Rela (RELA proto-oncogene, NF-kB subunit) - Rat Genome Database

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Gene: Rela (RELA proto-oncogene, NF-kB subunit) Rattus norvegicus
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Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
RGD ID: 727889
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of Schwann cell differentiation; positive regulation of miRNA transcription; and response to ischemia. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. Is active in synapse. Used to study Parkinsonism; encephalitis; status epilepticus; and steatotic liver disease. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); colitis; end stage renal disease; and liver cirrhosis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit); PARTICIPATES IN ceramide signaling pathway; interleukin-1 signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (+)-taxifolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: NFkB; nos2; nuclear factor kappa B subunit p65; nuclear factor kappaB subunit p65; transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,354,336 - 212,364,815 (+)NCBIGRCr8
mRatBN7.21202,925,001 - 202,935,484 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,924,945 - 202,935,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,277,590 - 211,288,062 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,370,406 - 218,380,885 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,061,451 - 211,071,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,992,770 - 221,003,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,992,770 - 221,003,249 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,928,092 - 227,938,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,262,669 - 208,273,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,416,121 - 208,426,601 (+)NCBI
Celera1200,460,753 - 200,471,232 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (IEP)
adenocarcinoma  (ISO)
Aicardi-Goutieres Syndrome 3  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
amphetamine abuse  (ISO)
anaplastic large cell lymphoma  (ISO)
arteriosclerosis  (IEP)
Autoinflammatory Disease, Familial, Behcet-Like-3  (ISO)
Bardet-Biedl syndrome  (ISO)
Barrett's esophagus  (ISO)
Brain Injuries  (IEP)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (IDA)
Cerebral Hemorrhage  (IDA)
cervix uteri carcinoma in situ  (ISO)
Childhood Schizophrenia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic obstructive pulmonary disease  (ISO)
colitis  (IEP,ISO)
Colonic Neoplasms  (ISO)
Crohn's disease  (ISO)
cryptorchidism  (ISO)
cystitis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Disease Progression  (ISO)
Drug Eruptions  (ISO)
Drug-Induced Dyskinesia  (IEP)
ductal carcinoma in situ  (ISO)
encephalitis  (IDA)
end stage renal disease  (IEP,ISO)
epilepsy  (IEP)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
glycogen storage disease V  (ISO)
Heat Stroke  (ISO)
Hemorrhagic Shock  (IEP,ISO)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
hypertension  (IEP,ISO)
Insulin Resistance  (IEP,ISO)
intellectual disability  (ISO)
Intestinal Reperfusion Injury  (IEP)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (IEP)
liver cirrhosis  (IEP)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
mastoiditis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
Myocardial Reperfusion Injury  (IDA,IEP)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinsonism  (IMP)
Pneumococcal Meningitis  (IEP)
primary biliary cholangitis  (ISO)
prostate adenocarcinoma  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP,ISO)
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations  (ISO)
renal cell carcinoma  (ISO)
renovascular hypertension  (IEP)
Reperfusion Injury  (IEP,ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IMP)
status epilepticus  (IDA)
steatotic liver disease  (IDA)
Stomach Neoplasms  (ISO)
Subarachnoid Hemorrhage  (ISO)
Transplant Rejection  (IEP)
traumatic brain injury  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveitis  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-Erythraline  (ISO)
(+)-isoborneol  (ISO)
(+)-pilocarpine  (EXP)
(+)-Pimaric acid  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (EXP,ISO)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-hinokiresinol  (ISO)
(-)-matairesinol  (ISO)
(-)-selegiline  (ISO)
(20S)-ginsenoside Rg3  (EXP,ISO)
(20S)-ginsenoside Rh2  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP)
(E)-roxithromycin  (EXP)
(R)-adrenaline  (EXP)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-(-)-perillyl alcohol  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17-hydroxyjolkinolide B  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2,2-tetramine  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,4-dinitrotoluene  (EXP)
2,5-dihydroxybenzoic acid  (ISO)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (EXP,ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcatechol  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-methylcatechol  (ISO)
4-nitroquinoline N-oxide  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (EXP,ISO)
7H-xanthine  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (EXP)
[6]-Shogaol  (ISO)
acenaphthoquinone  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
Aciculatin  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylic acid  (EXP)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
adenine  (EXP,ISO)
adenosine  (ISO)
afatinib  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
agmatine  (ISO)
agomelatine  (EXP)
agrimoniin  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (EXP,ISO)
alachlor  (ISO)
alantolactone  (ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (ISO)
aldosterone  (EXP)
Alisol B  (ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
allicin  (ISO)
allopurinol  (EXP,ISO)
alloxan  (EXP,ISO)
alloxanthine  (ISO)
allyl alcohol  (EXP)
allyl methyl disulfide  (ISO)
alogliptin  (EXP)
alpha-amanitin  (ISO)
alpha-D-galactose  (ISO)
alpha-methylhistamine  (ISO)
alpha-naphthoflavone  (ISO)
alpinumisoflavone  (ISO)
alternariol  (ISO)
Altertoxin II  (ISO)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
amidotrizoic acid  (ISO)
amifostine  (ISO)
amiloride  (EXP,ISO)
aminoguanidine  (EXP)
amlexanox  (ISO)
ammonia  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (EXP,ISO)
ampicillin  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (EXP,ISO)
Anetholtrithion  (ISO)
aniline  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
apremilast  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asarone  (ISO)
asbestos  (EXP)
asiatic acid  (ISO)
aspalathin  (ISO)
asperuloside  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (EXP,ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
Atractylodin  (ISO)
atrazine  (EXP)
atropine  (EXP)
aucubin  (ISO)
auranofin  (ISO)
aurantio-obtusin  (ISO)
aureusidin  (ISO)
azadirachtin A  (ISO)
aziridines  (ISO)
B 581  (ISO)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
Bardoxolone methyl  (ISO)
bazedoxifene  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benfotiamine  (ISO)
benomyl  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
Berbamine  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP,ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-Elemonic acid  (ISO)
beta-hexachlorocyclohexane  (EXP)
