CALM3 (calmodulin 3) - Rat Genome Database

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Gene: CALM3 (calmodulin 3) Canis lupus familiaris
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Symbol: CALM3
Name: calmodulin 3
RGD ID: 12283682
Description: ENCODES a protein that exhibits adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); calcium ion binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); autophagosome membrane docking (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calcium-mediated signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; ASSOCIATED WITH familial hypertrophic cardiomyopathy (ortholog); long QT syndrome (ortholog); long QT syndrome 1 (ortholog); FOUND IN cytoplasm (ortholog); growth cone (ortholog); mitochondrial membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: calmodulin; calmodulin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,284,729 - 109,294,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,286,155 - 109,294,391 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,764,035 - 108,773,479 (-)NCBI
ROS_Cfam_1.01109,810,758 - 109,820,206 (-)NCBI
UMICH_Zoey_3.11109,487,893 - 109,497,333 (-)NCBI
UNSW_CanFamBas_1.01109,121,990 - 109,131,419 (-)NCBI
UU_Cfam_GSD_1.01109,990,749 - 110,000,195 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
autophagosome membrane docking  (ISO)
calcium-mediated signaling  (ISO)
detection of calcium ion  (IEA)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
negative regulation of high voltage-gated calcium channel activity  (IEA)
negative regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
organelle localization by membrane tethering  (ISO)
positive regulation of cyclic-nucleotide phosphodiesterase activity  (IEA)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IEA)
positive regulation of protein dephosphorylation  (ISO)
positive regulation of ryanodine-sensitive calcium-release channel activity  (IBA)
regulation of cardiac muscle cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cyclase activity  (IEA)
regulation of cytokinesis  (IEA)
regulation of heart rate  (IEA)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
substantia nigra development  (ISO)

