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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases acetylationEXP 6480464CTDchromium hexavalent ion results in increased acetylation of RELA proteinPMID:35024197
Relamultiple interactionsEXP 6480464CTD[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of RELA protein; Resveratrol inhibits the reaction [chromium hexavalent ion results in increased acetylation of RELA protein]; S-allylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased expression of RELA protein]PMID:28988497 PMID:35024197
Relaincreases localizationISORELA (Homo sapiens)6480464CTDchromium hexavalent ion results in increased localization of RELA proteinPMID:23748240
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDchromium hexavalent ion results in increased activity of and affects the localization of RELA protein; Luteolin inhibits the reaction [chromium hexavalent ion results in increased activity of and affects the localization of RELA protein]; MIR143 inhibits the reaction [chromium hexavalent ion results in increased localization of RELA protein]PMID:23748240 PMID:25448439
Relamultiple interactionsISORela (Mus musculus)6480464CTD[chromium hexavalent ion promotes the reaction [RELA protein binds to PTGS2 promoter]] which results in increased expression of PTGS2 mRNA; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of RELA protein; Acetylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of RELA protein]; chromium hexavalent ion promotes the reaction [RELA protein binds to PTGS2 promoter]PMID:22472290 PMID:36880428
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