beta-ionone  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
betulin  (EXP)
betulinic acid  (EXP)
bezafibrate  (EXP)
bifenthrin  (EXP,ISO)
bilirubin IXalpha  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boldenone  (EXP)
boric acid  (EXP)
bortezomib  (ISO)
bosentan  (EXP,ISO)
brazilein  (ISO)
brazilin  (ISO)
budesonide  (EXP)
bufalin  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
butein  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cabazitaxel  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
Calcimycin  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium silicate  (ISO)
Calphostin C  (ISO)
calycosin  (EXP)
calyculin a  (ISO)
camptothecin  (EXP,ISO)
candesartan  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
captopril  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbendazim  (EXP)
CARBENOXOLONE  (ISO)
carbidopa  (ISO)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carfilzomib  (EXP)
carmustine  (EXP,ISO)
carnosic acid  (ISO)
carnosine  (ISO)
Carnosol  (ISO)
carrageenan  (EXP,ISO)
carvacrol  (ISO)
carvedilol  (EXP)
casticin  (ISO)
Casuarictin  (ISO)
catechol  (ISO)
CCCP  (ISO)
cefaloridine  (EXP)
cefoxitin  (ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceritinib  (ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
cetrorelix  (ISO)
cetylpyridinium  (ISO)
CGP 52608  (ISO)
chaetoglobosin A  (ISO)
chalcone  (ISO)
chalcones  (EXP)
chelerythrine  (ISO)
Chikusetsusaponin-IV  (ISO)
chitosan  (EXP)
chloroform  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
ciglitazone  (ISO)
cilostazol  (ISO)
cimetidine  (ISO)
Cinobufagin  (ISO)
cirsilineol  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citronellol  (EXP)
clenbuterol  (EXP)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
colistin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
cordycepin  (EXP,ISO)
corosolic acid  (ISO)
cortisol  (ISO)
cortisone  (ISO)
corynoline  (ISO)
coumarins  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
crotonaldehyde  (EXP)
Cryptotanshinone  (ISO)
cudraflavone B  (ISO)
cudratricusxanthone A  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclizine  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
D-ribofuranose  (ISO)
dabrafenib  (ISO)
daidzein  (ISO)
dapagliflozin  (EXP)
dapsone  (ISO)
DAPT  (EXP,ISO)
daunorubicin  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
Decursin  (ISO)
deferiprone  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP)
DENSPM  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP)
desloratadine  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
dexmedetomidine  (EXP)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
dibenziodolium  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (ISO)
dichloroacetyl chloride  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
dieckol  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydrogen  (EXP)
diiodine  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diltiazem  (ISO)
dimemorfan  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP,ISO)
diminazene diaceturate  (EXP)
Diosbulbin B  (ISO)
dioscin  (EXP)
diosgenin  (EXP,ISO)
diosmin  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP)
diquat  (EXP)
disodium cromoglycate  (EXP)
disodium selenite  (EXP,ISO)
docebenone  (ISO)
dodecanoic acid  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
edaravone  (EXP,ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
emamectin benzoate  (ISO)
embelin  (EXP)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ergosterol  (EXP)
ergothioneine  (EXP)
eriodictyol  (ISO)
erlotinib hydrochloride  (ISO)
esculetin  (ISO)
estriol  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethidium  (ISO)
ethyl acetate  (ISO)
ethylene glycol  (EXP)
ethylisopropylamiloride  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
eupatilin  (ISO)
Evodiamine  (ISO)
excitatory amino acid agonist  (EXP)
famotidine  (EXP)
Fargesin  (ISO)
fasudil  (EXP,ISO)
favipiravir  (EXP)
febuxostat  (EXP)
felodipine  (ISO)
fenbendazole  (ISO)
fenofibrate  (EXP,ISO)
fenpropathrin  (EXP)
ferroheme b  (ISO)
ferruginol  (ISO)
Fexofenadine hydrochloride  (ISO)
finasteride  (EXP)
fisetin  (EXP,ISO)
Flavokawain A  (ISO)
flavokawain B  (ISO)
flavone  (ISO)
flubendazole  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP,ISO)
fluticasone  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
fosinopril  (ISO)
Fraxinellone  (ISO)
friedelin  (ISO)
fructose  (EXP)
fucoidan  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
Fulvic acid  (ISO)
fumaric acid  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
Fusaric acid  (ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (ISO)
galangin  (EXP,ISO)
galanthamine  (EXP)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
Garcinol  (ISO)
gastrin-17  (ISO)
Gastrodin  (EXP,ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
gingerol  (ISO)
Ginkgolide A  (ISO)
Ginkgolide C  (EXP)
ginsenoside C-K  (EXP)
ginsenoside F1  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Re  (ISO)
gliclazide  (EXP)
gliotoxin  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (EXP,ISO)
glyburide  (EXP)
glycine betaine  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (EXP,ISO)
glyphosate  (EXP,ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
guggulsterone  (ISO)
GW 501516  (EXP)
GW 6471  (ISO)
gypenoside LXXV  (ISO)
haloperidol  (EXP)
harmaline  (ISO)
Harpagide  (ISO)
helenalin  (ISO)
heme b  (ISO)
hemin  (EXP)
heparin  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (ISO)
hinokiflavone  (ISO)
hispidulin  (ISO)
histamine  (EXP,ISO)
homocysteine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
huperzine A  (EXP)
hyaluronic acid  (EXP,ISO)
hydralazine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxysafflor yellow A  (ISO)
hydroxytyrosol  (ISO)
hypoxanthine  (ISO)
ibrutinib  (ISO)
ibuprofen  (ISO)
icariin  (EXP,ISO)
idelalisib  (ISO)
imidacloprid  (EXP)
immunological adjuvant  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
inulin  (ISO)
inuviscolide  (ISO)
iohexol  (ISO)
iomeprol  (ISO)
iopamidol  (ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) nitrilotriacetate  (EXP)
Isoangustone A  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoflurane  (EXP)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isothiocyanate  (ISO)
isotretinoin  (ISO)
isovitexin  (EXP)
ivermectin  (ISO)
jaceosidin  (ISO)
JBIR-99  (ISO)
JTE-013  (ISO)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
ketoconazole  (EXP)
KN-93  (ISO)
KT 5823  (ISO)
Kukoamine B  (ISO)
kuwanone G  (ISO)
kynurenic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-365260  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
L-methionine  (ISO)
L-proline betaine  (ISO)
L-selenocysteine  (ISO)
lactacystin  (ISO)
lactulose  (EXP)
lansoprazole  (EXP)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lentinan  (ISO)
Leonurine  (EXP,ISO)
leptomycin B  (ISO)
letrozole  (EXP)
levamisole  (ISO)
levofloxacin  (ISO)
Licochalcone B  (ISO)
licoricidin  (ISO)
limonene  (EXP)
linagliptin  (EXP,ISO)
linalyl acetate  (ISO)
linsidomine  (ISO)
linuron  (ISO)
lipoic acid  (EXP,ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lipoxin A4  (ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
liraglutide  (EXP)
lithium atom  (ISO)
lithium carbonate  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
lixisenatide  (ISO)
