Atp1a3 (ATPase Na+/K+ transporting subunit alpha 3)

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Gene: Atp1a3 (ATPase Na+/K+ transporting subunit alpha 3) Ictidomys tridecemlineatus

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Symbol:

Atp1a3

Name:

ATPase Na+/K+ transporting subunit alpha 3

RGD ID:

12450844

Description:

ENCODES a protein that exhibits amyloid-beta binding (ortholog); D1 dopamine receptor binding (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); blood circulation (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH alternating hemiplegia of childhood (ortholog); Alternating Hemiplegia of Childhood 2 (ortholog); autism spectrum disorder (ortholog); FOUND IN axon (ortholog); calyx of Held (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sodium/potassium-transporting ATPase subunit alpha-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	16,130,267 - 16,147,315 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936706	477,107 - 495,525 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936706	476,473 - 494,659 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alternating hemiplegia of childhood (ISO)

Alternating Hemiplegia of Childhood 2 (ISO)

autism spectrum disorder (ISO)

Benign Familial Neonatal Seizures, 1 (ISO)

bipolar disorder (ISO)

CAPOS Syndrome (ISO)

Carpenter Syndrome 2 (ISO)

congenital hypoplastic anemia (ISO)

congestive heart failure (ISO)

craniosynostosis (ISO)

craniosynostosis 1 (ISO)

developmental and epileptic encephalopathy 99 (ISO)

Developmental Disabilities (ISO)

Diamond-Blackfan anemia (ISO)

Dyskinesias (ISO)

dystonia (ISO)

dystonia 12 (ISO)

epilepsy (ISO)

esophageal atresia (ISO)

generalized dystonia (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

hemiplegia (ISO)

hydrocephalus (ISO)

intellectual disability (ISO)

maple syrup urine disease (ISO)

myoclonic-atonic epilepsy (ISO)

oculogyric crisis (ISO)

osteoarthritis (ISO)

Parkinsonism (ISO)

psychotic disorder (ISO)

quadriplegia (ISO)

schizophrenia (ISO)

syndromic intellectual disability (ISO)

Ventricular Dysfunction, Left (ISO)

Ventriculomegaly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult locomotory behavior (ISO)

blood circulation (ISO)

brain-derived neurotrophic factor receptor signaling pathway (ISO)

calcium-mediated signaling (ISO)

carboxylic acid transport (ISO)

cardiac muscle contraction (ISO)

cellular response to amyloid-beta (ISO)

cellular response to retinoic acid (ISO)

cellular response to thyroid hormone stimulus (ISO)

cerebral cortex development (ISO)

circadian rhythm (ISO)

cognition (ISO)

determination of adult lifespan (ISO)

ERK1 and ERK2 cascade (ISO)

establishment or maintenance of transmembrane electrochemical gradient (IEA)

fear response (ISO)

gamma-aminobutyric acid signaling pathway (ISO)

habituation (ISO)

intracellular potassium ion homeostasis (IEA)

intracellular sodium ion homeostasis (IEA)

ionotropic glutamate receptor signaling pathway (ISO)

L-ascorbic acid metabolic process (ISO)

learning (ISO)

locomotion (ISO)

locomotory behavior (ISO)

membrane depolarization (ISO)

memory (ISO)

motor behavior (ISO)

multicellular organism growth (ISO)

neurogenesis (ISO)

neuromuscular process (ISO)

neuromuscular process controlling balance (ISO)

neuron projection maintenance (IEA)

phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

pore complex assembly (ISO)

potassium ion import across plasma membrane (IEA)

potassium ion transport (IEA,ISO)

proton transmembrane transport (IEA)

regulation of cardiac muscle cell membrane potential (ISO)

regulation of short-term neuronal synaptic plasticity (ISO)

response to activity (ISO)

response to electrical stimulus (ISO)

response to environmental enrichment (ISO)

response to hormone (ISO)

response to immobilization stress (ISO)

response to lithium ion (ISO)

response to methamphetamine hydrochloride (ISO)

response to monoamine (ISO)

response to potassium ion (ISO)

response to stress (ISO)

response to temperature stimulus (ISO)

response to xenobiotic stimulus (ISO)

sleep (ISO)

social behavior (ISO)

sodium ion export across plasma membrane (IEA)

sodium ion transport (ISO)

thalamus development (ISO)

transmission of nerve impulse (ISO)

visual learning (ISO)

walking behavior (ISO)

