MGP (matrix Gla protein) - Rat Genome Database
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Gene: MGP (matrix Gla protein) Homo sapiens
Analyze
Symbol: MGP
Name: matrix Gla protein
RGD ID: 737291
Description: Predicted to be a structural constituent of bone. Predicted to be involved in cartilage condensation. Localizes to collagen-containing extracellular matrix and extracellular exosome. Implicated in arteriosclerosis; calcinosis; and myocardial infarction. Biomarker of cervix uteri carcinoma in situ; germinoma; prostate carcinoma; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell growth-inhibiting gene 36 protein; GIG36; MGLAP; NTI
Orthologs:
Mus musculus (house mouse) : Mgp (matrix Gla protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mgp (matrix Gla protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mgp (matrix Gla protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MGP (matrix Gla protein)
Canis lupus familiaris (dog) : MGP (matrix Gla protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mgp (matrix Gla protein)
Sus scrofa (pig) : MGP (matrix Gla protein)
Chlorocebus sabaeus (African green monkey) : MGP (matrix Gla protein)
Heterocephalus glaber (naked mole-rat) : Mgp (matrix Gla protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1214,880,864 - 14,885,857 (-)EnsemblGRCh38hg38GRCh38
GRCh381214,880,864 - 14,885,854 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371215,034,115 - 15,038,853 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,926,094 - 14,930,095 (-)NCBINCBI36hg18NCBI36
Build 341214,926,093 - 14,930,095NCBI
Celera1220,179,103 - 20,183,841 (-)NCBI
Cytogenetic Map12p12.3NCBI
HuRef1214,803,571 - 14,808,309 (-)NCBIHuRef
CHM1_11215,000,196 - 15,004,934 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetohydrazide  (ISO)
afimoxifene  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
arsenous acid  (EXP)
bacitracin  (ISO)
bazedoxifene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
coumarin  (EXP,ISO)
coumestrol  (EXP)
cyclosporin A  (EXP)
cytarabine  (EXP)
DDT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
Enterolactone  (EXP)
entinostat  (EXP)
ethylene glycol  (ISO)
ethylenediaminetetraacetic acid  (EXP)
etidronic acid  (ISO)
fipronil  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
graphite  (ISO)
hydralazine  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
ketoconazole  (ISO)
losartan  (ISO)
manganese(II) chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nevirapine  (ISO)
nickel atom  (EXP)
nicotine  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
paricalcitol  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenformin  (ISO)
phenobarbital  (EXP)
PhIP  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
phylloquinone  (EXP,ISO)
potassium dichromate  (ISO)
procymidone  (ISO)
progesterone  (EXP)
quercetin  (ISO)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
troglitazone  (EXP,ISO)
undecane  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vitamin K  (ISO)
warfarin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1939157   PMID:2216462   PMID:2394711   PMID:3387234   PMID:8061611   PMID:9610006   PMID:10737800   PMID:11684076   PMID:11741887   PMID:12207096   PMID:12477932   PMID:12721790  
PMID:14587031   PMID:14963895   PMID:15280384   PMID:15489334   PMID:15607035   PMID:15744522   PMID:15864013   PMID:15982861   PMID:16210837   PMID:16392639   PMID:16712791   PMID:16735944  
PMID:17014561   PMID:17509359   PMID:17643059   PMID:17670744   PMID:17724449   PMID:17848178   PMID:17890861   PMID:18222176   PMID:18286307   PMID:18369157   PMID:18401181   PMID:18841280  