References

Genomics

Comparative Map Data
CALM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,284,729 - 109,294,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,286,155 - 109,294,391 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,764,035 - 108,773,479 (-)NCBI
ROS_Cfam_1.01109,810,758 - 109,820,206 (-)NCBI
UMICH_Zoey_3.11109,487,893 - 109,497,333 (-)NCBI
UNSW_CanFamBas_1.01109,121,990 - 109,131,419 (-)NCBI
UU_Cfam_GSD_1.01109,990,749 - 110,000,195 (-)NCBI
CALM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1946,601,074 - 46,610,782 (+)EnsemblGRCh38hg38GRCh38
GRCh381946,601,074 - 46,610,782 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371947,104,331 - 47,114,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,796,352 - 51,805,879 (+)NCBINCBI36hg18NCBI36
Build 341951,796,351 - 51,805,878NCBI
Celera1943,908,038 - 43,917,566 (+)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1943,529,569 - 43,539,096 (+)NCBIHuRef
CHM1_11947,106,370 - 47,115,897 (+)NCBICHM1_1
Calm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,649,304 - 16,657,957 (-)NCBIGRCm39mm39
GRCm39 Ensembl716,649,304 - 16,658,039 (-)Ensembl
GRCm38716,915,379 - 16,924,032 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,915,379 - 16,924,114 (-)EnsemblGRCm38mm10GRCm38
MGSCv37717,500,728 - 17,509,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv36716,073,901 - 16,082,476 (-)NCBImm8
Celera714,121,809 - 14,130,463 (-)NCBICelera
Cytogenetic Map7A2NCBI
cM Map79.15NCBI
Calm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,590,668 - 77,597,776 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl177,589,230 - 77,592,207 (-)Ensembl
Rnor_6.0178,844,520 - 78,851,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,843,080 - 78,851,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0180,092,078 - 80,099,186 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,245,609 - 77,252,717 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1177,322,279 - 77,330,919 (-)NCBI
Celera172,075,982 - 72,079,075 (-)NCBICelera
RH 3.4 Map1793.6RGD
Cytogenetic Map1q21NCBI
Calm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574672,300 - 680,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955574672,441 - 680,924 (+)NCBIChiLan1.0ChiLan1.0
CALM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,121,687 - 52,131,135 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,121,687 - 52,131,135 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01943,593,069 - 43,602,550 (+)NCBIMhudiblu_PPA_v0panPan3
Calm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934918,853,317 - 18,861,294 (+)NCBI
SpeTri2.0NW_004936664471,446 - 480,858 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,506,674 - 52,516,703 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,506,979 - 52,516,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,824,454 - 47,834,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,957,012 - 39,966,562 (+)NCBI
ChlSab1.1 Ensembl639,957,320 - 39,966,581 (+)Ensembl
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)Ensembl
ChlSab1.1 Ensembl1460,027,801 - 60,044,951 (+)Ensembl
Vero_WHO_p1.0NW_02366607319,668,290 - 19,677,858 (+)NCBI
Calm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248326,957,775 - 6,966,505 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 15
Medium 15 15 66 18 18 18 18 18 21 24 30 18
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022424705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038467782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038528502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038592785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038656583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038690509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_533635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000049912   ⟹   ENSCAFP00000038604
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1109,286,172 - 109,294,391 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067425   ⟹   ENSCAFP00000051634
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1109,286,155 - 109,293,530 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071582   ⟹   ENSCAFP00000047426
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1109,286,172 - 109,294,391 (-)Ensembl
RefSeq Acc Id: XM_022424705   ⟹   XP_022280413
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11109,286,247 - 109,294,137 (-)NCBI
Dog10K_Boxer_Tasha1108,765,553 - 108,773,134 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038467780   ⟹   XP_038323708
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11109,487,893 - 109,497,333 (-)NCBI
RefSeq Acc Id: XM_038467781   ⟹   XP_038323709
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11109,489,410 - 109,495,623 (-)NCBI
RefSeq Acc Id: XM_038467782   ⟹   XP_038323710
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11109,489,410 - 109,496,988 (-)NCBI
RefSeq Acc Id: XM_038528500   ⟹   XP_038384428
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01109,990,749 - 110,000,195 (-)NCBI
RefSeq Acc Id: XM_038528501   ⟹   XP_038384429
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01109,992,267 - 109,998,483 (-)NCBI
RefSeq Acc Id: XM_038528502   ⟹   XP_038384430
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01109,992,267 - 109,999,850 (-)NCBI
RefSeq Acc Id: XM_038592783   ⟹   XP_038448711
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01109,121,990 - 109,131,419 (-)NCBI
RefSeq Acc Id: XM_038592784   ⟹   XP_038448712
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01109,123,508 - 109,129,708 (-)NCBI
RefSeq Acc Id: XM_038592785   ⟹   XP_038448713
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01109,123,508 - 109,131,074 (-)NCBI
RefSeq Acc Id: XM_038656581   ⟹   XP_038512509
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01109,810,758 - 109,820,206 (-)NCBI
RefSeq Acc Id: XM_038656582   ⟹   XP_038512510
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01109,812,276 - 109,818,494 (-)NCBI
RefSeq Acc Id: XM_038656583   ⟹   XP_038512511
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01109,812,276 - 109,819,861 (-)NCBI
RefSeq Acc Id: XM_038690509   ⟹   XP_038546437
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1108,765,553 - 108,771,767 (-)NCBI
RefSeq Acc Id: XM_533635   ⟹   XP_533635
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11109,284,729 - 109,294,491 (-)NCBI
Dog10K_Boxer_Tasha1108,764,035 - 108,773,479 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_533635   ⟸   XM_533635
- Peptide Label: isoform X1
- UniProtKB: E2REK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022280413   ⟸   XM_022424705
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000038604   ⟸   ENSCAFT00000049912
RefSeq Acc Id: ENSCAFP00000051634   ⟸   ENSCAFT00000067425
RefSeq Acc Id: ENSCAFP00000047426   ⟸   ENSCAFT00000071582
RefSeq Acc Id: XP_038323708   ⟸   XM_038467780
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038323710   ⟸   XM_038467782
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038323709   ⟸   XM_038467781
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038448711   ⟸   XM_038592783
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038448713   ⟸   XM_038592785
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038448712   ⟸   XM_038592784
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038512509   ⟸   XM_038656581
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038512511   ⟸   XM_038656583
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038512510   ⟸   XM_038656582
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038546437   ⟸   XM_038690509
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038384428   ⟸   XM_038528500
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038384430   ⟸   XM_038528502
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038384429   ⟸   XM_038528501
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000029151 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000038604 ENTREZGENE
NCBI Gene CALM3 ENTREZGENE
UniProt E2REK6 ENTREZGENE