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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vitamin D2
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Accession:CHEBI:28934 term browser browse the term
Definition:A vitamin D supplement and has been isolated from alfalfa.
Synonyms:related_synonym: (3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol;   (5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol;   (5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol;   Ergocalciferol;   Formula=C28H44O;   InChI=1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1;   InChIKey=MECHNRXZTMCUDQ-RKHKHRCZSA-N;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)CCC1=C)[C@H](C)\\C=C\\[C@H](C)C(C)C;   Vitamina D2;   activated ergosterol;   calciferol;   ercalciol;   ergocalciferolum;   oleovitamin D2;   viosterol
 alt_id: CHEBI:10007;   CHEBI:23937
 xref: Beilstein:1916682;   CAS:50-14-6;   DrugBank:DB00153;   Drug_Central:2838;   Gmelin:1310395;   HMDB:HMDB0000900;   KEGG:C05441;   KEGG:D00187;   LIPID_MAPS_instance:LMST03010000;   LIPID_MAPS_instance:LMST03010001;   MetaCyc:VITAMIN_D2;   PDBeChem:D2V;   PMID:24362707;   PMID:24780068;   PMID:24854739;   PPDB:107;   Patent:US1680818;   Patent:US1871136;   Patent:US1902785;   Patent:US2030792;   Wikipedia:Ergocalciferol


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paricalcitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of AADAC mRNA CTD PMID:17715259 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO paricalcitol results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adipor1 adiponectin receptor 1 increases expression ISO paricalcitol results in increased expression of ADIPOR1 protein CTD PMID:25037058 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of ALPL mRNA CTD PMID:17715259 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO paricalcitol inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]
[Phosphorus co-treated with paricalcitol] results in decreased expression of APOE mRNA
CTD PMID:17715259, PMID:25037058 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of B4GALT1 mRNA CTD PMID:17715259 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [paricalcitol co-treated with arsenic trioxide] results in decreased expression of BCL2 CTD PMID:15781666 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [paricalcitol co-treated with arsenic trioxide] results in decreased expression of BCL2L1 CTD PMID:15781666 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of BMP4 mRNA CTD PMID:17715259 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions ISO paricalcitol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; paricalcitol promotes the reaction [resveratrol results in increased expression of CAMP mRNA] CTD PMID:24039193 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
decreases expression
ISO
EXP
[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
paricalcitol results in increased expression of CCL2 mRNA
paricalcitol results in decreased expression of CCL2 protein
CTD PMID:17513326, PMID:20720404, PMID:25037058 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO paricalcitol results in increased expression of CCR2 mRNA CTD PMID:25037058
G Cd14 CD14 molecule increases expression
multiple interactions
ISO paricalcitol results in increased expression of CD14 protein
[Phosphorus co-treated with paricalcitol] results in increased expression of CD14 mRNA
CTD PMID:12618899, PMID:17715259 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of CES1 mRNA CTD PMID:17715259 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Col15a1 collagen type XV alpha 1 chain multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of COL15A1 mRNA CTD PMID:17715259 NCBI chr 5:62,840,360...62,950,240 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of COL1A1 mRNA CTD PMID:17715259 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO paricalcitol results in increased expression of COL3A1 mRNA CTD PMID:25037058 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cp ceruloplasmin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of CP mRNA CTD PMID:17715259 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cpn2 carboxypeptidase N subunit 2 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CPN2 mRNA CTD PMID:17715259 NCBI chr11:74,057,374...74,067,486
Ensembl chr11:74,057,361...74,067,413
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of CPT1A mRNA CTD PMID:17715259 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crip1 cysteine rich protein 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of CRIP1 mRNA CTD PMID:17715259 NCBI chr 6:137,959,171...137,967,042
Ensembl chr 6:137,959,171...137,967,042
JBrowse link
G Ctdspl CTD small phosphatase like multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CTDSPL mRNA CTD PMID:17715259 NCBI chr 8:127,065,292...127,726,248
Ensembl chr 8:127,702,534...127,726,127
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
paricalcitol results in decreased expression of CYBA protein
CTD PMID:20720404 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CYP1B1 mRNA CTD PMID:17715259 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO [arsenic trioxide results in decreased expression of CYP24A1] which results in increased activity of paricalcitol; [Phosphorus co-treated with paricalcitol] results in increased expression of CYP24A1 mRNA CTD PMID:15781666, PMID:17715259 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of CYP2B6 mRNA CTD PMID:17715259 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form] CTD PMID:21565836 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of EDNRB mRNA CTD PMID:17715259 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Eng endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Fbln2 fibulin 2 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of FBLN2 mRNA CTD PMID:17715259 NCBI chr 4:122,835,237...122,895,127
Ensembl chr 4:122,835,436...122,895,121
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA CTD PMID:25037058 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNA CTD PMID:17715259 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il11 interleukin 11 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of IL11 mRNA CTD PMID:17715259 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of IL1A mRNA CTD PMID:17715259 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL1B mRNA CTD PMID:17715259 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL1RN mRNA CTD PMID:17715259 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il24 interleukin 24 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL24 mRNA CTD PMID:17715259 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il36rn interleukin 36 receptor antagonist multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of IL36RN mRNA CTD PMID:17715259 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of IL6 mRNA CTD PMID:17715259 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO paricalcitol results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO paricalcitol results in increased expression of ITGAM protein CTD PMID:12618899 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Mapk13 mitogen activated protein kinase 13 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MAPK13 mRNA CTD PMID:17715259 NCBI chr20:6,018,374...6,027,467
Ensembl chr20:6,018,374...6,027,473
JBrowse link
G Meltf melanotransferrin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MELTF mRNA CTD PMID:17715259 NCBI chr11:72,135,311...72,158,106
Ensembl chr11:72,135,668...72,157,522
JBrowse link