loganin  (EXP,ISO)
lonafarnib  (ISO)
losartan  (EXP,ISO)
Lucidone  (ISO)
lupeol  (EXP,ISO)
lutein  (ISO)
luteolin  (EXP,ISO)
luzindole  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Macrosphelide B  (ISO)
Magnolol  (ISO)
malaoxon  (ISO)
malathion  (EXP,ISO)
Malonoben  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
Mecamylamine  (EXP)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
menadione  (ISO)
mercaptoethanol  (ISO)
mercaptopurine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP,ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl beta-cyclodextrin  (ISO)
Methyl palmitate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (EXP)
methylisothiazolinone  (ISO)
methyllycaconitine  (EXP,ISO)
methylmercury chloride  (ISO)
Methylthiouracil  (ISO)
metronidazole  (ISO)
mevalonic acid  (EXP,ISO)
mevinphos  (EXP)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
miquelianin  (ISO)
mirabegron  (EXP)
mirtazapine  (EXP)
mitomycin C  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (EXP,ISO)
monotropein  (ISO)
montelukast  (EXP,ISO)
morin  (EXP)
morphine  (EXP,ISO)
Morroniside  (EXP,ISO)
morusin  (ISO)
moxifloxacin  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (EXP,ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
N(5)-ethyl-L-glutamine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N,N-dimethylsphingosine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-phenylthiourea  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naproxen  (ISO)
Narciclasine  (ISO)
naringin  (ISO)
neoastilbin  (ISO)
neoechinulin A  (ISO)
neomycin  (ISO)
neratinib  (ISO)
nerolidol  (EXP)
neurotensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nifedipine  (EXP)
nifuroxazide  (EXP)
nilotinib  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
nitroflurbiprofen  (EXP,ISO)
nitroglycerin  (EXP)
nitroprusside  (EXP,ISO)
nocodazole  (ISO)
Nodularin  (ISO)
nonane  (EXP)
nonivamide  (ISO)
Nonylphenol  (EXP,ISO)
NORCANTHARIDIN  (EXP)
notoginsenoside R1  (EXP,ISO)
nystatin  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
O-acetyl-L-carnitine  (EXP)
o-anisidine  (ISO)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (ISO)
oligopeptide  (ISO)
Olmesartan medoxomil  (EXP)
omacetaxine mepesuccinate  (ISO)
omeprazole  (EXP,ISO)
organoselenium compound  (EXP)
orlistat  (EXP)
oroxylin A  (EXP,ISO)
ospemifene  (ISO)
osthole  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
oxybenzone  (EXP)
oxybutynin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP,ISO)
Paeonol  (EXP,ISO)
palmatine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (EXP,ISO)
patchouli alcohol  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP,ISO)
peptidoglycan  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pergolide  (ISO)
perillyl alcohol  (EXP)
perindopril  (EXP,ISO)
permethrin  (EXP)
peroxynitrous acid  (ISO)
pevonedistat  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenylephrine  (EXP)
phenylpropanolamine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phloretin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosalone  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Phytolaccoside E  (ISO)
piclamilast  (EXP)
pifithrin-?  (EXP,ISO)
pinitol  (EXP)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pipoxolan  (ISO)
Pirarubicin  (EXP)
pirfenidone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP,ISO)
poly(ethylene)  (ISO)
poly(I:C)  (ISO)
poly(vinyl chloride)  (ISO)
polyphosphates  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium bromate  (EXP)
potassium dichromate  (EXP,ISO)
prilocaine  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP)
proanthocyanidin  (EXP)
probenecid  (EXP)
procyanidin B3  (ISO)
prodigiosin  (EXP,ISO)
progesterone  (EXP,ISO)
propanil  (ISO)
prostaglandin E1  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (EXP)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Punicalagin  (EXP)
purine-6-thiol  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercitrin  (EXP)
quinazolines  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
rasagiline  (ISO)
rebaudioside A  (EXP)
regorafenib  (ISO)
resiquimod  (ISO)
resolvin D1  (EXP,ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
Rhein  (EXP,ISO)
Rhynchophylline  (EXP)
rimonabant  (ISO)
ritonavir  (ISO)
rivaroxaban  (EXP)
rivastigmine  (EXP)
Rizatriptan benzoate  (EXP)
rocaglamide  (ISO)
roflumilast  (EXP,ISO)
romidepsin  (ISO)
rosmarinic acid  (EXP,ISO)
rotenone  (EXP,ISO)
royal jelly  (EXP)
rubimaillin  (ISO)
Ruscogenin  (ISO)
rutin  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
salicylates  (EXP)
salicylic acid  (EXP)
Salidroside  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salsalate  (EXP)
sappanchalcone  (ISO)
sarpogrelate  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 290157  (ISO)
SCH 23390  (EXP)
SCH772984  (ISO)
scoparone  (ISO)
scopolamine  (ISO)
scutellarin  (ISO)
SDZ PSC 833  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
semaglutide  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP)
shikimic acid  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sinigrin  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SM-164  (ISO)
SNX-2112  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
sodium chromate  (ISO)
sodium disulfite  (EXP)
sodium fluoride  (EXP,ISO)
sodium hydrogencarbonate  (ISO)
Sodium oleate  (ISO)
sodium propionate  (ISO)
Sodium salicylate  (EXP,ISO)
solasodine  (ISO)
Soman  (EXP)
Sophoricoside  (ISO)
sorafenib  (ISO)
sorbinil  (ISO)
soyasaponin I  (ISO)
sphingosine 1-phosphate  (ISO)
splitomicin  (ISO)
squalene  (EXP)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
succinic acid  (ISO)
sucrose  (ISO)
sulfasalazine  (EXP,ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sumatriptan  (EXP)
surfactin  (ISO)
surfactin C  (ISO)
synephrine  (ISO)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
Tanshinone I  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (EXP,ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (EXP)
teprenone  (ISO)
terameprocol  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (EXP)
Timosaponin b ii  (ISO)
Tiron  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
tolterodine tartrate  (ISO)
toluene 2,4-diisocyanate  (ISO)
tomatidine  (ISO)
tranilast  (EXP)
trans-anethole  (EXP,ISO)
trans-caffeic acid  (EXP)
trans-chalcone  (ISO)
trans-ferulic acid  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (EXP,ISO)
trelagliptin  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triciribine  (EXP)
triclosan  (ISO)
trilobatin  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
Tropicamide  (EXP)
tropisetron  (EXP,ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
umbelliferone  (EXP)
undecan-2-one  (EXP,ISO)
urethane  (ISO)
ursolic acid  (ISO)
vadimezan  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vanillin  (EXP)
varenicline  (ISO)
venlafaxine hydrochloride  (EXP)
venom  (ISO)
verteporfin  (ISO)
vildagliptin  (EXP,ISO)
vincamine  (ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
vitamin K  (EXP)
Voacamine  (ISO)
vorinostat  (ISO)
wedelolactone  (EXP,ISO)
withaferin A  (ISO)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
WR-1065  (ISO)
xanthohumol  (ISO)
Y-27632  (EXP,ISO)
Yangonin  (ISO)
yohimbine  (EXP)
zearalenone  (EXP,ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zingiberene  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
