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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amoxicillin
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Accession:CHEBI:2676 term browser browse the term
Definition:A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.
Synonyms:exact_synonym: 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid;   AMPC;   AX;   Amolin;   Amopenixin;   Amoxicillin anhydrous;   Clamoxyl;   Formula=C16H19N3O5S;   InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14-/m1/s1;   InChIKey=LSQZJLSUYDQPKJ-NJBDSQKTSA-N;   Moxal;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O;   alpha-amino-p-hydroxybenzylpenicillin;   amoxicilina;   amoxicilline;   amoxicillinum;   amoxycilin;   amoxycillin;   p-hydroxyampicillin
 alt_id: CHEBI:133770
 xref: Beilstein:4274654;   CAS:26787-78-0;   DrugBank:DB01060;   Drug_Central:192;   HMDB:HMDB0015193;   KEGG:C06827;   KEGG:D07452;   LINCS:LSM-5654
 xref_mesh: MESH:D000658
 xref: PMID:10930630;   PMID:11431418;   PMID:11906332;   PMID:12569987;   PMID:12833570;   PMID:12850488;   PMID:16033609;   PMID:2083978;   PMID:24595455;   PMID:24631718;   PMID:24759068;   PMID:25998949;   PMID:27731424;   PMID:28987997;   PMID:29017833;   Patent:DE1942693;   Patent:GB1241844;   Patent:GB978178;   Patent:US3192198;   Reaxys:4274654;   VSDB:1741;   Wikipedia:Amoxicillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:51256


show annotations for term's descendants           Sort by:
amoxicillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Amoxicillin results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Amoxicillin results in decreased phosphorylation of AKT1 protein CTD PMID:36529298 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Amh anti-Mullerian hormone increases expression ISO Amoxicillin results in increased expression of AMH mRNA CTD PMID:36529298 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G Aqp5 aquaporin 5 decreases expression EXP Amoxicillin results in decreased expression of AQP5 protein CTD PMID:30031112 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209 		JBrowse link
G Casp3 caspase 3 increases expression ISO Amoxicillin results in increased expression of CASP3 mRNA; Amoxicillin results in increased expression of CASP3 protein CTD PMID:36529298 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity EXP Amoxicillin results in decreased activity of CAT protein CTD PMID:26429924 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Amoxicillin results in decreased expression of CXCL10 mRNA CTD PMID:25091725 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Amoxicillin results in decreased expression of CYP11A1 mRNA CTD PMID:36529298 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO Amoxicillin results in increased expression of CYP11B2 CTD PMID:17822730 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Amoxicillin results in decreased expression of CYP17A1 mRNA CTD PMID:36529298 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Amoxicillin results in increased expression of CYP19A1 CTD PMID:17822730 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
decreases activity		 ISO Amoxicillin inhibits the reaction [CYP2C8 protein results in decreased methylation of Aminopyrine]
Amoxicillin results in decreased activity of CYP2C8 protein		 CTD PMID:26763401
G Gfra1 GDNF family receptor alpha 1 decreases expression ISO Amoxicillin results in decreased expression of GFRA1 mRNA CTD PMID:36529298 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO Amoxicillin results in decreased activity of GSR protein CTD PMID:32196862 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Amoxicillin results in decreased phosphorylation of MAPK1 protein CTD PMID:36529298 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Amoxicillin results in decreased phosphorylation of MAPK3 protein CTD PMID:36529298 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Amoxicillin results in decreased expression of MKI67 mRNA; Amoxicillin results in decreased expression of MKI67 protein CTD PMID:36529298 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Amoxicillin results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression ISO Amoxicillin results in decreased expression of NR5A1 mRNA CTD PMID:36529298 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Amoxicillin results in decreased expression of PCNA mRNA; Amoxicillin results in decreased expression of PCNA protein CTD PMID:36529298 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO Amoxicillin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO Amoxicillin results in increased expression of SLC51A mRNA CTD PMID:34767876 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Amoxicillin results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Amoxicillin results in decreased expression of STAR mRNA; Amoxicillin results in decreased expression of STAR protein CTD PMID:36529298 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 decreases expression ISO Amoxicillin results in decreased expression of ZBTB16 mRNA; Amoxicillin results in decreased expression of ZBTB16 protein CTD PMID:36529298 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011 		JBrowse link
Augmentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of ABCB11 mRNA CTD PMID:34767876 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of AKR1B10 mRNA CTD PMID:34767876 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Casp3 caspase 3 increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP3 protein CTD PMID:30273099 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of CASP9 protein CTD PMID:30273099 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic increases secretion EXP Amoxicillin-Potassium Clavulanate Combination results in increased secretion of CYCS protein CTD PMID:30273099 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP27A1 mRNA CTD PMID:34767876 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP7A1 mRNA CTD PMID:34767876 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP8B1 mRNA CTD PMID:34767876 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of FGF19 mRNA CTD PMID:34767876 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of G6PD mRNA CTD PMID:34767876 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA CTD PMID:34767876 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLM mRNA CTD PMID:34767876 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GGT1 protein CTD PMID:34767876 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of GOT1 protein CTD PMID:30273099 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Amoxicillin-Potassium Clavulanate Combination results in increased activity of GPT protein CTD PMID:30273099 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GPX2 mRNA CTD PMID:34767876 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GSR mRNA CTD PMID:34767876 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of ME1 mRNA CTD PMID:34767876 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of NR0B2 mRNA CTD PMID:34767876 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC10A1 mRNA CTD PMID:34767876 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc51a solute carrier family 51 member A decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC51A mRNA CTD PMID:34767876 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of SLC7A11 mRNA CTD PMID:34767876 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Tkt transketolase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of TKT mRNA CTD PMID:34767876 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of TXNRD1 mRNA CTD PMID:34767876 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        aetiopathogenetic role 19257
          allergen 17703
            penicillin 314
              amoxicillin 45
                amoxicillanyl group 0
                amoxicillin diketopiperazine 0
                amoxicillin trihydrate + 24
                amoxicilloyl group + 0
                amoxicilloyl polylysine 0
                amoxicilloyl-L-lysine + 0
                amoxicilloyl-butylamine 0
                ampicillanyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19794
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19548
                              organochalcogen compound 19307
                                organooxygen compound 19223
                                  carbon oxoacid 18687
                                    carboxylic acid 18684
                                      carboacyl group 17720
                                        univalent carboacyl group 17720
                                          carbamoyl group 17571
                                            carboxamide 17571
                                              lactam 8395
                                                beta-lactam 830
                                                  beta-lactam antibiotic 815
                                                    penams 314
                                                      penicillanic acids 314
                                                        penicillanic acid 314
                                                          6-aminopenicillanic acid 314
                                                            penicillin 314
                                                              penicillin allergen 311
                                                                amoxicillin 45
                                                                  amoxicillanyl group 0
                                                                  amoxicillin diketopiperazine 0
                                                                  amoxicillin trihydrate + 24
                                                                  amoxicilloyl group + 0
                                                                  amoxicilloyl polylysine 0
                                                                  amoxicilloyl-L-lysine + 0
                                                                  amoxicilloyl-butylamine 0
                                                                  ampicillanyl group 0
paths to the root