CTDSPL (CTD small phosphatase like) - Rat Genome Database

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Pathways
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Gene: CTDSPL (CTD small phosphatase like) Homo sapiens
Analyze
Symbol: CTDSPL
Name: CTD small phosphatase like
RGD ID: 1345284
HGNC Page HGNC:16890
Description: Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Located in extracellular exosome. Biomarker of lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C3orf8; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CTD small phosphatase-like protein; CTDSP-like; HYA22; NIF-like protein; NLI-interacting factor 1; nuclear LIM interactor-interacting factor 1; PSR1; RB protein serine phosphatase from chromosome 3; RBSP3; SCP3; small C-terminal domain phosphatase 3; small CTD phosphatase 3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38337,861,880 - 37,984,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl337,861,880 - 37,984,469 (+)EnsemblGRCh38hg38GRCh38
GRCh37337,903,371 - 38,025,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36337,878,673 - 38,000,964 (+)NCBINCBI36Build 36hg18NCBI36
Build 34337,878,672 - 38,000,964NCBI
Celera337,838,040 - 37,960,332 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef337,846,293 - 37,968,646 (+)NCBIHuRef
CHM1_1337,855,336 - 37,977,609 (+)NCBICHM1_1
T2T-CHM13v2.0337,866,043 - 37,988,649 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methylcholine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
dorsomorphin  (EXP)
fenvalerate  (ISO)
folic acid  (ISO)
FR900359  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
indometacin  (EXP)
lipopolysaccharide  (EXP)
mitomycin C  (EXP)
nickel atom  (EXP)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (EXP)
phenobarbital  (EXP)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pirinixic acid  (EXP)
potassium chromate  (EXP)
progesterone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
triacsin C  (EXP)
trichostatin A  (EXP)
urethane  (EXP)
valproic acid  (EXP)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays. Dmitriev AA, etal., Epigenetics. 2012 May;7(5):502-13. doi: 10.4161/epi.19801. Epub 2012 May 1.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9179494   PMID:10617616   PMID:11145967   PMID:11278802   PMID:11572868   PMID:11884399   PMID:12052871   PMID:12543795   PMID:12721286   PMID:14645848   PMID:15009212   PMID:15051889  
PMID:16882717   PMID:17085434   PMID:17903305   PMID:19004823   PMID:19016758   PMID:19047128   PMID:19056867   PMID:19140316   PMID:19322201   PMID:19478941   PMID:19885927   PMID:20193080  
PMID:20379614   PMID:20412120   PMID:21643017   PMID:21873635   PMID:26186194   PMID:27414789   PMID:27458253   PMID:27880917   PMID:28065597   PMID:28514442   PMID:28611215   PMID:29382357  
PMID:29672635   PMID:29987050   PMID:31774910   PMID:32296183   PMID:32973332   PMID:33961781   PMID:37341065  


Genomics

Comparative Map Data
CTDSPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38337,861,880 - 37,984,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl337,861,880 - 37,984,469 (+)EnsemblGRCh38hg38GRCh38
GRCh37337,903,371 - 38,025,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36337,878,673 - 38,000,964 (+)NCBINCBI36Build 36hg18NCBI36
Build 34337,878,672 - 38,000,964NCBI
Celera337,838,040 - 37,960,332 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef337,846,293 - 37,968,646 (+)NCBIHuRef
CHM1_1337,855,336 - 37,977,609 (+)NCBICHM1_1
T2T-CHM13v2.0337,866,043 - 37,988,649 (+)NCBIT2T-CHM13v2.0
Ctdspl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,751,313 - 118,873,187 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,755,521 - 118,873,066 (+)EnsemblGRCm39 Ensembl
