | Dog | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 12513191 | Tprg1l | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | NW_004936737 | 253752 | 258767 | Squirrel | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 14168178 | TPRG1L | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (inferred); identical protein binding (inferred); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | | | | Pig | 19 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18733598 | TPRG1L | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (inferred); identical protein binding (inferred); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 18913493 | Tprg1l | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 626072176 | Tprg1l | tumor protein p63 regulated 1 like | ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); negative regulation of synaptic transmission (ortholog); regulation of synaptic transmission, glutamatergic (ortholog); FOUND IN caly ='font-weight:700;'>calyx of Held (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 708563 | Tspoap1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of neurotransmitter secretion (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (orthol og); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide | 10 | 73053414 | 73083640 | Rat | 102 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1332420 | Tspoap1 | TSPO associated protein 1 | Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Predicted to be involved in regulation of neurotransmitter secretion. Is active in calyx of Held and glutamatergic synapse. Is expressed in lung. Human ortholog(s) of this gene implicated in dystonia 22, adult-onset and dystonia 22, juvenile-onset. Orthologous to human TSPOAP1 (TSPO associated protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 87649022 | 87676754 | Mouse | 113 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8858992 | Tspoap1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of neurotransmitter secretion (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (orthol og); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog) | NW_004955451 | 4707440 | 4733179 | Chinchilla | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 11924019 | TSPOAP1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (inferred); regulation of presynaptic cytosolic calcium i on concentration (inferred); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (inferred); cytoplasm (inferred); glutamatergic synapse (inferred) | 17 | 52376707 | 52404160 | Bonobo | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 12345272 | TSPOAP1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (inferred); regulation of presynaptic cytosolic calcium i on concentration (inferred); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (inferred); cytoplasm (inferred); glutamatergic synapse (inferred) | 9 | 32949912 | 32972830 | Dog | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 12676649 | Tspoap1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (inferred); regulation of presynaptic cytosolic calcium i on concentration (inferred); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (inferred); cytoplasm (inferred); glutamatergic synapse (inferred) | NW_004936490 | 4766564 | 4793174 | Squirrel | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 14165963 | TSPOAP1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (inferred); regulation of presynaptic cytosolic calcium i on concentration (inferred); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (inferred); cytoplasm (inferred); glutamatergic synapse (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 18618459 | TSPOAP1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (inferred); regulation of presynaptic cytosolic calcium i on concentration (inferred); ASSOCIATED WITH Bardet-Biedl syndrome (ortholog); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (inferred); cytoplasm (inferred); glutamatergic synapse (inferred) | | | | Green Monkey | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 18936805 | Tspoap1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (inferred); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (inferred); INVOLVED IN regulation of neurotransmitter secretion (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (orthol og); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog) | | | | Naked Mole-Rat | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 626139109 | Tspoap1 | TSPO associated protein 1 | ENCODES a protein that exhibits benzodiazepine receptor binding (ortholog); voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels (ortholog); INVOLVED IN regulation of neurotransmitter secretion (ortholog); ASSOCIATED WITH Bardet-Biedl syndrome (orthol og); COVID-19 (ortholog); dystonia (ortholog); FOUND IN calyx of Held (ortholog); cytoplasm (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 1620603 | Ttc22 | tetratricopeptide repeat domain 22 | Is expressed in anal canal; bladder; epidermis; external naris epithelium; and renal calyx. Orthologous to human TTC22 (tetratricopeptide repeat domain 22). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 106479646 | 106497393 | Mouse | 47 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1620684 | Ugt2b38 | UDP glucuronosyltransferase 2 family, polypeptide B38 | Predicted to enable glucuronosyltransferase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Is expressed in renal calyx. Orthologous to several human genes including UG T2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 87557798 | 87572062 | Mouse | 47 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614780 | Unc13a | unc-13 homolog A | Enables calmodulin binding activity and diacylglycerol binding activity. Involved in several processes, including positive regulation of glutamate receptor signaling pathway; positive regulation of synaptic plasticity; and regulated exocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and synaptic vesicle maturation. Located in axon; neuromuscular junction; and presynapse. Is active in calyx of Held; glutamatergic synapse; and presynaptic active zone. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 72079356 | 72124418 | Mouse | 214 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9062927 | Unc13a | unc-13 homolog A | ENCODES a protein that exhibits calmodulin binding (ortholog); diacylglycerol binding (ortholog); identical protein binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); dense core granule priming (ortholog); PARTICIPATES IN insulin secreti on pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | NW_004955524 | 725353 | 769745 | Chinchilla | 71 | description | gene, protein-coding, MODEL [RefSeq] |
| 11736397 | UNC13A | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | 19 | 17088654 | 17175559 | Bonobo | 83 | description | gene, protein-coding, MODEL [RefSeq] |
| 12057537 | UNC13A | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | 20 | 45179275 | 45237544 | Dog | 84 | description | gene, protein-coding, MODEL [RefSeq] |
| 12440495 | Unc13a | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | NW_004936596 | 3311358 | 3370833 | Squirrel | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 14151078 | UNC13A | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 85 | description | gene, protein-coding, MODEL [RefSeq] |
| 18541377 | UNC13A | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | | | | Green Monkey | 83 | description | gene, protein-coding, MODEL [RefSeq] |
| 18933999 | Unc13a | unc-13 homolog A | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); innervation (ortholog); PARTICIPATES IN insul in secretion pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); cerebellar ataxia (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | | | | Naked Mole-Rat | 88 | description | gene, protein-coding, MODEL [RefSeq] |
| 626031156 | Unc13a | unc-13 homolog A | ENCODES a protein that exhibits calmodulin binding (ortholog); diacylglycerol binding (ortholog); identical protein binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); dense core granule docking (ortholog); dense core granule priming (ortholog); PARTICIPATES IN insulin secreti on pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); autistic disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); excitatory synapse (ortholog) | | | | Black Rat | 71 | description | gene, protein-coding, MODEL [RefSeq] |
| 1551198 | Unc13b | unc-13 homolog B | Predicted to enable GTP-dependent protein binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Involved in several processes, including positive regulation of defense response to bacterium; regulated exocytosis; and regulation of synaptic plasticity. Acts upstream of or wi thin chemical synaptic transmission; innervation; and neuromuscular junction development. Located in several cellular components, including early phagosome; presynaptic active zone; and ribbon synapse. Is active in calyx of Held; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 43046193 | 43264873 | Mouse | 197 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11739172 | UNC13B | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | 9 | 35011350 | 35255148 | Bonobo | 71 | description | gene, protein-coding, MODEL [RefSeq] |
| 12093093 | UNC13B | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | 11 | 51707968 | 51941148 | Dog | 73 | description | gene, protein-coding, MODEL [RefSeq] |
| 12696246 | Unc13b | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | NW_004936524 | 3320859 | 3369865 | Squirrel | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 14198098 | UNC13B | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | | | | Pig | 72 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18683445 | UNC13B | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | | | | Green Monkey | 71 | description | gene, protein-coding, MODEL [RefSeq] |
