Aak1 (AP2 associated kinase 1) - Rat Genome Database

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Gene: Aak1 (AP2 associated kinase 1) Heterocephalus glaber
Analyze
Symbol: Aak1
Name: AP2 associated kinase 1
RGD ID: 18915648
Description: ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); Notch binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN positive regulation of Notch signaling pathway (ortholog); presynaptic endocytosis (ortholog); protein stabilization (ortholog); ASSOCIATED WITH genetic disease (ortholog); tooth agenesis (ortholog); FOUND IN calyx of Held (ortholog); cell leading edge (ortholog); clathrin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AP2-associated protein kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247623,723,113 - 3,866,417 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247623,722,429 - 3,873,105 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
Aak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247623,723,113 - 3,866,417 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247623,722,429 - 3,873,105 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
AAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38269,457,997 - 69,643,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl269,457,997 - 69,674,349 (-)EnsemblGRCh38hg38GRCh38
GRCh37269,685,129 - 69,870,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,538,631 - 69,724,481 (-)NCBINCBI36Build 36hg18NCBI36
Celera269,535,200 - 69,722,074 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef269,421,353 - 69,607,695 (-)NCBIHuRef
CHM1_1269,614,737 - 69,800,612 (-)NCBICHM1_1
T2T-CHM13v2.0269,470,304 - 69,656,050 (-)NCBIT2T-CHM13v2.0
Aak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,826,252 - 86,980,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,826,499 - 86,980,205 (+)EnsemblGRCm39 Ensembl
GRCm38686,849,274 - 87,003,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,849,517 - 87,003,223 (+)EnsemblGRCm38mm10GRCm38
MGSCv37686,799,511 - 86,953,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36686,815,474 - 86,957,498 (+)NCBIMGSCv36mm8
Celera688,789,320 - 88,942,625 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.75NCBI
Aak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,845,012 - 121,009,170 (+)NCBIGRCr8
mRatBN7.24119,300,128 - 119,451,834 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4124,774,675 - 124,914,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,549,404 - 120,688,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,173,657 - 119,313,191 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBICelera
Cytogenetic Map4q34NCBI
Aak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542415,483,465 - 15,627,664 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBIChiLan1.0ChiLan1.0
AAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21256,769,969 - 56,957,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A56,773,915 - 56,961,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,506,651 - 69,686,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,626,408 - 70,804,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,638,470 - 70,804,579 (-)Ensemblpanpan1.1panPan2
AAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,181,584 - 68,336,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1068,134,902 - 68,335,988 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1068,071,405 - 68,227,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01069,203,126 - 69,359,380 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1069,199,727 - 69,359,723 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,888,872 - 69,077,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01069,184,012 - 69,340,378 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,481,396 - 69,637,824 (-)NCBIUU_Cfam_GSD_1.0
Aak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629214,673,456 - 14,855,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,729,727 - 13,897,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,720,687 - 13,897,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl372,794,158 - 72,968,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1372,793,977 - 72,960,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11437,492,885 - 37,669,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1437,576,872 - 37,658,050 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604574,325,972 - 74,505,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000027141   ⟹   ENSHGLP00000026902
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247623,723,113 - 3,866,417 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000027142   ⟹   ENSHGLP00000026903
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247623,723,113 - 3,866,417 (+)Ensembl
RefSeq Acc Id: XM_004849927   ⟹   XP_004849984
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247623,722,430 - 3,873,105 (+)NCBI
RefSeq Acc Id: XM_013074038   ⟹   XP_012929492
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247623,722,429 - 3,873,105 (+)NCBI
RefSeq Acc Id: XM_021262508   ⟹   XP_021118167
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247623,722,430 - 3,873,105 (+)NCBI
RefSeq Acc Id: XR_001183824
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247623,722,430 - 3,873,105 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004849984 (Get FASTA)   NCBI Sequence Viewer  
  XP_012929492 (Get FASTA)   NCBI Sequence Viewer  
  XP_021118167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB11004 (Get FASTA)   NCBI Sequence Viewer  
  EHB11005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026902
  ENSHGLP00000026903
Reference Protein Sequences
RefSeq Acc Id: XP_012929492   ⟸   XM_013074038
- Peptide Label: isoform X1
- UniProtKB: G5BNZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004849984   ⟸   XM_004849927
- Peptide Label: isoform X2
- UniProtKB: G5BNZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021118167   ⟸   XM_021262508
- Peptide Label: isoform X3
- UniProtKB: G5BNZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000026902   ⟸   ENSHGLT00000027141
RefSeq Acc Id: ENSHGLP00000026903   ⟸   ENSHGLT00000027142


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019132 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027141 ENTREZGENE
  ENSHGLT00000027142 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Aak1 ENTREZGENE
PANTHER AP2-ASSOCIATED PROTEIN KINASE 1 UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt G5BNZ4 ENTREZGENE, UniProtKB/TrEMBL