GRCm389118,926,536 - 119,044,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9118,926,453 - 119,043,998 (+)EnsemblGRCm38mm10GRCm38
MGSCv379118,835,654 - 118,953,237 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369118,775,151 - 118,892,696 (+)NCBIMGSCv36mm8
Celera9119,394,549 - 119,512,016 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.07NCBI
Ctdspl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,520,478 - 127,644,999 (+)NCBIGRCr8
mRatBN7.28118,642,729 - 118,767,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,642,672 - 118,767,117 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,244,175 - 124,368,918 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,443,118 - 122,567,868 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,275,667 - 120,400,578 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,065,292 - 127,726,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,702,534 - 127,726,127 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,919,687 - 126,943,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48123,960,578 - 123,993,452 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18123,974,546 - 124,009,969 (+)NCBI
Celera8117,907,827 - 117,940,703 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ctdspl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554214,705,664 - 4,831,726 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554214,705,664 - 4,831,463 (+)NCBIChiLan1.0ChiLan1.0
CTDSPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2237,816,360 - 37,938,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1337,821,114 - 37,943,502 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0337,761,101 - 37,883,330 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,093,899 - 38,166,485 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,127,971 - 38,166,485 (+)Ensemblpanpan1.1panPan2
CTDSPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,616,264 - 7,760,595 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,725,446 - 7,758,067 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,687,460 - 7,802,513 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0237,934,233 - 8,049,568 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1237,748,828 - 7,863,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0237,889,843 - 8,005,071 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,882,182 - 7,997,474 (+)NCBIUU_Cfam_GSD_1.0
Ctdspl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,090,974 - 194,201,910 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,228,036 - 27,340,483 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,228,512 - 27,340,483 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTDSPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,707,444 - 22,825,400 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,707,736 - 22,828,773 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21324,871,071 - 24,994,198 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTDSPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,418,855 - 1,536,527 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,418,848 - 1,536,457 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606310,149,434 - 10,267,766 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctdspl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477320,158,045 - 20,290,992 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477320,154,468 - 20,290,975 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTDSPL
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p25.3-22.2(chr3:11463328-38919543)x3 copy number gain See cases [RCV000051720] Chr3:11463328..38919543 [GRCh38]
Chr3:11504802..38961034 [GRCh37]
Chr3:11479802..38936038 [NCBI36]
Chr3:3p25.3-22.2		 pathogenic