Cellular Component

axon (IEA,ISO)

calyx of Held (ISO)

cell surface (ISO)

cytoplasm (ISO)

dendritic spine head (ISO)

dendritic spine neck (ISO)

endoplasmic reticulum (IEA)

Golgi apparatus (IEA)

membrane (IEA)

myelin sheath (ISO)

neuron to neuron synapse (ISO)

neuronal cell body (IEA)

nucleus (ISO)

organelle membrane (IEA)

photoreceptor inner segment (ISO)

plasma membrane (IEA,ISO)

postsynapse (ISO)

presynaptic membrane (ISO)

protein-containing complex (ISO)

sarcolemma (ISO)

sodium:potassium-exchanging ATPase complex (IEA,ISO)

synapse (ISO)

Molecular Function

amyloid-beta binding (IEA,ISO)

ATP binding (IEA)

ATP hydrolysis activity (IEA)

D1 dopamine receptor binding (ISO)

heparan sulfate proteoglycan binding (ISO)

metal ion binding (IEA)

P-type potassium transmembrane transporter activity (IEA)

P-type sodium:potassium-exchanging transporter activity (IEA)

P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential (ISO)

protein binding (ISO)

protein-folding chaperone binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

acebutolol pharmacodynamics pathway (ISO)

adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway (ISO)

alfentanil pharmacodynamics pathway (ISO)

amiloride pharmacodynamics pathway (ISO)

amiodarone pharmacodynamics pathway (ISO)

amlodipine pharmacodynamics pathway (ISO)

atenolol pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

betaxolol pharmacodynamics pathway (ISO)

bisoprolol pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

bupivacaine pharmacodynamics pathway (ISO)

bupranolol drug pathway (ISO)

bupranolol pharmacodynamics pathway (ISO)

buprenorphine pharmacodynamics pathway (ISO)

carvedilol pharmacodynamics pathway (ISO)

chloroprocaine pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

citalopram pharmacodynamics pathway (ISO)

cocaine pharmacodynamics pathway (ISO)

codeine and morphine pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

desipramine pharmacodynamics pathway (ISO)

diltiazem pharmacodynamics pathway (ISO)

diphenoxylate pharmacodynamics pathway (ISO)

disopyramide pharmacodynamics pathway (ISO)

dobutamine pharmacodynamics pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

escitalopram pharmacodynamics pathway (ISO)

esmolol pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

ethylmorphine pharmacodynamics pathway (ISO)

fentanyl pharmacodynamics pathway (ISO)

flecainde pharmacodynamics pathway (ISO)

fluoxetine pharmacodynamics pathway (ISO)

fosphenytoin pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

heroin pharmacodynamics pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydrocodone pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

hydromorphone pharmacodynamics pathway (ISO)

ibutilide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

imipramine pharmacodynamics pathway (ISO)

isoprenaline pharmacodynamics pathway (ISO)

isradipine pharmacodynamics pathway (ISO)

lactose degradation pathway (ISO)

levacetylmethadol pharmacodynamics pathway (ISO)

levobunolol pharmacodynamics pathway (ISO)

levobupivacaine phgarmacodynamics pathway (ISO)

levorphanol pharmacodynamics pathway (ISO)

lidocaine pharmacodynamics pathway (ISO)

lysinuric protein intolerance pathway (ISO)

mepivacaine pharmacodynamics pathway (ISO)

methadone pharmacodynamics pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

metoprolol pharmacodynamics pathway (ISO)

