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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:75095
Term: chrysin
Definition: A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.
Chemical ID: MESH:C043561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDchrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein]; chrysin inhibits the reaction [Testosterone results in increased activity of RELA protein]PMID:21167192 PMID:23194824 PMID:29247772
Reladecreases expressionISORELA (Homo sapiens)6480464CTDchrysin results in decreased expression of RELA proteinPMID:30578657
Relaincreases activityISORELA (Homo sapiens)6480464CTDchrysin results in increased activity of RELA proteinPMID:18457675
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein]; chrysin inhibits the reaction [nickel chloride affects the localization of RELA protein]; SB 203580 inhibits the reaction [chrysin results in increased activity of RELA protein]PMID:18457675 PMID:21515303 PMID:30016632
Relamultiple interactionsISORela (Mus musculus)6480464CTDchrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]PMID:29054324
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