GRCh38/hg38 3p22.3-22.1(chr3:33728406-40662451)x3 copy number gain See cases [RCV000134924] Chr3:33728406..40662451 [GRCh38]
Chr3:33769898..40703942 [GRCh37]
Chr3:33744902..40678946 [NCBI36]
Chr3:3p22.3-22.1		 pathogenic
GRCh38/hg38 3p26.3-22.1(chr3:53308-41381521)x3 copy number gain See cases [RCV000141810] Chr3:53308..41381521 [GRCh38]
Chr3:94991..41423012 [GRCh37]
Chr3:69991..41398016 [NCBI36]
Chr3:3p26.3-22.1		 pathogenic
NM_001008392.2(CTDSPL):c.80-8666_80-2299del deletion Gestational diabetes mellitus uncontrolled [RCV000161273]|Normal pregnancy [RCV000161274]|Preeclampsia [RCV000161272] Chr3:37938390..37944757 [GRCh38]
Chr3:37979881..37986248 [GRCh37]
Chr3:3p22.2		 not provided
GRCh37/hg19 3p22.2-21.31(chr3:37028313-49929220)x3 copy number gain See cases [RCV000240519] Chr3:37028313..49929220 [GRCh37]
Chr3:3p22.2-21.31		 likely pathogenic
GRCh37/hg19 3p22.2(chr3:37891706-38877793)x3 copy number gain See cases [RCV000599294] Chr3:37891706..38877793 [GRCh37]
Chr3:3p22.2		 uncertain significance
GRCh37/hg19 3p22.2(chr3:37341745-38109534)x3 copy number gain See cases [RCV000447481] Chr3:37341745..38109534 [GRCh37]
Chr3:3p22.2		 uncertain significance
NC_000003.11:g.(?_37493846)_(38991873_?)del deletion Brugada syndrome [RCV000531304] Chr3:37493846..38991873 [GRCh37]
Chr3:3p22.2		 pathogenic|uncertain significance
GRCh37/hg19 3p22.2(chr3:37347773-38109534)x3 copy number gain See cases [RCV000445940] Chr3:37347773..38109534 [GRCh37]
Chr3:3p22.2		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
NM_001008392.2(CTDSPL):c.785G>A (p.Arg262Gln) single nucleotide variant Inborn genetic diseases [RCV003252204] Chr3:37980821 [GRCh38]
Chr3:38022312 [GRCh37]
Chr3:3p22.2		 uncertain significance
GRCh37/hg19 3p24.3-21.31(chr3:16923595-45249923)x2,3 copy number gain not provided [RCV000682249] Chr3:16923595..45249923 [GRCh37]
Chr3:3p24.3-21.31		 pathogenic
GRCh37/hg19 3p22.2(chr3:38021661-38510752)x3 copy number gain not provided [RCV000682254] Chr3:38021661..38510752 [GRCh37]
Chr3:3p22.2		 uncertain significance
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29		 pathogenic
GRCh37/hg19 3p22.2(chr3:37973595-37990100)x0 copy number loss not provided [RCV000742366] Chr3:37973595..37990100 [GRCh37]
Chr3:3p22.2		 benign
GRCh37/hg19 3p22.2(chr3:37979059-37990100)x1 copy number loss not provided [RCV000742367] Chr3:37979059..37990100 [GRCh37]
Chr3:3p22.2		 benign
GRCh37/hg19 3p22.2(chr3:37979059-37996268)x1 copy number loss not provided [RCV000742368] Chr3:37979059..37996268 [GRCh37]
Chr3:3p22.2		 benign
GRCh37/hg19 3p22.2(chr3:37979059-38009700)x1 copy number loss not provided [RCV000742369] Chr3:37979059..38009700 [GRCh37]
Chr3:3p22.2		 benign
NC_000003.12:g.(?_37452365)_(38950372_?)del deletion Brugada syndrome [RCV000823258] Chr3:37452365..38950372 [GRCh38]
Chr3:37493856..38991863 [GRCh37]
Chr3:3p22.2		 pathogenic
GRCh37/hg19 3p22.2(chr3:37347149-38120470)x3 copy number gain not provided [RCV000849269] Chr3:37347149..38120470 [GRCh37]
Chr3:3p22.2		 uncertain significance
GRCh37/hg19 3p22.2(chr3:37987092-38194369)x3 copy number gain not provided [RCV001005425] Chr3:37987092..38194369 [GRCh37]
Chr3:3p22.2		 uncertain significance
NC_000003.12:g.(?_37452365)_(38950372_?)dup duplication Heterotaxy, visceral, 4, autosomal [RCV001031367] Chr3:37493856..38991863 [GRCh37]
Chr3:3p22.2		 uncertain significance
NC_000003.11:g.(?_37493856)_(38991863_?)dup duplication Heterotaxy, visceral, 4, autosomal [RCV001324195] Chr3:37493856..38991863 [GRCh37]
Chr3:3p22.2		 uncertain significance
GRCh37/hg19 3p22.2(chr3:37347773-38109534) copy number gain not specified [RCV002053340] Chr3:37347773..38109534 [GRCh37]
Chr3:3p22.2		 uncertain significance
