Ptprj (protein tyrosine phosphatase receptor type J) - Rat Genome Database

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Gene: Ptprj (protein tyrosine phosphatase receptor type J) Mus musculus
Analyze
Symbol: Ptprj
Name: protein tyrosine phosphatase receptor type J
RGD ID: 736434
MGI Page MGI
Description: Enables protein tyrosine phosphatase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of cell migration; and regulation of signal transduction. Acts upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung squamous cell carcinoma; and thrombocytopenia. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI450271; BET; By; Byp; CD148; colon tumor susceptibility 1; DEP-; DEP-1; HPTP beta-like tyrosine phosphatase; protein-tyrosine phosphatase eta; protein-tyrosine phosphatase receptor type J; Ptpb2; PTPbeta2; R-PTP-eta; R-PTP-J; receptor-type tyrosine-protein phosphatase eta; RP; RPTPJ; Scc; Scc-; Scc-1; Scc1; susceptibility to colon cancer 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm13767   Gm13768   Gm18953  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,260,100 - 90,411,102 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,260,098 - 90,410,939 (-)EnsemblGRCm39 Ensembl
GRCm38290,429,756 - 90,580,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl290,429,754 - 90,580,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37290,269,913 - 90,420,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,233,731 - 90,381,407 (-)NCBIMGSCv36mm8
Celera291,810,313 - 91,967,158 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (EXP)
chlorpyrifos  (EXP)
clofibrate  (EXP)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
diclofenac  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
hydralazine  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
N-nitrosodiethylamine  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
SB 431542  (ISO)
sodium fluoride  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
tungsten  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IMP)
blood coagulation  (IMP)
glucose homeostasis  (IMP)
heart development  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (IDA,ISO)
negative regulation of cell population proliferation  (IMP,ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of insulin receptor signaling pathway  (IMP)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IDA,ISO)
negative regulation of T cell receptor signaling pathway  (IDA,ISO)
negative regulation of vascular permeability  (ISO)
obsolete calcium-mediated signaling using intracellular calcium source  (IGI)
oligodendrocyte differentiation  (IMP)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive chemotaxis  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell-matrix adhesion  (IDA)
positive regulation of Fc receptor mediated stimulatory signaling pathway  (IGI)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of macrophage chemotaxis  (IDA)
positive regulation of MAPK cascade  (IGI)
positive regulation of peptidyl-tyrosine phosphorylation  (IGI)
positive regulation of phagocytosis  (IGI)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of platelet activation  (IMP)
positive regulation of tumor necrosis factor production  (IGI)
regulation of cell adhesion  (ISO)
vasculogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal follicular B cell morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal pericyte morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal transitional stage B cell morphology  (IAGP)
abnormal vascular branching morphogenesis  (IAGP)
abnormal vascular development  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal vascular smooth muscle morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent atrioventricular cushions  (IAGP)
anemia  (IAGP)
decreased B cell number  (IAGP)
decreased body weight  (IAGP)
decreased embryo size  (IAGP)
decreased immature B cell number  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased mature B cell number  (IAGP)
delayed heart looping  (IAGP)
distended pericardium  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of vascular branching  (IAGP)
impaired macrophage phagocytosis  (IAGP)
increased B-2 B cell number  (IAGP)
increased marginal zone B cell number  (IAGP)
increased tumor incidence  (IAGP)
increased vascular endothelial cell number  (IAGP)
infertility  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
microcephaly  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
thin myocardium  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
2. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
3. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers. Mita Y, etal., J Cancer Res Clin Oncol. 2010 Feb;136(2):249-59. doi: 10.1007/s00432-009-0656-7. Epub 2009 Aug 12.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1347918   PMID:1932742   PMID:2044862   PMID:7838537   PMID:8549806   PMID:8575779   PMID:8577718   PMID:8940077   PMID:8944029   PMID:9823776   PMID:10349636   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:12089527   PMID:12466851   PMID:12588999   PMID:12771128   PMID:12833140   PMID:12913111   PMID:14562056   PMID:14610273   PMID:15294945   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16792508   PMID:18249142   PMID:18308476   PMID:19139271   PMID:19246339   PMID:19268662   PMID:19727691   PMID:20345711   PMID:21098033  
PMID:21262971   PMID:21267068   PMID:21469128   PMID:21543337   PMID:21873635   PMID:22078799   PMID:22246030   PMID:22815804   PMID:23065825   PMID:23281368   PMID:23543053   PMID:23580664  
PMID:23840844   PMID:23889985   PMID:24016860   PMID:25830095   PMID:26063811   PMID:27364551   PMID:27568566   PMID:27859601   PMID:27889108   PMID:28912580   PMID:28924218   PMID:29301754  
PMID:29880609   PMID:30082414   PMID:30429161   PMID:31598898   PMID:32016283   PMID:32325033   PMID:33605542   PMID:33784491   PMID:37875230   PMID:38187761  


Genomics

Comparative Map Data
Ptprj
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,260,100 - 90,411,102 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,260,098 - 90,410,939 (-)EnsemblGRCm39 Ensembl
GRCm38290,429,756 - 90,580,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl290,429,754 - 90,580,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv37290,269,913 - 90,420,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,233,731 - 90,381,407 (-)NCBIMGSCv36mm8
Celera291,810,313 - 91,967,158 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.19NCBI
PTPRJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,980,559 - 48,170,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,980,425 - 48,170,839 (+)EnsemblGRCh38hg38GRCh38
GRCh371148,002,111 - 48,192,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,958,686 - 48,148,970 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,958,688 - 48,146,246NCBI
Celera1148,154,504 - 48,344,533 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,683,384 - 47,903,543 (+)NCBIHuRef
CHM1_11148,001,881 - 48,191,974 (+)NCBICHM1_1
T2T-CHM13v2.01148,150,119 - 48,340,376 (+)NCBIT2T-CHM13v2.0
Ptprj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8396,861,785 - 97,017,702 (-)NCBIGRCr8
mRatBN7.2376,405,917 - 76,561,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl376,405,927 - 76,562,260 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx379,890,269 - 80,046,200 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0388,488,786 - 88,644,719 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,341,245 - 86,497,188 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,233,519 - 79,390,956 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,233,525 - 79,390,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0385,947,682 - 86,099,287 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4374,796,764 - 74,935,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1374,693,135 - 74,831,912 (-)NCBI
Celera375,621,921 - 75,777,388 (-)NCBICelera
Cytogenetic Map3q24NCBI
Ptprj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422399,357 - 443,054 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955422396,266 - 438,792 (-)NCBIChiLan1.0ChiLan1.0
PTPRJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2950,196,084 - 50,386,550 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,215,619 - 50,406,485 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,941,134 - 48,130,538 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11148,518,844 - 48,672,844 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1148,613,761 - 48,670,494 (+)Ensemblpanpan1.1panPan2
PTPRJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11841,586,262 - 41,635,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1841,586,112 - 41,635,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,315,308 - 40,366,352 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,238,579 - 42,289,675 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,238,586 - 42,285,426 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11841,727,516 - 41,778,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,280,105 - 41,331,461 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,009,997 - 42,061,288 (-)NCBIUU_Cfam_GSD_1.0
Ptprj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,050,113 - 19,123,158 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,165,304 - 1,211,817 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,161,764 - 1,234,800 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRJ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl214,548,428 - 14,724,474 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1214,548,489 - 14,724,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2215,632,255 - 16,007,397 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,137,896 - 17,328,836 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,135,907 - 17,328,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038114,433,977 - 114,653,560 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprj
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624767945,553 - 1,051,138 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624767942,786 - 1,051,112 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptprj
1574 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3336
Count of miRNA genes:800
Interacting mature miRNAs:1063
Transcripts:ENSMUST00000111493, ENSMUST00000111495, ENSMUST00000129323, ENSMUST00000168621
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
11532731Sluc31a_msusceptibility to lung cancer 31a (mouse)288015003122015170Mouse
1301897Scc2_mcolon tumor susceptibility 2 (mouse)Not determined28572426990410991Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
11049565Lmr28g_mleishmaniasis resistance 28g (mouse)286095716120095823Mouse
1300852Lmr14_mleishmaniasis resistance 14 (mouse)Not determined286095716120095823Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
4142223Femwf4_mfemur work to failure 4 (mouse)Not determined88143423122143570Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11038697Ltpr2d_mLeishmania tropica response 2d (mouse)286095716120095823Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
1301834Bits1_mbitterness sensitivity 1 (mouse)Not determined287440643121440778Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
11038698Ltpr2c_mLeishmania tropica response 2c (mouse)286095716120095823Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse

Markers in Region
AI450271  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1-2UniSTS
Whitehead/MRC_RH21267.03UniSTS
AW555355  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38290,568,634 - 90,568,751UniSTSGRCm38
MGSCv37290,408,791 - 90,408,908UniSTSGRCm37
Celera291,955,117 - 91,955,234UniSTS
Cytogenetic Map2E1-2UniSTS
Whitehead/MRC_RH21268.57UniSTS
D2Mit272  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38290,515,788 - 90,515,903UniSTSGRCm38
MGSCv37290,355,945 - 90,356,060UniSTSGRCm37
Celera291,896,606 - 91,896,733UniSTS
Cytogenetic Map2E1-2UniSTS
cM Map247.5UniSTS
Whitehead Genetic249.2UniSTS
Whitehead_YAC2 UniSTS
D45212  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1-2UniSTS
Whitehead/MRC_RH21266.61UniSTS
PMC151692P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1-2UniSTS
BB238754  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38290,538,243 - 90,538,328UniSTSGRCm38
MGSCv37290,378,400 - 90,378,485UniSTSGRCm37
Celera291,924,660 - 91,924,745UniSTS
Cytogenetic Map2E1-2UniSTS
Whitehead/MRC_RH21264.19UniSTS
Ptprj  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2E1-2UniSTS
cM Map250.19UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001135657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH011894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL935132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL954341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL954378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY038891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY039232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB865926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D45212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ133576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000111493   ⟹   ENSMUSP00000107119
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,263,233 - 90,301,680 (-)Ensembl
GRCm38.p6 Ensembl290,432,889 - 90,471,336 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111495   ⟹   ENSMUSP00000107121
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,260,100 - 90,309,514 (-)Ensembl
GRCm38.p6 Ensembl290,429,756 - 90,479,170 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129323
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,260,098 - 90,260,789 (-)Ensembl
GRCm38.p6 Ensembl290,429,754 - 90,430,445 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168621   ⟹   ENSMUSP00000129592
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl290,263,233 - 90,410,939 (-)Ensembl
GRCm38.p6 Ensembl290,432,889 - 90,580,647 (-)Ensembl
RefSeq Acc Id: NM_001135657   ⟹   NP_001129129
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,260,100 - 90,309,518 (-)NCBI
GRCm38290,429,756 - 90,479,174 (-)NCBI
MGSCv37290,269,913 - 90,420,804 (-)RGD
Celera291,810,313 - 91,967,158 (-)NCBI
Celera239,833,497 - 39,834,087 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008982   ⟹   NP_033008
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,263,233 - 90,410,939 (-)NCBI
GRCm38290,432,889 - 90,580,595 (-)NCBI
MGSCv37290,269,913 - 90,420,804 (-)RGD
Celera291,810,313 - 91,967,158 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498991   ⟹   XP_006499054