antiviral innate immune response  (ISO)
canonical NF-kappaB signal transduction  (IBA,ISO)
cellular response to angiotensin  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (IBA,IDA,IEP,ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to nicotine  (ISO)
cellular response to peptidoglycan  (ISO)
cellular response to tumor necrosis factor  (IDA,ISO)
chromatin organization  (ISO)
cytokine-mediated signaling pathway  (ISO)
defense response  (ISO)
defense response to tumor cell  (ISO)
DNA-templated transcription  (ISO)
hair follicle development  (ISO)
inflammatory response  (IBA,ISO)
innate immune response  (IBA)
interleukin-1-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
liver development  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of insulin receptor signaling pathway  (IMP)
negative regulation of miRNA transcription  (ISO)
negative regulation of non-canonical NF-kappaB signal transduction  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein sumoylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuropeptide signaling pathway  (ISO)
non-canonical NF-kappaB signal transduction  (IBA,ISO)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell population proliferation  (IMP,ISO)
positive regulation of chondrocyte differentiation  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of miRNA metabolic process  (ISO)
positive regulation of miRNA transcription  (IMP,ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of Schwann cell differentiation  (IMP)
positive regulation of T cell receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
postsynapse to nucleus signaling pathway  (ISO)
prolactin signaling pathway  (ISO)
protein catabolic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of inflammatory response  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to amino acid  (IEP)
response to bacterium  (ISO)
response to cAMP  (IEP)
response to cobalamin  (IEP)
response to cytokine  (IBA,IEP)
response to ethanol  (IEP)
response to hydrogen peroxide  (IEP)
response to insulin  (IEP)
response to interleukin-1  (ISO)
response to ischemia  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to muramyl dipeptide  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (IEP)
response to progesterone  (IEP)
response to UV-B  (ISO)
response to xenobiotic stimulus  (IEP)
toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor TLR6:TLR2 signaling pathway  (ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation. Abdulla D, etal., Drug Metab Dispos. 2005 Oct;33(10):1521-31. Epub 2005 Jul 8.
2. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
3. Selective up-regulation of I kappaB-alpha in ischemic penumbra following focal cerebral ischemia. Aronowski J, etal., Neuroreport. 2000 May 15;11(7):1529-33.
4. Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Bai D, etal., Sci Rep. 2016 Feb 24;6:22068. doi: 10.1038/srep22068.
5. Effect of early insulin therapy on nuclear factor kappaB and cytokine gene expressions in the liver and skeletal muscle of high-fat diet, streptozotocin-treated diabetic rats. Bi Y, etal., Acta Diabetol. 2008 May 24.
6. Activation of striatal inflammatory mediators and caspase-3 is central to haloperidol-induced orofacial dyskinesia. Bishnoi M, etal., Eur J Pharmacol. 2008 Jun 14.
7. Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension. Bivol LM, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R438-47. Epub 2007 Nov 21.
8. Upregulation of nuclear factor-kappaB (NF-kappaB) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus or disease outcome in cervical cancer. Branca M, etal., Diagn Cytopathol. 2006 Aug;34(8):555-63.
9. The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats. Cao JP, etal., Brain Res Bull. 2008 Jul 30;76(5):505-11. Epub 2008 Apr 9.
10. Fas-associated death-domain protein inhibits TNF-alpha mediated NF-kappaB activation in cardiomyocytes. Chao W, etal., Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2073-80. doi: 10.1152/ajpheart.01216.2004. Epub 2005 Jun 24.
11. Glutamine decreases intestinal nuclear factor kappa B activity and pro-inflammatory cytokine expression after traumatic brain injury in rats. Chen G, etal., Inflamm Res. 2008 Feb;57(2):57-64.
12. Progesterone prevents traumatic brain injury-induced intestinal nuclear factor kappa B activation and proinflammatory cytokines expression in male rats. Chen G, etal., Mediators Inflamm. 2007;2007:93431.
13. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-kappaB/COX-2/PGE2. Chen J, etal., Hum Reprod. 2012 Sep;27(9):2585-97. doi: 10.1093/humrep/des254. Epub 2012 Jul 9.
14. Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. Chen J, etal., Mol Med Report. 2011 Jun 2. doi: 10.3892/mmr.2011.501.
15. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Cheshire JL and Baldwin AS Jr, Mol Cell Biol. 1997 Nov;17(11):6746-54.
16. Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity. Choi JJ, etal., Free Radic Res. 2007 May;41(5):555-62.
17. High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure. Choy MK, etal., Genome Med. 2010 Jun 14;2(6):37. doi: 10.1186/gm158.
18. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
19. Postshock mesenteric lymph induces endothelial NF-kappaB activation. Damle SS, etal., J Surg Res. 2007 Nov;143(1):136-40. Epub 2007 Aug 20.
20. Pentoxifylline attenuates lung injury and modulates transcription factor activity in hemorrhagic shock. Deree J, etal., J Surg Res. 2007 Nov;143(1):99-108.
21. Hepatic transcription factor activation and proinflammatory mediator production is attenuated by hypertonic saline and pentoxifylline resuscitation after hemorrhagic shock. Deree J, etal., J Trauma. 2008 May;64(5):1230-8; discussion 1238-9.
22. Activation of nuclear factor-kappaB in human prostate carcinogenesis and association to biochemical relapse. Domingo-Domenech J, etal., Br J Cancer. 2005 Nov 28;93(11):1285-94.
23. Diabetes-induced atrophy is associated with a muscle-specific alteration in NF-kappaB activation and expression. Frier BC, etal., Cell Stress Chaperones. 2008 Jul 17.
24. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
25. Tamoxifen treatment for breast cancer enforces a distinct gene-expression profile on the human endometrium: an exploratory study. Gielen SC, etal., Endocr Relat Cancer. 2005 Dec;12(4):1037-49.
26. Spatial coordination of cell-adhesion molecules and redox cycling of iron in the microvascular inflammatory response to pulmonary injury. Gorbunov NV, etal., Antioxid Redox Signal. 2007 Apr;9(4):483-95.
27. Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats. Gu JW, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Dec;291(6):R1817-24. Epub 2006 Jul 13.
28. Differential alterations of NF-kappaB to oxidative stress in primary basal forebrain cultures. Gu Z, etal., Int J Dev Neurosci. 2000 Apr-Jun;18(2-3):185-92.
29. Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Gupta S, etal., Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H20-9. Epub 2005 Mar 4.
30. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Gurova KV, etal., Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17448-53. Epub 2005 Nov 15.
31. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
32. Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-kappaB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. Huang C, etal., Oncol Rep. 2009 Jul;22(1):89-95.