PMID:18971553   PMID:19151998   PMID:19190822   PMID:19199708   PMID:19327888   PMID:19350115   PMID:19352064   PMID:19453261   PMID:19661459   PMID:19712474   PMID:19730704   PMID:19913121  
PMID:20133489   PMID:20368306   PMID:20452482   PMID:20479029   PMID:20551380   PMID:20628086   PMID:20673868   PMID:21143859   PMID:21294711   PMID:21724703   PMID:21765215   PMID:21870514  
PMID:21873635   PMID:22115341   PMID:22239033   PMID:22796540   PMID:22819559   PMID:22992285   PMID:23046575   PMID:23062766   PMID:23110920   PMID:23223140   PMID:23233942   PMID:23307874  
PMID:23504408   PMID:23563003   PMID:23677904   PMID:23877986   PMID:23979707   PMID:24029658   PMID:24210635   PMID:24228496   PMID:24281054   PMID:24445527   PMID:24458983   PMID:24762216  
PMID:24804215   PMID:24835435   PMID:25190488   PMID:25421980   PMID:25458708   PMID:25528106   PMID:25871831   PMID:25957430   PMID:25974989   PMID:25987667   PMID:25990696   PMID:26016598  
PMID:26040031   PMID:26544073   PMID:26618253   PMID:26771974   PMID:26981564   PMID:27009385   PMID:27068509   PMID:27100101   PMID:27119839   PMID:27172275   PMID:27348051   PMID:27547048  
PMID:27559042   PMID:27951533   PMID:28411264   PMID:28605143   PMID:28654853   PMID:28734846   PMID:28821877   PMID:28855172   PMID:29303985   PMID:29529056   PMID:29635270   PMID:29777408  
PMID:29788226   PMID:30257426   PMID:30617055   PMID:30717170   PMID:31025895   PMID:31215457   PMID:31264274   PMID:31510823   PMID:31589964   PMID:31804541   PMID:32092076   PMID:32584873  


Genomics

Comparative Map Data
MGP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1214,880,864 - 14,885,857 (-)EnsemblGRCh38hg38GRCh38
GRCh381214,880,864 - 14,885,854 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371215,034,115 - 15,038,853 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,926,094 - 14,930,095 (-)NCBINCBI36hg18NCBI36
Build 341214,926,093 - 14,930,095NCBI
Celera1220,179,103 - 20,183,841 (-)NCBI
Cytogenetic Map12p12.3NCBI
HuRef1214,803,571 - 14,808,309 (-)NCBIHuRef
CHM1_11215,000,196 - 15,004,934 (-)NCBICHM1_1
Mgp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,849,433 - 136,852,821 (-)NCBI
GRCm386136,872,435 - 136,875,823 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,872,435 - 136,875,823 (-)EnsemblGRCm38mm10GRCm38
MGSCv376136,820,956 - 136,824,326 (-)NCBIGRCm37mm9NCBIm37
MGSCv366136,836,632 - 136,840,001 (-)NCBImm8
Celera6139,906,448 - 139,909,847 (-)NCBICelera
Cytogenetic Map6G1NCBI
Mgp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04170,856,783 - 170,860,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,856,751 - 170,860,225 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,113,783 - 235,117,184 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,910,595 - 173,913,917 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14174,155,718 - 174,159,041 (-)NCBI
Celera4158,349,108 - 158,352,430 (-)NCBICelera
Cytogenetic Map4q43NCBI
Mgp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541311,615,078 - 11,618,024 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541311,614,851 - 11,618,090 (-)NCBIChiLan1.0ChiLan1.0
MGP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11215,284,635 - 15,288,794 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01214,887,806 - 14,891,796 (-)NCBIMhudiblu_PPA_v0panPan3
