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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:paricalcitol
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Accession:CHEBI:7931 term browser browse the term
Definition:A seco-cholestane that has formula C27H44O3.
Synonyms:exact_synonym: (1R,3R,7E)-17beta-[(2R,3E,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-9,10-secoestra-5,7-diene-1,3-diol
 related_synonym: 19-Nor-1alpha,25-dihydroxyvitamin D2;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1;   InChIKey=BPKAHTKRCLCHEA-UBFJEZKGSA-N;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1C[C@@H](O)C[C@H](O)C1)[C@H](C)\\C=C\\[C@H](C)C(C)(C)O;   Zemplar
 xref: CAS:131918-61-1;   DrugBank:DB00910;   Drug_Central:2066;   KEGG:C08127;   KEGG:D00930
 xref_mesh: MESH:C084656
 xref: Patent:EP387077;   Patent:US5587497;   Wikipedia:Paricalcitol


show annotations for term's descendants           Sort by:
paricalcitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAC arylacetamide deacetylase multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of AADAC mRNA CTD PMID:17715259 NCBI chr 3:151,814,116...151,828,488
Ensembl chr 3:151,814,073...151,828,488 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing increases expression ISO paricalcitol results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G ADIPOR1 adiponectin receptor 1 increases expression ISO paricalcitol results in increased expression of ADIPOR1 protein CTD PMID:25037058 NCBI chr 1:202,940,825...202,958,572
Ensembl chr 1:202,940,826...202,958,572 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of ALPL mRNA CTD PMID:17715259 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G APOE apolipoprotein E multiple interactions ISO
EXP		 paricalcitol inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]
[Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNA		 CTD PMID:17715259 PMID:25037058 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G B4GALT1 beta-1,4-galactosyltransferase 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of B4GALT1 mRNA CTD PMID:17715259 NCBI chr 9:33,104,077...33,185,089
Ensembl chr 9:33,104,082...33,167,356 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [paricalcitol co-treated with arsenic trioxide] results in decreased expression of BCL2 CTD PMID:15781666 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP [paricalcitol co-treated with arsenic trioxide] results in decreased expression of BCL2L1 CTD PMID:15781666 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BMP4 bone morphogenetic protein 4 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of BMP4 mRNA CTD PMID:17715259 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G CAMP cathelicidin antimicrobial peptide multiple interactions EXP paricalcitol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; paricalcitol promotes the reaction [resveratrol results in increased expression of CAMP mRNA] CTD PMID:24039193 NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases expression
decreases expression		 ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
paricalcitol results in increased expression of CCL2 mRNA
paricalcitol results in decreased expression of CCL2 protein		 CTD PMID:17513326 PMID:20720404 PMID:25037058 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 increases expression ISO paricalcitol results in increased expression of CCR2 mRNA CTD PMID:25037058 NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940 		JBrowse link
G CD14 CD14 molecule increases expression
multiple interactions		 EXP paricalcitol results in increased expression of CD14 protein
[Phosphorus co-treated with paricalcitol] results in increased expression of CD14 mRNA		 CTD PMID:12618899 PMID:17715259 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700 		JBrowse link
G CES1 carboxylesterase 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of CES1 mRNA CTD PMID:17715259 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G COL15A1 collagen type XV alpha 1 chain multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of COL15A1 mRNA CTD PMID:17715259 NCBI chr 9:98,943,907...99,070,787
Ensembl chr 9:98,943,179...99,070,787 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of COL1A1 mRNA CTD PMID:17715259 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL3A1 collagen type III alpha 1 chain increases expression ISO paricalcitol results in increased expression of COL3A1 mRNA CTD PMID:25037058 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746 		JBrowse link
G CP ceruloplasmin multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of CP mRNA CTD PMID:17715259 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829 		JBrowse link
G CPN2 carboxypeptidase N subunit 2 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of CPN2 mRNA CTD PMID:17715259 NCBI chr 3:194,339,768...194,351,328
Ensembl chr 3:194,339,768...194,351,328 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of CPT1A mRNA CTD PMID:17715259 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CRIP1 cysteine rich protein 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of CRIP1 mRNA CTD PMID:17715259 NCBI chr14:105,486,886...105,488,947
Ensembl chr14:105,486,317...105,488,947 		JBrowse link
G CTDSPL CTD small phosphatase like multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA CTD PMID:17715259 NCBI chr 3:37,861,880...37,984,469
Ensembl chr 3:37,861,880...37,984,469 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of CXCL8 mRNA CTD PMID:17715259 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions
decreases expression		 ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
paricalcitol results in decreased expression of CYBA protein		 CTD PMID:20720404 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of CYP1B1 mRNA CTD PMID:17715259 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 multiple interactions EXP