33. Expression of Toll-Like Receptors 2, 4 and Nuclear Factor Kappa B in Mucosal Lesions of Human Otitis: Pattern and Relationship in a Clinical Immunohistochemical Study. Jesic S, etal., Ann Otol Rhinol Laryngol. 2014 Apr 1.
34. MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. Jing H, etal., J Surg Res. 2012 Jul;176(1):63-73. doi: 10.1016/j.jss.2011.09.001. Epub 2011 Sep 29.
35. Acetaldehyde inhibits NF-kappaB activation through IkappaBalpha preservation in rat Kupffer cells. Jokelainen K, etal., Biochem Biophys Res Commun. 1998 Dec 30;253(3):834-6.
36. Brain synapses contain inducible forms of the transcription factor NF-kappa B. Kaltschmidt C, etal., Mech Dev. 1993 Oct;43(2-3):135-47.
37. Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. Kretzmann NA, etal., Inflamm Bowel Dis. 2008 Jul 11.
38. Nuclear localization of nuclear factor-kappaB p65 in primary prostate tumors is highly predictive of pelvic lymph node metastases. Lessard L, etal., Clin Cancer Res. 2006 Oct 1;12(19):5741-5.
39. Clinical significance of nuclear factor (NF)-kappaB levels in urothelial carcinoma of the urinary bladder. Levidou G, etal., Virchows Arch. 2008 Mar;452(3):295-304.
40. NF-kappaB regulates prenatal stress-induced cognitive impairment in offspring rats. Li H, etal., Behav Neurosci. 2008 Apr;122(2):331-9.
41. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Li Q, etal., Cell Biol Toxicol. 2021 Jul 31. pii: 10.1007/s10565-021-09638-5. doi: 10.1007/s10565-021-09638-5.
42. Histone demethylase JARID1B regulates proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension via nuclear factor-kappa B (NFkB). Li Y, etal., Cardiovasc Pathol. 2018 Nov-Dec;37:8-14. doi: 10.1016/j.carpath.2018.07.004. Epub 2018 Aug 3.
43. [Effects of Chaiqin Chengqi Decoction on activation of nuclear factor-kappaB in pancreas of rats with acute necrotizing pancreatitis] Li YH, etal., Zhong Xi Yi Jie He Xue Bao. 2008 Feb;6(2):180-4.
44. TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats. Lin ZP, etal., Mol Med Rep. 2020 Aug;22(2):651-660. doi: 10.3892/mmr.2020.11134. Epub 2020 May 7.
45. NF-kappaB site interacts with Sp factors and up-regulates the NR1 promoter during neuronal differentiation. Liu A, etal., J Biol Chem 2004 Apr 23;279(17):17449-58. Epub 2004 Feb 16.
46. Glial cell line-derived neurotrophic factor contributes to alcoholic-induced liver injury by regulating the NF-κB pathway. Liu X, etal., Alcohol Clin Exp Res. 2022 May;46(5):724-735. doi: 10.1111/acer.14815. Epub 2022 Apr 8.
47. Analysis of nucleotide-binding oligomerization domain proteins in a murine model of pneumococcal meningitis. Liu X, etal., BMC Infect Dis. 2014 Dec 2;14(1):648.
48. [Study on changes of protein phosphorylation of p65, IkappaBalpha and IkappaBepsilon in lymphocytes of rats in progress of aging and interventional effect of Epimedium flavonoids] Liu XY, etal., Zhongguo Zhong Yao Za Zhi. 2008 Jan;33(1):73-6.
49. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. Liu YP, etal., Eur J Pharmacol. 2007 Dec 22;577(1-3):28-34. Epub 2007 Aug 30.
50. MicroRNA-145 Protects against Myocardial Ischemia Reperfusion Injury via CaMKII-Mediated Antiapoptotic and Anti-Inflammatory Pathways. Liu Z, etal., Oxid Med Cell Longev. 2019 Sep 10;2019:8948657. doi: 10.1155/2019/8948657. eCollection 2019.
51. Linderae radix ethanol extract attenuates alcoholic liver injury via attenuating inflammation and regulating gut microbiota in rats. Lou Z, etal., Braz J Med Biol Res. 2019;52(6):e7628. doi: 10.1590/1414-431X20197628. Epub 2019 May 16.
52. Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation. Lubin FD, etal., J Neurochem. 2007 Nov;103(4):1381-95. Epub 2007 Aug 28.
53. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
54. Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells. Michalke M, etal., FEBS Lett. 2000 Jan 7;465(1):64-8.
55. Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats. Miyazaki A, etal., Graefes Arch Clin Exp Ophthalmol. 2008 May;246(5):747-57. Epub 2007 Dec 18.
56. Activation of nuclear factor-kappa B is linked to resistance to neoadjuvant chemotherapy in breast cancer patients. Montagut C, etal., Endocr Relat Cancer. 2006 Jun;13(2):607-16.
57. Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. Narayanan BA, etal., Clin Cancer Res. 2004 Nov 15;10(22):7727-37.
58. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
59. [NF-kappaB subunit p65/RelA expression in ovarian carcinoma: prognostic impact and link to COX-2 overexpression] Niesporek S, etal., Verh Dtsch Ges Pathol. 2007;91:243-9.
60. Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB. Nishida M, etal., Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6662-7. doi: 10.1073/pnas.1017640108. Epub 2011 Apr 4.
61. Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter. Novitskiy G, etal., J Biol Chem 2004 Apr 9;279(15):15639-44. Epub 2004 Jan 13.
62. Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB. Oka D, etal., Int J Cancer. 2007 Jun 15;120(12):2576-81.
63. Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma. Oya M, etal., Carcinogenesis. 2003 Mar;24(3):377-84.
64. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
65. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
66. Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta. Pizzi M, etal., J Biol Chem. 2002 Jun 7;277(23):20717-23. Epub 2002 Mar 23.
67. Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. Planavila A, etal., J Biol Chem. 2005 Apr 29;280(17):17464-71. Epub 2005 Feb 22.
68. Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction. Quiroz Y, etal., Am J Physiol Renal Physiol. 2008 Feb;294(2):F336-44. Epub 2007 Dec 12.
69. Nuclear factor-kappaB decoy amelioration of spinal cord injury-induced inflammation and behavior outcomes. Rafati DS, etal., J Neurosci Res. 2008 Feb 15;86(3):566-80.
70. MOLECULAR CLASSIFICATION OF BREAST CARCINOMA IN SITU. Raju U, etal., Curr Genomics. 2006 Dec;7(8):523-532.
71. Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression. Ramdass B, etal., Gynecol Oncol. 2007 Feb;104(2):352-61. Epub 2006 Nov 13.
72. GOA pipeline RGD automated data pipeline
73. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
74. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
75. Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence. Ross JS, etal., Clin Cancer Res. 2004 Apr 1;10(7):2466-72.
