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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:132853
Term: acteoside
Definition: A glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid.
Chemical ID: MESH:C058956
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases phosphorylationISORELA (Homo sapiens)6480464CTDacteoside results in decreased phosphorylation of RELA proteinPMID:23527233
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDacteoside results in increased phosphorylation of RELA proteinPMID:23527233
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDacteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]PMID:21756928
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