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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects abundanceISORela (Mus musculus)6480464CTDRELA protein affects the abundance of GlutathionePMID:20159942
Relaincreases glutathionylationISORELA (Homo sapiens)6480464CTDGlutathione results in increased glutathionylation of RELA proteinPMID:20116392 PMID:20351055
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; [cinnamaldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] results in increased glutathionylation of RELA protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]PMID:16219905 PMID:17640567 PMID:20351055
Relamultiple interactionsISORela (Mus musculus)6480464CTDGlutathione affects the reaction [Sodium Selenite results in increased expression of RELA mRNA]; Glutathione inhibits the reaction [Alcohols results in increased expression of RELA protein]PMID:18449455 PMID:28803762
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