76. The Protective Effect of CAPE on Hepatic Ischemia/Reperfusion Injury in Rats. Saavedra-Lopes M, etal., J Surg Res. 2008 Mar 13.
77. A nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats. Sawada H, etal., Chest. 2007 Oct;132(4):1265-74.
78. NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival. Scatena M, etal., J Cell Biol. 1998 May 18;141(4):1083-93.
79. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Sheu WH, etal., Obesity (Silver Spring). 2008 May;16(5):1033-8. Epub 2008 Mar 6.
80. Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model. Shukla S, etal., Prostate. 2005 Aug 1;64(3):224-39.
81. ANTIAPOPTOTIC AND ANTI-INFLAMMATORY EFFECTS OF HYDROGEN SULFIDE IN A RAT MODEL OF REGIONAL MYOCARDIAL I/R. Sivarajah A, etal., Shock. 2008 Jul 16.
82. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
83. Amitriptyline induces nuclear transcription factor-kappaB-dependent glutamate transporter upregulation in chronic morphine-infused rats. Tai YH, etal., Neuroscience. 2008 May 15;153(3):823-31. Epub 2008 Mar 6.
84. Basic fibroblast growth factor stimulates fibronectin expression through phospholipase C gamma, protein kinase C alpha, c-Src, NF-kappaB, and p300 pathway in osteoblasts. Tang CH, etal., J Cell Physiol. 2007 Apr;211(1):45-55.
85. Diminished expression of transcription factors nuclear factor kappaB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice. Torroella-Kouri M, etal., Cancer Res. 2005 Nov 15;65(22):10578-84.
86. Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activities. Trecca D, etal., Oncogene. 1997 Feb 20;14(7):791-9.
87. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Tyagi A, etal., Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3248-55.
88. Indirect down-regulation of nuclear NF-kappaB levels by cobalamin in the spinal cord and liver of the rat. Veber D, etal., J Neurosci Res. 2008 May 1;86(6):1380-7.
89. Demethylation of miR-9-3 and miR-193a genes suppresses proliferation and promotes apoptosis in non-small cell lung cancer cell lines. Wang J, etal., Cell Physiol Biochem. 2013;32(6):1707-19. doi: 10.1159/000356605. Epub 2013 Dec 13.
90. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Wang W, etal., Clin Cancer Res. 1999 Jan;5(1):119-27.
91. Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia. Wang X, etal., Brain Res. 2008 Oct 9;1234:8-15. Epub 2008 Aug 5.
92. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
93. Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase. Wei Y, etal., Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E345-51. Epub 2007 Dec 11.
94. Cytosolic glucocorticoid receptor interaction with nuclear factor-kappa B proteins in rat liver cells. Widen C, etal., Biochem J. 2003 Jul 1;373(Pt 1):211-20.
95. Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Wu R, etal., Am J Respir Crit Care Med. 2007 Oct 15;176(8):805-13. Epub 2007 Jul 12.
96. Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis. Wu S, etal., J Biol Chem. 2007 Nov 16;282(46):33698-706. Epub 2007 Sep 19.
97. Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. Xie C, etal., J Cell Physiol. 2015 Aug;230(8):1906-15. doi: 10.1002/jcp.24921.
98. MicroRNA-27a/b mediates endothelin-1-induced PPAR¿ reduction and proliferation of pulmonary artery smooth muscle cells. Xie X, etal., Cell Tissue Res. 2017 Sep;369(3):527-539. doi: 10.1007/s00441-017-2625-9. Epub 2017 May 8.
99. Evidence for activation of nuclear factor kappaB in obstructive sleep apnea. Yamauchi M, etal., Sleep Breath. 2006 Dec;10(4):189-93.
100. [Molecular mechanism of berberine in improving insulin resistance induced by free fatty acid through inhibiting nuclear trascription factor-kappaB p65 in 3T3-L1 adipocytes] Yi P, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Dec;27(12):1099-104.
101. Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype. Yoon C, etal., J Neurosci. 2008 Apr 2;28(14):3738-46.
102. Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid. Yu N, etal., Neurochem Res. 2017 Aug;42(8):2167-2177. doi: 10.1007/s11064-017-2224-x. Epub 2017 Mar 16.
103. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-kappaB-dependent transcriptional activity. Yu SS, etal., Br J Pharmacol. 2013 Jan;168(1):117-28. doi: 10.1111/j.1476-5381.2012.01903.x.
104. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
105. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
106. PANAX NOTOGINSENG SAPONINS ATTENUATE ATHEROSCLEROSIS IN RATS BY REGULATING THE BLOOD LIPID PROFILE AND AN ANTI-INFLAMMATORY ACTION. Zhang YG, etal., Clin Exp Pharmacol Physiol. 2008 Jul 9.
107. Altered biliary epithelial cell and monocyte responses to lipopolysaccharide as a TLR ligand in patients with primary biliary cirrhosis. Zhao J, etal., Scand J Gastroenterol. 2011 Apr;46(4):485-94. doi: 10.3109/00365521.2010.539624. Epub 2011 Jan 28.
108. Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats. Zhao LL, etal., J Zhejiang Univ Sci B. 2008 Jun;9(6):448-54.
109. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. Zhao X, etal., J Neurochem. 2007 May;101(3):652-63. Epub 2007 Jan 23.
110. Açaí (Euterpe oleracea Mart.) attenuates alcohol-induced liver injury in rats by alleviating oxidative stress and inflammatory response. Zhou J, etal., Exp Ther Med. 2018 Jan;15(1):166-172. doi: 10.3892/etm.2017.5427. Epub 2017 Nov 1.
111. Nuclear factor kappaB p65 phosphorylation in orthodontic tooth movement. Zuo J, etal., J Dent Res. 2007 Jun;86(6):556-9.