MGP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2731,734,660 - 31,738,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12731,735,301 - 31,738,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mgp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365872,601,419 - 2,605,848 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl557,665,248 - 57,669,764 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1557,665,272 - 57,669,360 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,054,230 - 61,058,317 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MGP
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1114,776,209 - 14,780,947 (-)Ensembl
ChlSab1.11114,776,668 - 14,780,796 (-)NCBI
Mgp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475223,146,025 - 23,149,266 (+)NCBI

Position Markers
D12S1925  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371215,034,869 - 15,035,125UniSTSGRCh37
Build 361214,926,136 - 14,926,392RGDNCBI36
Celera1220,179,857 - 20,180,113RGD
Cytogenetic Map12p12.3UniSTS
HuRef1214,804,325 - 14,804,581UniSTS
Stanford-G3 RH Map12832.0UniSTS
GeneMap99-G3 RH Map12832.0UniSTS
SHGC-12684  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371215,034,834 - 15,035,045UniSTSGRCh37
Build 361214,926,101 - 14,926,312RGDNCBI36
Celera1220,179,822 - 20,180,033RGD
Cytogenetic Map12p12.3UniSTS
HuRef1214,804,290 - 14,804,501UniSTS
GeneMap99-G3 RH Map12832.0UniSTS
RH93429  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371215,034,039 - 15,034,230UniSTSGRCh37
Build 361214,925,306 - 14,925,497RGDNCBI36
Celera1220,179,027 - 20,179,218RGD
Cytogenetic Map12p12.3UniSTS
HuRef1214,803,495 - 14,803,686UniSTS
GeneMap99-GB4 RH Map1269.91UniSTS
G44728  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371215,035,002 - 15,035,184UniSTSGRCh37
Build 361214,926,269 - 14,926,451RGDNCBI36
Celera1220,179,990 - 20,180,172RGD
Cytogenetic Map12p12.3UniSTS
HuRef1214,804,458 - 14,804,640UniSTS
GDB:214849  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371215,038,562 - 15,038,991UniSTSGRCh37
Build 361214,929,829 - 14,930,258RGDNCBI36
Celera1220,183,550 - 20,183,979RGD
Cytogenetic Map12p12.3UniSTS
HuRef1214,808,018 - 14,808,447UniSTS
STS-X53331  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371215,035,002 - 15,035,162UniSTSGRCh37
Build 361214,926,269 - 14,926,429RGDNCBI36
Celera1220,179,990 - 20,180,150RGD
Cytogenetic Map12p12.3UniSTS
HuRef1214,804,458 - 14,804,618UniSTS
GeneMap99-GB4 RH Map1268.17UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:850
Count of miRNA genes:473
Interacting mature miRNAs:520
Transcripts:ENST00000228938, ENST00000507170, ENST00000539261, ENST00000545199
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 739 1525 582 19 37 2 813 263 104 33 376 717 18 1 375 712 2
Medium 1565 785 899 375 572 229 3304 1878 1462 332 966 689 149 829 2072 4
Low 38 660 218 211 757 214 48 33 2129 19 47 80 2 4
Below cutoff 85 21 26 18 273 19 149 22 37 31 64 110 5 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW997681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY542304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF699158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB069816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB108937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ004248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  N85639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000228938   ⟹   ENSP00000228938
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1214,881,898 - 14,885,857 (-)Ensembl
RefSeq Acc Id: ENST00000507170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1214,883,054 - 14,885,854 (-)Ensembl
RefSeq Acc Id: ENST00000539261   ⟹   ENSP00000445907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1214,880,864 - 14,885,854 (-)Ensembl
RefSeq Acc Id: ENST00000545199   ⟹   ENSP00000445436
