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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [RELA protein modified form binds to IL6 promoter]]; fulvestrant inhibits the reaction [bisphenol A results in increased expression of RELA protein]; fulvestrant inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased phosphorylation of RELA protein]PMID:24771768 PMID:27522653 PMID:28390675
Relamultiple interactionsISORela (Mus musculus)6480464CTDFulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]]; Fulvestrant inhibits the reaction [sodium arsenite results in increased expression of RELA mRNA]; Fulvestrant inhibits the reaction [sodium arsenite results in increased expression of RELA protein]PMID:24722370 PMID:30684567
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