ISO		 [arsenic trioxide results in decreased expression of CYP24A1] which results in increased activity of paricalcitol; [Phosphorus co-treated with paricalcitol] results in increased expression of CYP24A1 mRNA CTD PMID:15781666 PMID:17715259 NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of CYP2B6 mRNA CTD PMID:17715259 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP paricalcitol results in increased expression of CYP3A4 mRNA CTD PMID:11723248 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G EDN1 endothelin 1 multiple interactions ISO paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form] CTD PMID:21565836 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDNRB endothelin receptor type B multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of EDNRB mRNA CTD PMID:17715259 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529 		JBrowse link
G ENG endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 9:127,815,016...127,854,658
Ensembl chr 9:127,815,013...127,854,658 		JBrowse link
G FBLN2 fibulin 2 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of FBLN2 mRNA CTD PMID:17715259 NCBI chr 3:13,549,125...13,638,404
Ensembl chr 3:13,549,125...13,638,422 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA CTD PMID:25037058 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G ID3 inhibitor of DNA binding 3 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNA CTD PMID:17715259 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501 		JBrowse link
G IL11 interleukin 11 multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of IL11 mRNA CTD PMID:17715259 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of IL1A mRNA CTD PMID:17715259 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of IL1B mRNA CTD PMID:17715259 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1RN interleukin 1 receptor antagonist multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of IL1RN mRNA CTD PMID:17715259 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL24 interleukin 24 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of IL24 mRNA CTD PMID:17715259 NCBI chr 1:206,897,443...206,904,139
Ensembl chr 1:206,897,443...206,904,139 		JBrowse link
G IL36RN interleukin 36 receptor antagonist multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of IL36RN mRNA CTD PMID:17715259 NCBI chr 2:113,058,638...113,064,744
Ensembl chr 2:113,058,638...113,065,382 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of IL6 mRNA CTD PMID:17715259 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGA2 integrin subunit alpha 2 decreases expression ISO paricalcitol results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G ITGAM integrin subunit alpha M increases expression EXP paricalcitol results in increased expression of ITGAM protein CTD PMID:12618899 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G MAPK13 mitogen-activated protein kinase 13 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of MAPK13 mRNA CTD PMID:17715259 NCBI chr 6:36,130,513...36,144,521
Ensembl chr 6:36,127,809...36,144,524 		JBrowse link
G MELTF melanotransferrin multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of MELTF mRNA CTD PMID:17715259 NCBI chr 3:197,001,740...197,029,817
Ensembl chr 3:196,980,590...197,029,835 		JBrowse link
G MGP matrix Gla protein multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of MGP mRNA CTD PMID:17715259 NCBI chr12:14,880,864...14,885,854
Ensembl chr12:14,880,864...14,885,857 		JBrowse link
G MRPL33 mitochondrial ribosomal protein L33 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of MRPL33 mRNA CTD PMID:17715259 NCBI chr 2:27,771,719...27,779,733
Ensembl chr 2:27,771,717...27,988,087 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the localization of NCOR1 protein; [Phosphorus co-treated with paricalcitol] results in decreased expression of NCOR1 protein CTD PMID:17715259 NCBI chr17:16,029,157...16,215,534
Ensembl chr17:16,029,065...16,218,185 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO [paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
paricalcitol results in decreased expression of NOS2 protein		 CTD PMID:20720404 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression		 ISO [paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein
paricalcitol results in increased expression of NOS3 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:21565836 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NPY neuropeptide Y increases expression ISO paricalcitol results in increased expression of NPY mRNA CTD PMID:25037058 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of NR4A1 mRNA CTD PMID:17715259 NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of NR4A2 mRNA CTD PMID:17715259 NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348 		JBrowse link
G PEX11A peroxisomal biogenesis factor 11 alpha multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of PEX11A mRNA CTD PMID:17715259 NCBI chr15:89,681,535...89,690,754
Ensembl chr15:89,677,764...89,690,783 		JBrowse link
G POSTN periostin multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in decreased expression of POSTN mRNA CTD PMID:17715259 NCBI chr13:37,562,585...37,598,768
Ensembl chr13:37,562,583...37,598,844 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased localization of PPARG protein CTD PMID:17715259 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO paricalcitol results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PRKCA protein kinase C alpha multiple interactions
decreases expression		 ISO paricalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]
paricalcitol results in decreased expression of PRKCA protein modified form		 CTD PMID:21565836 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS1 mRNA CTD PMID:17715259 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 EXP
ISO		 [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS2 mRNA
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein
paricalcitol results in decreased expression of PTGS2 protein		 CTD PMID:17715259 PMID:20720404 PMID:25037058 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTH parathyroid hormone decreases secretion
decreases expression		 EXP paricalcitol results in decreased secretion of PTH protein
paricalcitol results in decreased expression of PTH protein		 CTD PMID:12631365 PMID:15898824 NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181 		JBrowse link
G RARRES1 retinoic acid receptor responder 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of RARRES1 mRNA CTD PMID:17715259 NCBI chr 3:158,696,892...158,732,457
Ensembl chr 3:158,696,892...158,732,489 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased localization of RELA protein CTD PMID:17715259 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G REN renin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of REN1 mRNA CTD PMID:17715259 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G SELL selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702 		JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of SERPINE1 mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of SERPINE1 protein CTD PMID:17715259 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SMAD2 SMAD family member 2 decreases phosphorylation
multiple interactions		 ISO paricalcitol results in decreased phosphorylation of SMAD2 protein
Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein]		 CTD PMID:17513326 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression
multiple interactions		 ISO paricalcitol results in increased expression of SOD1 protein
[paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 decreases expression
multiple interactions		 ISO paricalcitol results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein		 CTD PMID:20720404 PMID:25037058 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOD3 superoxide dismutase 3 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of SOD3 mRNA CTD PMID:17715259 NCBI chr 4:24,795,573...24,800,842
Ensembl chr 4:24,789,912...24,800,842 		JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions
increases expression		 EXP
ISO		 [Phosphorus co-treated with paricalcitol] results in increased expression of SPP1 mRNA
paricalcitol results in increased expression of SPP1 mRNA
[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA		 CTD PMID:17715259 PMID:25037058 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases expression		 ISO Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
paricalcitol results in decreased expression of TGFB1 mRNA; paricalcitol results in decreased expression of TGFB1 protein		 CTD PMID:17513326 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB3 transforming growth factor beta 3 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of TGFB3 mRNA CTD PMID:17715259 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011 		JBrowse link
G THBD thrombomodulin multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of THBD mRNA; [Phosphorus co-treated with paricalcitol] results in increased expression of THBD protein CTD PMID:17715259 NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672 		JBrowse link
G THBS1 thrombospondin 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of THBS1 mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of THBS1 protein CTD PMID:17715259 NCBI chr15:39,581,079...39,599,466
Ensembl chr15:39,581,079...39,599,466 		JBrowse link
G TNF tumor necrosis factor decreases expression
multiple interactions		 ISO paricalcitol results in decreased expression of TNF protein
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein		 CTD PMID:20720404 PMID:25037058 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b multiple interactions EXP [Phosphorus co-treated with paricalcitol] affects the expression of TNFRSF11B mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of TNFRSF11B protein CTD PMID:17715259 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TNFSF11 TNF superfamily member 11 increases expression ISO paricalcitol results in increased expression of TNFSF11 mRNA; paricalcitol results in increased expression of TNFSF11 protein CTD PMID:17352647 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TNXB tenascin XB multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of TNXB mRNA CTD PMID:17715259 NCBI chr 6:32,041,153...32,109,338
Ensembl chr 6:32,041,153...32,115,334 		JBrowse link
G TREM1 triggering receptor expressed on myeloid cells 1 multiple interactions EXP [Phosphorus co-treated with paricalcitol] results in increased expression of TREM1 mRNA CTD PMID:17715259 NCBI chr 6:41,267,385...41,286,682
Ensembl chr 6:41,267,926...41,286,682 		JBrowse link
G VDR vitamin D receptor multiple interactions
affects binding		 EXP [Phosphorus co-treated with paricalcitol] results in increased expression of VDR protein; [Phosphorus co-treated with paricalcitol] results in increased localization of VDR protein; paricalcitol binds to and affects the activity of VDR protein
paricalcitol binds to VDR protein		 CTD PMID:15898824 PMID:16076355 PMID:17715259 NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048 		JBrowse link
G VWF von Willebrand factor decreases expression ISO paricalcitol results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr12:5,948,877...6,124,670
Ensembl chr12:5,948,877...6,124,770 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        pesticide 20542
          rodenticide 10918
            vitamin D2 83
              paricalcitol 83
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic polycyclic compound 18807
                                  steroid 15867
                                    hydroxy steroid 15544
                                      hydroxy seco-steroid 2798
                                        vitamin D 2793
                                          vitamin D2 83
                                            paricalcitol 83
paths to the root