Calm1 (calmodulin 1) - Rat Genome Database

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Pathways
Gene: Calm1 (calmodulin 1) Chinchilla lanigera
Analyze
Symbol: Calm1
Name: calmodulin 1
RGD ID: 8824130
Description: ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); calcium channel inhibitor activity (ortholog); INVOLVED IN autophagosome membrane docking (ortholog); calcineurin-mediated signaling (ortholog); cell surface receptor signaling pathway via JAK-STAT (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH achondrogenesis type IA (ortholog); alcohol dependence (ortholog); alcohol withdrawal syndrome (ortholog); FOUND IN calcium channel complex (ortholog); calyx of Held (ortholog); catalytic complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calmodulin; calmodulin 1 (phosphorylase kinase, delta)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543812,842,437 - 12,854,028 (+)Ensembl
ChiLan1.0NW_00495543812,842,437 - 12,854,028 (+)NCBIChiLan1.0ChiLan1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome membrane docking  (ISO)
calcineurin-mediated signaling  (ISO)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to type II interferon  (ISO)
detection of calcium ion  (ISO)
establishment of protein localization to membrane  (ISO)
establishment of protein localization to mitochondrial membrane  (ISO)
G2/M transition of mitotic cell cycle  (ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
negative regulation of high voltage-gated calcium channel activity  (ISO)
negative regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
organelle localization by membrane tethering  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
presynaptic endocytosis  (ISO)
regulation of cardiac muscle cell action potential  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISO)
regulation of cell communication by electrical coupling involved in cardiac conduction  (ISO)
regulation of cytokinesis  (ISO)
regulation of heart rate  (ISO)
regulation of high voltage-gated calcium channel activity  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of synaptic vesicle endocytosis  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
substantia nigra development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adenosine monophosphate-activated protein kinase (AMPK) signaling pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway   (ISO)
glycogen degradation pathway  (ISO)
ibutilide pharmacodynamics pathway   (ISO)
insulin responsive facilitative sugar transporter mediated glucose transport pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
N-cadherin signaling pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway   (ISO)
p38 MAPK signaling pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
type II interferon signaling pathway   (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Calm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543812,842,437 - 12,854,028 (+)Ensembl
ChiLan1.0NW_00495543812,842,437 - 12,854,028 (+)NCBIChiLan1.0ChiLan1.0
CALM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381490,396,502 - 90,408,268 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1490,396,502 - 90,408,268 (+)Ensemblhg38GRCh38
GRCh371490,862,846 - 90,874,612 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361489,933,126 - 89,944,363 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341489,933,129 - 89,944,148NCBI
Celera1470,910,477 - 70,921,767 (+)NCBICelera
Cytogenetic Map14q32.11NCBI
HuRef1471,038,153 - 71,049,443 (+)NCBIHuRef
CHM1_11490,801,276 - 90,812,578 (+)NCBICHM1_1
T2T-CHM13v2.01484,621,229 - 84,632,993 (+)NCBIT2T-CHM13v2.0
Calm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912100,165,694 - 100,176,083 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12100,165,694 - 100,176,073 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812100,199,435 - 100,209,824 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,199,435 - 100,209,814 (+)Ensemblmm10GRCm38
MGSCv3712101,437,751 - 101,448,016 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612100,600,591 - 100,610,856 (+)NCBIMGSCv36mm8
Celera12101,426,181 - 101,436,442 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1250.43NCBI
Calm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86125,217,191 - 125,227,855 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6125,217,246 - 125,225,381 (+)EnsemblGRCr8
mRatBN7.26119,487,691 - 119,495,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6119,487,621 - 119,498,227 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6119,649,410 - 119,657,616 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06119,946,208 - 119,954,273 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06119,281,076 - 119,289,141 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06124,217,241 - 124,225,292 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,217,241 - 124,225,292 (+)Ensemblrn6Rnor6.0
Rnor_5.06133,444,207 - 133,452,258 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46124,477,601 - 124,485,669 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6117,015,915 - 117,023,918 (+)NCBICelera
RGSC_v3.16124,481,414 - 124,491,549 (+)NCBI
Cytogenetic Map6q32NCBI
CALM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21591,541,950 - 91,553,249 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11490,758,463 - 90,769,755 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01471,015,099 - 71,026,322 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11490,367,086 - 90,378,361 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,121,687 - 52,131,135 (+)EnsemblpanPan2panpan1.1
PanPan1.1 Ensembl2A48,204,518 - 48,220,697 (-)EnsemblpanPan2panpan1.1
CALM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1861,398,231 - 61,408,874 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl861,398,244 - 61,406,195 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha860,978,989 - 60,989,622 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0861,672,887 - 61,680,835 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl861,672,892 - 61,683,535 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1861,353,922 - 61,364,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0861,402,765 - 61,413,376 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0861,731,734 - 61,739,644 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Calm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864014,480,463 - 14,488,619 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648817,580,454 - 17,588,507 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648817,580,425 - 17,588,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7112,160,806 - 112,171,744 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.17112,160,823 - 112,171,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27118,728,008 - 118,738,940 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CALM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12468,133,446 - 68,145,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2468,133,428 - 68,145,180 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605355,415,057 - 55,426,335 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473412,030,001 - 12,041,772 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473412,030,264 - 12,041,682 (-)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000016632   ⟹   ENSCLAP00000016468
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543812,842,437 - 12,854,028 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000016633   ⟹   ENSCLAP00000016469
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543812,843,132 - 12,850,542 (+)Ensembl
RefSeq Acc Id: XM_005390283   ⟹   XP_005390340
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543812,842,437 - 12,854,028 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005390340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005386.1
  ENSCLAP00000016468
  ENSCLAP00000016468.1
  ENSCLAP00000016469.1
  ENSCLAP00000025915.1
RefSeq Acc Id: XP_005390340   ⟸   XM_005390283
- UniProtKB: A0A8C2YQS9 (UniProtKB/TrEMBL),   A0A8C2YVA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000016469   ⟸   ENSCLAT00000016633
Ensembl Acc Id: ENSCLAP00000016468   ⟸   ENSCLAT00000016632
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003822 UniProtKB/TrEMBL
  ENSCLAG00000011322 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAG00000018045 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005482.1 UniProtKB/TrEMBL
  ENSCLAT00000016632 ENTREZGENE
  ENSCLAT00000016632.1 UniProtKB/TrEMBL
  ENSCLAT00000016633.1 UniProtKB/TrEMBL
  ENSCLAT00000026219.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro CALM/Myosin/TropC-like UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
NCBI Gene Calm1 ENTREZGENE
PANTHER CALMODULIN LIKE 3 UniProtKB/TrEMBL
  MYOSIN LIGHT CHAIN 1, 3 UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8C2VJH9_CHILA UniProtKB/TrEMBL
  A0A8C2YQS9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YVA7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Calm1  calmodulin 1    calmodulin 1 (phosphorylase kinase, delta)  Symbol and/or name change 5135510 APPROVED