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1214,881,891 - 14,884,245 (-)Ensembl
RefSeq Acc Id: NM_000900   ⟹   NP_000891
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381214,880,864 - 14,885,854 (-)NCBI
GRCh371215,034,115 - 15,038,853 (-)ENTREZGENE
Build 361214,926,094 - 14,930,095 (-)NCBI Archive
HuRef1214,803,571 - 14,808,309 (-)ENTREZGENE
CHM1_11215,000,196 - 15,004,934 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001190839   ⟹   NP_001177768
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381214,880,864 - 14,885,854 (-)NCBI
GRCh371215,034,115 - 15,038,853 (-)ENTREZGENE
HuRef1214,803,571 - 14,808,309 (-)ENTREZGENE
CHM1_11215,000,196 - 15,004,934 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000891   ⟸   NM_000900
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P08493 (UniProtKB/Swiss-Prot),   A0A024RAX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177768   ⟸   NM_001190839
- Peptide Label: isoform 1 precursor
- UniProtKB: P08493 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000228938   ⟸   ENST00000228938
RefSeq Acc Id: ENSP00000445436   ⟸   ENST00000545199
RefSeq Acc Id: ENSP00000445907   ⟸   ENST00000539261
Protein Domains
Gla

Promoters
RGD ID:7223309
Promoter ID:EPDNEW_H17400
Type:initiation region
Name:MGP_1
Description:matrix Gla protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381214,885,854 - 14,885,914EPDNEW
RGD ID:6851120
Promoter ID:EP73357
Type:multiple initiation site
Name:HS_MGP
Description:Matrix Gla protein.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361214,930,055 - 14,930,115EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000900.5(MGP):c.43del (p.Ala14_Val15insTer) deletion Keutel syndrome [RCV000015415] Chr12:14885749 [GRCh38]
Chr12:15038683 [GRCh37]
Chr12:12p12.3
pathogenic
NM_000900.5(MGP):c.62-2A>G single nucleotide variant Keutel syndrome [RCV000015416] Chr12:14884247 [GRCh38]
Chr12:15037181 [GRCh37]
Chr12:12p12.3
pathogenic
NM_000900.5(MGP):c.87T>A (p.Tyr29Ter) single nucleotide variant Keutel syndrome [RCV000015417] Chr12:14884220 [GRCh38]
Chr12:15037154 [GRCh37]
Chr12:12p12.3
pathogenic
NM_000900.5(MGP):c.94+1G>A single nucleotide variant Keutel syndrome [RCV000015418]|not provided [RCV000497665] Chr12:14884212 [GRCh38]
Chr12:15037146 [GRCh37]
Chr12:12p12.3
pathogenic|likely pathogenic
NM_000900.5(MGP):c.23C>T (p.Ala8Val) single nucleotide variant Keutel syndrome [RCV000280828]|not provided [RCV000964329]|not specified [RCV000173173] Chr12:14885769 [GRCh38]
Chr12:15038703 [GRCh37]
Chr12:12p12.3
benign|likely benign
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22
pathogenic
GRCh38/hg38 12p13.2-12.3(chr12:12388842-15540422)x1 copy number loss See cases [RCV000052780] Chr12:12388842..15540422 [GRCh38]
Chr12:12541776..15693356 [GRCh37]
Chr12:12433043..15584623 [NCBI36]
Chr12:12p13.2-12.3
pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.2-12.3(chr12:12363649-15280588)x1 copy number loss See cases [RCV000135331] Chr12:12363649..15280588 [GRCh38]
Chr12:12514722..15433522 [GRCh37]
Chr12:12405989..15324789 [NCBI36]
Chr12:12p13.2-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.2(chr12:1258274-20657577)x3 copy number gain See cases [RCV000141905] Chr12:1258274..20657577 [GRCh38]
Chr12:1367440..20810511 [GRCh37]
Chr12:1237701..20701778 [NCBI36]
Chr12:12p13.33-12.2
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:64620-34682902)x4 copy number gain See cases [RCV000142149] Chr12:64620..34682902 [GRCh38]
Chr12:173786..34835837 [GRCh37]
Chr12:44047..34727104 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.2-12.3(chr12:11121039-15908154)x1 copy number loss See cases [RCV000142882] Chr12:11121039..15908154 [GRCh38]