| 18906532 | Unc13b | unc-13 homolog B | ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVID-19 (ortholog); FOUND IN caly style='font-weight:700;'>calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | | | | Naked Mole-Rat | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 625845760 | Unc13b | unc-13 homolog B | ENCODES a protein that exhibits calmodulin binding (ortholog); GTP-dependent protein binding (ortholog); syntaxin binding (ortholog); INVOLVED IN acrosomal vesicle exocytosis (ortholog); cellular response to glucose stimulus (ortholog); chemical synaptic transmission (ortholog); ASSOCIATED WITH COVI D-19 (ortholog); FOUND IN calyx of Held (ortholog); cytosol (ortholog); early phagosome (ortholog) | | | | Black Rat | 58 | description | gene, protein-coding, MODEL [RefSeq] |
| 628592 | Unc13c | unc-13 homolog C | ENCODES a protein that exhibits calmodulin binding; syntaxin binding; syntaxin-1 binding; INVOLVED IN synaptic vesicle priming; chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); ASSOCIATED WITH clubfoot (ortholog); FOUND IN synaptic vesicle membrane; < span style='font-weight:700;'>calyx of Held (ortholog); parallel fiber to Purkinje cell synapse (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 8 | 83127650 | 83553822 | Rat | 116 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 735420 | Unc13c | unc-13 homolog C | Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Involved in negative regulation of synaptic plasticity and synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission. Is active in calyx of Held and par allel fiber to Purkinje cell synapse. Is expressed in several structures, including brain; limb interdigital region; molar; olfactory epithelium; and spinal cord mantle layer. Orthologous to human UNC13C (unc-13 homolog C). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 73386704 | 73915421 | Mouse | 114 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9037059 | Unc13c | unc-13 homolog C | ENCODES a protein that exhibits calmodulin binding (ortholog); syntaxin binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH clubfoot (o rtholog); FOUND IN calyx of Held (ortholog); parallel fiber to Purkinje cell synapse (ortholog); presynapse (ortholog) | NW_004955409 | 889912 | 1325136 | Chinchilla | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 11864531 | UNC13C | unc-13 homolog C | ENCODES a protein that exhibits calmodulin binding (ortholog); syntaxin binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH clubfoot (o rtholog); FOUND IN calyx of Held (ortholog); parallel fiber to Purkinje cell synapse (ortholog); presynapse (ortholog) | 15 | 32914784 | 33563610 | Bonobo | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 12318442 | UNC13C | unc-13 homolog C | ENCODES a protein that exhibits syntaxin binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH clubfoot (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog); synaptic vesicle membrane (ortholog) | 30 | 19519177 | 20096633 | Dog | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12717183 | Unc13c | unc-13 homolog C | ENCODES a protein that exhibits syntaxin binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH clubfoot (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog) | NW_004936471 | 15691357 | 16225590 | Squirrel | 35 | description | gene, protein-coding, MODEL [RefSeq] |
| 14007147 | UNC13C | unc-13 homolog C | ENCODES a protein that exhibits syntaxin binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); ASSOCIATED WITH clubfoot (ortholog); FOUND IN calyx of Held (ortholog); presynapse (ortholog); synaptic vesicle membrane (ortholog) | | | | Pig | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 18354538 | UNC13C | unc-13 homolog C | ENCODES a protein that exhibits calmodulin binding (ortholog); syntaxin binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH clubfoot (o rtholog); FOUND IN calyx of Held (ortholog); parallel fiber to Purkinje cell synapse (ortholog); presynapse (ortholog) | | | | Green Monkey | 14 | description | gene, protein-coding, MODEL [RefSeq] |
| 18918697 | Unc13c | unc-13 homolog C | ENCODES a protein that exhibits syntaxin binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); ASSOCIATED WITH clubfoot (ortholog); FOUND IN calyx of Held (ortholog); parallel fiber to P urkinje cell synapse (ortholog); presynapse (ortholog) | | | | Naked Mole-Rat | 34 | description | gene, protein-coding, MODEL [RefSeq] |
| 20866774 | UNC13C | unc-13 homolog C | ENCODES a protein that exhibits calcium ion binding (inferred); calmodulin binding (inferred); diacylglycerol binding (inferred); INVOLVED IN chemical synaptic transmission (inferred); dense core granule priming (inferred); exocytosis (inferred); FOUND IN calyx of Held (inferred); cytoplasm (inferred); membrane (inferred) | | | | Green Monkey | 29 | description | gene, protein-coding |
| 625951862 | Unc13c | unc-13 homolog C | ENCODES a protein that exhibits calmodulin binding (ortholog); syntaxin binding (ortholog); syntaxin-1 binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); negative regulation of synaptic plasticity (ortholog); synaptic vesicle exocytosis (ortholog); ASSOCIATED WITH clubfoot (o rtholog); FOUND IN calyx of Held (ortholog); parallel fiber to Purkinje cell synapse (ortholog); presynapse (ortholog) | | | | Black Rat | 14 | description | gene, protein-coding, MODEL [RefSeq] |