G Mgp matrix Gla protein multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MGP mRNA CTD PMID:17715259 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Mrpl33 mitochondrial ribosomal protein L33 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of MRPL33 mRNA CTD PMID:17715259 NCBI chr 6:26,130,278...26,138,498
Ensembl chr 6:26,130,488...26,138,414
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the localization of NCOR1 protein; [Phosphorus co-treated with paricalcitol] results in decreased expression of NCOR1 protein CTD PMID:17715259 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO [paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
paricalcitol results in decreased expression of NOS2 protein
CTD PMID:20720404 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
ISO [paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein
paricalcitol results in increased expression of NOS3 protein
CTD PMID:20720404, PMID:25037058 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP paricalcitol inhibits the reaction [EDN1 protein results in increased expression of NPPA mRNA]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:21565836 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y increases expression ISO paricalcitol results in increased expression of NPY mRNA CTD PMID:25037058 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of NR4A1 mRNA CTD PMID:17715259 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of NR4A2 mRNA CTD PMID:17715259 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of PEX11A mRNA CTD PMID:17715259 NCBI chr 1:141,474,189...141,481,270
Ensembl chr 1:141,474,180...141,481,315
JBrowse link
G Postn periostin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of POSTN mRNA CTD PMID:17715259 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased localization of PPARG protein CTD PMID:17715259 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO paricalcitol results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
EXP paricalcitol inhibits the reaction [EDN1 protein results in increased expression of PRKCA protein modified form]; paricalcitol inhibits the reaction [Phenylephrine results in increased expression of PRKCA protein modified form]
paricalcitol results in decreased expression of PRKCA protein modified form
CTD PMID:21565836 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS1 mRNA CTD PMID:17715259 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO [Phosphorus co-treated with paricalcitol] results in increased expression of PTGS2 mRNA
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein
paricalcitol results in decreased expression of PTGS2 protein
CTD PMID:17715259, PMID:20720404, PMID:25037058 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth parathyroid hormone decreases secretion
decreases expression
ISO paricalcitol results in decreased secretion of PTH protein
paricalcitol results in decreased expression of PTH protein
CTD PMID:12631365, PMID:15898824 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Rarres1 retinoic acid receptor responder 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of RARRES1 mRNA CTD PMID:17715259 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased localization of RELA protein CTD PMID:17715259 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in decreased expression of REN1 mRNA CTD PMID:17715259 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sell selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of SERPINE1 mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of SERPINE1 protein CTD PMID:17715259 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad2 SMAD family member 2 decreases phosphorylation
multiple interactions
EXP paricalcitol results in decreased phosphorylation of SMAD2 protein
Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein]
CTD PMID:17513326 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
ISO paricalcitol results in increased expression of SOD1 protein
[paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein
CTD PMID:20720404, PMID:25037058 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
multiple interactions
ISO paricalcitol results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein
CTD PMID:20720404, PMID:25037058 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of SOD3 mRNA CTD PMID:17715259 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
ISO [Phosphorus co-treated with paricalcitol] results in increased expression of SPP1 mRNA
paricalcitol results in increased expression of SPP1 mRNA
[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
CTD PMID:17715259, PMID:25037058 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
paricalcitol results in decreased expression of TGFB1 mRNA; paricalcitol results in decreased expression of TGFB1 protein
CTD PMID:17513326 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of TGFB3 mRNA CTD PMID:17715259 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Thbd thrombomodulin multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of THBD mRNA; [Phosphorus co-treated with paricalcitol] results in increased expression of THBD protein CTD PMID:17715259 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of THBS1 mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of THBS1 protein CTD PMID:17715259 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO paricalcitol results in decreased expression of TNF protein
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein
CTD PMID:20720404, PMID:25037058 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO [Phosphorus co-treated with paricalcitol] affects the expression of TNFRSF11B mRNA; [Phosphorus co-treated with paricalcitol] results in decreased expression of TNFRSF11B protein CTD PMID:17715259 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression EXP paricalcitol results in increased expression of TNFSF11 mRNA; paricalcitol results in increased expression of TNFSF11 protein CTD PMID:17352647 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnxb tenascin XB multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of TNXB mRNA CTD PMID:17715259
G Trem1 triggering receptor expressed on myeloid cells 1 multiple interactions ISO [Phosphorus co-treated with paricalcitol] results in increased expression of TREM1 mRNA CTD PMID:17715259 NCBI chr 9:14,727,887...14,743,371
Ensembl chr 9:14,727,976...14,809,447
JBrowse link
G Vdr vitamin D receptor multiple interactions
affects binding
ISO [Phosphorus co-treated with paricalcitol] results in increased expression of VDR protein; [Phosphorus co-treated with paricalcitol] results in increased localization of VDR protein; paricalcitol binds to and affects the activity of VDR protein
paricalcitol binds to VDR protein
CTD PMID:15898824, PMID:16076355, PMID:17715259 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vwf von Willebrand factor decreases expression ISO paricalcitol results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pesticide 16264
          rodenticide 5927
            vitamin D2 81
              1alpha,25-dihydroxyvitamin D2 0
              25-hydroxyvitamin D2 0
              paricalcitol 81
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic polycyclic compound 16384
                                  steroid 12788
                                    hydroxy steroid 12371
                                      hydroxy seco-steroid 2656
                                        vitamin D 2651
                                          vitamin D2 81
                                            1alpha,25-dihydroxyvitamin D2 0
                                            25-hydroxyvitamin D2 0
                                            paricalcitol 81
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.