Chr12:11273638..16061088 [GRCh37]
Chr12:11164905..15952355 [NCBI36]
Chr12:12p13.2-12.3
likely pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:148034-34178799)x4 copy number gain See cases [RCV000240164] Chr12:148034..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
chr12:10074776-18800953 complex variant complex Ductal breast carcinoma [RCV000207105] Chr12:10074776..18800953 [GRCh37]
Chr12:12p13.31-12.3
uncertain significance
NM_000900.5(MGP):c.304A>G (p.Thr102Ala) single nucleotide variant Keutel syndrome [RCV000327610]|not specified [RCV000274275] Chr12:14882147 [GRCh38]
Chr12:15035081 [GRCh37]
Chr12:12p12.3
benign
GRCh37/hg19 12p12.3(chr12:15034827-15677320)x1 copy number loss See cases [RCV000240366] Chr12:15034827..15677320 [GRCh37]
Chr12:12p12.3
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:89061-34178799)x3 copy number gain See cases [RCV000240487] Chr12:89061..34178799 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
NM_000900.5(MGP):c.*538C>G single nucleotide variant Keutel syndrome [RCV000282285] Chr12:14881601 [GRCh38]
Chr12:15034535 [GRCh37]
Chr12:12p12.3
likely benign|uncertain significance
NM_000900.5(MGP):c.234T>C (p.Leu78=) single nucleotide variant Keutel syndrome [RCV000268825]|not provided [RCV000900342] Chr12:14882217 [GRCh38]
Chr12:15035151 [GRCh37]
Chr12:12p12.3
likely benign|uncertain significance
NM_000900.4(MGP):c.-117C>T single nucleotide variant Keutel syndrome [RCV000286565] Chr12:14885908 [GRCh38]
Chr12:15038842 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.*604A>G single nucleotide variant Keutel syndrome [RCV000350370] Chr12:14881535 [GRCh38]
Chr12:15034469 [GRCh37]
Chr12:12p12.3
benign|uncertain significance
NM_000900.5(MGP):c.46G>A (p.Val16Ile) single nucleotide variant Keutel syndrome [RCV000375389] Chr12:14885746 [GRCh38]
Chr12:15038680 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.62-9del deletion Keutel syndrome [RCV000329643] Chr12:14884254 [GRCh38]
Chr12:15037188 [GRCh37]
Chr12:12p12.3
likely benign
NM_000900.5(MGP):c.*27T>G single nucleotide variant Keutel syndrome [RCV000272500] Chr12:14882112 [GRCh38]
Chr12:15035046 [GRCh37]
Chr12:12p12.3
benign|likely benign
NM_000900.5(MGP):c.207T>C (p.Asn69=) single nucleotide variant Keutel syndrome [RCV000333259]|not provided [RCV000980929] Chr12:14882244 [GRCh38]
Chr12:15035178 [GRCh37]
Chr12:12p12.3
benign|likely benign|uncertain significance
NM_000900.5(MGP):c.-63G>A single nucleotide variant Keutel syndrome [RCV000335996] Chr12:14885854 [GRCh38]
Chr12:15038788 [GRCh37]
Chr12:12p12.3
benign
NM_000900.5(MGP):c.*140T>C single nucleotide variant Keutel syndrome [RCV000358329] Chr12:14881999 [GRCh38]
Chr12:15034933 [GRCh37]
Chr12:12p12.3
likely benign|uncertain significance
NM_000900.5(MGP):c.*615A>G single nucleotide variant Keutel syndrome [RCV000295426] Chr12:14881524 [GRCh38]
Chr12:15034458 [GRCh37]
Chr12:12p12.3
benign|likely benign
NM_000900.5(MGP):c.*755G>T single nucleotide variant Keutel syndrome [RCV000389719] Chr12:14881384 [GRCh38]
Chr12:15034318 [GRCh37]
Chr12:12p12.3
benign|likely benign
NM_000900.5(MGP):c.*343G>A single nucleotide variant Keutel syndrome [RCV000297486] Chr12:14881796 [GRCh38]
Chr12:15034730 [GRCh37]
Chr12:12p12.3
benign|likely benign
NM_000900.5(MGP):c.115A>C (p.Asn39His) single nucleotide variant Keutel syndrome [RCV001110547]|not provided [RCV000890972]|not specified [RCV000273459] Chr12:14883027 [GRCh38]
Chr12:15035961 [GRCh37]
Chr12:12p12.3
benign|likely benign
NM_000900.5(MGP):c.62-18dup duplication Keutel syndrome [RCV000293303] Chr12:14884253..14884254 [GRCh38]