NC_000003.11:g.(?_37034542)_(38835501_?)dup duplication Heterotaxy, visceral, 4, autosomal [RCV001900394] Chr3:37034542..38835501 [GRCh37]
Chr3:3p22.2		 uncertain significance
NC_000003.11:g.(?_16710965)_(41275270_?)del deletion not provided [RCV001958625] Chr3:16710965..41275270 [GRCh37]
Chr3:3p24.3-22.1		 pathogenic
NM_001008392.2(CTDSPL):c.137T>C (p.Phe46Ser) single nucleotide variant Inborn genetic diseases [RCV002817779] Chr3:37947114 [GRCh38]
Chr3:37988605 [GRCh37]
Chr3:3p22.2		 uncertain significance
NM_001008392.2(CTDSPL):c.274G>A (p.Ala92Thr) single nucleotide variant Inborn genetic diseases [RCV002974153] Chr3:37964577 [GRCh38]
Chr3:38006068 [GRCh37]
Chr3:3p22.2		 uncertain significance
NM_001008392.2(CTDSPL):c.16A>G (p.Ile6Val) single nucleotide variant Inborn genetic diseases [RCV002660113] Chr3:37862215 [GRCh38]
Chr3:37903706 [GRCh37]
Chr3:3p22.2		 uncertain significance
NM_001008392.2(CTDSPL):c.793G>A (p.Asp265Asn) single nucleotide variant Inborn genetic diseases [RCV002984442] Chr3:37980829 [GRCh38]
Chr3:38022320 [GRCh37]
Chr3:3p22.2		 uncertain significance
NM_001008392.2(CTDSPL):c.362C>T (p.Ser121Leu) single nucleotide variant Inborn genetic diseases [RCV002959829] Chr3:37964665 [GRCh38]
Chr3:38006156 [GRCh37]
Chr3:3p22.2		 uncertain significance
NM_001008392.2(CTDSPL):c.250G>A (p.Val84Ile) single nucleotide variant Inborn genetic diseases [RCV003300508] Chr3:37957126 [GRCh38]
Chr3:37998617 [GRCh37]
Chr3:3p22.2		 uncertain significance
NM_001008392.2(CTDSPL):c.266G>A (p.Ser89Asn) single nucleotide variant Inborn genetic diseases [RCV003344738] Chr3:37957142 [GRCh38]
Chr3:37998633 [GRCh37]
Chr3:3p22.2		 uncertain significance
GRCh37/hg19 3p22.2(chr3:37338764-38109534)x3 copy number gain not provided [RCV003484126] Chr3:37338764..38109534 [GRCh37]
Chr3:3p22.2		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR100hsa-miR-100-5pOncomiRDBexternal_infoNANA21643017

Predicted Target Of
Summary Value
Count of predictions:5712
Count of miRNA genes:1142
Interacting mature miRNAs:1412
Transcripts:ENST00000273179, ENST00000310189, ENST00000416688, ENST00000435525, ENST00000436654, ENST00000443503, ENST00000447745, ENST00000486978
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D3S4237  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,022,439 - 38,022,584UniSTSGRCh37
Build 36337,997,443 - 37,997,588RGDNCBI36
Celera337,956,811 - 37,956,956RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,965,125 - 37,965,270UniSTS
Stanford-G3 RH Map31630.0UniSTS
NCBI RH Map3348.1UniSTS
GeneMap99-G3 RH Map31528.0UniSTS
D3S3077  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,010,912 - 38,011,114UniSTSGRCh37
Build 36337,985,916 - 37,986,118RGDNCBI36
Celera337,945,284 - 37,945,486RGD
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map3p22.2UniSTS
HuRef337,953,598 - 37,953,800UniSTS
RH36200  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,907,677 - 37,907,782UniSTSGRCh37
Build 36337,882,681 - 37,882,786RGDNCBI36
Celera337,842,048 - 37,842,153RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,850,301 - 37,850,406UniSTS
GeneMap99-GB4 RH Map3130.65UniSTS
SHGC-33953  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,004,757 - 38,004,860UniSTSGRCh37
Build 36337,979,761 - 37,979,864RGDNCBI36
Celera337,939,128 - 37,939,231RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,947,442 - 37,947,545UniSTS
Stanford-G3 RH Map31616.0UniSTS
GeneMap99-G3 RH Map31514.0UniSTS
A009X11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,922,226 - 37,922,375UniSTSGRCh37
Build 36337,897,230 - 37,897,379RGDNCBI36
Celera337,856,597 - 37,856,746RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,864,848 - 37,864,997UniSTS
GeneMap99-GB4 RH Map3133.3UniSTS
NCBI RH Map3328.0UniSTS
SHGC-81988  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,991,350 - 37,991,675UniSTSGRCh37