mexiletine pharmacodynamics pathway (ISO)

nadolol pharmacodynamics pathway (ISO)

nalbuphine pharmacodynamics pathway (ISO)

naloxone pharmacodynamics pathway (ISO)

naltrexone pharmacodynamics pathway (ISO)

nebivolol pharmacodynamics pathway (ISO)

nicotine pharmacodynamics pathway (ISO)

nifedipine pharmacodynamics pathway (ISO)

nimodipine pharmacodynamics pathway (ISO)

nisoldipine pharmacodynamics pathway (ISO)

nitrendipine pharmacodynamics pathway (ISO)

oxybuprocaine pharmacodynamics pathway (ISO)

oxycodone pharmacodynamics pathway (ISO)

oxymorphone pharmacodynamics pathway (ISO)

penbutolol pharmacodynamics pathway (ISO)

pentazocine pharmacodynamics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

pindolol pharmacodynamics pathway (ISO)

prilocaine pharmacodynamics pathway (ISO)

procainamide pharmacodynamics pathway (ISO)

procaine pharmacodynamics pathway (ISO)

propranolol pharmacodynamics pathway (ISO)

quinidine pharmacodynamics pathway (ISO)

remifentanil pharmacodynamics pathway (ISO)

ropivacaine pharmacodynamics pathway (ISO)

sotalol pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

timolol pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

tramadol pharmacodynamics pathway (ISO)

trehalose degradation pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

verapamil pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Atp1a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	16,130,267 - 16,147,315 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936706	477,107 - 495,525 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936706	476,473 - 494,659 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP1A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	41,966,582 - 41,994,230 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	41,966,582 - 41,997,497 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	42,470,734 - 42,498,382 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	47,162,574 - 47,190,222 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	47,162,575 - 47,190,222	NCBI
Celera	19	39,270,362 - 39,298,001 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	38,902,456 - 38,930,242 (-)	NCBI		HuRef
CHM1_1	19	42,472,364 - 42,500,045 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	44,785,945 - 44,813,592 (-)	NCBI		T2T-CHM13v2.0

Atp1a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	24,677,592 - 24,705,338 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	24,677,592 - 24,705,383 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	24,978,167 - 25,006,077 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	24,978,167 - 25,005,958 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	25,763,186 - 25,790,914 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	24,686,927 - 24,714,655 (-)	NCBI		MGSCv36	mm8
Celera	7	19,593,974 - 19,621,705 (-)	NCBI		Celera
Cytogenetic Map	7	A3	NCBI
cM Map	7	13.73	NCBI

Atp1a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	89,700,645 - 89,729,782 (-)	NCBI		GRCr8
mRatBN7.2	1	80,572,790 - 80,601,936 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	80,572,796 - 80,601,918 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	85,965,362 - 85,994,505 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	94,516,223 - 94,545,362 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	87,721,120 - 87,750,267 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	81,852,423 - 81,881,565 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	81,852,429 - 81,881,549 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	83,104,725 - 83,133,845 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	80,280,714 - 80,309,834 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	80,358,824 - 80,387,945 (-)	NCBI
Celera	1	75,018,852 - 75,047,865 (-)	NCBI		Celera
RH 3.4 Map	1	842.5	RGD
RH 2.0 Map	1	501.2	RGD
Cytogenetic Map	1	q21	NCBI

Atp1a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955555	869,325 - 893,542 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955555	869,508 - 892,510 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP1A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	48,071,671 - 48,099,363 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	49,940,042 - 49,967,977 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	38,854,243 - 38,882,034 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	47,357,926 - 47,383,736 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	47,358,281 - 47,384,716 (-)	Ensembl	panpan1.1		panPan2

ATP1A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	112,325,988 - 112,346,056 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	112,325,289 - 112,346,916 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	111,758,069 - 111,778,105 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	112,945,619 - 112,965,659 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	112,945,448 - 112,986,321 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	112,498,938 - 112,518,971 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	112,135,175 - 112,155,359 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	113,061,496 - 113,081,538 (+)	NCBI		UU_Cfam_GSD_1.0