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,262,183 - 90,411,102 (-)NCBI
GRCm38290,432,889 - 90,580,694 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498992   ⟹   XP_006499055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,262,188 - 90,309,466 (-)NCBI
GRCm38290,432,889 - 90,479,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498993   ⟹   XP_006499056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,262,188 - 90,309,466 (-)NCBI
GRCm38290,432,889 - 90,479,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006498994   ⟹   XP_006499057
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,262,188 - 90,309,522 (-)NCBI
GRCm38290,432,889 - 90,479,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159700   ⟹   XP_036015593
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39290,262,188 - 90,410,684 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033008   ⟸   NM_008982
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8CIW9 (UniProtKB/Swiss-Prot),   Q64455 (UniProtKB/Swiss-Prot),   Q541R5 (UniProtKB/Swiss-Prot),   Q3UHL5 (UniProtKB/Swiss-Prot),   Q3UH64 (UniProtKB/Swiss-Prot),   Q8K3Q2 (UniProtKB/Swiss-Prot),   E9Q4S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129129   ⟸   NM_001135657
- Peptide Label: isoform 2
- UniProtKB: A2AWF9 (UniProtKB/TrEMBL),   E9Q4S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006499054   ⟸   XM_006498991
- Peptide Label: isoform X1
- UniProtKB: E9Q4S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006499057   ⟸   XM_006498994
- Peptide Label: isoform X5
- UniProtKB: A2AWF8 (UniProtKB/TrEMBL),   E9Q4S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006499056   ⟸   XM_006498993
- Peptide Label: isoform X3
- UniProtKB: E9Q4S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006499055   ⟸   XM_006498992
- Peptide Label: isoform X2
- UniProtKB: E9Q4S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000107121   ⟸   ENSMUST00000111495
RefSeq Acc Id: ENSMUSP00000107119   ⟸   ENSMUST00000111493
RefSeq Acc Id: ENSMUSP00000129592   ⟸   ENSMUST00000168621
RefSeq Acc Id: XP_036015593   ⟸   XM_036159700
- Peptide Label: isoform X4
- UniProtKB: E9Q4S7 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64455-F1-model_v2 AlphaFold Q64455 1-1238 view protein structure

Promoters
RGD ID:6832225
Promoter ID:MM_KWN:30394
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver
Transcripts:ENSMUST00000111493
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36290,311,131 - 90,312,447 (-)MPROMDB
RGD ID:6832409
Promoter ID:MM_KWN:30395
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Spleen
Transcripts:NM_001135657,   OTTMUST00000033611,   OTTMUST00000033612
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36290,318,146 - 90,319,732 (+)MPROMDB
RGD ID:6832226
Promoter ID:MM_KWN:30399
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:ENSMUST00000026352,   UC008KSV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36290,420,331 - 90,421,122 (-)MPROMDB
RGD ID:6877848
Promoter ID:EPDNEW_M2375
Type:multiple initiation site
Name:Ptprj_2
Description:Mus musculus protein tyrosine phosphatase, receptor type, J ,transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2376  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38290,479,173 - 90,479,233EPDNEW
RGD ID:6877850
Promoter ID:EPDNEW_M2376
Type:initiation region
Name:Ptprj_1
Description:Mus musculus protein tyrosine phosphatase, receptor type, J ,transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2375  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38290,580,595 - 90,580,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104574 AgrOrtholog
Ensembl Genes ENSMUSG00000025314 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000111493 ENTREZGENE
  ENSMUST00000111493.8 UniProtKB/TrEMBL
  ENSMUST00000111495 ENTREZGENE
  ENSMUST00000111495.9 UniProtKB/TrEMBL
  ENSMUST00000168621 ENTREZGENE
  ENSMUST00000168621.3 UniProtKB/TrEMBL
  ENSMUST00000168621.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104574 ENTREZGENE
NCBI Gene 19271 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_tm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptprj PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AWF8 ENTREZGENE, UniProtKB/TrEMBL
  A2AWF9 ENTREZGENE, UniProtKB/TrEMBL
  E9Q4S7 ENTREZGENE, UniProtKB/TrEMBL
  PTPRJ_MOUSE UniProtKB/Swiss-Prot
  Q3UH64 ENTREZGENE
  Q3UHL5 ENTREZGENE
  Q3V2L7_MOUSE UniProtKB/TrEMBL
  Q541R5 ENTREZGENE
  Q61373_MOUSE UniProtKB/TrEMBL
  Q64455 ENTREZGENE
  Q8CIW9 ENTREZGENE
  Q8K3Q2 ENTREZGENE
UniProt Secondary Q3UH64 UniProtKB/Swiss-Prot
  Q3UHL5 UniProtKB/Swiss-Prot
  Q541R5 UniProtKB/Swiss-Prot
  Q8CIW9 UniProtKB/Swiss-Prot
  Q8K3Q2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-16 Ptprj  protein tyrosine phosphatase receptor type J  Ptprj  protein tyrosine phosphatase, receptor type, J  Symbol and/or name change 5135510 APPROVED