Build 36337,966,354 - 37,966,679RGDNCBI36
Celera337,925,715 - 37,926,040RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,934,029 - 37,934,354UniSTS
TNG Radiation Hybrid Map323939.0UniSTS
SHGC-132579  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,977,837 - 37,978,033UniSTSGRCh37
Build 36337,952,841 - 37,953,037RGDNCBI36
Celera337,912,201 - 37,912,397RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,920,516 - 37,920,712UniSTS
TNG Radiation Hybrid Map323953.0UniSTS
A009X46  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,004,703 - 38,004,803UniSTSGRCh37
Build 36337,979,707 - 37,979,807RGDNCBI36
Celera337,939,074 - 37,939,174RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,947,388 - 37,947,488UniSTS
GeneMap99-GB4 RH Map3135.41UniSTS
D3S4385  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,914,715 - 37,914,971UniSTSGRCh37
Build 36337,889,719 - 37,889,975RGDNCBI36
Celera337,849,086 - 37,849,342RGD
HuRef337,857,339 - 37,857,595UniSTS
D3S4393  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,903,708 - 37,904,002UniSTSGRCh37
Build 36337,878,712 - 37,879,006RGDNCBI36
Celera337,838,079 - 37,838,373RGD
HuRef337,846,332 - 37,846,626UniSTS
SHGC-34330  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,922,371 - 37,922,506UniSTSGRCh37
Build 36337,897,375 - 37,897,510RGDNCBI36
Celera337,856,742 - 37,856,877RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,864,993 - 37,865,128UniSTS
GeneMap99-GB4 RH Map3131.96UniSTS
Whitehead-RH Map3141.7UniSTS
NCBI RH Map3325.5UniSTS
GeneMap99-G3 RH Map31514.0UniSTS
RH44586  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,922,256 - 37,922,407UniSTSGRCh37
Build 36337,897,260 - 37,897,411RGDNCBI36
Celera337,856,627 - 37,856,778RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,864,878 - 37,865,029UniSTS
GeneMap99-GB4 RH Map3132.79UniSTS
SHGC-36278  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,977,973 - 37,978,087UniSTSGRCh37
Build 36337,952,977 - 37,953,091RGDNCBI36
Celera337,912,337 - 37,912,451RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,920,652 - 37,920,766UniSTS
Stanford-G3 RH Map31605.0UniSTS
NCBI RH Map3346.8UniSTS
GeneMap99-G3 RH Map31503.0UniSTS
RH16286  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,004,615 - 38,004,776UniSTSGRCh37
Build 36337,979,619 - 37,979,780RGDNCBI36
Celera337,938,986 - 37,939,147RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,947,300 - 37,947,461UniSTS
GeneMap99-GB4 RH Map3135.41UniSTS
NCBI RH Map3358.6UniSTS
RH12233  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,022,439 - 38,022,603UniSTSGRCh37
Build 36337,997,443 - 37,997,607RGDNCBI36
Celera337,956,811 - 37,956,975RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,965,125 - 37,965,289UniSTS
GeneMap99-GB4 RH Map3133.68UniSTS
NCBI RH Map3358.6UniSTS
G29265  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,025,243 - 38,025,379UniSTSGRCh37
Build 36338,000,247 - 38,000,383RGDNCBI36
Celera337,959,615 - 37,959,751RGD
Cytogenetic Map3p21.3UniSTS
HuRef337,967,929 - 37,968,065UniSTS
CTDSPL_3523  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,023,240 - 38,024,145UniSTSGRCh37
Build 36337,998,244 - 37,999,149RGDNCBI36
Celera337,957,612 - 37,958,517RGD
HuRef337,965,926 - 37,966,831UniSTS
G32964  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37338,004,703 - 38,004,803UniSTSGRCh37
Celera337,939,074 - 37,939,174UniSTS
Cytogenetic Map3p21.3UniSTS
HuRef337,947,388 - 37,947,488UniSTS
G32937  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37337,922,226 - 37,922,375UniSTSGRCh37
Celera337,856,597 - 37,856,746UniSTS
Cytogenetic Map3p21.3UniSTS
HuRef337,864,848 - 37,864,997UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2408 1866 1141 336 439 179 3741 1348 2196 408 1366 1544 168 1104 2205 4