Chr12:15037187..15037188 [GRCh37]
Chr12:12p12.3
benign
NM_000900.5(MGP):c.*552A>T single nucleotide variant Keutel syndrome [RCV000402689] Chr12:14881587 [GRCh38]
Chr12:15034521 [GRCh37]
Chr12:12p12.3
benign
NM_000900.4(MGP):c.-66C>A single nucleotide variant Keutel syndrome [RCV000403720] Chr12:14885857 [GRCh38]
Chr12:15038791 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.157A>G (p.Lys53Glu) single nucleotide variant Keutel syndrome [RCV000785068]|not provided [RCV000886013]|not specified [RCV000395553] Chr12:14882985 [GRCh38]
Chr12:15035919 [GRCh37]
Chr12:12p12.3
benign|likely benign
NM_000900.5(MGP):c.*476T>C single nucleotide variant Keutel syndrome [RCV000337252] Chr12:14881663 [GRCh38]
Chr12:15034597 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.*339T>C single nucleotide variant Keutel syndrome [RCV000361758] Chr12:14881800 [GRCh38]
Chr12:15034734 [GRCh37]
Chr12:12p12.3
benign|likely benign
NM_000900.5(MGP):c.*251T>C single nucleotide variant Keutel syndrome [RCV000303564] Chr12:14881888 [GRCh38]
Chr12:15034822 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.237C>T (p.Cys79=) single nucleotide variant Keutel syndrome [RCV000363615] Chr12:14882214 [GRCh38]
Chr12:15035148 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.*455del deletion Keutel syndrome [RCV000406288] Chr12:14881684 [GRCh38]
Chr12:15034618 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.84T>C (p.Ser28=) single nucleotide variant Keutel syndrome [RCV000387694] Chr12:14884223 [GRCh38]
Chr12:15037157 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.*315dup duplication Keutel syndrome [RCV000395879] Chr12:14881823..14881824 [GRCh38]
Chr12:15034757..15034758 [GRCh37]
Chr12:12p12.3
uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:173786-37869301)x3 copy number gain See cases [RCV000449191] Chr12:173786..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-12.1(chr12:173786-25286865)x3 copy number gain See cases [RCV000449287] Chr12:173786..25286865 [GRCh37]
Chr12:12p13.33-12.1
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain See cases [RCV000447551] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-12.2(chr12:173786-20026080)x3 copy number gain See cases [RCV000446050] Chr12:173786..20026080 [GRCh37]
Chr12:12p13.33-12.2
pathogenic
NM_000900.5(MGP):c.62-638G>C single nucleotide variant not provided [RCV000434617] Chr12:14884883 [GRCh38]
Chr12:15037817 [GRCh37]
Chr12:12p12.3
uncertain significance
GRCh37/hg19 12p13.33-11.1(chr12:189578-34756150) copy number gain See cases [RCV000446017] Chr12:189578..34756150 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_000900.5(MGP):c.56G>A (p.Cys19Tyr) single nucleotide variant not provided [RCV000497490] Chr12:14885736 [GRCh38]
Chr12:15038670 [GRCh37]
Chr12:12p12.3
likely pathogenic|uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:565369-34835837)x3 copy number gain See cases [RCV000511580] Chr12:565369..34835837 [GRCh37]
Chr12:12p13.33-11.1
likely pathogenic
GRCh37/hg19 12p13.33-11.22(chr12:173786-28219229)x3 copy number gain See cases [RCV000510961] Chr12:173786..28219229 [GRCh37]
Chr12:12p13.33-11.22
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x2,3 copy number gain not provided [RCV000683478] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q11(chr12:173786-37869107)x3 copy number gain not provided [RCV000683480] Chr12:173786..37869107 [GRCh37]
Chr12:12p13.33-q11
pathogenic
GRCh37/hg19 12p13.33-11.1(chr12:173786-34835837)x3 copy number gain not provided [RCV000683479] Chr12:173786..34835837 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-11.21(chr12:191619-31733044)x3 copy number gain not provided [RCV000750245] Chr12:191619..31733044 [GRCh37]