Additional References at PubMed
PMID:1406630   PMID:3091258   PMID:3140380   PMID:7603567   PMID:7739562   PMID:7959007   PMID:8246997   PMID:8289784   PMID:8441377   PMID:9120401   PMID:9425125   PMID:9437432  
PMID:10227969   PMID:10498867   PMID:10521409   PMID:10660609   PMID:10747850   PMID:10849440   PMID:11567019   PMID:11931770   PMID:12048232   PMID:12527755   PMID:12598936   PMID:12748188  
PMID:12761501   PMID:12924514   PMID:12947408   PMID:14568984   PMID:14961764   PMID:15220916   PMID:15465828   PMID:15489227   PMID:15616591   PMID:15621209   PMID:15661922   PMID:15665736  
PMID:15684432   PMID:15695822   PMID:15790681   PMID:15793859   PMID:15802625   PMID:15817708   PMID:15845452   PMID:15876188   PMID:15923614   PMID:15944286   PMID:15946255   PMID:15983725  
PMID:15989798   PMID:15994334   PMID:16015706   PMID:16079150   PMID:16115032   PMID:16135962   PMID:16207754   PMID:16230799   PMID:16249387   PMID:16260493   PMID:16306362   PMID:16316526  
PMID:16316997   PMID:16317091   PMID:16322063   PMID:16344406   PMID:16481354   PMID:16513650   PMID:16643855   PMID:16705144   PMID:16707502   PMID:16822942   PMID:16855770   PMID:16875840  
PMID:16908285   PMID:16923814   PMID:17029595   PMID:17041012   PMID:17082476   PMID:17278014   PMID:17320758   PMID:17347452   PMID:17350185   PMID:17396235   PMID:17487688   PMID:17546582  
PMID:17615156   PMID:17785205   PMID:17881497   PMID:17891781   PMID:17935821   PMID:18045535   PMID:18073330   PMID:18074385   PMID:18090225   PMID:18212740   PMID:18279996   PMID:18296632  
PMID:18346469   PMID:18378183   PMID:18505784   PMID:18590796   PMID:18693253   PMID:18703048   PMID:18704302   PMID:18922796   PMID:18986327   PMID:18989778   PMID:19058135   PMID:19067778  
PMID:19111928   PMID:19247578   PMID:19338389   PMID:19404405   PMID:19460707   PMID:19506532   PMID:19551494   PMID:19557165   PMID:19619491   PMID:19887633   PMID:20007738   PMID:20143141  
PMID:20187708   PMID:20407877   PMID:20442316   PMID:20495289   PMID:20547752   PMID:20640583   PMID:20667985   PMID:20826536   PMID:20836702   PMID:20855265   PMID:20945364   PMID:20965833  
PMID:21072211   PMID:21097510   PMID:21131967   PMID:21162200   PMID:21169355   PMID:21310825   PMID:21323644   PMID:21343177   PMID:21343296   PMID:21368742   PMID:21402781   PMID:21474709  
PMID:21515354   PMID:21518763   PMID:21550382   PMID:21556775   PMID:21564349   PMID:21592969   PMID:21598036   PMID:21617130   PMID:21619797   PMID:21675116   PMID:21764683   PMID:21830064  
PMID:21874024   PMID:21932136   PMID:21941782   PMID:21984552   PMID:22004609   PMID:22065573   PMID:22106405   PMID:22227519   PMID:22244329   PMID:22286145   PMID:22302604   PMID:22357537  
PMID:22381070   PMID:22389501   PMID:22403241   PMID:22476978   PMID:22528217   PMID:22592403   PMID:22659586   PMID:22749778   PMID:22943758   PMID:22948157   PMID:23082119   PMID:23091055  
PMID:23165517   PMID:23178297   PMID:23184950   PMID:23249427   PMID:23262141   PMID:23278698   PMID:23425217   PMID:23457503   PMID:23603904   PMID:23619365   PMID:23631839   PMID:23729669  
PMID:23762333   PMID:23769970   PMID:23811396   PMID:23859035   PMID:23878390   PMID:23996632   PMID:24141017   PMID:24223152   PMID:24265774   PMID:24501220   PMID:24519937   PMID:24605601  
PMID:24704266   PMID:24717912   PMID:24724624   PMID:24768298   PMID:24823858   PMID:24833547   PMID:24842692   PMID:24955228   PMID:25152367   PMID:25171482   PMID:25200138   PMID:25214282  
PMID:25327529   PMID:25411248   PMID:25515214   PMID:25635047   PMID:25695672   PMID:25759242   PMID:25762865   PMID:25804640   PMID:25858763   PMID:26125466   PMID:26130762   PMID:26229403  
PMID:26268439   PMID:26280903   PMID:26435691   PMID:26438340   PMID:26439929   PMID:26449460   PMID:26454173   PMID:26477714   PMID:26526450   PMID:26567049   PMID:26649771   PMID:26686249  
PMID:26718002   PMID:26744383   PMID:26764146   PMID:27169686   PMID:27214337   PMID:27363337   PMID:27412936   PMID:27431018   PMID:27438966   PMID:27474069   PMID:27687740   PMID:27736973  
PMID:27901470   PMID:27916733   PMID:27957800   PMID:28245468   PMID:28257878   PMID:28359050   PMID:28560440   PMID:28935810   PMID:28988741   PMID:29147463   PMID:29272024   PMID:29303021  
PMID:29324390   PMID:29359143   PMID:29524303   PMID:29813070   PMID:29860993   PMID:29907783   PMID:30213522   PMID:30449218   PMID:30497068   PMID:30521085   PMID:30522932   PMID:30616245  
PMID:30619251   PMID:30935684   PMID:31096078   PMID:31971058   PMID:31975410   PMID:32114772   PMID:32124969   PMID:32240615   PMID:32396274   PMID:32594339   PMID:32935630   PMID:33383282  
PMID:33435858   PMID:33537798   PMID:33580994   PMID:33864663   PMID:34294375   PMID:34411492   PMID:34920740   PMID:35488974   PMID:35609523   PMID:35851539   PMID:37493703   PMID:37976702  
PMID:37980653   PMID:38679120   PMID:38710294  


Genomics

Comparative Map Data
Rela
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,354,336 - 212,364,815 (+)NCBIGRCr8
mRatBN7.21202,925,001 - 202,935,484 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,924,945 - 202,935,484 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,277,590 - 211,288,062 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,370,406 - 218,380,885 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,061,451 - 211,071,930 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01220,992,770 - 221,003,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,992,770 - 221,003,249 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,928,092 - 227,938,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,262,669 - 208,273,148 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,416,121 - 208,426,601 (+)NCBI
Celera1200,460,753 - 200,471,232 (+)NCBICelera
Cytogenetic Map1q43NCBI
RELA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,653,601 - 65,663,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,653,599 - 65,663,090 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,421,072 - 65,431,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,178,393 - 65,186,951 (-)NCBINCBI36Build 36hg18NCBI36
Build 341165,178,392 - 65,186,951NCBI
Celera1162,747,772 - 62,757,128 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,748,056 - 61,757,436 (-)NCBIHuRef
CHM1_11165,305,002 - 65,314,374 (-)NCBICHM1_1
T2T-CHM13v2.01165,647,771 - 65,658,027 (-)NCBIT2T-CHM13v2.0
Rela
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,686,993 - 5,698,162 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,687,511 - 5,698,158 (+)EnsemblGRCm39 Ensembl
GRCm38195,637,442 - 5,648,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,637,483 - 5,648,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,637,490 - 5,648,130 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,637,490 - 5,648,130 (+)NCBIMGSCv36mm8
Celera195,507,082 - 5,517,707 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Rela
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,603,345 - 19,611,516 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,602,930 - 19,612,263 (+)NCBIChiLan1.0ChiLan1.0
RELA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,883,435 - 66,892,833 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,926,207 - 67,935,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01161,012,839 - 61,022,225 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,347,859 - 64,357,461 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,347,859 - 64,356,868 (-)Ensemblpanpan1.1panPan2
