CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: amoxicillin
Accession: CHEBI:2676
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Definition: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.
Synonyms: exact_synonym: 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
related_synonym: (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid; AMPC; AX; Amolin; Amopenixin; Amoxicillin anhydrous; Clamoxyl; Formula=C16H19N3O5S; InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1; InChIKey=LSQZJLSUYDQPKJ-NJBDSQKTSA-N; Moxal; SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O; alpha-amino-p-hydroxybenzylpenicillin; amoxicilina; amoxicilline; amoxicillinum; amoxycilin; amoxycillin; p-hydroxyampicillin
alt_id: CHEBI:133770
xref: Beilstein:4274654; CAS:26787-78-0; DrugBank:DB01060; Drug_Central:192; HMDB:HMDB0015193; KEGG:C06827; KEGG:D07452; LINCS:LSM-5654
xref_mesh: MESH:D000658
xref: PMID:10930630; PMID:11431418; PMID:11906332; PMID:12569987; PMID:12833570; PMID:12850488; PMID:16033609; PMID:2083978; PMID:24595455; PMID:24631718; PMID:24759068; PMID:25998949; PMID:27731424; PMID:28987997; PMID:29017833; Patent:DE1942693; Patent:GB1241844; Patent:GB978178; Patent:US3192198; Reaxys:4274654; VSDB:1741; Wikipedia:Amoxicillin
cyclic_relationship: is_conjugate_acid_of CHEBI:51256
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Amoxicillin results in increased expression of AKR1B10 mRNA
CTD
PMID:28444390
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Amoxicillin results in decreased phosphorylation of AKT1 protein
CTD
PMID:36529298
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Amh
anti-Mullerian hormone
increases expression
ISO
Amoxicillin results in increased expression of AMH mRNA
CTD
PMID:36529298
NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
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Aqp5
aquaporin 5
decreases expression
EXP
Amoxicillin results in decreased expression of AQP5 protein
CTD
PMID:30031112
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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Casp3
caspase 3
increases expression
ISO
Amoxicillin results in increased expression of CASP3 mRNA; Amoxicillin results in increased expression of CASP3 protein
CTD
PMID:36529298
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
decreases activity
EXP
Amoxicillin results in decreased activity of CAT protein
CTD
PMID:26429924
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cxcl10
C-X-C motif chemokine ligand 10
decreases expression
ISO
Amoxicillin results in decreased expression of CXCL10 mRNA
CTD
PMID:25091725
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression
ISO
Amoxicillin results in decreased expression of CYP11A1 mRNA
CTD
PMID:36529298
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
increases expression
ISO
Amoxicillin results in increased expression of CYP11B2
CTD
PMID:17822730
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
Amoxicillin results in decreased expression of CYP17A1 mRNA
CTD
PMID:36529298
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression
ISO
Amoxicillin results in increased expression of CYP19A1
CTD
PMID:17822730
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
multiple interactions decreases activity
ISO
Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine] Amoxicillin results in decreased activity of CYP2C8 protein
CTD
PMID:26763401
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Gfra1
GDNF family receptor alpha 1
decreases expression
ISO
Amoxicillin results in decreased expression of GFRA1 mRNA
CTD
PMID:36529298
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
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Gsr
glutathione-disulfide reductase
decreases activity
ISO
Amoxicillin results in decreased activity of GSR protein
CTD
PMID:32196862
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Amoxicillin results in decreased phosphorylation of MAPK1 protein
CTD
PMID:36529298
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Amoxicillin results in decreased phosphorylation of MAPK3 protein
CTD
PMID:36529298
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Amoxicillin results in decreased expression of MKI67 mRNA; Amoxicillin results in decreased expression of MKI67 protein
CTD
PMID:36529298
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
Amoxicillin results in increased expression of NQO1 mRNA
CTD
PMID:28444390
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr5a1
nuclear receptor subfamily 5, group A, member 1
decreases expression
ISO
Amoxicillin results in decreased expression of NR5A1 mRNA
CTD
PMID:36529298
NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
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Pcna
proliferating cell nuclear antigen
decreases expression
ISO
Amoxicillin results in decreased expression of PCNA mRNA; Amoxicillin results in decreased expression of PCNA protein
CTD
PMID:36529298
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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RT1-Bb
RT1 class II, locus Bb
affects expression
ISO
Amoxicillin affects the expression of HLA-DQB1 mRNA
CTD
PMID:25811541
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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Slc51a
solute carrier family 51 member A
increases expression
ISO
Amoxicillin results in increased expression of SLC51A mRNA
CTD
PMID:34767876
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
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Srxn1
sulfiredoxin 1
increases expression
ISO
Amoxicillin results in increased expression of SRXN1 mRNA
CTD
PMID:28444390
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Star
steroidogenic acute regulatory protein
decreases expression
ISO
Amoxicillin results in decreased expression of STAR mRNA; Amoxicillin results in decreased expression of STAR protein
CTD
PMID:36529298
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Zbtb16
zinc finger and BTB domain containing 16
decreases expression
ISO
Amoxicillin results in decreased expression of ZBTB16 mRNA; Amoxicillin results in decreased expression of ZBTB16 protein
CTD
PMID:36529298
NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of ABCB11 mRNA
CTD
PMID:34767876
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of AKR1B10 mRNA
CTD
PMID:34767876
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
G
Casp3
caspase 3
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP3 protein
CTD
PMID:30273099
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP9 protein
CTD
PMID:30273099
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cycs
cytochrome c, somatic
increases secretion
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased secretion of CYCS protein
CTD
PMID:30273099
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP27A1 mRNA
CTD
PMID:34767876
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP7A1 mRNA
CTD
PMID:34767876
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP8B1 mRNA
CTD
PMID:34767876
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Fgf19
fibroblast growth factor 19
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of FGF19 mRNA
CTD
PMID:34767876
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
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G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of G6PD mRNA
CTD
PMID:34767876
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA
CTD
PMID:34767876
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLM mRNA
CTD
PMID:34767876
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Ggt1
gamma-glutamyltransferase 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GGT1 protein
CTD
PMID:34767876
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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Got1
glutamic-oxaloacetic transaminase 1
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of GOT1 protein
CTD
PMID:30273099
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Amoxicillin-Potassium Clavulanate Combination results in increased activity of GPT protein
CTD
PMID:30273099
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx2
glutathione peroxidase 2
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GPX2 mRNA
CTD
PMID:34767876
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Gsr
glutathione-disulfide reductase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of GSR mRNA
CTD
PMID:34767876
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Me1
malic enzyme 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of ME1 mRNA
CTD
PMID:34767876
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of NR0B2 mRNA
CTD
PMID:34767876
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC10A1 mRNA
CTD
PMID:34767876
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
G
Slc51a
solute carrier family 51 member A
decreases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC51A mRNA
CTD
PMID:34767876
NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
G
Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of SLC7A11 mRNA
CTD
PMID:34767876
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Tkt
transketolase
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of TKT mRNA
CTD
PMID:34767876
NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
Amoxicillin-Potassium Clavulanate Combination results in increased expression of TXNRD1 mRNA
CTD
PMID:34767876
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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