ATP1A3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	49,905,847 - 49,927,633 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	49,905,851 - 49,927,437 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	45,929,174 - 45,946,082 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP1A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	36,166,586 - 36,195,343 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	36,166,262 - 36,195,363 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	14,408,818 - 14,437,805 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp1a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624907	715,094 - 736,432 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624907	715,109 - 736,040 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021735208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000004042 ⟹ ENSSTOP00000003626

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936706	477,107 - 495,525 (+)	Ensembl

RefSeq Acc Id:

XM_021735208 ⟹ XP_021590883

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	16,130,267 - 16,147,315 (+)	NCBI
SpeTri2.0	NW_004936706	476,473 - 494,659 (+)	NCBI

Sequence:

show sequence

ATGAAGAGAGACACAGGCCAGCAGGAGAGGCAGGGCTCGCAGGGCCGGTGTCCCTCTGGAATCC
CTTCTCGCCCGCAGTCTGGTGGCTCTGACAGCTATCGTGTCGCCACCTCGCAGGACAAAAAAGA
TGACAAGGGCTCGCCCAAGAAGAGCAAGGGCAAGGAGCGCCGGGACCTGGATGACCTCAAGAAG
GAGGTGGCTATGACAGAGCACAAAATGTCCGTGGAAGAGGTCTGCCGGAAATACAACACGGACT
GCGTGCAGGGTCTGACGCATAGCAAAGCCCAGGAGATCCTGGCCCGGGATGGGCCCAACGCGCT
CACGCCACCGCCTACCACTCCAGAATGGGTCAAGTTCTGCCGCCAGCTCTTCGGGGGCTTCTCC
ATTCTGCTGTGGATTGGGGCCATCCTCTGTTTCCTGGCCTATGGCATCCAGGCAGGCACTGAAG
ATGACCCCTCTGGTGACAATCTGTACCTGGGCATTGTGCTGGCAGCTGTAGTGATCATCACTGG
CTGCTTCTCCTACTACCAGGAGGCCAAGAGCTCCAAGATCATGGAGTCCTTCAAGAACATGGTT
CCCCAGCAAGCACTGGTGATCAGGGAAGGTGAGAAGATGCAGGTGAATGCTGAGGAGGTGGTGG
TTGGGGACTTGGTAGAGATCAAGGGCGGAGACCGAGTCCCAGCCGACCTGCGAATCATCTCGGC
CCATGGCTGCAAGGTGGACAACTCTTCCCTGACCGGCGAATCTGAGCCCCAGACCCGCTCTCCC
GACTGCACACATGACAACCCCTTGGAGACTCGGAACATCACCTTCTTTTCCACCAACTGCGTAG
AAGGCACGGCTAGGGGTGTGGTGGTGGCCACTGGTGACCGCACTGTCATGGGCCGCATCGCCAC
CCTGGCCTCAGGCCTGGAGGTGGGCAAGACGCCCATCGCCATTGAGATCGAGCACTTCATTCAG
CTCATCACTGGTGTGGCCGTCTTCCTGGGCGTCTCCTTCTTCATCCTCTCCCTCATTCTCGGGT
ACAGCTGGCTTGAGGCTGTCATCTTCCTCATCGGCATCATCGTGGCCAATGTCCCAGAGGGTCT
GCTGGCCACTGTCACTGTGTGTCTGACCCTGACTGCCAAGCGCATGGCTCGGAAGAACTGTCTA