RELA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,550,003 - 51,558,861 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,550,040 - 51,558,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,158,512 - 50,167,377 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,587,297 - 52,596,161 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,587,329 - 52,596,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,687,144 - 51,696,009 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,261,264 - 51,270,127 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,051,615 - 52,060,481 (+)NCBIUU_Cfam_GSD_1.0
Rela
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,359,432 - 7,368,234 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,801,636 - 3,809,813 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,800,142 - 3,810,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RELA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,593,969 - 6,603,469 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,594,869 - 6,602,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,699,452 - 5,707,267 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RELA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,576,059 - 8,585,561 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,576,542 - 8,586,516 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,871,180 - 105,881,402 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rela
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,732,938 - 20,741,272 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,732,813 - 20,742,016 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rela
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:331
Count of miRNA genes:186
Interacting mature miRNAs:216
Transcripts:ENSRNOT00000045233
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat

Markers in Region
UniSTS:144339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21202,928,647 - 202,928,735 (+)MAPPERmRatBN7.2
Rnor_6.01220,996,417 - 220,996,504NCBIRnor6.0
Rnor_5.01227,931,739 - 227,931,826UniSTSRnor5.0
RGSC_v3.41208,266,316 - 208,266,403UniSTSRGSC3.4
Celera1200,464,400 - 200,464,487UniSTS
Cytogenetic Map1q43UniSTS
RH131235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21202,935,103 - 202,935,323 (+)MAPPERmRatBN7.2
Rnor_6.01221,002,873 - 221,003,092NCBIRnor6.0
Rnor_5.01227,938,195 - 227,938,414UniSTSRnor5.0
RGSC_v3.41208,272,772 - 208,272,991UniSTSRGSC3.4
Celera1200,470,856 - 200,471,075UniSTS
RH 3.4 Map11547.4UniSTS
Cytogenetic Map1q43UniSTS
BF419700  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21202,923,539 - 202,923,635 (+)MAPPERmRatBN7.2
Rnor_6.01220,991,309 - 220,991,404NCBIRnor6.0
Rnor_5.01227,926,631 - 227,926,726UniSTSRnor5.0
RGSC_v3.41208,261,207 - 208,261,302UniSTSRGSC3.4
Celera1200,459,293 - 200,459,388UniSTS
RH 3.4 Map11550.1UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000045233   ⟹   ENSRNOP00000044552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,924,976 - 202,935,484 (+)Ensembl
Rnor_6.0 Ensembl1220,992,770 - 221,003,249 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096964   ⟹   ENSRNOP00000079173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,925,218 - 202,935,480 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098164   ⟹   ENSRNOP00000088637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,925,218 - 202,935,480 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099757   ⟹   ENSRNOP00000098008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,925,218 - 202,935,480 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100435   ⟹   ENSRNOP00000080281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1202,924,945 - 202,935,466 (+)Ensembl
RefSeq Acc Id: NM_199267   ⟹   NP_954888
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,354,336 - 212,364,815 (+)NCBI
mRatBN7.21202,925,001 - 202,935,480 (+)NCBI
Rnor_6.01220,992,770 - 221,003,249 (+)NCBI
Rnor_5.01227,928,092 - 227,938,571 (+)NCBI
RGSC_v3.41208,262,669 - 208,273,148 (+)RGD
Celera1200,460,753 - 200,471,232 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079521   ⟹   XP_038935449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81212,355,132 - 212,364,815 (+)NCBI
mRatBN7.21202,925,797 - 202,935,484 (+)NCBI
RefSeq Acc Id: NP_954888   ⟸   NM_199267
- UniProtKB: Q7TQN4 (UniProtKB/TrEMBL),   A0A2Z5ZBL4 (UniProtKB/TrEMBL),   A0A8I6A5H5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044552   ⟸   ENSRNOT00000045233
RefSeq Acc Id: XP_038935449   ⟸   XM_039079521
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000079173   ⟸   ENSRNOT00000096964
Ensembl Acc Id: ENSRNOP00000098008   ⟸   ENSRNOT00000099757
Ensembl Acc Id: ENSRNOP00000080281   ⟸   ENSRNOT00000100435
Ensembl Acc Id: ENSRNOP00000088637   ⟸   ENSRNOT00000098164
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQN4-F1-model_v2 AlphaFold Q7TQN4 1-550 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690666
Promoter ID:EPDNEW_R1191
Type:initiation region
Name:Rela_1
Description:RELA proto-oncogene, NF-kB subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01220,992,742 - 220,992,802EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727889 AgrOrtholog
BioCyc Gene G2FUF-56666 BioCyc
Ensembl Genes ENSRNOG00000030888 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045233.4 UniProtKB/TrEMBL
  ENSRNOT00000096964.1 UniProtKB/TrEMBL
  ENSRNOT00000098164.1 UniProtKB/TrEMBL
  ENSRNOT00000099757.1 UniProtKB/TrEMBL
  ENSRNOT00000100435.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121610 IMAGE-MGC_LOAD
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_NFkappaB UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NF_Rel_dor UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RelA UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_CS UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report rno:309165 UniProtKB/TrEMBL
MGC_CLONE MGC:95012 IMAGE-MGC_LOAD
NCBI Gene 309165 ENTREZGENE
PANTHER PTHR24169 UniProtKB/TrEMBL
  PTHR24169:SF1 UniProtKB/TrEMBL
Pfam RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
PhenoGen Rela PhenoGen
PRINTS NFKBTNSCPFCT UniProtKB/TrEMBL
PROSITE REL_1 UniProtKB/TrEMBL
  REL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030888 RatGTEx
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP Ig_E-set UniProtKB/TrEMBL
  P53_like_DNA_bnd UniProtKB/TrEMBL
UniProt A0A2Z5ZBL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMV7_RAT UniProtKB/TrEMBL
  A0A8I6A5H5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATQ5_RAT UniProtKB/TrEMBL
  F7F7J5_RAT UniProtKB/TrEMBL
  Q7TQN4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Rela  RELA proto-oncogene, NF-kB subunit  Rela  v-rel avian reticuloendotheliosis viral oncogene homolog A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Rela  v-rel avian reticuloendotheliosis viral oncogene homolog A  Rela  v-rel reticuloendotheliosis viral oncogene homolog A (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Rela  v-rel reticuloendotheliosis viral oncogene homolog A (avian)      Symbol and Name status set to approved 1299863 APPROVED