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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amoxicillin trihydrate
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Accession:CHEBI:51254 term browser browse the term
Definition:A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.
Synonyms:exact_synonym: 6beta-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2,2-dimethylpenam-3alpha-carboxylic acid trihydrate
 related_synonym: Amoxipen;   BRL 2333;   Clamoxyl;   Formula=C16H25N3O8S;   InChI=1S/C16H19N3O5S.3H2O/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7;;;/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24);3*1H2/t9-,10-,11+,14-;;;/m1.../s1;   InChIKey=MQXQVCLAUDMCEF-CWLIKTDRSA-N;   Larotid;   Moxaline;   Polymox;   Robamox;   SMILES=O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O;   Trimox;   Zimox
 xref: Beilstein:7507120;   CAS:61336-70-7;   DrugBank:DB01060;   KEGG:D00229


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Augmentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of ABCB11 mRNA CTD PMID:34767876 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of AKR1B10 mRNA CTD PMID:34767876 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP27A1 mRNA CTD PMID:34767876 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP7A1 mRNA CTD PMID:34767876 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP8B1 mRNA CTD PMID:34767876 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of FGF19 mRNA CTD PMID:34767876 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of G6PD mRNA CTD PMID:34767876 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLC mRNA CTD PMID:34767876 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GCLM mRNA CTD PMID:34767876 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GGT1 protein CTD PMID:34767876 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GPX2 mRNA CTD PMID:34767876 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of GSR mRNA CTD PMID:34767876 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Me1 malic enzyme 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of ME1 mRNA CTD PMID:34767876 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of NR0B2 mRNA CTD PMID:34767876 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC10A1 mRNA CTD PMID:34767876 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression ISO Amoxicillin-Potassium Clavulanate Combination results in decreased expression of SLC51A mRNA CTD PMID:34767876 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of SLC7A11 mRNA CTD PMID:34767876 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Tkt transketolase increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of TKT mRNA CTD PMID:34767876 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Amoxicillin-Potassium Clavulanate Combination results in increased expression of TXNRD1 mRNA CTD PMID:34767876 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        antimicrobial agent 17945
          amoxicillin trihydrate 19
            Augmentin 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        carboacyl group 17687
                                          univalent carboacyl group 17687
                                            carbamoyl group 17531
                                              carboxamide 17531
                                                lactam 8382
                                                  beta-lactam 814
                                                    beta-lactam antibiotic 800
                                                      penams 299
                                                        penicillanic acids 299
                                                          penicillanic acid 299
                                                            6-aminopenicillanic acid 299
                                                              penicillin 299
                                                                penicillin allergen 296
                                                                  amoxicillin 27
                                                                    amoxicillin trihydrate 19
                                                                      Augmentin 19
paths to the root