GTGAAGAACCTGGAGGCTGTGGAGACCCTGGGCTCTACATCCACCATTTGCTCAGACAAGACGG
GGACCCTCACCCAGAACCGCATGACGGTGGCCCACATGTGGTTTGACAATCAGATCCACGAGGC
TGACACCACTGAGGATCAGTCAGGCACCTCCTTTGACAAGAGCTCACACACGTGGGTGGCCCTG
TCCCACATCGCCGGACTCTGCAACCGTGCTGTCTTCAAAGGCGGTCAAGACAACATCCCTGTAC
TTAAGAGGGACGTGGCCGGGGATGCCTCCGAGTCTGCCCTACTCAAATGCATCGAGCTGTCCTC
CGGCTCCGTGAAGCTGATGCGTGAACGCAACAAGAAAGTAGCCGAGATCCCCTTCAACTCCACC
AACAAATACCAGCTATCCATCCATGAGACCGAGGACCCCAATGACAACCGATACCTGCTGGTGA
TGAAGGGCGCCCCCGAACGCATCCTGGACCGCTGCTCCACGATCCTGCTGCAGGGCAAGGAGCA
GCCACTGGACGAGGAGATGAAGGAAGCCTTCCAAAATGCCTACCTGGAGCTTGGGGGCCTGGGC
GAGCGCGTGCTCGGTTTCTGCCATTACTACCTGCCCGAGGAGCAGTTCCCCAAGGGCTTCGCCT
TCGACTGTGATGACGTGAACTTCACCACAGACAACCTCTGCTTCGTGGGCCTCATGTCCATGAT
TGACCCTCCCCGGGCAGCTGTCCCTGACGCCGTGGGCAAATGCCGGAGCGCAGGCATCAAGGTC
ATCATGGTCACGGGCGATCACCCCATCACAGCCAAGGCCATCGCCAAGGGTGTGGGCATCATCT
CCGAGGGCAATGAGACTGTGGAGGACATCGCCGCCCGGCTTAACATCCCTGTCAGCCAGGTCAA
CCCACGGGATGCCAAGGCCTGTGTGATCCACGGCACCGACCTCAAGGACTTCACCTCTGAGCAA
ATCGACGAGATCCTACAGAATCACACTGAGATCGTCTTTGCCCGCACCTCCCCACAGCAGAAGC
TCATCATCGTGGAGGGCTGTCAGAGACAGGGAGCAATTGTGGCCGTGACTGGCGATGGTGTGAA
CGACTCCCCTGCTCTGAAGAAAGCTGACATTGGGGTGGCCATGGGCATTGCTGGCTCTGATGTC
TCTAAGCAGGCAGCCGACATGATTCTATTGGATGACAACTTTGCCTCCATTGTCACGGGTGTGG
AAGAGGGCCGCCTGATCTTTGACAACCTGAAGAAGTCCATCGCCTACACCCTCACCAGCAACAT
CCCCGAGATCACGCCCTTCCTGCTCTTCATCATGGCCAACATCCCGCTGCCCCTGGGCACCATT
ACCATCCTTTGTATCGACCTGGGCACAGACATGGTCCCTGCCATCTCCTTGGCCTATGAGGCTG
CTGAGAGCGACATCATGAAGAGACAGCCCAGGAACCCTCGGACAGACAAGCTGGTCAATGAGCG
ACTCATCAGCATGGCCTATGGGCAGATCGGAATGATCCAGGCTCTTGGTGGCTTTTTCTCCTAC
TTTGTGATCCTGGCAGAAAATGGCTTCCTACCCGGCAACCTGGTGGGCATCCGGCTCAACTGGG
ATGACCGCACCGTCAACGACCTGGAGGACAGTTACGGGCAGCAGTGGACCTACGAGCAGAGGAA
GGTGGTGGAGTTCACGTGCCACACGGCCTTCTTTGTGAGCATCGTGGTGGTCCAGTGGGCGGAT
CTGATCATCTGCAAGACCCGGAGGAACTCAGTGTTCCAGCAGGGCATGAAGAACAAAATCTTGA
TCTTCGGCTTATTTGAGGAGACGGCCCTCGCTGCCTTCCTGTCCTACTGCCCTGGCATGGACGT
GGCCCTTCGCATGTACCCCCTCAAGCCCAGCTGGTGGTTCTGTGCCTTCCCCTACAGTTTCCTC
ATCTTCGTCTACGATGAAATCCGCAAACTCATCCTGCGCAGGAACCCAGGGGGTTGGGTGGAGA
AAGAAACCTACTACTGACCTCAGCCCTGCCACGTCGCCACCTCCTCCCTGCCCCCAAGCCCAGG
ACGTCCCCTCCGGACCCCCCATTTTGTATTCTGGGGGAGGGACCCTCTCTCCCTGTGGTCCCCC
CTTGGCACCCCCTCGATCACCTCCTGCCCTCTCTCTGGCTGGCTTCTCTCCCCCACGGCCCTGG
CCTCCCTCCTCCCTCTTTTCTGTGTCTCTCTCCCCTCTTCAGCCCTCTCCTGCCTCCCCCAACC
CCCTCCCTGGGCTCTTTTTTACTCCCCCTCAGCCACCCCCCACCCCCCAACGGCTGATGCCATC
TCTGGTTCTGGACAATTATCAAATATATCAGTGGGGAGAGAGAAGCGC