Low 30 1085 585 288 1061 286 615 848 1537 11 93 66 6 1 100 583 2 2
Below cutoff 1 36 276 1 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017005520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047447182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054344907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI143812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI192993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ575644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ575645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY279532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY364238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000273179   ⟹   ENSP00000273179
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,861,880 - 37,984,469 (+)Ensembl
RefSeq Acc Id: ENST00000310189
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,954,417 - 37,981,125 (+)Ensembl
RefSeq Acc Id: ENST00000416688   ⟹   ENSP00000404977
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,861,921 - 37,968,432 (+)Ensembl
RefSeq Acc Id: ENST00000435525   ⟹   ENSP00000408183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,862,178 - 37,947,171 (+)Ensembl
RefSeq Acc Id: ENST00000436654   ⟹   ENSP00000409600
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,862,184 - 37,982,442 (+)Ensembl
RefSeq Acc Id: ENST00000443503   ⟹   ENSP00000398288
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,861,960 - 37,984,469 (+)Ensembl
RefSeq Acc Id: ENST00000447745   ⟹   ENSP00000407443
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,964,637 - 37,984,468 (+)Ensembl
RefSeq Acc Id: ENST00000486978
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl337,944,714 - 37,975,786 (+)Ensembl
RefSeq Acc Id: NM_001008392   ⟹   NP_001008393
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38337,861,880 - 37,984,469 (+)NCBI
GRCh37337,903,669 - 38,025,960 (+)ENTREZGENE
Build 36337,878,673 - 38,000,964 (+)NCBI Archive
HuRef337,846,293 - 37,968,646 (+)ENTREZGENE
CHM1_1337,855,336 - 37,977,609 (+)NCBI
T2T-CHM13v2.0337,866,043 - 37,988,649 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005808   ⟹   NP_005799
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38337,861,880 - 37,984,469 (+)NCBI
GRCh37337,903,669 - 38,025,960 (+)ENTREZGENE
Build 36337,878,673 - 38,000,964 (+)NCBI Archive
HuRef337,846,293 - 37,968,646 (+)ENTREZGENE
CHM1_1337,855,336 - 37,977,609 (+)NCBI
T2T-CHM13v2.0337,866,043 - 37,988,649 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017005519   ⟹   XP_016861008
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38337,861,880 - 37,984,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017005520   ⟹   XP_016861009
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38337,882,586 - 37,984,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047447182   ⟹   XP_047303138
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38337,861,880 - 37,984,469 (+)NCBI
RefSeq Acc Id: XM_054344905   ⟹   XP_054200880
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0337,866,043 - 37,988,649 (+)NCBI
RefSeq Acc Id: XM_054344906   ⟹   XP_054200881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0337,866,043 - 37,988,649 (+)NCBI
RefSeq Acc Id: XM_054344907   ⟹   XP_054200882
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0337,886,749 - 37,988,649 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001008393   ⟸   NM_001008392
- Peptide Label: isoform 1
- UniProtKB: Q70KI4 (UniProtKB/Swiss-Prot),   Q3ZTU0 (UniProtKB/Swiss-Prot),   Q7Z5Q2 (UniProtKB/Swiss-Prot),   O15194 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_005799   ⟸   NM_005808
- Peptide Label: isoform 2
- UniProtKB: O15194 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016861008   ⟸   XM_017005519
- Peptide Label: isoform X1
- UniProtKB: H7C353 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016861009   ⟸   XM_017005520
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000404977   ⟸   ENST00000416688
RefSeq Acc Id: ENSP00000398288   ⟸   ENST00000443503
RefSeq Acc Id: ENSP00000273179   ⟸   ENST00000273179
RefSeq Acc Id: ENSP00000407443   ⟸   ENST00000447745
RefSeq Acc Id: ENSP00000408183   ⟸   ENST00000435525
RefSeq Acc Id: ENSP00000409600   ⟸   ENST00000436654
RefSeq Acc Id: XP_047303138   ⟸   XM_047447182
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054200880   ⟸   XM_054344905
- Peptide Label: isoform X1
- UniProtKB: H7C353 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054200881   ⟸   XM_054344906
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054200882   ⟸   XM_054344907
- Peptide Label: isoform X3
Protein Domains
FCP1 homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O15194-F1-model_v2 AlphaFold O15194 1-276 view protein structure

Promoters
RGD ID:6863954
Promoter ID:EPDNEW_H5142
Type:initiation region
Name:CTDSPL_1
Description:CTD small phosphatase like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5143  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38337,861,880 - 37,861,940EPDNEW
RGD ID:6863956
Promoter ID:EPDNEW_H5143
Type:initiation region
Name:CTDSPL_2
Description:CTD small phosphatase like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H5142  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38337,862,093 - 37,862,153EPDNEW
RGD ID:6800808
Promoter ID:HG_KWN:44394
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_005808,   OTTHUMT00000342391,   OTTHUMT00000342392,   OTTHUMT00000342399
Position:
Human AssemblyChrPosition (strand)Source
Build 36337,877,161 - 37,878,282 (+)MPROMDB
RGD ID:6800805
Promoter ID:HG_KWN:44399
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:OTTHUMT00000342398
Position:
Human AssemblyChrPosition (strand)Source
Build 36337,991,116 - 37,991,616 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16890 AgrOrtholog
COSMIC CTDSPL COSMIC
Ensembl Genes ENSG00000144677 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000273179 ENTREZGENE
  ENST00000273179.10 UniProtKB/Swiss-Prot
  ENST00000416688.6 UniProtKB/TrEMBL
  ENST00000435525.1 UniProtKB/TrEMBL
  ENST00000436654 ENTREZGENE
  ENST00000436654.2 UniProtKB/TrEMBL
  ENST00000443503 ENTREZGENE
  ENST00000443503.6 UniProtKB/Swiss-Prot
  ENST00000447745.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000144677 GTEx
HGNC ID HGNC:16890 ENTREZGENE
Human Proteome Map CTDSPL Human Proteome Map
InterPro Dullard_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FCP1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_Pol_CTD_Phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10217 UniProtKB/Swiss-Prot
NCBI Gene 10217 ENTREZGENE
OMIM 608592 OMIM
PANTHER CTD SMALL PHOSPHATASE-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DULLARD PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA128394571 PharmGKB
PROSITE FCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CPDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CTDSL_HUMAN UniProtKB/Swiss-Prot
  F8WED2_HUMAN UniProtKB/TrEMBL
  H7C2B9_HUMAN UniProtKB/TrEMBL
  H7C2S4_HUMAN UniProtKB/TrEMBL
  H7C353 ENTREZGENE, UniProtKB/TrEMBL
  O15194 ENTREZGENE
  Q3ZTU0 ENTREZGENE
  Q70KI4 ENTREZGENE
  Q7Z5Q2 ENTREZGENE
UniProt Secondary Q3ZTU0 UniProtKB/Swiss-Prot
  Q70KI4 UniProtKB/Swiss-Prot
  Q7Z5Q2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-10 CTDSPL  CTD small phosphatase like    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like  Symbol and/or name change 5135510 APPROVED