Chr12:12p13.33-11.21
pathogenic
GRCh37/hg19 12p12.3(chr12:15023267-15035081)x0 copy number loss not provided [RCV000750304] Chr12:15023267..15035081 [GRCh37]
Chr12:12p12.3
benign
NM_000900.5(MGP):c.198C>T (p.His66=) single nucleotide variant Keutel syndrome [RCV001110546]|not provided [RCV000903207] Chr12:14882253 [GRCh38]
Chr12:15035187 [GRCh37]
Chr12:12p12.3
benign|uncertain significance
GRCh37/hg19 12p13.33-q11(chr12:274676-37869301)x4 copy number gain not provided [RCV001006470] Chr12:274676..37869301 [GRCh37]
Chr12:12p13.33-q11
pathogenic
NM_000900.5(MGP):c.42G>A (p.Ala14=) single nucleotide variant not provided [RCV000917058] Chr12:14885750 [GRCh38]
Chr12:15038684 [GRCh37]
Chr12:12p12.3
likely benign
NM_000900.5(MGP):c.61+10T>G single nucleotide variant not provided [RCV000923616] Chr12:14885721 [GRCh38]
Chr12:15038655 [GRCh37]
Chr12:12p12.3
likely benign
NM_000900.5(MGP):c.299G>A (p.Arg100Gln) single nucleotide variant not provided [RCV000967255] Chr12:14882152 [GRCh38]
Chr12:15035086 [GRCh37]
Chr12:12p12.3
likely benign
GRCh37/hg19 12p13.33-11.1(chr12:173786-34496628)x3 copy number gain not provided [RCV000847209] Chr12:173786..34496628 [GRCh37]
Chr12:12p13.33-11.1
pathogenic
NM_000900.5(MGP):c.77T>C (p.Met26Thr) single nucleotide variant Keutel syndrome [RCV001112526] Chr12:14884230 [GRCh38]
Chr12:15037164 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.33C>T (p.Ala11=) single nucleotide variant not provided [RCV000910069] Chr12:14885759 [GRCh38]
Chr12:15038693 [GRCh37]
Chr12:12p12.3
likely benign
GRCh37/hg19 12p13.2-12.3(chr12:11737824-16780886)x1 copy number loss not provided [RCV001006482] Chr12:11737824..16780886 [GRCh37]
Chr12:12p13.2-12.3
pathogenic
NM_000900.5(MGP):c.*176C>G single nucleotide variant Keutel syndrome [RCV001109761] Chr12:14881963 [GRCh38]
Chr12:15034897 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.*531T>C single nucleotide variant Keutel syndrome [RCV001113774] Chr12:14881608 [GRCh38]
Chr12:15034542 [GRCh37]
Chr12:12p12.3
uncertain significance
NM_000900.5(MGP):c.*206A>G single nucleotide variant Keutel syndrome [RCV001109760] Chr12:14881933 [GRCh38]
Chr12:15034867 [GRCh37]
Chr12:12p12.3
benign
NM_000900.5(MGP):c.*720C>A single nucleotide variant Keutel syndrome [RCV001113773] Chr12:14881419 [GRCh38]
Chr12:15034353 [GRCh37]
Chr12:12p12.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7060 AgrOrtholog
COSMIC MGP COSMIC
Ensembl Genes ENSG00000111341 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000228938 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000445436 UniProtKB/TrEMBL
  ENSP00000445907 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000228938 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000539261 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000545199 UniProtKB/TrEMBL
GTEx ENSG00000111341 GTEx
HGNC ID HGNC:7060 ENTREZGENE
Human Proteome Map MGP Human Proteome Map
InterPro GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Osteocalcin/MGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4256 ENTREZGENE
OMIM 154870 OMIM
  245150 OMIM
PANTHER PTHR10109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MGP RGD, PharmGKB
PRINTS GLABONE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.365706 ENTREZGENE
UniProt A0A024RAX0 ENTREZGENE, UniProtKB/TrEMBL
  H0YGZ6_HUMAN UniProtKB/TrEMBL
  MGP_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0M8W5 UniProtKB/Swiss-Prot
  B2R519 UniProtKB/Swiss-Prot
  J3KMX7 UniProtKB/Swiss-Prot
  Q2TU41 UniProtKB/Swiss-Prot
  Q567P9 UniProtKB/Swiss-Prot
  Q6ICN5 UniProtKB/Swiss-Prot