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Protein Sequences


Protein RefSeqs	XP_021590883	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000003626.3

RefSeq Acc Id:

XP_021590883 ⟸ XM_021735208

- UniProtKB:

I3M3H5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKRDTGQQERQGSQGRCPSGIPSRPQSGGSDSYRVATSQDKKDDKGSPKKSKGKERRDLDDLKK
EVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFS
ILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSP
DCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQ
LITGVAVFLGVSFFILSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVAL
SHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNST
NKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLG
ERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKV
IMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQ
IDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDV
SKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTI
TILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSY
FVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWAD
LIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFL
IFVYDEIRKLILRRNPGGWVEKETYY

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Ensembl Acc Id:

ENSSTOP00000003626 ⟸ ENSSTOT00000004042

Protein Domains

Cation-transporting P-type ATPase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000004030	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000004042.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1110.10	UniProtKB/TrEMBL
	3.40.50.1000	UniProtKB/TrEMBL
	Calcium-transporting ATPase, cytoplasmic transduction domain A	UniProtKB/TrEMBL
	Calcium-transporting ATPase, transmembrane domain	UniProtKB/TrEMBL
InterPro	ATPase_P-typ_cation-transptr_C	UniProtKB/TrEMBL
	ATPase_P-typ_cation-transptr_N	UniProtKB/TrEMBL
	ATPase_P-typ_cyto_dom_N	UniProtKB/TrEMBL
	ATPase_P-typ_P_site	UniProtKB/TrEMBL
	ATPase_P-typ_TM_dom_sf	UniProtKB/TrEMBL
	ATPase_P-typ_transduc_dom_A_sf	UniProtKB/TrEMBL
	Cation_transp_ATPase_P-type	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	HAD_sf	UniProtKB/TrEMBL
	P-type_ATPase_IIC	UniProtKB/TrEMBL
	P_typ_ATPase	UniProtKB/TrEMBL
	P_typ_ATPase_HD_dom	UniProtKB/TrEMBL
NCBI Gene	Atp1a3	ENTREZGENE
PANTHER	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA	UniProtKB/TrEMBL
	SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-3	UniProtKB/TrEMBL
Pfam	Cation_ATPase	UniProtKB/TrEMBL
	Cation_ATPase_C	UniProtKB/TrEMBL
	Cation_ATPase_N	UniProtKB/TrEMBL
	E1-E2_ATPase	UniProtKB/TrEMBL
PRINTS	CATATPASE	UniProtKB/TrEMBL
	NAKATPASE	UniProtKB/TrEMBL
PROSITE	ATPASE_E1_E2	UniProtKB/TrEMBL
SMART	Cation_ATPase_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
	SSF81653	UniProtKB/TrEMBL
	SSF81660	UniProtKB/TrEMBL
	SSF81665	UniProtKB/TrEMBL
UniProt	I3M3H5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB